Biomedical and environmental sciences : BES最新文献_第9页

Association between Exposure of Rare Earth Elements and Outcomes of In Vitro Fertilization-Embryo Transfer in Beijing. 稀土元素暴露与北京体外受精-胚胎移植结果之间的关系。

Biomedical and environmental sciences : BES Pub Date : 2024-08-20 DOI: 10.3967/bes2024.123

Yu Tong Wang, Jing Li, Shi Rong Xu, Sheng Li Lin, Zhen Chen Hou, Lin Lin Wang, Ya Li Huang, Yue Sun, Wei Guo, Lai Lai Yan, Ying Wang, Chan Tian

{"title":"Association between Exposure of Rare Earth Elements and Outcomes of In Vitro Fertilization-Embryo Transfer in Beijing.","authors":"Yu Tong Wang, Jing Li, Shi Rong Xu, Sheng Li Lin, Zhen Chen Hou, Lin Lin Wang, Ya Li Huang, Yue Sun, Wei Guo, Lai Lai Yan, Ying Wang, Chan Tian","doi":"10.3967/bes2024.123","DOIUrl":"10.3967/bes2024.123","url":null,"abstract":"Objective: The study aimed to investigate the impact of rare earth elements (REEs) exposure on pregnancy outcomes of in vitro fertilization-embryo transfer (IVF-ET) by analyzing samples from spouses.Methods: A total of 141 couples were included. Blood and follicular fluid from the wives and semen plasma from the husbands, were analyzed for REEs using inductively coupled plasma mass spectrometry (ICP-MS). Spearman's correlation coefficients and the Mann-Whitney U test were used to assess correlations and compare REE concentrations among three types of samples, respectively. Logistic models were utilized to estimate the individual REE effect on IVF-ET outcomes, while BKMR and WQS models explored the mixture of REE interaction effects on IVF-ET outcomes.Results: Higher La concentration in semen (median 0.089 ng/mL, P = 0.03) was associated with a lower fertilization rate. However, this effect was not observed after artificial selection intervention through intracytoplasmic sperm injection (ICSI) ( P = 0.27). In semen, the REEs mixture did not exhibit any significant association with clinical pregnancy.Conclusion: Our study revealed a potential association between high La exposure in semen and a decline in fertilization rate, but not clinical pregnancy rate. This is the first to report REEs concentrations in follicular fluid with La, Ce, Pr, and Nd found at significantly lower concentrations than in serum, suggesting that these four REEs may not accumulate in the female reproductive system. However, at the current exposure levels, mixed REEs exposure did not exhibit reproductive toxicity.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"37 8","pages":"876-886"},"PeriodicalIF":0.0,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142094318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multi-omics Approach Reveals Influenza-A Virus Target Genes Associated Genomic, Clinical and Immunological Characteristics in Cancers. 多组学方法揭示甲型流感病毒靶基因在癌症中的相关基因组、临床和免疫学特征

Biomedical and environmental sciences : BES Pub Date : 2024-07-20 DOI: 10.3967/bes2024.094

Jiao Jiao Wang, Yong Liao, Ping Lian Yang, Wei le Ye, Yong Liu, Chun Xia Xiao, Wei Xiong Liao, Chun Bo Chen, Zhi Ping Liu, Zun Nan Huang

{"title":"Multi-omics Approach Reveals Influenza-A Virus Target Genes Associated Genomic, Clinical and Immunological Characteristics in Cancers.","authors":"Jiao Jiao Wang, Yong Liao, Ping Lian Yang, Wei le Ye, Yong Liu, Chun Xia Xiao, Wei Xiong Liao, Chun Bo Chen, Zhi Ping Liu, Zun Nan Huang","doi":"10.3967/bes2024.094","DOIUrl":"https://doi.org/10.3967/bes2024.094","url":null,"abstract":"Objective: To examine the precise function of influenza A virus target genes (IATGs) in malignancy.Methods: Using multi-omics data from the TCGA and TCPA datasets, 33 tumor types were evaluated for IATGs. IATG expression in cancer cells was analyzed using transcriptome analysis. Copy number variation (CNV) was assessed using GISTICS 2.0. Spearman's analysis was used to correlate mRNA expression with methylation levels. GSEA was used for the enrichment analysis. Pearson's correlation analysis was used to examine the association between IATG mRNA expression and IC50. The ImmuCellAI algorithm was used to calculate the infiltration scores of 24 immune cell types.Results: In 13 solid tumors, IATG mRNA levels were atypically expressed. Except for UCS, UVM, KICH, PCPG, THCA, CHOL, LAMI, and MESO, most cancers contained somatic IATG mutations. The main types of CNVs in IATGs are heterozygous amplifications and deletions. In most tumors, IATG mRNA expression is adversely associated with methylation. RT-PCR demonstrated that EGFR, ANXA5, CACNA1C, CD209, UVRAG were upregulated and CLEC4M was downregulated in KIRC cell lines, consistent with the TCGA and GTEx data.Conclusion: Genomic changes and clinical characteristics of IATGs were identified, which may offer fresh perspectives linking the influenza A virus to cancer.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"37 7","pages":"698-715"},"PeriodicalIF":0.0,"publicationDate":"2024-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142094301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatial Dynamics of Chickenpox Outbreaks in Rapidly Developing Regions: Implications for Global Public Health. 快速发展地区水痘爆发的空间动态：对全球公共卫生的影响

Biomedical and environmental sciences : BES Pub Date : 2024-07-20 DOI: 10.3967/bes2024.068

Li Wang, Miao Miao Wang, Cheng Dong Xu, Pei Han Wang, Mei Ying You, Zi Han Li, Xin Mei Chen, Xin Yu Liu, Xu Dong Li, Yuan Yuan Wang, Yue Hua Hu, Da Peng Yin

{"title":"Spatial Dynamics of Chickenpox Outbreaks in Rapidly Developing Regions: Implications for Global Public Health.","authors":"Li Wang, Miao Miao Wang, Cheng Dong Xu, Pei Han Wang, Mei Ying You, Zi Han Li, Xin Mei Chen, Xin Yu Liu, Xu Dong Li, Yuan Yuan Wang, Yue Hua Hu, Da Peng Yin","doi":"10.3967/bes2024.068","DOIUrl":"https://doi.org/10.3967/bes2024.068","url":null,"abstract":"Objective: The occurrence of chickenpox in rapidly developing areas poses substantial seasonal risk to children. However, certain factors influencing local chickenpox outbreaks have not been studied. Here, we examined the relationship between spatial clustering, heterogeneity of chickenpox outbreaks, and socioeconomic factors in Southern China.Methods: We assessed chickenpox outbreak data from Southern China between 2006 and 2021, comprising both relatively fast-growing parts and slower sub-regions, and provides a representative sample of many developing regions. We analyzed the spatial clustering attributes associated with chickenpox outbreaks using Moran's I and local indicators of spatial association and quantified their socioeconomic determinants using Geodetector q statistics.Results: There were significant spatial heterogeneity in the risk of chickenpox outbreaks, with strong correlations between chickenpox risk and various factors, particularly demographics and living environment. Furthermore, interactive effects among specific are factors, such as population density and per capita residential building area, percentage of households with toilets, percentage of rental housing, exhibited q statistics of 0.28, 0.25, and 0.24, respectively.Conclusion: This study provides valuable insights into the spatial dynamics of chickenpox outbreaks in rapidly developing regions, revealing the socioeconomic factors affecting disease transmission. These implications extend the formulation of effective public health strategies and interventions to prevent and control chickenpox outbreaks in similar global contexts.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"37 7","pages":"687-697"},"PeriodicalIF":0.0,"publicationDate":"2024-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142094304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of High Sodium Diet on Neovascularization and Osseointegration around Titanium Implant: An in Vivo and in Vitro Study. 高钠饮食对钛种植体周围血管新生和骨结合的影响：体内和体外研究。

Biomedical and environmental sciences : BES Pub Date : 2024-07-20 DOI: 10.3967/bes2024.077

Ke Yuan Xu, Xiao Ting Tang, Yun Xiang, Yi Ding Shen, Zhen Nan Deng, Ping Ping Ma, Xin Kun Shen

{"title":"Impact of High Sodium Diet on Neovascularization and Osseointegration around Titanium Implant: An in Vivo and in Vitro Study.","authors":"Ke Yuan Xu, Xiao Ting Tang, Yun Xiang, Yi Ding Shen, Zhen Nan Deng, Ping Ping Ma, Xin Kun Shen","doi":"10.3967/bes2024.077","DOIUrl":"https://doi.org/10.3967/bes2024.077","url":null,"abstract":"Objective: A high sodium (HS) diet is believed to affect bone metabolism processes. Clarifying its impact on osseointegration of titanium (Ti) implants holds significant implications for postoperative dietary management of implanted patients.Methods: This investigation probed the impact of sodium ions (Na +) on neovascularization and osteogenesis around Ti implants in vivo, utilizing micro-computed tomography, hematoxylin and eosin staining, and immunohistochemical analyses. Concurrently, in vitro experiments assessed the effects of varied Na + concentrations and exposure durations on human umbilical vein endothelial cells (HUVECs) and MC3T3-E1 cells.Results: In vivo, increased dietary sodium (0.8%-6.0%) led to a substantial decline in CD34 positive HUVECs and new bone formation around Ti implants, alongside an increase in inflammatory cells. In vitro, an increase in Na + concentration (140-150 mmol/L) adversely affected the proliferation, angiogenesis, and migration of HUVECs, especially with prolonged exposure. While MC3T3-E1 cells initially exhibited less susceptibility to high Na + concentrations compared to HUVECs during short-term exposure, prolonged exposure to a HS environment progressively diminished their proliferation, differentiation, and osteogenic capabilities.Conclusion: These findings suggest that HS diet had a negative effect on the early osseointegration of Ti implants by interfering with the process of postoperative vascularized bone regeneration.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"37 7","pages":"739-753"},"PeriodicalIF":0.0,"publicationDate":"2024-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142094298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex Disparities in the Association of Blood Pressure Parameters and Arterial Sclerosis Risk. 血压参数与动脉硬化风险之间的性别差异。

Biomedical and environmental sciences : BES Pub Date : 2024-07-20 DOI: 10.3967/bes2024.093

Dong Dong Zhang, Wei Ling Chen, Min Qi Gu, Xi Li, Yu Ying Wu, Xue Ru Fu, Ping Tang, Fu Lan Hu, Jing Li, Xi Zhuo Sun, Dong Sheng Hu, Ming Zhang

引用次数: 0

Advances in the Application of Molecular Diagnostic Techniques to Brucellosis. 布鲁氏菌病分子诊断技术的应用进展。

Biomedical and environmental sciences : BES Pub Date : 2024-07-20 DOI: 10.3967/bes2024.106

Hai Wen Liu, Hai Jiang

引用次数: 0

Efficacy of a Nutritional Cream Intervention to Treat Depression in Rescuers: A Randomized Controlled Trial. 营养膏干预治疗救援人员抑郁症的效果：随机对照试验

Biomedical and environmental sciences : BES Pub Date : 2024-07-20 DOI: 10.3967/bes2024.096

Qiao Wang, Heng Yu Luan, Chun Yan Li, Ru Fang Gong, Qiong Xuan Li, Jia Yi Deng, Xiao Yong Sai

{"title":"Efficacy of a Nutritional Cream Intervention to Treat Depression in Rescuers: A Randomized Controlled Trial.","authors":"Qiao Wang, Heng Yu Luan, Chun Yan Li, Ru Fang Gong, Qiong Xuan Li, Jia Yi Deng, Xiao Yong Sai","doi":"10.3967/bes2024.096","DOIUrl":"https://doi.org/10.3967/bes2024.096","url":null,"abstract":"Objective: To explore the effectiveness of a nutritional intervention in rescuers who screened positive for depression.Methods: A randomized controlled trial design was employed. From June to August, 2022, 4,460 rescuers were screened using the Self-Rating Depression Scale (SDS), and 1,615 positive cases were identified. Thirty-one volunteers were recruited and randomly divided into a nutritional intervention group and a control group. The intervention group received health education and nutritional intervention (a compound paste therapy primarily composed of red roses and Seville orange flowers), while the control group received psychological education. SDS scores were assessed before and after the intervention.Results: There was a statistically significant decline in SDS scores in the nutritional intervention group after the intervention ( P < 0.05). Furthermore, the SDS scores of the intervention group were significantly lower than those of the control group, both before and after the intervention ( P < 0.05). No severe adverse reactions were observed during safety evaluation.Conclusion: The nutritional intervention effectively reduced the depression scores in rescuers. Early nutritional intervention is recommended for rescuers who initially screen positive for depression.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"37 7","pages":"754-761"},"PeriodicalIF":0.0,"publicationDate":"2024-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142094296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic Variations and Nonalcoholic Fatty Liver Disease: Field Synopsis, Systematic Meta-Analysis, and Epidemiological Evidence. 遗传变异与非酒精性脂肪肝：现场概要、系统性元分析和流行病学证据。

Biomedical and environmental sciences : BES Pub Date : 2024-07-20 DOI: 10.3967/bes2024.079

Ya Mei Li, Xiang Xiao, Jie Wang, Yi Xu Liu, Xiong Feng Pan, Hai Bin Yu, Jia You Luo, Mi Yang Luo

{"title":"Genetic Variations and Nonalcoholic Fatty Liver Disease: Field Synopsis, Systematic Meta-Analysis, and Epidemiological Evidence.","authors":"Ya Mei Li, Xiang Xiao, Jie Wang, Yi Xu Liu, Xiong Feng Pan, Hai Bin Yu, Jia You Luo, Mi Yang Luo","doi":"10.3967/bes2024.079","DOIUrl":"https://doi.org/10.3967/bes2024.079","url":null,"abstract":"Objective: To systematically summarize the published literature on the genetic variants associated with nonalcoholic fatty liver disease (NAFLD).Methods: Literature from Web of Science, PubMed, and Embase between January 1980 and September 2022 was systematically searched. Meta-analyses of the genetic variants were conducted using at least five data sources. The epidemiologic credibility of the significant associations was graded using the Venice criteria.Results: Based on literature screening, 399 eligible studies were included, comprising 381 candidate gene association, 16 genome-wide association, and 2 whole-exome sequencing studies. We identified 465 genetic variants in 173 genes in candidate gene association studies, and 25 genetic variants in 17 genes were included in the meta-analysis. The meta-analysis identified 11 variants in 10 genes that were significantly associated with NAFLD, with cumulative epidemiological evidence of an association graded as strong for two variants in two genes ( HFE, TNF), moderate for four variants in three genes ( TM6SF2, GCKR, and ADIPOQ), and weak for five variants in five genes ( MBOAT7, PEMT, PNPLA3, LEPR, and MTHFR).Conclusion: This study identified six variants in five genes that had moderate to strong evidence of an association with NAFLD, which may help understand the genetic architecture of NAFLD risk.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"37 7","pages":"762-773"},"PeriodicalIF":0.0,"publicationDate":"2024-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142094297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Regulatory Role and Mechanism of Circadian Rhythm in Hemoglobin Co-cultured Neurovascular Unit. 血红蛋白共培养神经血管单元昼夜节律的调节作用和机制

Biomedical and environmental sciences : BES Pub Date : 2024-07-20 DOI: 10.3967/bes2024.090

Fang Xue, Wen Chao Chen, Xia Lian, Guang Hui He, Jing Yuan Tian, Ying Hong Liu, Gai Qing Wang

{"title":"The Regulatory Role and Mechanism of Circadian Rhythm in Hemoglobin Co-cultured Neurovascular Unit.","authors":"Fang Xue, Wen Chao Chen, Xia Lian, Guang Hui He, Jing Yuan Tian, Ying Hong Liu, Gai Qing Wang","doi":"10.3967/bes2024.090","DOIUrl":"10.3967/bes2024.090","url":null,"abstract":"Objective: Intracranial hemorrhage (ICH), the second most common subtype of stroke, exacerbates the disruption of the blood-brain barrier (BBB), leading to vasogenic edema, plasma protein extravasation, and infiltration of neurotoxic substances. The clearance capacity of the brain plays a crucial role in maintaining BBB homeostasis and facilitating patient recovery after hemorrhage. This study aimed to investigate the effect of circadian rhythms on BBB function, neuronal damage, and clearance capabilities.Methods: The transwell model and hemoglobin were co-cultured to simulate the BBB environment after ICH. After intervention with different light groups, neuronal apoptosis was determined, glial phagocytosis was analyzed, the expression of endogenous clearing-related proteins aquaporin 4 (AQP4) and low-density lipoprotein receptor-related protein 1 (LRP1) was detected by western blotting and immunofluorescence dual standard method, and the expression of the tight junction protein occludin and melatonin receptor 1A (MTNR1A) was quantitatively analyzed.Results: Circadian rhythms play a key role in maintaining the integrity of the BBB, reducing oxidative stress-induced neuronal damage, and improving microglial phagocytosis. Meanwhile, the expression of occludin and MTNR1A in neurovascular unit (NVU) co-cultured with hemoglobin improved the expression of AQP4 and LRP1, the key proteins in the NVU's endogenous brain clearance system.Conclusion: Circadian rhythm (alternating black and white light) protects the NVU BBB function after ICH, promotes the expression of proteins related to the clearance of the hematoma, provides new evidence for the clinical treatment of patients recovering from ICH, and improves the circadian rhythm to promote brain metabolism and hematoma clearance.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"37 7","pages":"726-738"},"PeriodicalIF":0.0,"publicationDate":"2024-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142094305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Autophagy Alleviates Cold Exposure-induced Tight Junction Injury in Murine Ileum. 自噬可缓解冷暴露诱发的小鼠回肠紧密连接损伤

Biomedical and environmental sciences : BES Pub Date : 2024-07-20 DOI: 10.3967/bes2024.120

Jing Ru Guo, Jing Xu, Lei Chong Chen, Hui Jie Hu, Jun Shu Nie, Jian Bin Yuan, Li Ma, Jing Jing Lu, Hong Ji, Bin Xu

引用次数: 0