Biomedical and environmental sciences : BES最新文献_第9页

Metabolomic Changes in Mice Induced by Copper Exposure: Systematic Analysis and Exploration of Toxicity Mechanisms. 铜暴露引起的小鼠代谢组学变化：毒性机制的系统分析和探索。

Biomedical and environmental sciences : BES Pub Date : 2025-01-20 DOI: 10.3967/bes2024.179

Shuai Xiao, Lin Qiang Gong, Shi Yuan Zhao, Xue Chu, Feng Feng Li, Ya Zhou Zhang, Fang Qiang Song, Pei Jiang

引用次数: 0

Glycemic Control and Diabetes Duration in Relation to Subsequent Myocardial Infarction among Patients with Coronary Heart Disease and Type 2 Diabetes. 冠心病和2型糖尿病患者血糖控制和糖尿病病程与继发心肌梗死的关系

Biomedical and environmental sciences : BES Pub Date : 2025-01-20 DOI: 10.3967/bes2024.187

Fu Rong Li, Yan Dou, Chun Bao Mo, Shuang Wang, Jing Zheng, Dong Feng Gu, Feng Chao Liang

{"title":"Glycemic Control and Diabetes Duration in Relation to Subsequent Myocardial Infarction among Patients with Coronary Heart Disease and Type 2 Diabetes.","authors":"Fu Rong Li, Yan Dou, Chun Bao Mo, Shuang Wang, Jing Zheng, Dong Feng Gu, Feng Chao Liang","doi":"10.3967/bes2024.187","DOIUrl":"10.3967/bes2024.187","url":null,"abstract":"Objective: This study aimed to investigate the impact of glycemic control and diabetes duration on subsequent myocardial infarction (MI) in patients with both coronary heart disease (CHD) and type 2 diabetes (T2D).Methods: We conducted a retrospective cohort study of 33,238 patients with both CHD and T2D in Shenzhen, China. Patients were categorized into 6 groups based on baseline fasting plasma glucose (FPG) levels and diabetes duration (from the date of diabetes diagnosis to the baseline date) to examine their combined effects on subsequent MI. Cox proportional hazards regression models were used, with further stratification by age, sex, and comorbidities to assess potential interactions.Results: Over a median follow-up of 2.4 years, 2,110 patients experienced MI. Compared to those with optimal glycemic control (FPG < 6.1 mmol/L) and shorter diabetes duration (< 10 years), the fully-adjusted hazard ratio ( HR) (95% Confidence Interval [95% CI]) for those with a diabetes duration of ≥ 10 years and FPG > 8.0 mmol/L was 1.93 (95% CI: 1.59, 2.36). The combined effects of FPG and diabetes duration on MI were largely similar across different age, sex, and comorbidity groups, although the excess risk of MI associated with long-term diabetes appeared to be more pronounced among those with atrial fibrillation.Conclusion: Our study indicates that glycemic control and diabetes duration significant influence the subsequent occurrence of MI in patients with both CHD and T2D. Tailored management strategies emphasizing strict glycemic control may be particularly beneficial for patients with longer diabetes duration and atrial fibrillation.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"38 1","pages":"27-36"},"PeriodicalIF":0.0,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nogo-A Protein Mediates Oxidative Stress and Synaptic Damage Induced by High-Altitude Hypoxia in the Rat Hippocampus. Nogo-A蛋白介导高海拔缺氧大鼠海马氧化应激和突触损伤。

Biomedical and environmental sciences : BES Pub Date : 2025-01-20 DOI: 10.3967/bes2024.112

Jin Yu Fang, Huai Cun Liu, Yan Fei Zhang, Quan Cheng Cheng, Zi Yuan Wang, Xuan Fang, Hui Ru Ding, Wei Guang Zhang, Chun Hua Chen

{"title":"Nogo-A Protein Mediates Oxidative Stress and Synaptic Damage Induced by High-Altitude Hypoxia in the Rat Hippocampus.","authors":"Jin Yu Fang, Huai Cun Liu, Yan Fei Zhang, Quan Cheng Cheng, Zi Yuan Wang, Xuan Fang, Hui Ru Ding, Wei Guang Zhang, Chun Hua Chen","doi":"10.3967/bes2024.112","DOIUrl":"10.3967/bes2024.112","url":null,"abstract":"Objective: High-altitude hypoxia exposure often damages hippocampus-dependent learning and memory. Nogo-A is an important axonal growth inhibitory factor. However, its function in high-altitude hypoxia and its mechanism of action remain unclear.Methods: In an in vivo study, a low-pressure oxygen chamber was used to simulate high-altitude hypoxia, and genetic or pharmacological intervention was used to block the Nogo-A/NgR1 signaling pathway. Contextual fear conditioning and Morris water maze behavioral tests were used to assess learning and memory in rats, and synaptic damage in the hippocampus and changes in oxidative stress levels were observed. In vitro, SH-SY5Y cells were used to assess oxidative stress and mitochondrial function with or without Nogo-A knockdown in Oxygen Glucose-Deprivation/Reperfusion (OGD/R) models.Results: Exposure to acute high-altitude hypoxia for 3 or 7 days impaired learning and memory in rats, triggered oxidative stress in the hippocampal tissue, and reduced the dendritic spine density of hippocampal neurons. Blocking the Nogo-A/NgR1 pathway ameliorated oxidative stress, synaptic damage, and the learning and memory impairment induced by high-altitude exposure.Conclusion: Our results demonstrate the detrimental role of Nogo-A protein in mediating learning and memory impairment under high-altitude hypoxia and suggest the potential of the Nogo-A/NgR1 signaling pathway as a crucial therapeutic target for alleviating learning and memory dysfunction induced by high-altitude exposure.Graphical abstract: available in www.besjournal.com.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"38 1","pages":"79-93"},"PeriodicalIF":0.0,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of Associated Factors and Microbiota of Different Oral Niches in Early Childhood Caries. 儿童早期龋病不同口腔生态位相关因素及菌群调查

Biomedical and environmental sciences : BES Pub Date : 2025-01-20 DOI: 10.3967/bes2024.186

Shuai Tang, Ze Jun Zheng, Ze Kun Li, Qing Wang, Shuang Zhu, Tong Yang, Gang Ding

引用次数: 0

A Case Study on Garbage Code Redistribution Methods for Heart Failure at City Level by Two Approaches. 基于两种方法的城市级心力衰竭垃圾代码再分配方法研究

Biomedical and environmental sciences : BES Pub Date : 2025-01-20 DOI: 10.3967/bes2024.173

Li Qun Liu, Ze Min Cai, Xue Wei Wang, Chun Ping Wang, Xiang Yun Ma, Xian Feng Meng, Bo Fu Ning, Ning Li, Xia Wan

引用次数: 0

Trend of Relationship Models between Public and Private Hospitals in China Using Coopetition Theory. 基于合作理论的中国公立医院与民营医院关系模式发展趋势

Biomedical and environmental sciences : BES Pub Date : 2024-12-20 DOI: 10.3967/bes2024.138

Peiqiang Yu, Zhan Shu, Yuanyuan Xu, Bo Sun

引用次数: 0

Long-Term Exposure to Low-Level Ambient Air Pollution and Mortality among 0.3 Million Chinese Older Adults. 中国30万老年人长期暴露于低水平环境空气污染与死亡率

Biomedical and environmental sciences : BES Pub Date : 2024-12-20 DOI: 10.3967/bes2024.183

Likun Liu, Xueli Yuan, Wenqing Ni, Jing Wei, Tingting Liu, Ruijun Xu, Yingxin Li, Zihua Zhong, Yi Zheng, Sihan Liang, Rui Wang, Jian Xu, Yuewei Liu

{"title":"Long-Term Exposure to Low-Level Ambient Air Pollution and Mortality among 0.3 Million Chinese Older Adults.","authors":"Likun Liu, Xueli Yuan, Wenqing Ni, Jing Wei, Tingting Liu, Ruijun Xu, Yingxin Li, Zihua Zhong, Yi Zheng, Sihan Liang, Rui Wang, Jian Xu, Yuewei Liu","doi":"10.3967/bes2024.183","DOIUrl":"https://doi.org/10.3967/bes2024.183","url":null,"abstract":"Objective: Evidence that long-term exposure to ambient air pollution increases mortality among older adults, particularly those residing in low-level air pollution locations, remains scarce. This study investigated the potential links between long-term low-level air pollution exposure and mortality among Chinese older adults.Methods: A population-based study with 317,464 individuals aged ≥ 65 years was conducted in Shenzhen, China during 2018 and 2020. Logistic regression models were used to analyze the associations between long-term exposure to air pollution and all-cause mortality, as the primary outcome, as well as non-accidental, cancer and cardiovascular mortality.Results: Significant associations of PM 1, PM 2.5, PM 10, SO 2, CO, and O 3 exposures with a higher risk of all-cause mortality were found. Adjusted odds ratio ( OR) for each 1 µg/m 3 increment was 1.49 [95% confidence interval ( CI): 1.46, 1.53] for PM 1, 1.30 (1.27, 1.32) for PM 2.5, 1.05 (1.04, 1.06) for PM 10, 5.84 (5.39, 6.32) for SO 2, 1.04 (1.04, 1.05) for CO, and 1.02 (1.00, 1.03) for O 3, respectively. Long-term PM 1, PM 2.5, PM 10, SO 2, and CO exposures also elevated the risks of non-accidental, cancer and cardiovascular mortality.Conclusion: Long-term low-level air pollution exposure was associated with an increased mortality risk among Chinese older adults.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"37 12","pages":"1362-1372"},"PeriodicalIF":0.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Genetic Association between CDKN1A and Heart Failure: Genome-Wide Exploration of m ⁶A-SNPs and Mendelian Randomization. CDKN1A与心力衰竭之间的遗传关联：m 6A-SNPs的全基因组探索和孟德尔随机化。

Biomedical and environmental sciences : BES Pub Date : 2024-12-20 DOI: 10.3967/bes2024.172

Ziyi Yang, Zhennan Lin, Xiaotong Ning, Xingbo Mo, Laiyuan Wang, Xiangfeng Lu, Shufeng Chen

{"title":"The Genetic Association between CDKN1A and Heart Failure: Genome-Wide Exploration of m 6A-SNPs and Mendelian Randomization.","authors":"Ziyi Yang, Zhennan Lin, Xiaotong Ning, Xingbo Mo, Laiyuan Wang, Xiangfeng Lu, Shufeng Chen","doi":"10.3967/bes2024.172","DOIUrl":"https://doi.org/10.3967/bes2024.172","url":null,"abstract":"Objective: N6-methyladenosine (m 6A) is a common epigenetic modification in eukaryotes. In this study, we explore the potential impact of m 6A-associated single nucleotide polymorphisms (m 6A-SNPs) on heart failure (HF).Methods: Data from genome-wide association studies (GWAS) investigating HF in humans and from m 6A-SNPs datasets were used to identify HF-associated m 6A-SNPs. Their functions were explored using expression quantitative trait locus (eQTL), gene expression, and gene enrichment analyses. Mediation protein quantitative trait locus (pQTL)-Mendelian randomization (MR) was used to investigate the potential mechanism between critical protein levels and risk factors for HF.Results: We screened 44 HF-associated m 6A-SNPs, including 10 m 6A-SNPs that showed eQTL signals and differential expressions in HF. The SNP rs1801270 in CDKN1A showed the strongest association with HF ( P = 7.75 × 10 -6). Additionally, MR verified the genetic association between the CDKN1A protein and HF, as well as the mediating effect of blood pressure (BP) in this pathway. Higher circulating level of CDKN1A was associated with a lower risk of HF (odds ratio [ OR] = 0.82, 95% confidence interval [ CI]: 0.69 to 0.99). The proportions of hypertension, systolic BP, and diastolic BP were 48.10%, 28.94%, and 18.02%, respectively. Associations of PDIA6 ( P = 1.30 × 10 -2) and SMAD3 ( P = 4.80 × 10 -2) with HF were also detected.Conclusion: Multiple HF-related m 6A-SNPs were identified in this study. Genetic associations of CDKN1A and other proteins with HF and its risk factors were demonstrated, providing new ideas for further exploration of the molecular mechanisms of HF.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"37 12","pages":"1397-1413"},"PeriodicalIF":0.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship of Ambient Humidity with Cardiovascular Diseases: A Prospective Study of 24,510 Adults in a General Population. 环境湿度与心血管疾病的关系：一项24510名普通人群成年人的前瞻性研究

Biomedical and environmental sciences : BES Pub Date : 2024-12-20 DOI: 10.3967/bes2024.156

Congyi Zheng, Jiamin Wu, Haosu Tang, Xin Wang, Ye Tian, Xue Cao, Yixin Tian, Runqing Gu, Yuxin Song, Xuyan Pei, Jiayuan Qiu, Zujiao Nie, Minmei He, Gang Huang, Zengwu Wang

{"title":"Relationship of Ambient Humidity with Cardiovascular Diseases: A Prospective Study of 24,510 Adults in a General Population.","authors":"Congyi Zheng, Jiamin Wu, Haosu Tang, Xin Wang, Ye Tian, Xue Cao, Yixin Tian, Runqing Gu, Yuxin Song, Xuyan Pei, Jiayuan Qiu, Zujiao Nie, Minmei He, Gang Huang, Zengwu Wang","doi":"10.3967/bes2024.156","DOIUrl":"https://doi.org/10.3967/bes2024.156","url":null,"abstract":"Objective: This study aimed to explore the association between humidity exposure and the risk of cardiovascular disease (CVD), utilizing follow-up data and relative humidity (RH) metric assessments.Methods: We extracted the baseline data from the China Hypertension Survey (CHS) of 24,510 enrolled participants aged ≥ 35 years without a history of CVD between 2012 and 2015 and followed them up from 2018 to 2019. The National Meteorological Information Center (NMIC) of the China Meteorological Administration (CMA) provided the quality-controlled relative humidity (RH) datasets. Cox proportional hazards models were used to estimate hazard ratios ( HRs) for CVD in relation to RH.Results: During the follow-up period (2018-2019), 973 patients with CVD were identified. The HR of CVD risk was 1.17 (95% CI: 1.04-1.31) per 10% increase in summer mean RH. Compared with participants in the 3 rd quintile group, those in the 1 st and 5 th quintiles of RH had a higher risk of CVD. For summer mean RH, the HRs (95% CIs) for the 1 st and 5 th quintiles were 1.34 (1.04-1.71) and 1.44 (1.14-1.83), respectively. The relationship (\"U\" shape) between summer mean RH and the risk of CVD was nonlinear. Stratified analyses indicated that the risk of CVD was substantially influenced by the summer mean RH in female, older individuals, and those in southern China.Conclusion: Unsuitable (too high or low) humidity environments affect the risk of CVD. Our study highlights those future policies for adapting to climate change should consider the humidity-CVD relationship.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"37 12","pages":"1352-1361"},"PeriodicalIF":0.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PM _2.5-Metabolic Syndrome Causal Association: A Mendelian Randomization Study. PM 2.5-代谢综合征因果关系：孟德尔随机研究。

Biomedical and environmental sciences : BES Pub Date : 2024-12-20 DOI: 10.3967/bes2024.153

Fan Ding, Ning Ma, Shi Zhao, Qingan Wang, Zhanbing Ma, Yuhong Zhang, Yi Zhao, Yu Zhao

引用次数: 0