Biomedical and environmental sciences : BES最新文献

{"title":"Mito-TEMPO Ameliorates Sodium Palmitate Induced Ferroptosis in MIN6 Cells through PINK1/Parkin-Mediated Mitophagy.","authors":"Baolei Chang, Yanyu Su, Tingting Li, Yanxia Zheng, Ruirui Yang, Heng Lu, Hao Wang, Yusong Ding","doi":"10.3967/bes2024.111","DOIUrl":"https://doi.org/10.3967/bes2024.111","url":null,"abstract":"<p><strong>Objective: </strong>Mitochondrial reactive oxygen species (mtROS) could cause damage to pancreatic β-cells, rendering them susceptible to oxidative damage. Hence, investigating the potential of the mitochondria-targeted antioxidant (Mito-TEMPO) to protect pancreatic β-cells from ferroptosis by mitigating lipid peroxidation becomes crucial.</p><p><strong>Methods: </strong>MIN6 cells were cultured <i>in</i> <i>vitro</i> with 100 μmol/L sodium palmitate (SP) to simulate diabetes. FerroOrange was utilized for the detection of Fe ²⁺ fluorescence staining, BODIPY581/591C11 for lipid reactive oxygen species, and MitoSox-Red for mtROS. Alterations in mitophagy levels were assessed through the co-localization of lysosomal and mitochondrial fluorescence. Western blotting was employed to quantify protein levels of Acsl4, GPX4, FSP1, FE, PINK1, Parkin, TOMM20, P62, and LC3. Subsequently, interventions were implemented using Mito-TEMPO and Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) to observe changes in ferroptosis and mitophagy within MIN6 cells.</p><p><strong>Results: </strong>We found that SP induced a dose-dependent increase in Fe ²⁺ and lipid ROS in MIN6 cells while decreasing the expression levels of GPX4 and FSP1 proteins. Through bioinformatics analysis, it has been uncovered that mitophagy assumes a crucial role within the ferroptosis pathway associated with diabetes. Additionally, SP decreased the expression of mitophagy-related proteins PINK1 and Parkin, leading to mtROS overproduction. Conversely, Mito-TEMPO effectively eliminated mtROS while activating the mitophagy pathways involving PINK1 and Parkin, thereby reducing the occurrence of ferroptosis in MIN6 cells. CCCP also demonstrated efficacy in reducing ferroptosis in MIN6 cells.</p><p><strong>Conclusion: </strong>In summary, Mito-TEMPO proved effective in attenuating mtROS production and initiating mitophagy pathways mediated by PINK1 and Parkin in MIN6 cells. Consequently, this decreased iron overload and lipid peroxidation, ultimately safeguarding the cells from ferroptosis.</p>","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"37 10","pages":"1128-1141"},"PeriodicalIF":0.0,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thyroid Nodule Prevalence and Iodine Nutrition: Influencing Factors in Coastal Areas.","authors":"Lijin Wang, Jiani Wu, Xiaoyan Wu, Ying Lan, Meng He, Diqun Chen, Zhihui Chen, Muhua Wang","doi":"10.3967/bes2024.164","DOIUrl":"https://doi.org/10.3967/bes2024.164","url":null,"abstract":"","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"37 10","pages":"1221-1226"},"PeriodicalIF":0.0,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Marital Status as a Moderator: Exploring the Relationship between Social Engagement and Depressive Symptoms in China's Older Adult Population.","authors":"Jianlun Wu, Yaping Ye, Man Zhang, Ruichen Cong, Yitao Chen, Pengfei Yu, Qing Guo","doi":"10.3967/bes2024.134","DOIUrl":"https://doi.org/10.3967/bes2024.134","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to explore the complex relationship between social engagement and depressive symptoms among older adults in China, focusing particularly on the moderating role of marital status.</p><p><strong>Methods: </strong>This study used data from the latest Chinese Longitudinal Healthy Longevity Survey (CLHLS). The analysis used the latent class analysis to delineate personality clusters and hierarchical linear regression, supplemented by the PROCESS macro, to investigate the effects of social engagement and marital status on depressive symptoms.</p><p><strong>Results: </strong>The analysis encompassed 7,789 respondents (mean age: 82.53 [ <i>s</i> = 11.20] years), with 54% female. The personality analysis categorized participants into four clusters, with the majority (77.60%) classified as Confident Idealists, who exhibited the lowest levels of depressive symptoms. Hierarchical linear regression analysis yielded several significant findings: Higher levels of social engagement were significantly associated with fewer depressive symptoms ( <i>t</i> = -7.932, <i>P</i> < 0.001, <i>B</i> = -0.463). Marital status was a significant factor; married individuals reported fewer depressive symptoms compared to their unmarried counterparts ( <i>t</i> = -6.368, <i>P</i> < 0.001, <i>B</i> = -0.750). There was a significant moderating effect of marital status on the relationship between social engagement and depressive symptoms ( <i>t</i> = -2.092, <i>P</i> = 0.037, <i>B</i> = -0.217).</p><p><strong>Conclusion: </strong>This study demonstrates that, among Chinese older adults, both social engagement and marital status significantly influence depressive symptoms. Higher social engagement, particularly in other activities like doing household chores, gardening, reading newspapers or books, and playing cards or Mahjong, is associated with fewer depressive symptoms, especially among married individuals.</p>","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"37 10","pages":"1142-1157"},"PeriodicalIF":0.0,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Residential Greenness and Cardiometabolic Risk Factors among Adults in Rural Xinjiang Uygur Autonomous Region, China: A Cross-Sectional Study.","authors":"Leyao Jian, Bo Yang, Rulin Ma, Shuxia Guo, Jia He, Yu Li, Yusong Ding, Dongsheng Rui, Yidan Mao, Xin He, Xueying Sun, Shengyu Liao, Heng Guo","doi":"10.3967/bes2024.085","DOIUrl":"https://doi.org/10.3967/bes2024.085","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to explore the relationships between residential greenness and cardiometabolic risk factors among rural adults in Xinjiang Uygur Autonomous Region (Xinjiang) and thus provide a theoretical basis and data support for improving the health of residents in this region.</p><p><strong>Methods: </strong>We recruited 9,723 adult rural residents from the 51st Regiment of the Third Division of the Xinjiang Production and Construction Corps in September 2016. The normalized difference vegetation index (NDVI) was used to estimate residential greenness. The generalized linear mixed model (GLMM) was used to examine the association between residential greenness and cardiometabolic risk factors.</p><p><strong>Results: </strong>Higher residential greenness was associated with lower cardiometabolic risk factor prevalence. After adjustments were made for age, sex, education, and marital status, for each interquartile range (IQR) increase of NDVI _500-m, the risk of hypertension was reduced by 10.3% ( <i>OR</i> = 0.897, 95% <i>CI</i> = 0.836-0.962), the risk of obesity by 20.5% ( <i>OR</i> = 0.795, 95% <i>CI</i> = 0.695-0.910), the risk of type 2 diabetes by 15.1% ( <i>OR</i> = 0.849, 95% <i>CI</i> = 0.740-0.974), and the risk of dyslipidemia by 10.5% ( <i>OR</i> = 0.895, 95% <i>CI</i> = 0.825-0.971). Risk factor aggregation was reduced by 20.4% ( <i>OR</i> = 0.796, 95% <i>CI</i> = 0.716-0.885) for the same. Stratified analysis showed that NDVI _500-m was associated more strongly with hypertension, dyslipidemia, and risk factor aggregation among male participants. The association of NDVI _500-m with type 2 diabetes was stronger among participants with a higher education level. PM ₁₀ and physical activity mediated 1.9%-9.2% of the associations between NDVI _500-m and obesity, dyslipidemia, and risk factor aggregation.</p><p><strong>Conclusion: </strong>Higher residential greenness has a protective effect against cardiometabolic risk factors among rural residents in Xinjiang. Increasing the area of green space around residences is an effective measure to reduce the burden of cardiometabolic-related diseases among rural residents in Xinjiang.</p>","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"37 10","pages":"1184-1194"},"PeriodicalIF":0.0,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emergence of Multidrug-Resistant <i>Proteus mirabilis</i> Harboring both <i>bla</i> _NDM-1 and <i>cfr</i> genes.","authors":"Meiqing Sun, Xiuhong Yang, Beibei Miao, Jingyi Zhang, Shuang Meng, Zhe Feng, Juan Li","doi":"10.3967/bes2024.146","DOIUrl":"https://doi.org/10.3967/bes2024.146","url":null,"abstract":"","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"37 10","pages":"1208-1212"},"PeriodicalIF":0.0,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Report on Cardiovascular Health and Diseases in China 2023: An Updated Summary.","authors":"National Center For Cardiovascular Diseases The Writing Committee Of The Report On Cardiovascular Health And Diseases In China","doi":"10.3967/bes2024.162","DOIUrl":"https://doi.org/10.3967/bes2024.162","url":null,"abstract":"<p><p>Since 1990, China has made considerable progress in resolving the problem of \"treatment difficulty\" of cardiovascular diseases (CVD). The prevalent unhealthy lifestyle among Chinese residents has exposed a massive proportion of the population to CVD risk factors, and this situation is further worsened due to the accelerated aging population in China. CVD remains one of the greatest threats to the health of Chinese residents. In terms of the proportions of disease mortality among urban and rural residents in China, CVD has persistently ranked first. In 2021, CVD accounted for 48.98% and 47.35% of deaths in rural and urban areas, respectively. Two out of every five deaths can be attributed to CVD. To implement a national policy \"focusing on the primary health institute and emphasizing prevention\" and truly achieve a shift of CVD prevention and treatment from hospitals to communities, the National Center for Cardiovascular Diseases has organized experts from relevant fields across China to compile the \"Report on Cardiovascular Health and Diseases in China\" annually since 2005. The 2024 report is established based on representative, published, and high-quality big-data research results from cross-sectional and cohort population epidemiological surveys, randomized controlled clinical trials, large sample registry studies, and typical community prevention and treatment cases, along with data from some projects undertaken by the National Center for Cardiovascular Diseases. These firsthand data not only enrich the content of the current report but also provide a more timely and comprehensive reflection of the status of CVD prevention and treatment in China.</p>","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"37 9","pages":"949-992"},"PeriodicalIF":0.0,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142482981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Projecting the Dynamic Trends of Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome: Modeling the Epidemic in Sichuan Province, China.","authors":"Yuan Li, Qin Xi Liu, Rong Sheng Luan, Yi Yang, Tao Wu, Bi Hui Yang","doi":"10.3967/bes2024.080","DOIUrl":"https://doi.org/10.3967/bes2024.080","url":null,"abstract":"<p><strong>Objective: </strong>Our study aimed to provide a comprehensive overview of the current status and dynamic trends of the human immunodeficiency virus (HIV) prevalence in Sichuan, the second most heavily affected province in China, and to explore future interventions.</p><p><strong>Methods: </strong>The epidemiological, behavioral, and population census data from multiple sources were analyzed to extract inputs for an acquired immunodeficiency syndrome (AIDS) epidemic model (AEM). Baseline curves, derived from historical trends in HIV prevalence, were used, and the AEM was employed to examine future intervention scenarios.</p><p><strong>Results: </strong>In 2015, the modeled data suggested an adult HIV prevalence of 0.191% in Sichuan, with an estimated 128,766 people living with HIV/AIDS and 16,983 individuals with newly diagnosed infections. Considering current high-risk behaviors, the model predicts an increase in the adult prevalence to 0.306% by 2025, projecting an estimated 212,168 people living with HIV/AIDS and 16,555 individuals with newly diagnosed infections.</p><p><strong>Conclusion: </strong>Heterosexual transmission will likely emerge as the primary mode of AIDS transmission in Sichuan. Furthermore, we anticipate a stabilization in the incidence of AIDS with a concurrent increase in prevalence. Implementing comprehensive intervention measures aimed at high-risk groups could effectively alleviate the spread of AIDS in Sichuan.</p>","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"37 9","pages":"1003-1014"},"PeriodicalIF":0.0,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142482978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DNA Methylation of KLRC1 and KLRC3 in Autoimmune Thyroiditis: Perspective of Different Water Iodine Exposure.","authors":"Yao Chen, Jin Jin Liu, Meng Ying Qu, Bing Xuan Ren, Huai Yong Wu, Li Zhang, Zheng Zhou, Li Xiang Liu, Hong Mei Shen","doi":"10.3967/bes2024.103","DOIUrl":"https://doi.org/10.3967/bes2024.103","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to identify differentially methylated genes (DMGs) associated with natural killer cells in patients with autoimmune thyroiditis (AIT), focusing on the influence of varying water iodine exposure levels.</p><p><strong>Methods: </strong>Participants were divided into categories based on median water iodine (MWI) concentrations: iodine-fortified areas (IFA, MWI < 10 µg/L), iodine-adequate areas (IAA, 40 ≤ MWI ≤ 100 µg/L), and iodine-excessive areas (IEA, MWI > 300 µg/L). A total of 176 matched AIT cases and controls were recruited and divided into 89, 40, and 47 pairs for IFA, IAA, and IEA, respectively. DMGs were identified using 850K BeadChip analysis for 10/10 paired samples. Validation of DNA methylation and mRNA expression levels of the DMGs was conducted using MethylTarget™ and QRT-PCR for 176/176 paired samples.</p><p><strong>Results: </strong><i>KLRC1</i>, <i>KLRC3</i>, and <i>SH2D1B</i> were identified as significant DMGs. Validation revealed that <i>KLRC1</i> was hypomethylated and highly expressed, whereas <i>KLRC3</i> was hypermethylated and highly expressed in individuals with AIT. Furthermore, <i>KLRC1</i> was hypomethylated and highly expressed in both IFA and IEA.</p><p><strong>Conclusion: </strong>The DNA methylation status of <i>KLRC1</i> and <i>KLRC3</i> may play crucial roles in AIT pathogenesis. Additionally, DNA methylation of <i>KLRC1</i>seems to be influenced by different iodine concentrations in water.</p>","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"37 9","pages":"1044-1055"},"PeriodicalIF":0.0,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142482972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disparities in the Levels of Whole-Blood Epstein-Barr Virus between the Cancer and Non-Cancer Populations in Zhejiang, China.","authors":"Qing Jun Jia, Meichun Zeng, Qi Chen","doi":"10.3967/bes2024.101","DOIUrl":"https://doi.org/10.3967/bes2024.101","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the prevalence of Epstein-Barr virus (EBV) infection in patients with and without cancer.</p><p><strong>Methods: </strong>A total of 26,648 participants who underwent whole-blood EBV DNA (WBEBV) assays between January 1, 2020, and August 31, 2023, were included. The chi-square test was used for categorical data analysis, and R software was used to analyze the differences in EBV DNA load levels and the diagnostic capabilities of WBEBV.</p><p><strong>Results: </strong>Positive rates were 10.2% and 25.4% for healthy controls (HC) and patients, respectively. The positivity rate for EBV-associated neoplasms (EN) was the highest at 7.53%, followed by leukemia (Le) at 5.49%. The subgroup analysis showed that the positivity rate for abnormal proliferation or hyperplasia (APH) was 31.9%, followed by 30.5% for Le. The WBEBV of patients with transplants (TP), especially living-related transplants (LT), was the highest among all subgroups. WBEBV at diagnosis was used to differentiate between infectious mononucleosis (IM) and chronic active Epstein-Barr virus (CAEBV), with a sensitivity of 67.4% (95% confidence interval [ <i>CI</i>]: 57.6-75.8) and specificity of 72% (95% <i>CI</i>: 63.3-79.3). We conclude that the prevalence of EBV infection is low in the healthy population in this region and that a high EBV load at baseline is more common in LT, IM, and Lymphocyte Leukemia (LL).</p><p><strong>Conclusion: </strong>This study used a large-sample survey to characterize the prevalence of whole-blood EBV levels in various diseases, including the stages and subtypes. The EBV detection rate was higher in patients with malignant disease than in those with benign disease. Our study provides clinicians with baseline information regarding EBV-associated diseases.</p>","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"37 9","pages":"993-1002"},"PeriodicalIF":0.0,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142482962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MicroRNA-451 from Human Umbilical Cord-Derived Mesenchymal Stem Cell Exosomes Inhibits Alveolar Macrophage Autophagy <i>via</i> Tuberous Sclerosis Complex 1/Mammalian Target of Rapamycin Pathway to Attenuate Burn-Induced Acute Lung Injury in Rats.","authors":"Zhi Gang Jia, Lin Li, Peng Zhao, Guo Fei, Shuang Ru Li, Qin Qin Song, Guang Peng Liu, Ji Song Liu","doi":"10.3967/bes2024.128","DOIUrl":"https://doi.org/10.3967/bes2024.128","url":null,"abstract":"<p><strong>Objective: </strong>Our previous studies established that microRNA (miR)-451 from human umbilical cord mesenchymal stem cell-derived exosomes (hUC-MSC-Exos) alleviates acute lung injury (ALI). This study aims to elucidate the mechanisms by which miR-451 in hUC-MSC-Exos reduces ALI by modulating macrophage autophagy.</p><p><strong>Methods: </strong>Exosomes were isolated from hUC-MSCs. Severe burn-induced ALI rat models were treated with hUC-MSC-Exos carrying the miR-451 inhibitor. Hematoxylin-eosin staining evaluated inflammatory injury. Enzyme-linked immunosorbnent assay measured lipopolysaccharide (LPS), tumor necrosis factor-α, and interleukin-1β levels. qRT-PCR detected miR-451 and tuberous sclerosis complex 1 (TSC1) expressions. The regulatory role of miR-451 on TSC1 was determined using a dual-luciferase reporter system. Western blotting determined TSC1 and proteins related to the mammalian target of rapamycin (mTOR) pathway and autophagy. Immunofluorescence analysis was conducted to examine exosomes phagocytosis in alveolar macrophages and autophagy level.</p><p><strong>Results: </strong>hUC-MSC-Exos with miR-451 inhibitor reduced burn-induced ALI and promoted macrophage autophagy. MiR-451 could be transferred from hUC-MSCs to alveolar macrophages <i>via</i> exosomes and directly targeted TSC1. Inhibiting miR-451 in hUC-MSC-Exos elevated TSC1 expression and inactivated the mTOR pathway in alveolar macrophages. Silencing TSC1 activated mTOR signaling and inhibited autophagy, while TSC1 knockdown reversed the autophagy from the miR-451 inhibitor-induced.</p><p><strong>Conclusion: </strong>miR-451 from hUC-MSC exosomes improves ALI by suppressing alveolar macrophage autophagy through modulation of the TSC1/mTOR pathway, providing a potential therapeutic strategy for ALI.</p>","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"37 9","pages":"1030-1043"},"PeriodicalIF":0.0,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142482977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}