Biomedical and environmental sciences : BES最新文献

{"title":"Association between Ambient Temperature and Chronic Pain among Middle-aged and Older Adults in China: A Nationwide Cross-sectional Study.","authors":"Ye Luo, Matthew Deng Zhang, Fang Wang, Ying Ji, Min Ye, Jun Peng Zhu","doi":"10.3967/bes2026.093","DOIUrl":"https://doi.org/10.3967/bes2026.093","url":null,"abstract":"","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"39 9","pages":"1143-1147"},"PeriodicalIF":4.1,"publicationDate":"2026-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149186926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Nationwide Cross-Sectional Study of Chronic Urticaria in Chinese Adults with Cardiometabolic Diseases: Epidemiology, Risk Factors, and Effect on Disease Management.","authors":"Zhi Hui Yang, Xiao Zhang, Wen Chen, Zuo Tao Zhao, Tao Huang, Li Min Wang","doi":"10.3967/bes2026.084","DOIUrl":"https://doi.org/10.3967/bes2026.084","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the epidemiology and risk factors for chronic urticaria (CU) in Chinese adults with cardiometabolic diseases (CMDs), and its effect on CMD recognition and management.</p><p><strong>Methods: </strong>We conducted a nationwide cross-sectional analysis using data from the 2018-2019 China Chronic Disease and Risk Factor Surveillance, which included 118,036 adults with CMDs. Weighted CU prevalence and CMD awareness, treatment, and control rates (stratified by CU status) were estimated using a complex survey design, whereas risk factors for CU were identified using multivariable logistic regression.</p><p><strong>Results: </strong>The weighted CU prevalence among patients with CMDs was 2.90%, peaking at 3.94% in 60-69-year-old individuals, and was higher in females (3.41%) than in males (2.56%), especially in rural areas. Key risk factors included current smoking (odds ratio [ <i>OR</i>] 1.17, 95% confidence interval [ <i>CI</i>]: 1.06-1.29) and abnormal sleep duration (< 5 h: <i>OR</i> 1.79, 95% <i>CI</i>: 1.61-1.99; > 10 h: <i>OR</i> 1.39, 95% <i>CI</i>: 1.19-1.61). Patients with CU showed stronger association with improved CMD awareness (hypertension: 50.71% <i>vs.</i> 40.27%; diabetes: 47.14% <i>vs.</i> 36.21%; dyslipidemia: 30.71% <i>vs.</i> 17.12%) and treatment rates (hypertension: 41.37% <i>vs.</i> 34.22%; diabetes: 41.31% <i>vs.</i> 32.52%; dyslipidemia: 18.29% <i>vs</i>. 9.94%) than non-CU patients but with comparable control rates.</p><p><strong>Conclusion: </strong>CU is prevalent in patients with CMD and associated with distinct demographic and lifestyle risk factors. Although CU facilitates earlier detection of CMD, it does not improve disease control, indicating the need for integrated dermatology-cardiometabolic care.</p>","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"39 9","pages":"1081-1092"},"PeriodicalIF":4.1,"publicationDate":"2026-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149186967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood Manganese Exposure and Risk of Cognitive Impairment in Older Adults: Evidence from Prospective Cohort Study.","authors":"Yue Chen, Wan Ying Shi, Hui Jie Chang, Liang Ding, Chen Chen, Ying Li Qu, Zhen Yi Yin, Yong Mei Wang, Zhan Hong Xue, Fan Ye Long, Lu Xi Wei, Cai Hong Jiang, Pei Pei Dong, Ying Zhu, Yue Bin Lyu, Xiao Ming Shi","doi":"10.3967/bes2026.086","DOIUrl":"https://doi.org/10.3967/bes2026.086","url":null,"abstract":"<p><strong>Objective: </strong>The prospective cohort study aimed to examine the link between blood Manganese (Mn) concentrations and incident cognitive impairment risk in Chinese elderly individuals.</p><p><strong>Methods: </strong>This study enrolled 6,868 individuals aged 60 years and above from two cohort studies from 2017 to 2024. High-resolution inductively coupled plasma mass spectrometry was employed to quantify blood Mn concentrations. Cognitive function was evaluated by Mini-Mental State Examination (MMSE). <i>Cox</i> proportional hazards models were used to assess the association between blood Mn levels and risk of cognitive impairment, while linear mixed-effects models were used to examine their associations with MMSE and domain-specific cognitive scores. Restricted cubic spline (RCS) was confirmed to explore the dose-response relationship.</p><p><strong>Results: </strong>During an average follow-up of 4.00 years, 1,138 developed cognitive impairment. The mean blood Mn concentration across all participants was 11.297 ± 3.763 µg/L. After full adjustment for covariates, higher blood Mn levels (per interquartile range [ <i>IQR</i>] increase) were significantly associated with greater declines in MMSE score ( <i>β</i> = -0.033, 95% confidence interval [ <i>CI</i>]: -0.048, -0.018) and in multiple domain-specific scores, including orientation, attention and calculation, language, naming, and recall, with the strongest associations observed for naming ( <i>β</i> = -0.043, 95% <i>CI</i>: -0.070, -0.015) and recall ( <i>β</i> = -0.047, 95% <i>CI</i>: -0.064, -0.030). Individuals in the highest quartile ( <i>Q</i> _<i>4</i> ) of blood Mn levels exhibited a 28.5% greater risk of cognitive impairment (Adjusted hazard ratio [ <i>HR</i>] =1.285, 95% <i>CI</i>: 1.081, 1.526) versus the lowest quartile ( <i>Q</i> ₁) of blood Mn levels. The risk of cognitive impairment was 13.1% higher for each <i>IQR</i> increase in blood Mn ( <i>HR</i> = 1.131, 95% <i>CI</i>: 1.051, 1.217). A positive and linear dose-response pattern was confirmed by the RCS model ( <i>P</i> for non-linearity > 0.05).</p><p><strong>Conclusions: </strong>In this population-based prospective cohort study of older adults, higher blood Mn levels were significantly associated with poorer cognitive performance and an increased risk of cognitive impairment, with the most pronounced associations observed for naming and recall ability, suggesting that reducing Mn exposure could serve as a modifiable target for cognitive health protection among older adults.</p>","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"39 9","pages":"1030-1041"},"PeriodicalIF":4.1,"publicationDate":"2026-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149186982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LDH-related Metabolic Alterations in Alzheimer's Disease: Evidence from Clinical and Transcriptomic Analyses.","authors":"Qiao Song, Wen Li, Yang Liu, Si Gen Li, Le Yang Ju, Jing Rong Cao, Shuo Gao, Zhi Chen Liao, Ya Qi Wang, Yu Li Hou, Hai Xia Ma, Yun Xiu Zhang, Dian Dian Chen, Wen Shuo Yang, Xiang Yang, Qi Liang Li, Pei Chang Wang","doi":"10.3967/bes2026.083","DOIUrl":"https://doi.org/10.3967/bes2026.083","url":null,"abstract":"<p><strong>Objective: </strong>Reduced brain energy metabolism is a key feature of Alzheimer's disease (AD); however, lactate dehydrogenase (LDH)-related metabolic changes in AD are not fully understood. This study aimed to evaluate serum LDH activity in patients with mild cognitive impairment (MCI) and AD. We used public transcriptomic datasets to explore the features of LDHA and LDHB across brain regions, cell types, and co-expression networks.</p><p><strong>Method: </strong>In a retrospective clinical cohort of 132 healthy controls (HC), 87 patients with MCI, and 103 patients with AD, we compared serum LDH activity after adjusting for major clinical covariates. Next, we used public transcriptomic datasets [AlzData, Agora, CELLxGENE, and genotype-tissue expression (GTEx)] to evaluate regional and cell-type-specific expression patterns of LDHA and LDHB. We also characterized LDH-associated functional networks using GTEx normal brain data for baseline co-expression analysis and AD-related weighted gene co-expression network analysis (WGCNA).</p><p><strong>Results: </strong>Clinical cohort analysis showed that serum LDH activity was significantly decreased in patients with MCI and AD. Serum LDH activity did not significantly correlate with mini-mental state examination (MMSE) or montreal cognitive assessment (MoCA) scores. Brain transcriptomic analysis revealed that LDHA expression was significantly downregulated in AD-related regions (entorhinal cortex, hippocampus, and temporal cortex), whereas LDHB showed a downward trend in several AD-related regions. Both genes were detectable across multiple brain cell types with relatively prominent expression in neurons. Functional analysis showed that, under normal conditions, LDHA-correlated genes were broadly involved in glycolysis, vesicle trafficking, autophagy, and proteostasis, whereas LDHB-correlated genes were highly concentrated in mitochondrial oxidative phosphorylation and the citric acid (TCA) cycle. AD-related WGCNA showed region-dependent organization of LDHA- and LDHB-containing modules, with repeated enrichment in synaptic vesicle-related processes, mitochondrial respiration, autophagy, and proteostasis-related pathways.</p><p><strong>Conclusion: </strong>This study provides clinical and transcriptomic evidence of LDH-related metabolic alterations in patients with AD. Reduced serum LDH activity in MCI and AD, together with decreased LDHA/LDHB expression in AD-related brain regions and region-dependent LDH-associated co-expression networks, supports a potential link between LDH-related metabolism and mitochondrial energy metabolism, synaptic function, and proteostasis in AD. These findings should be interpreted as exploratory, and require validation through paired prospective and mechanistic studies.</p>","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"39 9","pages":"1042-1062"},"PeriodicalIF":4.1,"publicationDate":"2026-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149186988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immune Dysregulation and Metabolic Dysfunction in Alzheimer's Disease.","authors":"Wen Li, Hai Xia Ma, Qiao Song, Pei Chang Wang","doi":"10.3967/bes2026.096","DOIUrl":"https://doi.org/10.3967/bes2026.096","url":null,"abstract":"","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"39 9","pages":"1027-1029"},"PeriodicalIF":4.1,"publicationDate":"2026-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149186911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Multidimensional Measurement and Comparative Study of Healthy Life Expectancy in the Elderly Population in Jiangxi Province.","authors":"Lin Fu, Fen Fei Xu, Xin Ru Li, Yan Hong Zhang, Jie Chuan Hou, Song Bo Hu","doi":"10.3967/bes2026.071","DOIUrl":"https://doi.org/10.3967/bes2026.071","url":null,"abstract":"","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"39 9","pages":"1137-1142"},"PeriodicalIF":4.1,"publicationDate":"2026-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149187003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monocyte-to-albumin Ratio is Associated with Cognitive Function in Adults Aged Over 60.","authors":"Cong Cong Liu, Pei Chang Wang, Hai Xia Ma","doi":"10.3967/bes2026.085","DOIUrl":"https://doi.org/10.3967/bes2026.085","url":null,"abstract":"","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"39 9","pages":"1131-1136"},"PeriodicalIF":4.1,"publicationDate":"2026-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149186956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary Live Microbe Intake and Sarcopenia in Shanghai.","authors":"Xiao Yu Sun, Zheng Yuan Wang, Jia Yi Wu, Wei Lu, Ze Huan Shi, Li Ping Shen, Chen Yu Shen, Chen Chen Hu, Xue Song Xiang, Jia Jie Zang, Gui Ju Sun","doi":"10.3967/bes2026.095","DOIUrl":"https://doi.org/10.3967/bes2026.095","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the relationship between the dietary intake of live microbes and sarcopenia in adults living in Shanghai.</p><p><strong>Methods: </strong>Data were collected from 1,236 participants aged 50 years or more from the Shanghai Diet and Health Surveillance (SDHS). Dietary data were assessed using a standardized questionnaire. The participants were categorized into the low-, medium-, and high-dietary live microbial groups. Sarcopenia was defined according to the European Working Group on Sarcopenia in Older People (EWGSOP2019).</p><p><strong>Results: </strong>Yogurt and traditional Chinese fermented foods (pickled mustard and fermented tofu) were the primary dietary sources of live microbes in this cohort. Overall, participants without sarcopenia consumed foods with higher levels of live microbes than people with sarcopenia ( <i>P</i> < 0.001). Following stepwise adjustment for confounders, we found that individuals consuming a higher abundance of live dietary microbes were less likely to develop sarcopenia than individuals consuming a lower abundance of live dietary microbes. In the crude model, the odds ratio and 95% confidence interval for high live microbe intake were 0.46 (0.27, 0.76) ( <i>P</i> < 0.001) and the adjusted odds ratio (95% confidence interval) was 0.41 (0.22, 0.77) ( <i>P</i> = 0.007). Subgroup analyses identified no significant interaction effects for sex, age, diabetes, fatty liver disease, or overweight/obesity ( <i>P</i> > 0.05).</p><p><strong>Conclusion: </strong>A high dietary intake of live microbes may be associated with a lower risk of sarcopenia in the Chinese population.</p>","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"39 9","pages":"1104-1114"},"PeriodicalIF":4.1,"publicationDate":"2026-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149186985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of the Triglyceride-glucose Index and Its Obesity-related Indices with Microvascular Complications among Individuals with Type 2 Diabetes: A Prospective Cohort Study.","authors":"Xi Chen, Yu He Tan, Hao Wang, Ting Ting Geng, Ming Zhu Yuan, An Pan, Xu Fang Sun","doi":"10.3967/bes2026.098","DOIUrl":"https://doi.org/10.3967/bes2026.098","url":null,"abstract":"","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"39 9","pages":"1148-1155"},"PeriodicalIF":4.1,"publicationDate":"2026-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149186998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual-track Parallel and Integrated Innovation: Recent Advancements of Clinical Decision Support Systems in Cardiovascular Diseases from the Perspective of Integrative Chinese and Western Medicine.","authors":"Zi Han Jia, Lei Zhang, Lin Tong, Hui Fang Zhang, Hong Tao Li, Feng Xia Zhang, Si Wei Tian, Zhuang Guo, Si Qi Zhang, Yan Ma, Bing Li, Hua Min Zhang","doi":"10.3967/bes2026.094","DOIUrl":"https://doi.org/10.3967/bes2026.094","url":null,"abstract":"<p><p>Cardiovascular diseases (CVDs) are the leading causes of death worldwide, have a growing disease burden, and present multiple challenges for precision management. Clinical Decision Support Systems (CDSS) are tools that leverage information technology to assist clinicians in diagnosis and treatment decisions and provide references for clinical decision-making by offering personalized suggestions, prompts, or reminders. By integrating multisource data, evidence-based guidelines, and artificial intelligence algorithms, CDSS can support diagnosis, prescribing, and comorbidity management. Studies in hypertension have reported improvements in prescribing and blood pressure, while effects on major cardiovascular events and mortality require further evaluation. Notably, with the continuous development of informatization and digitalization of Traditional Chinese Medicine (TCM), traditional Chinese medicine clinical decision support systems (TCM-CDSS), as an innovative achievement integrating traditional medicine with modern information technology, have shown promise in supporting the prevention and treatment of CVDs. TCM-CDSS achieves an intelligent diagnosis and treatment closed loop from \"syndrome differentiation\" to \"formula recommendation\" by integrating TCM theory of \"principles, methods, formulas, and medicinals,\" renowned TCM experts' clinical experience, TCM knowledge graphs, and intelligent syndrome differentiation algorithms, providing a new paradigm for individualized diagnosis and treatment of CVDs such as hypertension and coronary heart disease (CHD). However, reviews addressing the integration of Chinese and Western medicine in cardiovascular CDSS remain limited. To address this knowledge gap, this review adopts a conceptual framework of \"dual-track parallel and integrated innovation\" to systematically elaborate on the current application status of CDSS across major CVDs. We critically stratified current clinical evidence tiers, highlighting the widespread reliance on retrospective studies and the urgent need for large-scale randomized controlled trials (RCTs). Furthermore, we propose that the future paradigm lies in mechanism-data, dual-driven hybrid architectures that quantitatively anchor Western physiological indicators to TCM macrosyndromes. Finally, we provide targeted solutions for the core technical bottlenecks, including Electronic Health Record workflow integration, cross-system comorbidity management, and grassroots application feasibility. These results provide an important reference for the precise treatment of CVDs and a basis for developing new paradigms for CVD prevention and treatment.</p>","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"39 9","pages":"1115-1130"},"PeriodicalIF":4.1,"publicationDate":"2026-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149186973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}