Biomedical and environmental sciences : BES最新文献

{"title":"An Investigation of the Association between Metabolic Syndrome and Osteoporosis Based on Chinese Health Examination Data.","authors":"Hongyu Chen, Mingyang Zheng, Qingli Cheng, Jiahui Zhao, Yansong Zheng","doi":"10.3967/bes2024.097","DOIUrl":"10.3967/bes2024.097","url":null,"abstract":"<p><strong>Objective: </strong>Because of the limited number of studies and small sample sizes, whether metabolic syndrome (MS) leads to the occurrence and progression of osteoporosis and the possible underlying mechanisms require further investigation. This study aimed to investigate the association between MS and osteoporosis, along with its influencing factors.</p><p><strong>Methods: </strong>This observational cross-sectional study included 139,470 individuals aged ≥ 18 years who underwent health examinations from September 2014 to March 2022. Based on bone mineral density (BMD) screening results, the participants were categorized into a suspected osteoporosis or non-osteoporosis group (control). Participants were further divided into those who met 0 MS criteria, 1 MS criterion, 2 MS criteria, and ≥ 3 MS criteria (MS group). Participants who had undergone health examinations at least twice formed the follow-up cohort; a self-matched analysis was performed on those with follow-up periods ≥ 5 years and unchanged MS grouping.</p><p><strong>Results: </strong>Several examination indicators in the suspected osteoporosis group showed statistically significant differences compared with the control group. The proportion of suspected osteoporosis in the MS group was significantly increased compared with that in the 0 MS criteria group (odds ratio [ <i>OR</i>]: 1.215, Z = 29.11, <i>P</i> < 0.001, 95% confidence interval: 1.199-1.231). After adjusting for age, sex, smoking, and alcohol consumption, the 2 MS criteria group and MS group still had <i>OR</i> values > 1 ( <i>P</i> < 0.001). In the follow-up cohort, the proportion of suspected osteoporosis increased gradually with an increase in the number of MS criteria met at baseline and during each follow-up visit ( <i>P</i> < 0.05), with the highest proportion observed in the MS group. However, the proportion of suspected osteoporosis did not increase significantly over time in the different MS groups ( <i>P</i> > 0.05). In the follow-up cohort, the proportion of individuals transitioning from normal BMD to suspected osteoporosis was higher in the MS group after ≥ 5 years of follow-up compared with the group meeting 0 MS criteria (0.08% versus 1.15%, <i>χ</i> ² = 10.76, <i>P</i> = 0.001). There was no significant difference in BMD values for the 0 MS criteria group after 5 years ( <i>P</i> > 0.05), whereas the other three groups experienced a significant decrease in BMD values after 5 years ( <i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>MS is an independent risk factor for osteoporosis, and the effect of risk factors related to MS on osteoporosis may exceed that of aging alone. The specific mechanisms warrant further investigation.</p>","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"37 12","pages":"1385-1396"},"PeriodicalIF":0.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Environmental Factors on Cardiopulmonary Health.","authors":"Shufeng Chen, Xiangfeng Lu","doi":"10.3967/bes2024.188","DOIUrl":"https://doi.org/10.3967/bes2024.188","url":null,"abstract":"","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"37 12","pages":"1349-1351"},"PeriodicalIF":0.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect and Mechanism of Action of BMSC-derived Exosomes on Gas Explosion-induced Blast Lung Injury.","authors":"Xiaoying Li, Jing He, Meng Deng, Hui Fan, Xiaofei Jin, Xuedan Deng, Wenjie Ren, Sanqiao Yao, Wu Yao, Changfu Hao","doi":"10.3967/bes2024.161","DOIUrl":"https://doi.org/10.3967/bes2024.161","url":null,"abstract":"","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"37 12","pages":"1441-1446"},"PeriodicalIF":0.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Polyaromatic Hydrocarbons and Allergy among the US General Population.","authors":"Chaochao Wen, Hui Chen, Guodong Ding, Angela Vinturache, Yongjun Zhang","doi":"10.3967/bes2024.184","DOIUrl":"https://doi.org/10.3967/bes2024.184","url":null,"abstract":"","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"37 12","pages":"1427-1434"},"PeriodicalIF":0.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"1,2-Propanediol Attenuates Radiation-Induced HaCaT Cell Injury by Inhibiting Oxidative Stress.","authors":"Yun Liu, Boyuan Ren, Yubin Liu, Qiang Li, Jiayan Jin, Chu-Tse Wu, Gangqiao Zhou, Jide Jin","doi":"10.3967/bes2024.189","DOIUrl":"https://doi.org/10.3967/bes2024.189","url":null,"abstract":"","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"37 12","pages":"1447-1452"},"PeriodicalIF":0.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex- and Type-specific Relationship of Childhood Maltreatment with General Obesity and Abdominal Adiposity in Chinese College Students.","authors":"Yingying Tong, Min Li, Yujie Su, Ting Tang, Ying Zhu, Ding Han, Xueying Zhang, Puyu Su, Wei Chen, Gengfu Wang","doi":"10.3967/bes2024.132","DOIUrl":"https://doi.org/10.3967/bes2024.132","url":null,"abstract":"","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"37 12","pages":"1435-1449"},"PeriodicalIF":0.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glyphosate Based-Herbicide Induced Nephrotoxicity through Oxidative Stress and the Imbalance of Osmotic Pressure in Mice.","authors":"Lei Qi, Jinfeng Zhu, Yanbo Qi, Hong Chao, Yu Cheng, Xiaolei Yang, Hongjie Li, Gang Li, Jicheng Liu","doi":"10.3967/bes2024.178","DOIUrl":"https://doi.org/10.3967/bes2024.178","url":null,"abstract":"","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"37 12","pages":"1453-1457"},"PeriodicalIF":0.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relevance of Household Chemical Usage to Respiratory Diseases in Older Adults in China.","authors":"Yongbin Zhu, Renzhang Liang, Lining Pu, Huihui Wang, Xiaoxue He, Degong Pan, Xue Zhang, Yueping Wu, Yanrong Wang, Liping Shi, Yue Yang, Jiangping Li","doi":"10.3967/bes2024.148","DOIUrl":"https://doi.org/10.3967/bes2024.148","url":null,"abstract":"<p><strong>Objective: </strong>This study investigated the association between household chemical use and respiratory disease (RD) in older Chinese adults.</p><p><strong>Methods: </strong>The data were from the 2018 China Longitudinal Health and Longevity Survey (CLHLS) database, which included 12,866 participants aged ≥ 65 years. The prevalence of RD was based on self-reported medical history, and patients were divided into diseased and non-diseased groups. The frequency of household chemical usage was divided into four categories, and a total score for eight household chemical usage categories was constructed. Binary logistic regression was used to determine the relationship between the frequency of household chemical use and RD, and a restricted cubic spline was used to determine the dose-response association.</p><p><strong>Result: </strong>After adjusting for all covariates, regular use of repellents [odds ratios ( <i>OR</i>) = 1.28, 95% <i>CI</i> 1.06-1.55] and oil removers ( <i>OR</i> = 1.28, 95% <i>CI</i> 1.03-1.58) were associated with RD. There was a dose-response association between the total score of household chemicals usage and RD risk ( <i>P</i> non-linearity > 0.05, <i>P</i> for trend < 0.01). Using patients with the total score below 9 as a reference, the <i>OR</i> for patients with the total score ranging from 25 to 32 is 2.33 (95% <i>CI</i> 1.25-4.09).</p><p><strong>Conclusion: </strong>Regular use of repellents and oil removers increased the risk of RD, and the dose-dependent relationship was also observed.</p>","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"37 12","pages":"1373-1384"},"PeriodicalIF":0.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunogenicity Evaluation of a SARS-CoV-2 BA.2 Subunit Vaccine Formulated with CpG 1826 plus alum Dual Adjuvant.","authors":"Yuhan Yan, Qiudong Su, Yao Yi, Liping Shen, Shengli Bi","doi":"10.3967/bes2024.129","DOIUrl":"https://doi.org/10.3967/bes2024.129","url":null,"abstract":"<p><strong>Objective: </strong>The present study aimed to evaluate the immunogenicity of BA.2 variant receptor binding domain (RBD) recombinant protein formulated with CpG 1826 plus alum dual adjuvant.</p><p><strong>Methods: </strong>The BA.2 variant RBD (residues 308-548) fusing TT-P ₂ epitope was obtained from prokaryotic expression system, purification technology and dialysis renaturation, which was designated as Sot protein. The soluble Sot protein formulated with CpG 1826 plus alum dual adjuvant was designated as Sot/CA subunit vaccine and then the BALB/c mice were intramuscularly administrated with two doses of the Sot/CA subunit vaccine at 14-day interval (day 0 and 14). On day 28, the number of effector T lymphocytes secreting IFN-γ and IL-4 in mice spleen were determined by enzyme-linked immunospot (ELISpot) assay. The serum IgG, IgG1 and IgG2a antibodies were examined by enzyme-linked immunosorbent assay (ELISA). In addition, the level of neutralizing antibodies (NAbs) induced by Sot/CA subunit vaccine was also evaluated by the microneutralization assay.</p><p><strong>Results: </strong>The high-purity soluble Sot protein with antigenicity was successfully obtained by the prokaryotic expression, protein purification and dialysis renaturation. The Sot/CA subunit vaccine induced a high level of IgG antibodies and NAbs, which were of cross-neutralizing activity against SARS-CoV-2 BA.2 and XBB.1.5 variants. Meanwhile, Sot/CA subunit vaccine also induced a high level of effector T lymphocytes secreting IFN-γ (635.00 ± 17.62) and IL-4 (279.20 ± 13.10), respectively. Combined with a decreased IgG1/IgG2a ratio in the serum, which indicating Sot/CA subunit vaccine induced a Th1-type predominant immune response.</p><p><strong>Conclusion: </strong>The Sot protein formulated with CpG 1826 plus alum dual adjuvant showed that the excellent cellular and humoral immunogenicity, which provided a scientific basis for the development of BA.2 variant subunit vaccines and references for the adjuvant application of subunit vaccines.</p>","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"37 12","pages":"1409-1420"},"PeriodicalIF":0.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elimination Progress of Human Rabies in Beijing, 1973-2023: A Descriptive Epidemiological Study.","authors":"Tao Zhou, Xiaomei Li, Cheng Gong, Ming Luo, Dan Zhao, Jingbin Pan, Ziang Li, Quanyi Wang, Luodan Suo, Li Lu","doi":"10.3967/bes2024.169","DOIUrl":"https://doi.org/10.3967/bes2024.169","url":null,"abstract":"","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"37 11","pages":"1338-1342"},"PeriodicalIF":0.0,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142820371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}