Biomedical and environmental sciences : BES最新文献

Job Preferences of Centers for Disease Control and Prevention Workers: A Discrete Choice Experiment in China. 疾病预防控制中心工作人员的职业偏好：中国的离散选择实验。

Biomedical and environmental sciences : BES Pub Date : 2025-06-20 DOI: 10.3967/bes2025.070

Yan Guo, Han Lin Nie, Hao Chen, Stephen Nicholas, Elizabeth Maitland, Si Si Chen, Lie Yu Huang, Xiu Min Zhang, Xue Feng Shi

{"title":"Job Preferences of Centers for Disease Control and Prevention Workers: A Discrete Choice Experiment in China.","authors":"Yan Guo, Han Lin Nie, Hao Chen, Stephen Nicholas, Elizabeth Maitland, Si Si Chen, Lie Yu Huang, Xiu Min Zhang, Xue Feng Shi","doi":"10.3967/bes2025.070","DOIUrl":"https://doi.org/10.3967/bes2025.070","url":null,"abstract":"Objective: This study explored the job choice preferences of Center for Disease Prevention and Control (CDC) workers to provide CDC management information and recommendations for optimizing employee retention and motivation policies.Methods: A discrete choice experiment was conducted in nine provinces across China. Seven key attributes were identified to analyze the job preferences of CDC workers. Mixed logit models, latent class models, and policy simulation tools were used.Results: A valid sample of 5,944 cases was included in the analysis. All seven attributes significantly influenced the job choices of CDC workers. Heterogeneity analyses identified two main groups based on different levels of preference for attribute utility. Income-prioritizers were concerned with income and opportunities for career development, whereas bianzhi-prioritizers were concerned with bianzhi and welfare benefits. The policy simulation analysis revealed that income-prioritizers had a relatively higher sensitivity to multiple job preference incentives.Conclusion: Income and bianzhi were the two key attributes influencing the job choices and retention preferences of CDC workers. Heterogeneity in job preferences was also identified. Based on the preference characteristics of different subgroups, policy content should be skewed to differentiate the importance of incentives.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"38 6","pages":"740-750"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144568223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Single-Cell and Multi-Dimensional Data Analysis of the Key Role of IDH2 in Cervical Squamous Cell Carcinoma Progression. IDH2在宫颈鳞癌进展中的关键作用的单细胞和多维数据分析。

Biomedical and environmental sciences : BES Pub Date : 2025-06-20 DOI: 10.3967/bes2025.067

Xiao Juan Liu, Zhen Peng Zhu, Chen Yang Hou, Hui Ma, Xiao Yan Li, Chun Xing Ma, Li Sha Shu, Hui Ying Zhang

引用次数: 0

Trajectory Modelling: A Novel Approach to Dig Value of Longitudinal Cohort Studies. 轨迹建模：一种挖掘纵向队列研究价值的新方法。

Biomedical and environmental sciences : BES Pub Date : 2025-06-20 DOI: 10.3967/bes2025.068

Si Yan Zhan

引用次数: 0

Occupational Hazard Factors and the Trajectory of Fasting Blood Glucose Changes in Chinese Male Steelworkers Based on Environmental Risk Scores: A Prospective Cohort Study. 基于环境风险评分的中国男性钢铁工人职业危害因素和空腹血糖变化轨迹：一项前瞻性队列研究。

Biomedical and environmental sciences : BES Pub Date : 2025-06-20 DOI: 10.3967/bes2025.058

Ming Xia Zou, Wei Du, Qin Kang, Yu Hao Xia, Nuo Yun Zhang, Liu Feng, Fei Yue Li, Tian Cheng Ma, Ya Jing Bao, Hong Min Fan

{"title":"Occupational Hazard Factors and the Trajectory of Fasting Blood Glucose Changes in Chinese Male Steelworkers Based on Environmental Risk Scores: A Prospective Cohort Study.","authors":"Ming Xia Zou, Wei Du, Qin Kang, Yu Hao Xia, Nuo Yun Zhang, Liu Feng, Fei Yue Li, Tian Cheng Ma, Ya Jing Bao, Hong Min Fan","doi":"10.3967/bes2025.058","DOIUrl":"10.3967/bes2025.058","url":null,"abstract":"Objective: We aimed to investigate the patterns of fasting blood glucose (FBG) trajectories and analyze the relationship between various occupational hazard factors and FBG trajectories in male steelworkers.Methods: The study cohort included 3,728 workers who met the selection criteria for the Tanggang Occupational Cohort (TGOC) between 2017 and 2022. A group-based trajectory model was used to identify the FBG trajectories. Environmental risk scores (ERS) were constructed using regression coefficients from the occupational hazard model as weights. Univariate and multivariate logistic regression analyses were performed to explore the effects of occupational hazard factors using the ERS on FBG trajectories.Results: FBG trajectories were categorized into three groups. An association was observed between high temperature, noise exposure, and FBG trajectory ( P < 0.05). Using the first quartile group of ERS1 as a reference, the fourth quartile group of ERS1 had an increased risk of medium and high FBG by 1.90 and 2.21 times, respectively (odds ratio [ OR] = 1.90, 95% confidence interval [ CI]: 1.17-3.10; OR = 2.21, 95% CI: 1.09-4.45).Conclusion: An association was observed between occupational hazards based on ERS and FBG trajectories. The risk of FBG trajectory levels increase with an increase in ERS.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"38 6","pages":"666-677"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144568225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between Solid Cooking Fuel Use and Frailty Trajectories: Findings from a Nationwide Cohort in China. 固体烹饪燃料使用与脆弱轨迹之间的关系：来自中国全国队列的研究结果。

Biomedical and environmental sciences : BES Pub Date : 2025-06-20 DOI: 10.3967/bes2025.022

Yang Liu, Bing Jie Wu, Bing Bing Fan, Chun Xia Li, Chang Su, Ai Dong Liu, Tao Zhang

{"title":"Association between Solid Cooking Fuel Use and Frailty Trajectories: Findings from a Nationwide Cohort in China.","authors":"Yang Liu, Bing Jie Wu, Bing Bing Fan, Chun Xia Li, Chang Su, Ai Dong Liu, Tao Zhang","doi":"10.3967/bes2025.022","DOIUrl":"https://doi.org/10.3967/bes2025.022","url":null,"abstract":"Objective: Burning solid cooking fuel contributes to household air pollution and is associated with frailty. However, how solid cooking fuel use contributes to the development of frailty has not been well illustrated.Methods: This study recruited 8,947 participants aged ≥ 45 years from the China Health and Retirement Longitudinal Study, 2011-2018. Group-based trajectory modeling was employed to identify frailty trajectories. Multinomial logistic regression was used to assess the association between solid cooking fuel use and frailty trajectories. Population-attributable fractions were used to estimate the frailty burden from solid fuel use.Results: We identified three frailty trajectories: low-stable ( n = 5,789), moderate-increasing ( n = 2,603), and fast-increasing ( n = 555). Solid fuel use was associated with higher odds of being in the moderate-increasing ( OR: 1.24, 95% CI: 1.08-1.42) and fast-increasing ( OR: 1.48, 95% CI: 1.14-1.92) trajectories. These associations were strengthened by longer solid fuel use ( P for trend < 0.001). Switching to clean fuel significantly reduced the risk of being in these trajectories compared with persistent solid fuel users. Without solid fuel, 8% of moderate- and 19% of fast-increasing trajectories demonstrated frailty development like the low-stable group.Conclusion: Solid cooking fuel use is associated with frailty trajectories in middle-aged and older Chinese populations.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"38 6","pages":"653-665"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144568217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Life-Course Trajectories of Body Mass Index, Insulin Resistance, and Incident Diabetes in Chinese Adults. 中国成人体重指数、胰岛素抵抗和糖尿病发病率的生命轨迹

Biomedical and environmental sciences : BES Pub Date : 2025-06-20 DOI: 10.3967/bes2025.072

Zhi Yuan Ning, Jing Lan Zhang, Bing Bing Fan, Yan Lin Qu, Chang Su, Tao Zhang

{"title":"Life-Course Trajectories of Body Mass Index, Insulin Resistance, and Incident Diabetes in Chinese Adults.","authors":"Zhi Yuan Ning, Jing Lan Zhang, Bing Bing Fan, Yan Lin Qu, Chang Su, Tao Zhang","doi":"10.3967/bes2025.072","DOIUrl":"10.3967/bes2025.072","url":null,"abstract":"Objective: This study aimed to explore the interplay between the life-course body mass index (BMI) trajectories and insulin resistance (IR) on incident diabetes.Methods: This longitudinal cohort included 2,336 participants who had BMI repeatedly measured 3-8 times between 1989 and 2009, as well as glucose and insulin measured in 2009. BMI trajectories were identified using a latent class growth mixed model. The interplay between BMI trajectories and IR on diabetes was explored using the four-way effect decomposition method. Logistic regression and mediation models were used to estimate the interaction and mediation effects, respectively.Results: Three distinct BMI trajectory groups were identified: low-stable ( n = 1,625), medium-increasing ( n = 613), and high-increasing ( n = 98). Both interaction and mediation effects of BMI trajectories and IR on incident diabetes were significant ( P < 0.05). The proportion of incident diabetes was higher in the IR-obesity than in the insulin-sensitivity (IS) obesity group (18.9% vs. 5.8%, P < 0.001). After adjusting for covariates, the odds ratios (95% confidence intervals) of the IR, IS-obesity, and IR-obesity groups vs. the normal group were 3.22 (2.05, 5.16), 2.05 (1.00, 3.97), and 7.98 (5.19, 12.62), respectively. IR mediated 10.7% of the total effect of BMI trajectories on incident diabetes ( P < 0.001).Conclusion: We found strong interactions and weak mediation effects of IR on the relationship between life-course BMI trajectories and incident diabetes. IS-obesity is associated with a lower risk of incident diabetes than IR-obesity.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"38 6","pages":"706-715"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144568224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between ABO Blood Types and the Risk of Gestational Diabetes Mellitus: A Prospective Cohort Study. ABO血型与妊娠期糖尿病风险的关系：一项前瞻性队列研究。

Biomedical and environmental sciences : BES Pub Date : 2025-06-20 DOI: 10.3967/bes2025.046

Shuang Hua Xie, Shuang Ying Li, Shao Fei Su, En Jie Zhang, Shen Gao, Yue Zhang, Jian Hui Liu, Min Hui Hu, Rui Xia Liu, Wen Tao Yue, Cheng Hong Yin

{"title":"Association between ABO Blood Types and the Risk of Gestational Diabetes Mellitus: A Prospective Cohort Study.","authors":"Shuang Hua Xie, Shuang Ying Li, Shao Fei Su, En Jie Zhang, Shen Gao, Yue Zhang, Jian Hui Liu, Min Hui Hu, Rui Xia Liu, Wen Tao Yue, Cheng Hong Yin","doi":"10.3967/bes2025.046","DOIUrl":"https://doi.org/10.3967/bes2025.046","url":null,"abstract":"Objective: To investigate the association between ABO blood types and gestational diabetes mellitus (GDM) risk.Methods: A prospective birth cohort study was conducted. ABO blood types were determined using the slide method. GDM diagnosis was based on a 75-g, 2-h oral glucose tolerance test (OGTT) according to the criteria of the International Association of Diabetes and Pregnancy Study Groups. Logistic regression was applied to calculate the odds ratios ( ORs) and 95% confidence intervals ( CIs) between ABO blood types and GDM risk.Results: A total of 30,740 pregnant women with a mean age of 31.81 years were enrolled in this study. The ABO blood types distribution was: type O (30.99%), type A (26.58%), type B (32.20%), and type AB (10.23%). GDM was identified in 14.44% of participants. Using blood type O as a reference, GDM risk was not significantly higher for types A ( OR = 1.05) or B ( OR = 1.04). However, women with type AB had a 19% increased risk of GDM ( OR = 1.19, 95% CI = 1.05-1.34; P < 0.05), even after adjusting for various factors. This increased risk for type AB was consistent across subgroup and sensitivity analyses.Conclusion: The ABO blood types may influence GDM risk, with type AB associated with a higher risk. Incorporating it-either as a single risk factor or in combination with other known factors-could help identify individuals at risk for GDM before or during early pregnancy.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"38 6","pages":"678-692"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144568216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploration of New Susceptible Genes associated with Non-Alcoholic Fatty Liver Disease among Children with Obesity Using Whole Exome Sequencing. 利用全外显子组测序探索与肥胖儿童非酒精性脂肪肝相关的新易感基因

Biomedical and environmental sciences : BES Pub Date : 2025-06-20 DOI: 10.3967/bes2025.045

Xiong Feng Pan, Cai Lian Wei, Jia You Luo, Jun Xia Yan, Xiang Xiao, Jie Wang, Yan Zhong, Mi Yang Luo

{"title":"Exploration of New Susceptible Genes associated with Non-Alcoholic Fatty Liver Disease among Children with Obesity Using Whole Exome Sequencing.","authors":"Xiong Feng Pan, Cai Lian Wei, Jia You Luo, Jun Xia Yan, Xiang Xiao, Jie Wang, Yan Zhong, Mi Yang Luo","doi":"10.3967/bes2025.045","DOIUrl":"https://doi.org/10.3967/bes2025.045","url":null,"abstract":"Objective: This study aimed to evaluate the association between susceptibility genes and non-alcoholic fatty liver disease (NAFLD) in children with obesity.Methods: We conducted a two-step case-control study. Ninety-three participants were subjected to whole-exome sequencing (exploratory set). Differential genes identified in the small sample were validated in 1,022 participants using multiplex polymerase chain reaction and high-throughput sequencing (validation set).Results: In the exploratory set, 14 genes from the NAFLD-associated pathways were identified. In the validation set, after adjusting for sex, age, and body mass index, ECI2 rs2326408 (dominant model: OR = 1.33, 95% CI: 1.02-1.72; additive model: OR = 1.22, 95% CI: 1.01-1.47), C6orf201 rs659305 (dominant model: OR = 1.30, 95% CI: 1.01-1.69; additive model: OR = 1.21, 95% CI: 1.00-1.45), CALML5 rs10904516 (pre-ad dominant model: OR = 1.36, 95% CI: 1.01-1.83; adjusted dominant model: OR = 1.40, 95% CI: 1.03-1.91; and pre-ad additive model: OR = 1.26, 95% CI: 1.04-1.66) polymorphisms were significantly associated with NAFLD in children with obesity ( P < 0.05). Interaction analysis revealed that the gene-gene interaction model of CALML5 rs10904516, COX11 rs17209882, and SCD5 rs3733228 was optional ( P < 0.05), demonstrating a negative interaction between the three genes.Conclusion: In the Chinese population, the CALML5 rs10904516, C6orf201 rs659305, and ECI2 rs2326408 variants could be genetic markers for NAFLD susceptibility.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"38 6","pages":"727-739"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144568220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations of White Blood Cell, Platelet Count, Platelet-to-White Blood Cell Ratio with Muscle Mass among Community-Dwelling Older Adults in China. 中国社区老年人白细胞、血小板计数、血小板/白细胞比值与肌肉质量的关系

Biomedical and environmental sciences : BES Pub Date : 2025-06-20 DOI: 10.3967/bes2025.051

Zhen Wei Zhang, Yu Ming Zhao, Hong Zhou Chen, Li Qi, Chen Chen, Jun Wang, Wen Hui Shi, Yue Bin Lyu, Xiao Ming Shi

{"title":"Associations of White Blood Cell, Platelet Count, Platelet-to-White Blood Cell Ratio with Muscle Mass among Community-Dwelling Older Adults in China.","authors":"Zhen Wei Zhang, Yu Ming Zhao, Hong Zhou Chen, Li Qi, Chen Chen, Jun Wang, Wen Hui Shi, Yue Bin Lyu, Xiao Ming Shi","doi":"10.3967/bes2025.051","DOIUrl":"https://doi.org/10.3967/bes2025.051","url":null,"abstract":"Objective: This study aimed to evaluate the relationships of white blood cell (WBC) count, platelet (PLT) count, and PLT-to-WBC ratio (PWR) with muscle mass in Chinese older adults.Methods: This cross-sectional analysis involved 4,033 Chinese older adults aged ≥ 65 years from the Healthy Ageing and Biomarkers Cohort Study. Muscle mass and total skeletal muscle mass index (TSMI) were measured by bioelectric impedance analysis. WBC, PLT, and PWR were measured using standard methods. Multivariate linear regression was used to examine the associations of WBC count, PLT count, and PWR with TSMI.Results: High WBC count, PLT count, and PWR were associated with low TSMI, with coefficients of -0.0091 (95% confidence interval [ CI]: -0.0142 to -0.0041), -0.0119 (95% CI: -0.0170 to -0.0068), and -0.0051 (95% CI: -0.0102 to -0.0001). The associations between the three inflammatory indices and TSMI were linear. Stratified analyses indicated that the relationship between inflammatory markers and TSMI was more evident in male participants and in individuals aged < 80 years than in their counterparts.Conclusion: Elevated WBC count, PLT count, and PWR correlated with muscle mass loss. This study highlights the importance of regular monitoring of inflammatory markers as a potential strategy for the screening and management of sarcopenia in older adults.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"38 6","pages":"693-705"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144568218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of Folic Acid Supplementation on Association between Short Inter-Pregnancy Intervals and Adverse Birth Outcomes: A Retrospective Cohort Study in Changsha, China. 叶酸补充在短妊娠间隔和不良分娩结局之间的作用：中国长沙的一项回顾性队列研究

Biomedical and environmental sciences : BES Pub Date : 2025-06-20 DOI: 10.3967/bes2025.057

Zhi Qing Zhao, Ling Chen, Wen Bin Ouyang, Jing Deng, Xiao Hui Chen, Xin Huang

引用次数: 0