Cardiology最新文献

{"title":"Overlooked Trigger of Migraine: Clinical Significance of Small- and Medium-Shunt Patent Foramen Ovale.","authors":"Jia-Ning Fan, Ming-Fei Li, Bei-Jian Zhang, Lei Zhang, Wan-Jiao Chen, Da-Wei Lin, Long Cheng, Shi-Qiang Hou, Dan-Dan Chen, Hai-Yan Chen, Yu-Hao Li, Xiao-Chun Zhang, Da-Xin Zhou, Jun-Bo Ge","doi":"10.1159/000546696","DOIUrl":"10.1159/000546696","url":null,"abstract":"<p><strong>Introduction: </strong>Patent foramen ovale (PFO) is a prevalent congenital heart malformation closely linked with migraine. The effect of PFO size on migraine remains controversial.</p><p><strong>Methods: </strong>This study analyzed migraine patients who underwent PFO closure at our institution from January 2020 through December 2022. Based on transthoracic echocardiography findings, the patients were classified into two groups through two distinct classification approaches: method A - permanent shunt (PS) group or non-PS group, and method B - large shunt under Valsalva maneuver (LSVM) group or small-to-moderate shunt under Valsalva maneuver (SMSVM) group. Migraine improvement and adverse events after PFO closure were recorded.</p><p><strong>Results: </strong>A total of 201 migraine patients were included in this study, 110 (54.7%) had PS and 118 (58.7%) had LSVM. The PS and LSVM groups experienced less migraine burden (57.1 ± 64.5 vs. 88.5 ± 96.5 h, p = 0.035; 59.7 ± 67.3 vs. 88.9 ± 96.6 h, p = 0.039). The LSVM group had shorter headache episode durations (11.0 ± 8.2 vs. 14.4 ± 12.3 years, p = 0.045). The PS and LSVM groups showed less absolute reduction in migraine burden (33.8 ± 55.2 vs. 71.2 ± 84.9 h, p = 0.032; 33.9 ± 50.5 vs. 76.3 ± 92.8 h, p = 0.008). The LSVM group had a lower rate of alleviation (79.7% vs. 95.2%, p = 0.018). Medium-to-large residual shunt (MLRS) and SMSVM were independent predictors of migraine improvement, and a history of cryptogenic stroke (CS) was a predictor of migraine termination.</p><p><strong>Conclusion: </strong>SMSVM PFO in migraine patients has significant clinical implications and positive intervention outcomes. Both SMSVM and MLRS are associated with migraine relief, and a history of CS is a predictor of migraine termination.</p>","PeriodicalId":9391,"journal":{"name":"Cardiology","volume":" ","pages":"339-348"},"PeriodicalIF":1.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Burden of Rheumatic Heart Disease in Chinese Children and Adolescents versus Adults: An Analysis from the \"Global Burden of Disease\" Study.","authors":"Chengqiang Lei, Jian Liu, Xiangyong Liu, Zhi Yang","doi":"10.1159/000546878","DOIUrl":"10.1159/000546878","url":null,"abstract":"<p><strong>Introduction: </strong>Rheumatic heart disease (RHD) is a globally important public health issue. China, as a populous country, has daunting challenges posed by RHD-related morbidity and mortality in the public health system. Evaluating and comparing the differences in the RHD burden of children and adolescents versus adults in China not only helps optimize domestic prevention and control strategies but also provides a reference for regional practices in RHD control.</p><p><strong>Methods: </strong>Open data from the 2021 Global Burden of Disease database were utilized to analyze the characteristics of the RHD burden of children, adolescents, and adults in China, including changes in morbidity and mortality. Joinpoint was utilized to calculate the average annual percentage change (AAPC). A comprehensive comparative analysis was undertaken on the differences in RHD burden in Chinese children, adolescents, and adults from multiple dimensions such as age, gender, and time.</p><p><strong>Results: </strong>From 1990 to 2021, the number of deaths of RHD in children and adolescents in China exhibited a declining trend compared to that in adults. In terms of the number of incidences, all age groups showed a declining trend except for those aged 55 and above, which manifested an upward trend. The crude incidence and crude mortality rates both declined during the same period, with their AAPC being -0.53 (95% CI: -0.61, -0.46) and -8.13 (95% CI: -8.65, -7.61) for those aged under 20 years, and -1.92 (95% CI: -2.05, -1.80) and -2.98 (95% CI: -3.18, -2.79) for those aged 20 years and above. The incidence and mortality rates had a bearing on patient age, with higher incidence rates observed in children and adolescents and higher mortality rates observed in adults. According to the analysis of gender differences, the incidence of children and adolescents was higher in men, while women always had a higher crude incidence rate (CIR) and mortality rate (CDR) than men (CIR in 2021: 21.31/100,000 for women vs. 20.08/100,000 for men; CDR: 0.05/100,000 for women vs. 0.06/100,000 for men). The mortality rate of adult women was particularly prominent. The number of cases in children and adolescents exhibited a \"W-shaped\" fluctuation, while the adult group showed an \"M-shaped\" trend. The overall CIR and CDR both exhibited a downward trend.</p><p><strong>Conclusion: </strong>The burden of RHD is linked to age and gender, with a high incidence in young people and a high mortality rate in adults. Women are more prone to develop the disease and have a higher risk of mortality. Given China's large and aging population, RHD remains a major public health challenge in China. Effective prevention and control strategies should be underscored.</p>","PeriodicalId":9391,"journal":{"name":"Cardiology","volume":" ","pages":"362-374"},"PeriodicalIF":1.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144367924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endomyocardial Biopsy: Evaluating the Impact of Updated Indications on Diagnostic Yield.","authors":"María Teresa Politi","doi":"10.1159/000545774","DOIUrl":"10.1159/000545774","url":null,"abstract":"","PeriodicalId":9391,"journal":{"name":"Cardiology","volume":" ","pages":"83-85"},"PeriodicalIF":1.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic Arterial Lactate Values Are Associated with 30-Day Mortality in Patients with Acute Myocardial Infarction and Cardiogenic Shock on Intra-Aortic Balloon Pump Circulatory Support.","authors":"Javier López Pais, Victor Jimenez Ramos, María López Pais, Guillermo Gallego Latorre, Luis Manuel López Barreiro","doi":"10.1159/000545746","DOIUrl":"10.1159/000545746","url":null,"abstract":"","PeriodicalId":9391,"journal":{"name":"Cardiology","volume":" ","pages":"302-303"},"PeriodicalIF":1.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanisms and Intervention Strategies of Trimethylamine N-Oxide in Abdominal Aortic Aneurysm.","authors":"Dilixiati Abudureheman, Shuake Janaerbieke, Yuhang Song, Shuo Han, Wufuer Yimaer, Huguo Wang","doi":"10.1159/000546190","DOIUrl":"10.1159/000546190","url":null,"abstract":"<p><p><p>Background: Abdominal aortic aneurysm (AAA) is a serious cardiovascular disease with high morbidity and mortality. The role of gut microbiota-derived metabolite trimethylamine N-oxide (TMAO) in AAA pathogenesis has attracted increasing attention. Summary: This review systematically summarizes the mechanisms by which TMAO promotes AAA development, including inflammatory activation, apoptosis induction, and extracellular matrix degradation. TMAO interacts with risk factors such as atherosclerosis and hypertension through pathways involving NF-κB, NLRP3 inflammasome, and endoplasmic reticulum stress. Intervention strategies targeting dietary precursors, gut microbiota, and key enzymes are critically evaluated. Key Messages: TMAO serves as both a biomarker and a therapeutic target for AAA. Future research should prioritize personalized dietary interventions and novel TMAO inhibitors to bridge translational gaps. </p>.</p>","PeriodicalId":9391,"journal":{"name":"Cardiology","volume":" ","pages":"265-284"},"PeriodicalIF":1.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12180771/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction Statement.","authors":"","doi":"10.1159/000550556","DOIUrl":"10.1159/000550556","url":null,"abstract":"<p><p>The accepted manuscript \"Cardiac Arrhythmias Associated with Brain Tumors: A Systematic Review\" [Cardiology. 2025, https://doi.org/10.1159/000549272] by Darshan Hullon, Eesha Farhan, Fatima Hussain, Abiya Ahad, Mandana Akhavan, and Mahmoud H. Abouelsoud has been retracted.After peer review, the accepted, unedited manuscript was published online as Early View. Before the final Version of Record was published, errors in the following references were identified: 21, 28, 29, 32, 33, and 34.The authors stated that the errors in the references arose due to some fields being incorrectly transcribed. The Editor did not find that the concerns had been addressed satisfactorily and, as a consequence, rescinded the acceptance decision and rejected the manuscript. Consequently, the published author's accepted manuscript has been retracted. The authors disagree with the retraction.</p>","PeriodicalId":9391,"journal":{"name":"Cardiology","volume":" ","pages":"264"},"PeriodicalIF":1.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147289336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Subclinical Hypothyroidism on Coagulation Parameters and Coronary Artery Disease Severity in Patients with Coronary Heart Disease.","authors":"Wei Guo, Li-Yuan Hou, Xin Yi","doi":"10.1159/000545904","DOIUrl":"10.1159/000545904","url":null,"abstract":"<p><strong>Introduction: </strong>This study evaluated the effect of subclinical hypothyroidism (SCH) on coagulation parameters and the progression of coronary artery disease in patients with coronary heart disease (CHD).</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 452 patients who were diagnosed with CHD through coronary angiography between January 2020 and December 2021 at the Department of Cardiology, Jining First People's Hospital. The patients were divided into three groups based on thyroid-stimulating hormone (TSH) levels: a normal thyroid function group (244 cases), a mild SCH group (162 cases), and a severe SCH group (46 cases). General demographic data, coagulation parameters, number of affected coronary vessels, stenosis location, and stenosis severity were compared across the groups.</p><p><strong>Results: </strong>(1) Significant differences were observed among the three groups in terms of sex, age, TSH, free tri-iodothyronine (FT3), free thyroxine (FT4), triglycerides, total cholesterol, low-density lipoprotein cholesterol, fibrinogen, prothrombin time, activated partial thromboplastin time, D-dimer, mean platelet volume, and platelet distribution width (p < 0.05). (2) The Gensini scores were 27 (17, 43.88) for the normal thyroid function group, 37.5 (25, 52.25) for the mild SCH group, and 48 (32.88, 73.75) for the severe SCH group, showing statistically significant differences (p < 0.05). (3) There was a positive correlation between Gensini score and TSH (r = 0.243, p < 0.05) and negative correlations between Gensini score and both FT3 (r = -0.139, p < 0.05) and FT4 (r = -0.12, p < 0.05). (4) TSH level, hypertension history, and lipoprotein(a) were identified as risk factors for Gensini score (p < 0.05).</p><p><strong>Conclusion: </strong>Patients with CHD and SCH present a hypercoagulable state and an elevated risk of thrombosis. TSH levels are linked to the severity of coronary artery stenosis, underscoring the importance of early thyroid function testing in patients with CHD to inform treatment decisions.</p>","PeriodicalId":9391,"journal":{"name":"Cardiology","volume":" ","pages":"151-161"},"PeriodicalIF":1.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Changes in Fasting Plasma Glucose before and after Heart Failure Diagnosis on All-Cause Mortality.","authors":"Boheng Zhang, Xiaokun Liu, Shouling Wu, Jing Yang, Qing Yue, Shuohua Chen, Quanle Han, Wei Wang, Qi Zhang","doi":"10.1159/000546661","DOIUrl":"10.1159/000546661","url":null,"abstract":"<p><strong>Introduction: </strong>Fasting plasma glucose (FPG) fluctuations are increasingly recognized as potential prognostic markers in cardiovascular diseases. However, the association between changes in FPG before and after heart failure (HF) diagnosis and long-term mortality remains unclear. This study aimed to evaluate the impact of FPG changes surrounding HF diagnosis on all-cause mortality to inform individualized HF management strategies.</p><p><strong>Methods: </strong>This prospective cohort study was conducted using data from the Kailuan study. A total of 3,533 patients newly diagnosed with HF were included after excluding individuals with a history of HF, malignancies, or missing FPG data. FPG levels measured before and after HF diagnosis were used to classify participants into five groups: significant decrease (Q1), mild decrease (Q2), stable (Q3), mild increase (Q4), and significant increase (Q5). The primary outcome was all-cause mortality, with follow-up through December 31, 2021. Survival outcomes were evaluated using Kaplan-Meier curves and multivariate Cox regression models.</p><p><strong>Results: </strong>During a mean follow-up of 5.63 ± 3.80 years, 1,446 all-cause deaths were recorded. Kaplan-Meier analysis demonstrated a significantly higher mortality risk associated with greater changes in FPG levels (log-rank p < 0.0001). In multivariable Cox models, both the Q1 (significant decrease) and Q5 (significant increase) groups exhibited elevated mortality risks compared to the Q3 (stable) group, with adjusted hazard ratios of 1.37 (95% CI: 1.12-1.67) and 1.35 (95% CI: 1.12-1.62), respectively.</p><p><strong>Conclusion: </strong>Significant changes in FPG before and after HF diagnosis are independently associated with increased all-cause mortality. These findings highlight the importance of maintaining glycemic stability and support the need for personalized glucose management strategies in patients with HF.</p>","PeriodicalId":9391,"journal":{"name":"Cardiology","volume":" ","pages":"308-321"},"PeriodicalIF":1.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal Decrease in Left Ventricular Size with Age: Impact on Mortality and Cardiovascular Hospitalization.","authors":"Israel Gotsman, Ayelet Shauer, Donna R Zwas, Andre Keren, Offer Amir, David Leibowitz","doi":"10.1159/000546673","DOIUrl":"10.1159/000546673","url":null,"abstract":"<p><p><p>Introduction: A small left ventricular (LV) chamber size may reflect adverse cardiac remodeling and have prognostic implications. The prognostic significance of reductions in LV size in hearts with normal baseline LV size remains unclear. This study investigated clinical characteristics and outcomes associated with longitudinal decreases in LV size in this population.</p><p><strong>Methods: </strong>We analyzed echocardiographic data from 6,232 adults with normal baseline left ventricular end-diastolic diameter (LVEDD), with a mean interval of 4.8 years between baseline and follow-up echocardiograms. Participants were categorized by LVEDD change from baseline: no change (<5 mm), decreased (≥5 mm), and increased (≥5 mm).</p><p><strong>Results: </strong>A decrease in LVEDD was observed in 24% of participants (mean change -9 ± 3 mm) and was significantly associated with older age, female sex, decreased volumes, concentric remodeling, and diastolic dysfunction. LVEDD increase (13%, 9 ± 4 mm) was associated with higher prevalence of cardiovascular comorbidities and reduced LVEF. Multivariable Cox regression showed decreased LVEDD was independently associated with increased mortality (HR 1.19, 95% CI: 1.03-1.37, p = 0.02). Sensitivity analysis using annual LVEDD change (>1 mm/year) demonstrated a significant association with mortality (HR 1.45, 95% CI: 1.26-1.66, p < 0.001) and the combined endpoint of death/cardiovascular hospitalization (HR 1.26, 95% CI: 1.12-1.41, p < 0.001). Restricted cubic spline analysis confirmed a U-shaped relationship between continuous LVEDD change and mortality. Furthermore, increase or decrease in LV end-diastolic volumes was associated with increased mortality and death/cardiovascular hospitalization.</p><p><strong>Conclusions: </strong>A progressive decrease in LVEDD in normal-sized hearts was independently associated with adverse outcomes, highlighting the prognostic importance of declining LV size. </p>.</p>","PeriodicalId":9391,"journal":{"name":"Cardiology","volume":" ","pages":"119-129"},"PeriodicalIF":1.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12215171/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endomyocardial Biopsy in Myocarditis: Assessing Safety and Prognostic Implications.","authors":"Mitra Chitsazan","doi":"10.1159/000545035","DOIUrl":"10.1159/000545035","url":null,"abstract":"","PeriodicalId":9391,"journal":{"name":"Cardiology","volume":" ","pages":"71-72"},"PeriodicalIF":1.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143954636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}