Biomedical and environmental sciences : BES最新文献_第9页

Downregulation of Serum PTEN Expression in Mercury-Exposed Population and PI3K/AKT Pathway-Induced Inflammation. 汞暴露人群血清 PTEN 表达下调与 PI3K/AKT 通路诱发的炎症

Biomedical and environmental sciences : BES Pub Date : 2024-04-20 DOI: 10.3967/bes2024.040

Peng Mei, En Min Ding, Hao Yang Yin, Xue Xue Ding, Huan Wang, Jian Feng Wang, Lei Han, Heng Dong Zhang, Bao Li Zhu

{"title":"Downregulation of Serum PTEN Expression in Mercury-Exposed Population and PI3K/AKT Pathway-Induced Inflammation.","authors":"Peng Mei, En Min Ding, Hao Yang Yin, Xue Xue Ding, Huan Wang, Jian Feng Wang, Lei Han, Heng Dong Zhang, Bao Li Zhu","doi":"10.3967/bes2024.040","DOIUrl":"10.3967/bes2024.040","url":null,"abstract":"Objective: This study investigated the impact of occupational mercury (Hg) exposure on human gene transcription and expression, and its potential biological mechanisms.Methods: Differentially expressed genes related to Hg exposure were identified and validated using gene expression microarray analysis and extended validation. Hg-exposed cell models and PTEN low-expression models were established in vitro using 293T cells. PTEN gene expression was assessed using qRT-PCR, and Western blotting was used to measure PTEN, AKT, and PI3K protein levels. IL-6 expression was determined by ELISA.Results: Combined findings from gene expression microarray analysis, bioinformatics, and population expansion validation indicated significant downregulation of the PTEN gene in the high-concentration Hg exposure group. In the Hg-exposed cell model (25 and 10 μmol/L), a significant decrease in PTEN expression was observed, accompanied by a significant increase in PI3K, AKT, and IL-6 expression. Similarly, a low-expression cell model demonstrated that PTEN gene knockdown led to a significant decrease in PTEN protein expression and a substantial increase in PI3K, AKT, and IL-6 levels.Conclusion: This is the first study to report that Hg exposure downregulates the PTEN gene, activates the PI3K/AKT regulatory pathway, and increases the expression of inflammatory factors, ultimately resulting in kidney inflammation.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140900212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidemiological Surveillance: Genetic Diversity of Rotavirus Group A in the Pearl River Delta, Guangdong, China in 2019. 流行病学监测：2019年中国广东珠江三角洲A组轮状病毒的遗传多样性》。

Biomedical and environmental sciences : BES Pub Date : 2024-03-20 DOI: 10.3967/bes2024.031

Jie Ying Jiang, Dan Liang, Li Wang, Yun Xiao, Yu Feng Liang, Bi Xia Ke, Juan Su, Hong Xiao, Tao Wang, Min Zou, Hong Jian Li, Chang Wen Ke

{"title":"Epidemiological Surveillance: Genetic Diversity of Rotavirus Group A in the Pearl River Delta, Guangdong, China in 2019.","authors":"Jie Ying Jiang, Dan Liang, Li Wang, Yun Xiao, Yu Feng Liang, Bi Xia Ke, Juan Su, Hong Xiao, Tao Wang, Min Zou, Hong Jian Li, Chang Wen Ke","doi":"10.3967/bes2024.031","DOIUrl":"https://doi.org/10.3967/bes2024.031","url":null,"abstract":"Objective: This study aimed to understand the epidemic status and phylogenetic relationships of rotavirus group A (RVA) in the Pearl River Delta region of Guangdong Province, China.Methods: This study included individuals aged 28 days-85 years. A total of 706 stool samples from patients with acute gastroenteritis collected between January 2019 and January 2020 were analyzed for 17 causative pathogens, including RVA, using a Gastrointestinal Pathogen Panel, followed by genotyping, virus isolation, and complete sequencing to assess the genetic diversity of RVA.Results: The overall RVA infection rate was 14.59% (103/706), with an irregular epidemiological pattern. The proportion of co-infection with RVA and other pathogens was 39.81% (41/103). Acute gastroenteritis is highly prevalent in young children aged 0-1 year, and RVA is the key pathogen circulating in patients 6-10 months of age with diarrhea. G9P[8] (58.25%, 60/103) was found to be the predominant genotype in the RVA strains, and the 41 RVA-positive strains that were successfully sequenced belonged to three different RVA genotypes in the phylogenetic analysis. Recombination analysis showed that gene reassortment events, selection pressure, codon usage bias, gene polymorphism, and post-translational modifications (PTMs) occurred in the G9P[8] and G3P[8] strains.Conclusion: This study provides molecular evidence of RVA prevalence in the Pearl River Delta region of China, further enriching the existing information on its genetics and evolutionary characteristics and suggesting the emergence of genetic diversity. Strengthening the surveillance of genotypic changes and gene reassortment in RVA strains is essential for further research and a better understanding of strain variations for further vaccine development.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140861255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship between Phenotypic Changes of Dendritic Cell Subsets and the Onset of Plateau Phase during Intermittent Interferon Therapy in Patients with CHB. 慢性阻塞性肺疾病患者间歇干扰素治疗期间树突状细胞亚群表型变化与高原期开始之间的关系

Biomedical and environmental sciences : BES Pub Date : 2024-03-20 DOI: 10.3967/bes2024.033

Liu Yang, Shi Yu Wang, Ting Ting Jiang, Wen Deng, Min Chang, Shu Ling Wu, Wei Hua Cao, Yao Lu, Ge Shen, Ru Yu Liu, Yuan Jiao Gao, Meng Jiao Xu, Lei Ping Hu, Lu Zhang, Yao Xie, Ming Hui Li

{"title":"Relationship between Phenotypic Changes of Dendritic Cell Subsets and the Onset of Plateau Phase during Intermittent Interferon Therapy in Patients with CHB.","authors":"Liu Yang, Shi Yu Wang, Ting Ting Jiang, Wen Deng, Min Chang, Shu Ling Wu, Wei Hua Cao, Yao Lu, Ge Shen, Ru Yu Liu, Yuan Jiao Gao, Meng Jiao Xu, Lei Ping Hu, Lu Zhang, Yao Xie, Ming Hui Li","doi":"10.3967/bes2024.033","DOIUrl":"https://doi.org/10.3967/bes2024.033","url":null,"abstract":"Objective: This study aimed to evaluate whether the onset of the plateau phase of slow hepatitis B surface antigen decline in patients with chronic hepatitis B treated with intermittent interferon therapy is related to the frequency of dendritic cell subsets and expression of the costimulatory molecules CD40, CD80, CD83, and CD86.Method: This was a cross-sectional study in which patients were divided into a natural history group (namely NH group), a long-term oral nucleoside analogs treatment group (namely NA group), and a plateau-arriving group (namely P group). The percentage of plasmacytoid dendritic cell and myeloid dendritic cell subsets in peripheral blood lymphocytes and monocytes and the mean fluorescence intensity of their surface costimulatory molecules were detected using a flow cytometer.Results: In total, 143 patients were enrolled (NH group, n = 49; NA group, n = 47; P group, n = 47). The results demonstrated that CD141/CD1c double negative myeloid dendritic cell (DNmDC)/lymphocytes and monocytes (%) in P group (0.041 [0.024, 0.069]) was significantly lower than that in NH group (0.270 [0.135, 0.407]) and NA group (0.273 [0.150, 0.443]), and CD86 mean fluorescence intensity of DNmDCs in P group (1832.0 [1484.0, 2793.0]) was significantly lower than that in NH group (4316.0 [2958.0, 5169.0]) and NA group (3299.0 [2534.0, 4371.0]), Adjusted P all < 0.001.Conclusion: Reduced DNmDCs and impaired maturation may be associated with the onset of the plateau phase during intermittent interferon therapy in patients with chronic hepatitis B.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140875089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of Thyroid Nodules with Various Elements in Urine and Blood Serum: A Case-Control Study. 甲状腺结节与尿液和血清中各种元素的关系：病例对照研究

Biomedical and environmental sciences : BES Pub Date : 2024-03-20 DOI: 10.3967/bes2024.035

Xiang Zhi Li, Cai Lian Wu, Li Ting Cen, Ming Le Huang, Min Min Huang, Mei Ting Qiu, Xiao Ling Lu

引用次数: 0

Effect of Maternal DEHP Exposure on Lipid Metabolism in Adult Male Rats and the Antagonistic Effect of Genistein. 母体接触 DEHP 对成年雄性大鼠脂质代谢的影响以及染料木素的拮抗作用

Biomedical and environmental sciences : BES Pub Date : 2024-03-20 DOI: 10.3967/bes2024.034

Yun Bo Zhang, Jiang Li Li, Jie Tian, Xiao Lin Na

引用次数: 0

Association of Serum Folate and Vitamin B ₁₂ Concentrations with Obesity in Chinese Children and Adolescents. 中国儿童和青少年血清叶酸和维生素 B 12 浓度与肥胖的关系

Biomedical and environmental sciences : BES Pub Date : 2024-03-20 DOI: 10.3967/bes2024.028

Qian Rang Zhu, E Kok Dieuwertje, Hailu Tesfaye Bekele, Koen Manusama, Jing Xian Zhang, Wei Xie, Wen Qi Zong, Hui Zuo, Jian Zhang, Ellen Kampman, Yue Dai

{"title":"Association of Serum Folate and Vitamin B 12 Concentrations with Obesity in Chinese Children and Adolescents.","authors":"Qian Rang Zhu, E Kok Dieuwertje, Hailu Tesfaye Bekele, Koen Manusama, Jing Xian Zhang, Wei Xie, Wen Qi Zong, Hui Zuo, Jian Zhang, Ellen Kampman, Yue Dai","doi":"10.3967/bes2024.028","DOIUrl":"https://doi.org/10.3967/bes2024.028","url":null,"abstract":"Objective: This study aimed to evaluate the associations of serum folate and/or vitamin B 12 concentrations with obesity among Chinese children and adolescents.Methods: A cross-sectional study was conducted including 3,079 Chinese children and adolescents, aged 6 to 17 years, from Jiangsu, China. Anthropometric indices, such as, children's body mass index (BMI), BMI z-scores, waist circumference, and waist-to-height ratio were utilized. Multivariable linear regression and generalized additive models were used to investigate the associations of serum folate and vitamin B 12 levels with anthropometric indices and odds of obesity.Results: We observed that serum vitamin B 12 concentrations were inversely associated with all anthropometric indices and the odds of general obesity [odds ratio ( OR) = 0.68; 95% confidence interval ( CI) = 0.59, 0.78] and abdominal obesity ( OR = 0.68; 95% CI = 0.60, 0.77). When compared to participants with both serum vitamin levels in the two middle quartiles, those with both serum folate and vitamin B 12 levels in the highest quartile were less prone to general ( OR = 0.31, 95% CI = 0.19, 0.50) or abdominal obesity ( OR = 0.46, 95% CI = 0.31, 0.67). Conversely, participants with vitamin B 12 levels in the lowest quartile alongside folate levels in the highest quartile had higher odds of abdominal obesity ( OR = 2.06, 95% CI = 1.09, 3.91).Conclusion: Higher serum vitamin B 12 concentrations, but not serum folate concentrations, were associated with lower odds of childhood obesity. Children and adolescents with high levels of vitamin B 12 and folate were less likely to be obese.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140872669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Iodine Nutrition, Thyroid-stimulating Hormone, and Related Factors of Postpartum Women from three Different Areas in China: A Cross-sectional Survey. 中国三个不同地区产后妇女的碘营养、促甲状腺激素及相关因素：横断面调查

Biomedical and environmental sciences : BES Pub Date : 2024-03-20 DOI: 10.3967/bes2024.029

Xiao Yun Shan, Yan Zou, Li Chun Huang, Shan Jiang, Wei Wen Zhou, Qiu Lan Qin, Chang Qing Liu, Xiao Yan Luo, Jia Xi Lu, De Qian Mao, Min Li, Zhen Yu Yang, Li Chen Yang

{"title":"Iodine Nutrition, Thyroid-stimulating Hormone, and Related Factors of Postpartum Women from three Different Areas in China: A Cross-sectional Survey.","authors":"Xiao Yun Shan, Yan Zou, Li Chun Huang, Shan Jiang, Wei Wen Zhou, Qiu Lan Qin, Chang Qing Liu, Xiao Yan Luo, Jia Xi Lu, De Qian Mao, Min Li, Zhen Yu Yang, Li Chen Yang","doi":"10.3967/bes2024.029","DOIUrl":"https://doi.org/10.3967/bes2024.029","url":null,"abstract":"Objective: Studies on the relationship between iodine, vitamin A (VA), and vitamin D (VD) and thyroid function are limited. This study aimed to analyze iodine and thyroid-stimulating hormone (TSH) status and their possible relationships with VA, VD, and other factors in postpartum women.Methods: A total of 1,311 mothers (896 lactating and 415 non-lactating) from Hebei, Zhejiang, and Guangxi provinces were included in this study. The urinary iodine concentration (UIC), TSH, VA, and VD were measured.Results: The median UIC of total and lactating participants were 142.00 µg/L and 139.95 µg/L, respectively. The median TSH, VA, and VD levels in all the participants were 1.89 mIU/L, 0.44 μg/mL, and 24.04 ng/mL, respectively. No differences in the UIC were found between lactating and non-lactating mothers. UIC and TSH levels were significantly different among the three provinces. The rural UIC was higher than the urban UIC. Obese mothers had a higher UIC and a higher prevalence of excessive TSH. Higher UICs and TSHs levels were observed in both the VD deficiency and insufficiency groups than in the VD-sufficient group. After adjustment, no linear correlation was observed between UIC and VA/VD. No interaction was found between vitamins A/D and UIC on TSH levels.Conclusion: The mothers in the present study had no iodine deficiency. Region, area type, BMI, and VD may be related to the iodine status or TSH levels.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140857538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prediction of Renal Function by Urinary Lead and Cadmium - Based on Classification Decision Tree and Logistic Regression Model. 根据尿铅和镉预测肾功能--基于分类决策树和逻辑回归模型

Biomedical and environmental sciences : BES Pub Date : 2024-03-20 DOI: 10.3967/bes2024.037

Yang Li, Qing Yao Wang, Qing Hua Tian, Qi An, Yu Tong Yang, Jia Chen Zhang, Shuang Jing Li, Han Zhou, Yun Fen Liang, Wei Tong Shen, Li Na Mu, Li Jian Lei

引用次数: 0

An exo Probe-based Reverse Transcription and Recombinase Polymerase Amplification for Rapid Detection of Feline Calicivirus in Cats. 基于外显子探针的反转录和重组聚合酶扩增技术用于快速检测猫的猫钙病毒。

Biomedical and environmental sciences : BES Pub Date : 2024-03-20 DOI: 10.3967/bes2024.036

Hong Yun Mu, Hong Lei Zhou, Zheng Jing, Wei Lu, Jian Wei Zhang

引用次数: 0

Estimating the Scarlet Fever Epidemics Using a Seasonal Autoregressive Fractionally Integrated Moving Average Model. 利用季节性自回归分数积分移动平均模型估算猩红热疫情

Biomedical and environmental sciences : BES Pub Date : 2024-03-20 DOI: 10.3967/bes2024.038

Yong Bin Wang, Chen Lu Xue, Pei Ping Zhou, Bing Jie Zhang, Chun Jie Xu

引用次数: 0