中国老年人的最佳 QT 校正公式:广州生物库队列研究。

IF 1.9 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS
Cardiology Pub Date : 2024-10-30 DOI:10.1159/000542238
Wen Bo Tian, Wei Sen Zhang, Chao Qiang Jiang, Xiang Yi Liu, Feng Zhu, Ya Li Jin, Tong Zhu, Tai Hing Lam, Kar Keung Cheng, Lin Xu
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引用次数: 0

摘要

引言目的:确定产生校正QT(QTc)的最佳QT校正公式和QTc过长的临界值,并研究其与中国老年人死亡率和心血管疾病(CVD)的关系:这项前瞻性研究纳入了广州生物库队列研究的 24,611 名 50 岁以上、2003-2008 年期间未患心血管疾病的中国人。QT间期用Bazett、Fridericia、Framingham和Hodges公式校正。QTc与心率回归的斜率和R2用于确定最佳校正公式。QTc 第 95 百分位数用于定义 QTc 延长。采用 Cox 回归检验 QTc 延长与死亡率和心血管疾病的关系。计算净再分类指数以评估风险再分类:结果:在平均 15.3 年的随访期间,共有 5,261 人死亡,5,539 人患心血管疾病。霍奇斯公式的心脏校正效果最佳,巴泽特公式的效果最差。经弗里德里西亚公式、弗莱明汉公式和霍奇斯公式校正的 QTc 延长与全因死亡率、心血管疾病死亡率和心血管疾病(尤其是冠心病、心肌梗死和缺血性中风)事件的关联强度相似,危险比分别约为 1.25、1.40 和 1.15。它们还将全因死亡率、心血管疾病死亡率和心血管疾病事件的风险再分类分别提高了约 5%、10% 和 6%。然而,巴泽特公式校正的 QTc 延长与心血管疾病的发生无关,也不能改善风险再分类:结论:霍奇斯公式在心率校正方面优于其他公式。Fridericia、Framingham和Hodges公式可用于死亡和心血管风险预测。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Optimal QT correction formula for older Chinese: Guangzhou Biobank Cohort Study.

Introduction: To identify the optimal QT correction formula for generating corrected QT (QTc) and cutoffs for prolonged QTc, and examine the associations with mortality and cardiovascular disease (CVD) in older Chinese.

Methods: A prospective study included 24,611 Chinese aged 50+ years and without CVD at 2003-2008 from Guangzhou Biobank Cohort Study. QT interval was corrected by Bazett, Fridericia, Framingham and Hodges formulas. The slope and R2 of the QTc and heart rate regression were used to determine the optimal correction formula. The 95th percentile of QTc was used to defined prolonged QTc. Cox regression was used to examine associations of prolonged QTc with mortality and CVD. The net reclassification index was calculated to assess risk reclassification.

Results: During an average follow-up of 15.3 years, 5,261 deaths and 5,539 CVD occurred. Optimal heart correction was observed for the Hodges formula, and Bazett formula performed the worst. Prolonged QTc corrected by Fridericia, Framingham and Hodges formulas had similar association strength with all-cause mortality, CVD mortality and incident CVD (especially coronary heart disease, myocardial infarction and ischemic stroke), with hazard ratios approximately being 1.25, 1.40 and 1.15, respectively. They also improved risk reclassification for all-cause mortality, CVD mortality and incident CVD by approximately 5%, 10% and 6%, respectively. However, prolonged QTc corrected by Bazett formula was not associated with incident CVD and did not improve risk reclassification.

Conclusions: Hodges formula outperformed other formulas for heart rate correction. Fridericia, Framingham and Hodges formulas can be used for death and cardiovascular risk prediction.

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来源期刊
Cardiology
Cardiology 医学-心血管系统
CiteScore
3.40
自引率
5.30%
发文量
56
审稿时长
1.5 months
期刊介绍: ''Cardiology'' features first reports on original clinical, preclinical and fundamental research as well as ''Novel Insights from Clinical Experience'' and topical comprehensive reviews in selected areas of cardiovascular disease. ''Editorial Comments'' provide a critical but positive evaluation of a recent article. Papers not only describe but offer critical appraisals of new developments in non-invasive and invasive diagnostic methods and in pharmacologic, nutritional and mechanical/surgical therapies. Readers are thus kept informed of current strategies in the prevention, recognition and treatment of heart disease. Special sections in a variety of subspecialty areas reinforce the journal''s value as a complete record of recent progress for all cardiologists, internists, cardiac surgeons, clinical physiologists, pharmacologists and professionals in other areas of medicine interested in current activity in cardiovascular diseases.
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