Evaluation of clinical and imaging factors of native T1 values in patients with stable coronary artery disease.

IF 1.9 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Cardiology Pub Date : 2025-07-17 DOI:10.1159/000547345

Runlan Luo, Qi'an Sun, Yi Zhao, Aihua Li, Hang Qu, Xiaoping Yu, Wei Wang

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引用次数: 0

Abstract

Introduction: Stable coronary artery disease (CAD) is a leading cause of cardiac morbidity and mortality worldwide, with elevated native T1 value linked to major adverse cardiovascular events (MACE). However, predictors of elevated native T1 value in stable CAD still need to be studied. This study aimed to identify clinical and imaging predictors of elevated native T1 values in CAD patients.

Methods: A total of 316 consecutive stable CAD patients (median age 58 years, 91.8% male) undergoing coronary computed tomography angiography (CCTA) and cardiovascular magnetic resonance (CMR) native T1 mapping were included, along with 30 age- and sex-matched healthy controls. Patients were divided into normal and elevated native T1 groups based on the normal global native T1 reference; logistic regressions were used to identify predictors.

Results: Patients with elevated native T1 values were more likely to be aged ≥60 years, abstain from alcohol, have abnormal electrocardiogram (ECG) findings, multi-vessel disease, non-calcified plaques, greater degrees of stenosis, stenosis ≥50% in two or three coronary arteries, and computed tomography-derived fractional flow reserve (CT-FFR) ≤0.8 (P<0.05). Multivariate logistic regression identified age ≥60 years (OR: 2.23, 95%CI: 1.15-4.30, P=0.018), stenosis ≥50% in two (OR: 13.27, 95%CI: 3.38-56.94, P<0.001) or three coronary arteries (OR: 114.19, 95%CI: 20.53-276.59, P<0.001) and left anterior descending FFR (LAD-FFR) ≤0.8 (OR:2.69, 95%CI: 1.16-6.29, P=0.021) as independent risk factors, whereas alcohol consumption (OR: 0.47, 95%CI: 0.25-0.88, P=0.019) was a predictor of normal native T1 values, with strong predictive performance (area under the curve =0.832, Brier Score=0.142).

Conclusion: Our findings help clinicians make individualized diagnosis and treatment of stable CAD patients, which also provide a foundation for predicting prognosis. (This research has been registered National Medical Research Registration and Filing Information System, numbered MR-32-24-030226).

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稳定期冠心病患者原生T1值的临床及影像学因素评价

稳定性冠状动脉疾病（CAD）是全球范围内心脏发病率和死亡率的主要原因，其原生T1值升高与主要不良心血管事件（MACE）有关。然而，在稳定型CAD中，原生T1值升高的预测因素仍需进一步研究。本研究旨在确定CAD患者原生T1值升高的临床和影像学预测因素。方法：共纳入316例连续稳定的CAD患者（中位年龄58岁，91.8%男性），接受冠状动脉ct血管造影（CCTA）和心血管磁共振（CMR）原生T1测绘，以及30例年龄和性别匹配的健康对照。根据整体天然T1正常参考值分为正常组和升高组；使用逻辑回归来确定预测因子。结果：原生T1值升高的患者年龄≥60岁、不饮酒、心电图异常、多支血管病变、非钙化斑块、狭窄程度较大、2、3支冠状动脉狭窄≥50%、CT-FFR≤0.8 (p)的可能性较大。我们的发现有助于临床医生对稳定型CAD患者进行个性化诊断和治疗，也为预测预后提供了基础。（本研究已在国家医学研究注册备案信息系统注册，编号MR-32-24-030226）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cardiology 医学-心血管系统

CiteScore

3.40

自引率

5.30%

发文量

审稿时长

1.5 months

期刊介绍： ''Cardiology'' features first reports on original clinical, preclinical and fundamental research as well as ''Novel Insights from Clinical Experience'' and topical comprehensive reviews in selected areas of cardiovascular disease. ''Editorial Comments'' provide a critical but positive evaluation of a recent article. Papers not only describe but offer critical appraisals of new developments in non-invasive and invasive diagnostic methods and in pharmacologic, nutritional and mechanical/surgical therapies. Readers are thus kept informed of current strategies in the prevention, recognition and treatment of heart disease. Special sections in a variety of subspecialty areas reinforce the journal''s value as a complete record of recent progress for all cardiologists, internists, cardiac surgeons, clinical physiologists, pharmacologists and professionals in other areas of medicine interested in current activity in cardiovascular diseases.