Biomedical and environmental sciences : BES最新文献_第10页

Reinfection and Risk Factors of SARS-CoV-2 during an Omicron Wave 2022 in Shanghai. 上海 2022 年 Omicron 波期间 SARS-CoV-2 的再感染和风险因素。

Biomedical and environmental sciences : BES Pub Date : 2024-02-20 DOI: 10.3967/bes2024.021

Pei Qin Wang, Xiao Hang Wang, Jian Wang, Zhi Wen Shi, Dong Mei Chu, Zhi Fei Wang, Mu Bai Zhang, Wei Liu, Zi Jie Zhou, Wei Fen Xie

引用次数: 0

Relationship of Retinal Nerve Fiber Layer Thickness and Retinal Vessel Calibers with Cognitive Impairment in the Asymptomatic Polyvascular Abnormalities Population. 无症状多血管异常人群视网膜神经纤维层厚度和视网膜血管口径与认知障碍的关系

Biomedical and environmental sciences : BES Pub Date : 2024-02-20 DOI: 10.3967/bes2024.020

Dan Dan Wang, An Xin Wang, Xiao Li Zhang, Wen Bin Wei, Shou Ling Wu, Xing Quan Zhao

{"title":"Relationship of Retinal Nerve Fiber Layer Thickness and Retinal Vessel Calibers with Cognitive Impairment in the Asymptomatic Polyvascular Abnormalities Population.","authors":"Dan Dan Wang, An Xin Wang, Xiao Li Zhang, Wen Bin Wei, Shou Ling Wu, Xing Quan Zhao","doi":"10.3967/bes2024.020","DOIUrl":"https://doi.org/10.3967/bes2024.020","url":null,"abstract":"Objective: Cognitive impairment (CI) in older individuals has a high morbidity rate worldwide, with poor diagnostic methods and susceptible population identification. This study aimed to investigate the relationship between different retinal metrics and CI in a particular population, emphasizing polyvascular status.Methods: We collected information from the Asymptomatic Polyvascular Abnormalities Community Study on retinal vessel calibers, retinal nerve fiber layer (RNFL) thickness, and cognitive function of 3,785 participants, aged 40 years or older. Logistic regression was used to analyze the relationship between retinal metrics and cognitive function. Subgroups stratified by different vascular statuses were also analyzed.Results: RNFL thickness was significantly thinner in the CI group (odds ratio: 0.973, 95% confidence interval: 0.953-0.994). In the subgroup analysis, the difference still existed in the non-intracranial arterial stenosis, non-extracranial carotid arterial stenosis, and peripheral arterial disease subgroups ( P < 0.05).Conclusion: A thin RNFL is associated with CI, especially in people with non-large vessel stenosis. The underlying small vessel change in RNFL and CI should be investigated in the future.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140867803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of Anemia in Patients with Diabetes Mellitus: A Systematic Review and Meta-Analysis. 糖尿病患者的贫血患病率：系统回顾与元分析》。

Biomedical and environmental sciences : BES Pub Date : 2024-01-20 DOI: 10.3967/bes2024.008

Monireh Faghir-Ganji, Narjes Abdolmohammadi, Maryam Nikbina, Alireza Amanollahi, Alireza Ansari-Moghaddam, Rozhan Rozhan, Hamidreza Baradaran

{"title":"Prevalence of Anemia in Patients with Diabetes Mellitus: A Systematic Review and Meta-Analysis.","authors":"Monireh Faghir-Ganji, Narjes Abdolmohammadi, Maryam Nikbina, Alireza Amanollahi, Alireza Ansari-Moghaddam, Rozhan Rozhan, Hamidreza Baradaran","doi":"10.3967/bes2024.008","DOIUrl":"10.3967/bes2024.008","url":null,"abstract":"Objective: Anemia is a common public health concern in patients with type 2 diabetes worldwide. This study aimed to identify the prevalence of anemia among patients with diabetes.Methods: Electronic databases, including PubMed, Scopus, Web of Sciences, and Google Scholar, were searched systematically for studies published between 2010 and 2021. After removing duplicates and inappropriate reports, the remaining manuscripts were reviewed and appraised using theNewcastle-Ottawa Scale (NOS) tool. A random-effects model was used to calculate the pooled estimates of the extracted data using Stata version 17. Heterogeneity of the studies was assessed using the Q statistic.Results: A total of 51 articles containing information on 26,485 patients with diabetes were included in this study. The articles were mainly from Asia (58.82%) and Africa (35.29%). The overall prevalence of anemia was 35.45% (95% CI: 30.30-40.76), with no evidence of heterogeneity by sex. Among the two continents with the highest number of studies, the prevalence of anemia in patients with diabetes was significantly higher in Asia [40.02; 95% CI: 32.72-47.54] compared to Africa [28.46; 95% CI: 21.90-35.50] ( P for heterogeneity = 0.029). Moreover, there has been an increasing trend in the prevalence of anemia in patients with diabetes over time, from [15.28; 95% CI: 9.83-22.21] in 2012 to [40.70; 95% CI: 10.21-75.93] in 2022.Conclusion: Globally, approximately 4 in 10 patients with diabetes suffer from anemia. Therefore, routine anemia screening and control programs every 3 months might be useful in improving the quality of life of these patients.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139704207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation between Combined Urinary Metal Exposure and Grip Strength under Three Statistical Models: A Cross-sectional Study in Rural Guangxi. 三种统计模型下综合尿液金属暴露与握力之间的相关性：广西农村地区横断面研究。

Biomedical and environmental sciences : BES Pub Date : 2024-01-20 DOI: 10.3967/bes2024.002

Yu Jian Liang, Jia Hui Rong, Xue Xiu Wang, Jian Sheng Cai, Li Dong Qin, Qiu Mei Liu, Xu Tang, Xiao Ting Mo, Yan Fei Wei, Yin Xia Lin, Shen Xiang Huang, Ting Yu Luo, Ruo Yu Gou, Jie Jing Cao, Chu Wu Huang, Yu Fu Lu, Jian Qin, Zhi Yong Zhang

{"title":"Correlation between Combined Urinary Metal Exposure and Grip Strength under Three Statistical Models: A Cross-sectional Study in Rural Guangxi.","authors":"Yu Jian Liang, Jia Hui Rong, Xue Xiu Wang, Jian Sheng Cai, Li Dong Qin, Qiu Mei Liu, Xu Tang, Xiao Ting Mo, Yan Fei Wei, Yin Xia Lin, Shen Xiang Huang, Ting Yu Luo, Ruo Yu Gou, Jie Jing Cao, Chu Wu Huang, Yu Fu Lu, Jian Qin, Zhi Yong Zhang","doi":"10.3967/bes2024.002","DOIUrl":"10.3967/bes2024.002","url":null,"abstract":"Objective: This study aimed to investigate the potential relationship between urinary metals copper (Cu), arsenic (As), strontium (Sr), barium (Ba), iron (Fe), lead (Pb) and manganese (Mn) and grip strength.Methods: We used linear regression models, quantile g-computation and Bayesian kernel machine regression (BKMR) to assess the relationship between metals and grip strength.Results: In the multimetal linear regression, Cu (β = -2.119), As (β = -1.318), Sr (β = -2.480), Ba (β = 0.781), Fe (β = 1.130) and Mn (β = -0.404) were significantly correlated with grip strength ( P < 0.05). The results of the quantile g-computation showed that the risk of occurrence of grip strength reduction was -1.007 (95% confidence interval: -1.362, -0.652; P < 0.001) when each quartile of the mixture of the seven metals was increased. Bayesian kernel function regression model analysis showed that mixtures of the seven metals had a negative overall effect on grip strength, with Cu, As and Sr being negatively associated with grip strength levels. In the total population, potential interactions were observed between As and Mn and between Cu and Mn ( P interactions of 0.003 and 0.018, respectively).Conclusion: In summary, this study suggests that combined exposure to metal mixtures is negatively associated with grip strength. Cu, Sr and As were negatively correlated with grip strength levels, and there were potential interactions between As and Mn and between Cu and Mn.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139704251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metallothionein 1E Alleviates Cadmium-induced Renal Cytotoxicity through Promoting Mitochondrial Functional Recovery. 金属硫蛋白 1E 通过促进线粒体功能恢复减轻镉诱导的肾细胞毒性

Biomedical and environmental sciences : BES Pub Date : 2024-01-20 DOI: 10.3967/bes2024.011

Si Hui Wen, Lu Bei Li, Hui Dan Huang, Ying Xie, Lei Luo

引用次数: 0

Exosome-Transmitted miR-224-5p Promotes Colorectal Cancer Cell Proliferation via Targeting ULK2 in p53-Dependent Manner. 外泌体传递的 miR-224-5p 通过靶向 p53 依赖性的 ULK2 促进结直肠癌细胞增殖

Biomedical and environmental sciences : BES Pub Date : 2024-01-20 DOI: 10.3967/bes2023.144

Le Mei Yang, Qi Zheng, Xiao Jia Liu, Xian Xian Li, Lim Veronica, Qi Chen, Zhong Hua Zhao, Shu Yang Wang

{"title":"Exosome-Transmitted miR-224-5p Promotes Colorectal Cancer Cell Proliferation via Targeting ULK2 in p53-Dependent Manner.","authors":"Le Mei Yang, Qi Zheng, Xiao Jia Liu, Xian Xian Li, Lim Veronica, Qi Chen, Zhong Hua Zhao, Shu Yang Wang","doi":"10.3967/bes2023.144","DOIUrl":"10.3967/bes2023.144","url":null,"abstract":"Objective: To investigate the role and molecular mechanism of exosomal miR-224-5p in colorectal cancer (CRC).Methods: The miR-224-5p expression in CRC patient tissues and cell-derived exosomes was measured by laser capture microdissection and qRT-PCR, respectively. Dual-luciferase reporter gene assay was used to determine the target gene of miR-224-5p. The protein expressions of p53 and unc-51 like kinase 2 (ULK2) in CRC cells were detected by western blot. Flow cytometry was used to detect cell cycle and apoptosis. Cell proliferation was measured by CCK8 and EdU assay.Results: The miR-224-5p expression was upregulated in CRC tissues and increased progressively with the rise of CRC stage. CRC cells secreted extracellular miR-224-5p mainly in an exosome-dependent manner, and then miR-224-5p could be transferred to surrounding tumor cells to regulate cell proliferation in the form of autocrine or paracrine. Moreover, ULK2 was characterized as a direct target of miR-224-5p and was downregulated in CRC tissues. Interestingly, ULK2 inhibited CRC cell proliferation in a p53-dependent manner. Furthermore, exosome-derived miR-224-5p partially reversed the proliferation regulation of ULK2 on CRC cells.Conclusion: Our findings demonstrate that exosome-transmitted miR-224-5p promotes p53-dependent cell proliferation by targeting ULK2 in CRC, which may offer promising targets for CRC prevention and therapy.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139704203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Joint Effects of Multipollutant Mixtures on Mortality in Chengdu, China. 中国成都多种污染物混合物对死亡率的共同影响。

Biomedical and environmental sciences : BES Pub Date : 2024-01-20 DOI: 10.3967/bes2024.010

Ying Zhang, Qi Qi Tian, Wen Dong Hu, Shao Bo Zhang, Shi Gong Wang, Can Jun Zheng

引用次数: 0

Predicting the Risk of Arterial Stiffness in Coal Miners Based on Different Machine Learning Models. 基于不同机器学习模型预测煤矿工人动脉硬化风险

Biomedical and environmental sciences : BES Pub Date : 2024-01-20 DOI: 10.3967/bes2024.009

Qian Wei Chen, Xue Zan Huang, Yu Ding, Feng Ren Zhu, Jia Wang, Yuan Jie Zou, Yuan Zhen Du, Ya Jun Zhang, Zi Wen Hui, Feng Lin Zhu, Min Mu

引用次数: 0

Prognostic Nutritional Index Associates with the Severity of Silicosis: A Study from a Tertiary Class A Prevention and Treatment Institute for Occupational Diseases in China. 预后营养指数与矽肺严重程度的关系：中国三级甲等职业病防治院的一项研究。

Biomedical and environmental sciences : BES Pub Date : 2024-01-20 DOI: 10.3967/bes2024.012

La Gu He, Yun Lai Liang, Lu Qi Yang, Hua Min Yuan

引用次数: 0

Risk Factors of Depression Screened by Two-Sample Mendelian Randomization Analysis: A Systematic Review. 通过双样本孟德尔随机分析筛选出的抑郁症风险因素：系统回顾

Biomedical and environmental sciences : BES Pub Date : 2024-01-20 DOI: 10.3967/bes2024.007

Han Lin Wang, Yan Feng Xue, Bao Qiu Cui, Hong Liu, Xin Xin Shen

{"title":"Risk Factors of Depression Screened by Two-Sample Mendelian Randomization Analysis: A Systematic Review.","authors":"Han Lin Wang, Yan Feng Xue, Bao Qiu Cui, Hong Liu, Xin Xin Shen","doi":"10.3967/bes2024.007","DOIUrl":"10.3967/bes2024.007","url":null,"abstract":"Objective: This study explored the potentially modifiable factors for depression and major depressive disorder (MDD) from the MR-Base database and further evaluated the associations between drug targets with MDD.Methods: We analyzed two-sample of Mendelian randomization (2SMR) using genetic variant depression ( n = 113,154) and MDD ( n = 208,811) from Genome-Wide Association Studies (GWAS). Separate calculations were performed with modifiable risk factors from MR-Base for 1,001 genomes. The MR analysis was performed by screening drug targets with MDD in the DrugBank database to explore the therapeutic targets for MDD. Inverse variance weighted (IVW), fixed-effect inverse variance weighted (FE-IVW), MR-Egger, weighted median, and weighted mode were used for complementary calculation.Results: The potential causal relationship between modifiable risk factors and depression contained 459 results for depression and 424 for MDD. Also, the associations between drug targets and MDD showed that SLC6A4, GRIN2A, GRIN2C, SCN10A, and IL1B expression are associated with an increased risk of depression. In contrast, ADRB1, CHRNA3, HTR3A, GSTP1, and GABRG2 genes are candidate protective factors against depression.Conclusion: This study identified the risk factors causally associated with depression and MDD, and estimated 10 drug targets with significant impact on MDD, providing essential information for formulating strategies to prevent and treat depression.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139704210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0