Biomedical and environmental sciences : BES最新文献_第10页

Short-term Association of Meteorological Elements on COVID-19 Pandemic in a Semi-arid City of Northwest China, 2021-2022. 2021-2022 年气象要素对中国西北半干旱城市 COVID-19 大流行的短期影响。

Biomedical and environmental sciences : BES Pub Date : 2024-05-20 DOI: 10.3967/bes2024.060

Feng Liu Feng, Yu Xia Ma, Bo Wen Cheng, Zong Rui Liu, Yu Han Zhao, Jie Yang

引用次数: 0

Association of Cytokines with Clinical Indicators in Patients with Drug-Induced Liver Injury. 细胞因子与药物性肝损伤患者临床指标的关系

Biomedical and environmental sciences : BES Pub Date : 2024-05-20 DOI: 10.3967/bes2024.054

Wei Hua Cao, Ting Ting Jiang, Ge Shen, Wen Deng, Shi Yu Wang, Zi Yu Zhang, Xin Xin Li, Yao Lu, Lu Zhang, Ru Yu Liu, Min Chang, Shu Ling Wu, Yuan Jiao Gao, Hong Xiao Hao, Xiao Xue Chen, Lei Ping Hu, Meng Jiao Xu, Wei Yi, Yao Xie, Ming Hui Li

{"title":"Association of Cytokines with Clinical Indicators in Patients with Drug-Induced Liver Injury.","authors":"Wei Hua Cao, Ting Ting Jiang, Ge Shen, Wen Deng, Shi Yu Wang, Zi Yu Zhang, Xin Xin Li, Yao Lu, Lu Zhang, Ru Yu Liu, Min Chang, Shu Ling Wu, Yuan Jiao Gao, Hong Xiao Hao, Xiao Xue Chen, Lei Ping Hu, Meng Jiao Xu, Wei Yi, Yao Xie, Ming Hui Li","doi":"10.3967/bes2024.054","DOIUrl":"https://doi.org/10.3967/bes2024.054","url":null,"abstract":"Objective: To explore characteristics of clinical parameters and cytokines in patients with drug-induced liver injury (DILI) caused by different drugs and their correlation with clinical indicators.Method: The study was conducted on patients who were up to Review of Uncertainties in Confidence Assessment for Medical Tests (RUCAM) scoring criteria and clinically diagnosed with DILI. Based on Chinese herbal medicine, cardiovascular drugs, non-steroidal anti-inflammatory drugs (NSAIDs), anti-infective drugs, and other drugs, patients were divided into five groups. Cytokines were measured by Luminex technology. Baseline characteristics of clinical biochemical indicators and cytokines in DILI patients and their correlation were analyzed.Results: 73 patients were enrolled. Age among five groups was statistically different ( P = 0.032). Alanine aminotransferase (ALT) ( P = 0.033) and aspartate aminotransferase (AST) ( P = 0.007) in NSAIDs group were higher than those in chinese herbal medicine group. Interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α) in patients with Chinese herbal medicine (IL-6: P < 0.001; TNF-α: P < 0.001) and cardiovascular medicine (IL-6: P = 0.020; TNF-α: P = 0.001) were lower than those in NSAIDs group. There was a positive correlation between ALT ( r = 0.697, P = 0.025), AST ( r = 0.721, P = 0.019), and IL-6 in NSAIDs group.Conclusion: Older age may be more prone to DILI. Patients with NSAIDs have more severe liver damage in early stages of DILI, TNF-α and IL-6 may partake the inflammatory process of DILI.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"37 5","pages":"494-502"},"PeriodicalIF":0.0,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141285651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The 10th China Obesity Science Conference Held in Beijing. 第十届中国肥胖科学大会在北京召开。

Biomedical and environmental sciences : BES Pub Date : 2024-05-20 DOI: 10.3967/bes2024.089

引用次数: 0

Microdeletion on Xq27.1 in a Chinese VACTERL-Like Family with Kidney and Anal Anomalies. 一个伴有肾脏和肛门异常的中国VACTERL-Like家族的Xq27.1微缺失病例

Biomedical and environmental sciences : BES Pub Date : 2024-05-20 DOI: 10.3967/bes2024.055

Min Li, Yu Lan Zhang, Kai Li Zhang, Ping Ping Li, Yu Han Lyu, Ya Xin Liang, Yue Yu

{"title":"Microdeletion on Xq27.1 in a Chinese VACTERL-Like Family with Kidney and Anal Anomalies.","authors":"Min Li, Yu Lan Zhang, Kai Li Zhang, Ping Ping Li, Yu Han Lyu, Ya Xin Liang, Yue Yu","doi":"10.3967/bes2024.055","DOIUrl":"https://doi.org/10.3967/bes2024.055","url":null,"abstract":"Objective: VATER/VACTERL-like association is associated with adverse pregnancy outcomes. Genetic evidence of this disorder is sporadic. In this study, we aimed to provide genetic insights to improve the diagnosis of VACTERL.Methods: We have described a Chinese family in which four members were affected by renal defects or agenesis, anal atresia, and anovaginal fistula, which is consistent with the diagnosis of a VACTERL-like association. Pedigree and genetic analyses were conducted using genome and exome sequencing.Results: Segregation analysis revealed the presence of a recessive X-linked microdeletion in two living affected individuals, harboring a 196-380 kb microdeletion on Xq27.1, which was identified by familial exome sequencing. Genome sequencing was performed on the affected male, confirming a -196 kb microdeletion in Xq27.1, which included a 28% loss of the CDR-1 gene. Four family members were included in the co-segregation analysis, and only VACTERL-like cases with microdeletions were reported in X27.1.Conclusion: These results suggest that the 196-380 kb microdeletion in Xq27.1 could be a possible cause of the VATER/VACTERL-like association. However, further genetic and functional analyses are required to confirm or rule out genetic background as the definitive cause of the VACTERL association.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"37 5","pages":"503-510"},"PeriodicalIF":0.0,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141285599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular Characterization of Coxsackievirus B1 Strains Isolated from Patients with Hand Foot and Mouth Disease in Yunnan, Southwest China. 从中国西南部云南手足口病患者中分离出的柯萨奇病毒 B1 株系的分子特征。

Biomedical and environmental sciences : BES Pub Date : 2024-05-20 DOI: 10.3967/bes2024.061

Dan Han Xu, Ming Zhang, Jun Wei Chen, Chang Zeng Feng, Yu Han Liu, Zhao Yang Chu, Wen Jing Liu, Li Li, Shao Hui Ma

引用次数: 0

Numerical Simulation on Radon Retardation Behavior of Covering Floats in Radon-Containing Water. 含氡水中覆盖浮体的氡阻滞行为数值模拟。

Biomedical and environmental sciences : BES Pub Date : 2024-04-20 DOI: 10.3967/bes2024.026

Shu Yuan Liu, Li Zhang, Yong Jun Ye, Ku Ke Ding

{"title":"Numerical Simulation on Radon Retardation Behavior of Covering Floats in Radon-Containing Water.","authors":"Shu Yuan Liu, Li Zhang, Yong Jun Ye, Ku Ke Ding","doi":"10.3967/bes2024.026","DOIUrl":"https://doi.org/10.3967/bes2024.026","url":null,"abstract":"Objective: This study aimed to efficiently reduce the release of radon from water bodies to protect the environment.Methods: Based on the sizes of the experimental setup and modular float, computational fluid dynamics (CFD) was used to assess the impact of the area coverage rate, immersion depth, diffusion coefficient, and radon transfer velocity at the gas-liquid interface on radon migration and exhalation of radon-containing water. Based on the numerical simulation results, an estimation model for the radon retardation rate was constructed. The effectiveness of the CFD simulation was evaluated by comparing the experimental and simulated variation values of the radon retardation rate with the coverage area rates.Results: The effect of radon transfer velocity on radon retardation in water bodies was minor and insignificant according to the appropriate value; therefore, an estimation model of the radon retardation rate of the coverage of a radon-containing water body was constructed using the synergistic impacts of three factors: area coverage rate, immersion depth, and diffusion coefficient. The deviation between the experimental and simulated results was < 4.3%.Conclusion: Based on the numerical simulation conditions, an estimation model of the radon retardation rate of covering floats in water bodies under the synergistic effect of multiple factors was obtained, which provides a reference for designing covering floats for radon retardation in radon-containing water.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"37 4","pages":"406-417"},"PeriodicalIF":0.0,"publicationDate":"2024-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140900331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Salidroside Ameliorates Lung Injury Induced by PM _2.5by Regulating SIRT1-PGC-1α in Mice. 水杨甙通过调节小鼠体内的SIRT1-PGC-1α改善PM 2.5诱发的肺损伤

Biomedical and environmental sciences : BES Pub Date : 2024-04-20 DOI: 10.3967/bes2024.041

Xiao Hong Li, Yu Mei Liu, Hui Shan, Jin Feng Tan, Jian Zhou, Yuan Jin Song, Si Qi Li, Chen Liu, Dong Qun Xu, Li Yu, Wan Wei Li

{"title":"Salidroside Ameliorates Lung Injury Induced by PM 2.5by Regulating SIRT1-PGC-1α in Mice.","authors":"Xiao Hong Li, Yu Mei Liu, Hui Shan, Jin Feng Tan, Jian Zhou, Yuan Jin Song, Si Qi Li, Chen Liu, Dong Qun Xu, Li Yu, Wan Wei Li","doi":"10.3967/bes2024.041","DOIUrl":"10.3967/bes2024.041","url":null,"abstract":"Objective: This study aimed to clarify the intervention effect of salidroside (SAL) on lung injury caused by PM 2.5 in mice and illuminate the function of SIRT1-PGC-1ɑ axis.Methods: Specific pathogen-free (SPF) grade male C57BL/6 mice were randomly assigned to the following groups: control group, SAL group, PM 2.5 group, SAL+PM 2.5 group. On the first day, SAL was given by gavage, and on the second day, PM 2.5 suspension was given by intratracheal instillation. The whole experiment consist of a total of 10 cycles, lasting 20 days. At the end of treatment, blood samples and lung tissues were collected and analyzed. Observation of pathological changes in lung tissue using inverted microscopy and transmission electron microscopy. The expression of inflammatory, antioxidants, apoptosis, and SIRT1-PGC-1ɑ proteins were detected by Western blotting.Results: Exposure to PM 2.5 leads to obvious morphological and pathologica changes in the lung of mice. PM 2.5 caused a decline in levels of antioxidant-related enzymes and protein expressions of HO-1, Nrf2, SOD2, SIRT1 and PGC-1ɑ, and an increase in the protein expressions of IL-6, IL-1β, Bax, caspase-9 and cleaved caspase-3. However, SAL reversed the aforementioned changes caused by PM 2.5 by activating the SIRT1-PGC-1α pathway.Conclusion: SAL can activate SIRT1-PGC-1ɑ to ameliorate PM 2.5-induced lung injury.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"37 4","pages":"367-376"},"PeriodicalIF":0.0,"publicationDate":"2024-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140900467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Barley Protein LFBEP-C1 from Lactiplantibacillus plantarum dy-1 Fermented Barley Extracts by Inhibiting Lipid Accumulation in a Caenorhabditis elegans Model. 植物乳杆菌 dy-1 发酵大麦提取物中的大麦蛋白 LFBEP-C1 在秀丽隐杆线虫模型中抑制脂质积累

Biomedical and environmental sciences : BES Pub Date : 2024-04-20 DOI: 10.3967/bes2024.042

Jia Yan Zhang, Meng Ting Liu, Yu Hao Liu, Huan Deng, Juan Bai, Jian Hua Xie, Xiang Xiao

{"title":"Barley Protein LFBEP-C1 from Lactiplantibacillus plantarum dy-1 Fermented Barley Extracts by Inhibiting Lipid Accumulation in a Caenorhabditis elegans Model.","authors":"Jia Yan Zhang, Meng Ting Liu, Yu Hao Liu, Huan Deng, Juan Bai, Jian Hua Xie, Xiang Xiao","doi":"10.3967/bes2024.042","DOIUrl":"10.3967/bes2024.042","url":null,"abstract":"Objective: This study aimed to investigate the lipid-lowering activity of LFBEP-C1 in high glucose-fed Caenorhabditis elegans (C. elegans).Methods: In this study, the fermented barley protein LFBEP-C1 was prepared and tested for its potential anti-obesity effects on C. elegans. The worms were fed Escherichia coli OP50 ( E. coli OP50), glucose, and different concentrations of LFBEP-C1. Body size, lifespan, movement, triglyceride content, and gene expression were analyzed. The results were analyzed using ANOVA and Tukey's multiple comparison test.Results: Compared with the model group, the head-swing frequency of C. elegans in the group of LFBEP-C1 at 20 μg/mL increased by 33.88%, and the body-bending frequency increased by 27.09%. This indicated that LFBEP-C1 improved the locomotive ability of C. elegans. The average lifespan of C. elegans reached 13.55 days, and the body length and width of the C. elegans decreased after LFBEP-C1 intake. Additionally, LFBEP-C1 reduced the content of lipid accumulation and triglyceride levels. The expression levels of sbp-1, daf-2, and mdt-15 significantly decreased, while those of daf-16, tph-1, mod-1, and ser-4 significantly increased after LFBEP-C1 intake. Changes in these genes explain the signaling pathways that regulate lipid metabolism.Conclusion: LFBEP-C1 significantly reduced lipid deposition in C. elegans fed a high-glucose diet and alleviated the adverse effects of a high-glucose diet on the development, lifespan, and exercise behavior of C. elegans. In addition, LFBEP-C1 regulated lipid metabolism mainly by mediating the expression of genes in the sterol regulatory element-binding protein, insulin, and 5-hydroxytryptamine signaling pathways.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"37 4","pages":"377-386"},"PeriodicalIF":0.0,"publicationDate":"2024-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140899977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic Effect of Rhodopseudomonas palustris-Bioconverted Extract of Lycium barbarum on Rats with Lead Exposure. 枸杞生物转化提取物对铅暴露大鼠的治疗效果

Biomedical and environmental sciences : BES Pub Date : 2024-04-20 DOI: 10.3967/bes2024.050

Hong Yang, Yi Sun, Shu Tong Chai, Yan Hui Liang, Ya Ni Liu, Guan E Yang

引用次数: 0

Lecanemab Unveiled: Exploring Alzheimer's Treatment Advancements, Assessing Strengths, Limitations, and Its Therapeutic Landscape Position. Lecanemab 揭开面纱：探索阿尔茨海默氏症治疗进展，评估其优势、局限性及其治疗格局定位。

Biomedical and environmental sciences : BES Pub Date : 2024-04-20 DOI: 10.3967/bes2024.047

Victor Abiola Adepoju, Okechukwu Innocent Onyezue, Safayet Jamil, Olalekan John Okesanya, Eliseo Lucero-Prisno Iii Don

引用次数: 0