Biomedical and environmental sciences : BES最新文献

ATM Activation is Key in Vasculogenic Mimicry Formation by Glioma Stem-like Cells. ATM激活是胶质瘤干样细胞形成血管生成模拟的关键。

Biomedical and environmental sciences : BES Pub Date : 2024-08-20 DOI: 10.3967/bes2024.127

Jing Xie, Jia Xin Tang, Yuan Li, Xue Kong, Wei Wang, Haibo Wu

{"title":"ATM Activation is Key in Vasculogenic Mimicry Formation by Glioma Stem-like Cells.","authors":"Jing Xie, Jia Xin Tang, Yuan Li, Xue Kong, Wei Wang, Haibo Wu","doi":"10.3967/bes2024.127","DOIUrl":"https://doi.org/10.3967/bes2024.127","url":null,"abstract":"Objective: Vasculogenic mimicry (VM) is a novel vasculogenic process integral to glioma stem cells (GSCs) in glioblastoma (GBM). However, the relationship between VM and ataxia-telangiectasia mutated (ATM) serine/threonine kinase activation, which confers chemoradiotherapy resistance, remains unclear.Methods: We investigated VM formation and phosphorylated ATM (pATM) levels by CD31/GFAP-periodic acid-Schiff dual staining and immunohistochemical staining in 145 GBM specimens. Glioma stem-like cells (GSLCs) derived from the formatted spheres of U87 and U251 cell lines and their pATM level and VM formation ability were examined using western blot and three-dimensional culture. For the examination of the function of pATM in VM formation by GSLCs, ATM knockdown by shRNAs and deactivated via ATM phosphorylation inhibitor KU55933 were studied.Results: VM and high pATM expression occurred in 38.5% and 41.8% of tumors, respectively, and were significantly associated with reduced progression-free and overall survival. Patients with VM-positive GBMs exhibited higher pATM levels ( r s = 0.425, P = 0.01). The multivariate analysis established VM as an independent negative prognostic factor ( P = 0.002). Furthermore, GSLCs expressed high levels of pATM and formed vascular-like networks in vitro. ATM inactivation or knockdown hindered VM-like network formation concomitant with the downregulation of pVEGFR-2, VE-cadherin, and laminin B2.Conclusion: VM may predict a poor GBM prognosis and is associated with pATM expression. We propose that pATM promotes VM through extracellular matrix modulation and VE-Cadherin / pVEGFR-2 activation, thereby highlighting ATM activation as a potential target for enhancing anti-angiogenesis therapies for GBM.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142094319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multivariate Analysis of Female Stress Urinary Incontinence and Establishment of a Prediction Model. 女性压力性尿失禁的多变量分析及预测模型的建立。

Biomedical and environmental sciences : BES Pub Date : 2024-08-20 DOI: 10.3967/bes2024.114

Lei Li, Lin Luo, Jun Nai Wang, Ying Hong, Jian Fang Geng

引用次数: 0

Secreted Frizzled-Related Protein 5 Mediates Wnt5a Expression in Microcystin-Leucine-Arginine-Induced Liver Lipid Metabolism Disorder in Mice. 分泌型Frizzled相关蛋白5在微囊藻-亮氨酸-精氨酸诱导的小鼠肝脂代谢紊乱中介导Wnt5a的表达

Biomedical and environmental sciences : BES Pub Date : 2024-08-20 DOI: 10.3967/bes2024.081

Mei Yan Yang, Fu Rong Yu, Qian Qian Ji, Hui Ying Zhang, Jia Xiang Zhang, Dao Jun Chen

{"title":"Secreted Frizzled-Related Protein 5 Mediates Wnt5a Expression in Microcystin-Leucine-Arginine-Induced Liver Lipid Metabolism Disorder in Mice.","authors":"Mei Yan Yang, Fu Rong Yu, Qian Qian Ji, Hui Ying Zhang, Jia Xiang Zhang, Dao Jun Chen","doi":"10.3967/bes2024.081","DOIUrl":"10.3967/bes2024.081","url":null,"abstract":"Objective: Microcystin-leucine-arginine (MC-LR) exposure induces lipid metabolism disorders in the liver. Secreted frizzled-related protein 5 (SFRP5) is a natural antagonist of winglesstype MMTV integration site family, member 5A (Wnt5a) and an anti-inflammatory adipocytokine. In this study, we aimed to investigate whether MC-LR can induce lipid metabolism disorders in hepatocytes and whether SFRP5, which has anti-inflammatory effects, can alleviate the effects of hepatic lipid metabolism by inhibiting the Wnt5a/Jun N-terminal kinase (JNK) pathway.Methods: We exposed mice to MC-LR in vivo to induce liver lipid metabolism disorders. Subsequently, mouse hepatocytes that overexpressed SFRP5 or did not express SFRP5 were exposed to MC-LR, and the effects of SFRP5 overexpression on inflammation and Wnt5a/JNK activation by MC-LR were observed.Results: MC-LR exposure induced liver lipid metabolism disorders in mice and significantly decreased SFRP5 mRNA and protein levels in a concentration-dependent manner. SFRP5 overexpression in AML12 cells suppressed MC-LR-induced inflammation. Overexpression of SFRP5 also inhibited Wnt5a and phosphorylation of JNK.Conclusion: MC-LR can induce lipid metabolism disorders in mice, and SFRP5 can attenuate lipid metabolism disorders in the mouse liver by inhibiting Wnt5a/JNK signaling.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142094328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synaptic Transmission of Primary Hippocampal Neurons was Enhanced after Terahertz Waves Exposure. 原发性海马神经元的突触传递在太赫兹波暴露后得到增强

Biomedical and environmental sciences : BES Pub Date : 2024-08-20 DOI: 10.3967/bes2024.099

Le Quan Song, Zhi Wei He, Jun Miao Pan, Ji Dong, Hao Yu Wang, Jing Zhang, Bin Wei Yao, Xin Ping Xu, Hui Wang, Li Zhao, Rui Yun Peng

引用次数: 0

TIPE2 is Essential for Apocynin-mediated Protection against Intestinal Ischemia/Reperfusion-induced Acute Lung Injury. TIPE2对阿朴霉素介导的肠缺血/再灌注诱导的急性肺损伤的保护作用至关重要

Biomedical and environmental sciences : BES Pub Date : 2024-08-20 DOI: 10.3967/bes2024.124

Hui Rong Jing, Wen Yan Jia, Xue Wen Tang

引用次数: 0

Predicting Acute Mountain Sickness Using Regional Sea-Level Cerebral Blood Flow. 利用区域海平面脑血流量预测急性晕山症

Biomedical and environmental sciences : BES Pub Date : 2024-08-20 DOI: 10.3967/bes2024.100

Hao Zhang, Jie Feng, Shi Yu Zhang, Wen Jia Liu, Lin Ma

{"title":"Predicting Acute Mountain Sickness Using Regional Sea-Level Cerebral Blood Flow.","authors":"Hao Zhang, Jie Feng, Shi Yu Zhang, Wen Jia Liu, Lin Ma","doi":"10.3967/bes2024.100","DOIUrl":"https://doi.org/10.3967/bes2024.100","url":null,"abstract":"Objective: To investigate the role of sea-level cerebral blood flow (CBF) in predicting acute mountain sickness (AMS) using three-dimensional pseudo-continuous arterial spin labeling (3D-pCASL).Methods: Forty-eight healthy volunteers reached an altitude of 3,650 m by air after undergoing a head magnetic resonance imaging (MRI) including 3D-pCASL at sea level. The CBF values of the bilateral anterior cerebral artery (ACA), middle cerebral artery (MCA), posterior cerebral artery (PCA), and posterior inferior cerebellar artery (PICA) territories and the laterality index (LI) of CBF were compared between the AMS and non-AMS groups. Statistical analyses were performed to determine the relationship between CBF and AMS, and the predictive performance was assessed using receiver operating characteristic (ROC) curves.Results: The mean cortical CBF in women (81.65 ± 2.69 mL/100 g/min) was higher than that in men (74.35 ± 2.12 mL/100 g/min) ( P < 0.05). In men, the cortical CBF values in the bilateral ACA, PCA, PICA, and right MCA were higher in patients with AMS than in those without. Cortical CBF in the right PCA best predicted AMS (AUC = 0.818). In women, the LI of CBF in the ACA was different between the AMS and non-AMS groups and predicted AMS with an AUC of 0.753.Conclusion: Although the mechanism and prediction of AMS are quite complicated, higher cortical CBF at sea level, especially the CBF of the posterior circulatory system, may be used for prediction in male volunteers using non-invasive 3D-pCASL.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142094327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Health Risk Assessment of Employees Exposed to Chlorination By-products of Recreational Water in Large Amusement Parks in Shanghai. 上海大型游乐园员工接触娱乐用水氯化副产物的健康风险评估。

Biomedical and environmental sciences : BES Pub Date : 2024-08-20 DOI: 10.3967/bes2024.082

Wei Zhao Cao, Yi Ming Zheng, Wen Xuan Zhao, Li Sha Shi, Yun Hui Zhang, Li Jun Zhang, Jian Chen

{"title":"Health Risk Assessment of Employees Exposed to Chlorination By-products of Recreational Water in Large Amusement Parks in Shanghai.","authors":"Wei Zhao Cao, Yi Ming Zheng, Wen Xuan Zhao, Li Sha Shi, Yun Hui Zhang, Li Jun Zhang, Jian Chen","doi":"10.3967/bes2024.082","DOIUrl":"https://doi.org/10.3967/bes2024.082","url":null,"abstract":"Objective: Chlorination is often used to disinfect recreational water in large amusement parks; however, the health hazards of chlorination disinfection by-products (DBPs) to occupational populations are unknown. This study aimed to assess the exposure status of chlorinated DBPs in recreational water and the health risks to employees of large amusement parks.Methods: Exposure parameters of employees of three large amusement parks in Shanghai were investigated using a questionnaire. Seven typical chlorinated DBPs in recreational water and spray samples were quantified by gas chromatography, and the health risks to amusement park employees exposed to chlorinated DBPs were evaluated according to the WHO's risk assessment framework.Results: Trichloroacetic acid, dibromochloromethane, bromodichloromethane, and dichloroacetic acid were detected predominantly in recreational water. The carcinogenic and non-carcinogenic risks of the five DBPs did not exceed the risk thresholds. In addition, the carcinogenic and non-carcinogenic risks of mixed exposure to DBPs were within the acceptable risk limits.Conclusion: Typical DBPs were widely detected in recreational water collected from three large amusement parks in Shanghai; however, the health risks of DBPs and their mixtures were within acceptable limits.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142094322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-Term Survival Trend of Gynecological Cancer: A Systematic Review of Population-Based Cancer Registration Data. 妇科癌症的长期生存趋势：基于人口的癌症登记数据的系统性回顾。

Biomedical and environmental sciences : BES Pub Date : 2024-08-20 DOI: 10.3967/bes2024.133

Xiao Hui Zhou, Dan Ni Yang, Yi Xin Zou, Dan Dan Tang, Jun Chen, Zhuo Ying Li, Qiu Ming Shen, Qun Xu, Yong Bing Xiang

{"title":"Long-Term Survival Trend of Gynecological Cancer: A Systematic Review of Population-Based Cancer Registration Data.","authors":"Xiao Hui Zhou, Dan Ni Yang, Yi Xin Zou, Dan Dan Tang, Jun Chen, Zhuo Ying Li, Qiu Ming Shen, Qun Xu, Yong Bing Xiang","doi":"10.3967/bes2024.133","DOIUrl":"https://doi.org/10.3967/bes2024.133","url":null,"abstract":"Gynecological cancer significantly affect the health of women. This review aimed to describe the global patterns and trends in the survival of patients with gynecological cancers. We searched PubMed, Embase, Web of Science, SinoMed, and SEER for survival analyses of cancer registration data of cervical, endometrial, and ovarian cancers published between 1980 and 2022. Globally, the highest 5-year observed survival rate for cervical cancer was 76.5% in Anshan, Liaoning, China (2008-2017). The 5-year observed survival rates of endometrial and ovarian cancers were higher in Finland (1995-1999, 82.5%) and Singapore (1988-1992, 62.0%). The 5-year relative survival rate of cervical cancer patients was higher in Haining, Zhejiang, China (2011-2014, 85.8%). Korea ranked first at 89.0% and 64.5% for endometrial and ovarian cancers, respectively. Survival rates have improved for cervical, endometrial, and ovarian cancers. Patients aged ≥ 75 years and those with advanced-stage disease had the worst 5-year survival rates. Survival rates were better for squamous cell carcinoma in cervical cancer, for endometrial carcinoma and mucinous adenocarcinoma in endometrial cancer, and for germ cell and sex-cord stromal tumors in ovarian cancer. Over the past four decades, the survival rates of gynecological cancers have increased globally, with notable increases in cervical and endometrial cancers. Survival rates are higher in developed countries, with a slow-growing trend. Future studies should focus on improving survival, especially in ovarian cancer patients.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142094324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Curcumin on Neuroinflammation and the Nrf2/HO-1 Pathway in Rat Brains Following Gas Explosion. 姜黄素对毒气爆炸后大鼠大脑神经炎症和 Nrf2/HO-1 通路的影响

Biomedical and environmental sciences : BES Pub Date : 2024-08-20 DOI: 10.3967/bes2024.116

Xin Wen Dong, Ya Guang Su, Zheng Luo, Lyu Fei Deng, Xiao Feng Han, Yi Fang Liang, San Qiao Yao, Wei Dong Wu, Jia Cao, Lin Qiang Tian, Yi Chun Bai, Wen Jie Ren

引用次数: 0

Molecular Investigation of Theileria in Ixodid Ticks from Changzhi, Shanxi Province, China. 中国山西省长治市蜱虫中忒伊勒氏菌的分子研究

Biomedical and environmental sciences : BES Pub Date : 2024-08-20 DOI: 10.3967/bes2024.098

Jia Cui, Hua Xiang Rao, Yi Ping Liu, Dong Mei Li, Juan Yu

引用次数: 0