Biomedical and environmental sciences : BES最新文献

Report on Cardiovascular Health and Diseases in China 2023: An Updated Summary. 2023 年中国心血管健康与疾病报告》：最新摘要。

Biomedical and environmental sciences : BES Pub Date : 2024-09-20 DOI: 10.3967/bes2024.162

National Center For Cardiovascular Diseases The Writing Committee Of The Report On Cardiovascular Health And Diseases In China

{"title":"Report on Cardiovascular Health and Diseases in China 2023: An Updated Summary.","authors":"National Center For Cardiovascular Diseases The Writing Committee Of The Report On Cardiovascular Health And Diseases In China","doi":"10.3967/bes2024.162","DOIUrl":"https://doi.org/10.3967/bes2024.162","url":null,"abstract":"Since 1990, China has made considerable progress in resolving the problem of \"treatment difficulty\" of cardiovascular diseases (CVD). The prevalent unhealthy lifestyle among Chinese residents has exposed a massive proportion of the population to CVD risk factors, and this situation is further worsened due to the accelerated aging population in China. CVD remains one of the greatest threats to the health of Chinese residents. In terms of the proportions of disease mortality among urban and rural residents in China, CVD has persistently ranked first. In 2021, CVD accounted for 48.98% and 47.35% of deaths in rural and urban areas, respectively. Two out of every five deaths can be attributed to CVD. To implement a national policy \"focusing on the primary health institute and emphasizing prevention\" and truly achieve a shift of CVD prevention and treatment from hospitals to communities, the National Center for Cardiovascular Diseases has organized experts from relevant fields across China to compile the \"Report on Cardiovascular Health and Diseases in China\" annually since 2005. The 2024 report is established based on representative, published, and high-quality big-data research results from cross-sectional and cohort population epidemiological surveys, randomized controlled clinical trials, large sample registry studies, and typical community prevention and treatment cases, along with data from some projects undertaken by the National Center for Cardiovascular Diseases. These firsthand data not only enrich the content of the current report but also provide a more timely and comprehensive reflection of the status of CVD prevention and treatment in China.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142482981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Projecting the Dynamic Trends of Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome: Modeling the Epidemic in Sichuan Province, China. 预测人类免疫缺陷病毒/获得性免疫缺陷综合征的动态趋势：中国四川省疫情模型。

Biomedical and environmental sciences : BES Pub Date : 2024-09-20 DOI: 10.3967/bes2024.080

Yuan Li, Qin Xi Liu, Rong Sheng Luan, Yi Yang, Tao Wu, Bi Hui Yang

{"title":"Projecting the Dynamic Trends of Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome: Modeling the Epidemic in Sichuan Province, China.","authors":"Yuan Li, Qin Xi Liu, Rong Sheng Luan, Yi Yang, Tao Wu, Bi Hui Yang","doi":"10.3967/bes2024.080","DOIUrl":"https://doi.org/10.3967/bes2024.080","url":null,"abstract":"Objective: Our study aimed to provide a comprehensive overview of the current status and dynamic trends of the human immunodeficiency virus (HIV) prevalence in Sichuan, the second most heavily affected province in China, and to explore future interventions.Methods: The epidemiological, behavioral, and population census data from multiple sources were analyzed to extract inputs for an acquired immunodeficiency syndrome (AIDS) epidemic model (AEM). Baseline curves, derived from historical trends in HIV prevalence, were used, and the AEM was employed to examine future intervention scenarios.Results: In 2015, the modeled data suggested an adult HIV prevalence of 0.191% in Sichuan, with an estimated 128,766 people living with HIV/AIDS and 16,983 individuals with newly diagnosed infections. Considering current high-risk behaviors, the model predicts an increase in the adult prevalence to 0.306% by 2025, projecting an estimated 212,168 people living with HIV/AIDS and 16,555 individuals with newly diagnosed infections.Conclusion: Heterosexual transmission will likely emerge as the primary mode of AIDS transmission in Sichuan. Furthermore, we anticipate a stabilization in the incidence of AIDS with a concurrent increase in prevalence. Implementing comprehensive intervention measures aimed at high-risk groups could effectively alleviate the spread of AIDS in Sichuan.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142482978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DNA Methylation of KLRC1 and KLRC3 in Autoimmune Thyroiditis: Perspective of Different Water Iodine Exposure. 自身免疫性甲状腺炎中 KLRC1 和 KLRC3 的 DNA 甲基化：不同水碘暴露的视角

Biomedical and environmental sciences : BES Pub Date : 2024-09-20 DOI: 10.3967/bes2024.103

Yao Chen, Jin Jin Liu, Meng Ying Qu, Bing Xuan Ren, Huai Yong Wu, Li Zhang, Zheng Zhou, Li Xiang Liu, Hong Mei Shen

{"title":"DNA Methylation of KLRC1 and KLRC3 in Autoimmune Thyroiditis: Perspective of Different Water Iodine Exposure.","authors":"Yao Chen, Jin Jin Liu, Meng Ying Qu, Bing Xuan Ren, Huai Yong Wu, Li Zhang, Zheng Zhou, Li Xiang Liu, Hong Mei Shen","doi":"10.3967/bes2024.103","DOIUrl":"https://doi.org/10.3967/bes2024.103","url":null,"abstract":"Objective: This study aimed to identify differentially methylated genes (DMGs) associated with natural killer cells in patients with autoimmune thyroiditis (AIT), focusing on the influence of varying water iodine exposure levels.Methods: Participants were divided into categories based on median water iodine (MWI) concentrations: iodine-fortified areas (IFA, MWI < 10 µg/L), iodine-adequate areas (IAA, 40 ≤ MWI ≤ 100 µg/L), and iodine-excessive areas (IEA, MWI > 300 µg/L). A total of 176 matched AIT cases and controls were recruited and divided into 89, 40, and 47 pairs for IFA, IAA, and IEA, respectively. DMGs were identified using 850K BeadChip analysis for 10/10 paired samples. Validation of DNA methylation and mRNA expression levels of the DMGs was conducted using MethylTarget™ and QRT-PCR for 176/176 paired samples.Results: KLRC1, KLRC3, and SH2D1B were identified as significant DMGs. Validation revealed that KLRC1 was hypomethylated and highly expressed, whereas KLRC3 was hypermethylated and highly expressed in individuals with AIT. Furthermore, KLRC1 was hypomethylated and highly expressed in both IFA and IEA.Conclusion: The DNA methylation status of KLRC1 and KLRC3 may play crucial roles in AIT pathogenesis. Additionally, DNA methylation of KLRC1seems to be influenced by different iodine concentrations in water.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142482972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Disparities in the Levels of Whole-Blood Epstein-Barr Virus between the Cancer and Non-Cancer Populations in Zhejiang, China. 中国浙江癌症和非癌症人群全血 Epstein-Barr 病毒水平的差异。

Biomedical and environmental sciences : BES Pub Date : 2024-09-20 DOI: 10.3967/bes2024.101

Qing Jun Jia, Meichun Zeng, Qi Chen

{"title":"Disparities in the Levels of Whole-Blood Epstein-Barr Virus between the Cancer and Non-Cancer Populations in Zhejiang, China.","authors":"Qing Jun Jia, Meichun Zeng, Qi Chen","doi":"10.3967/bes2024.101","DOIUrl":"https://doi.org/10.3967/bes2024.101","url":null,"abstract":"Objective: This study aimed to investigate the prevalence of Epstein-Barr virus (EBV) infection in patients with and without cancer.Methods: A total of 26,648 participants who underwent whole-blood EBV DNA (WBEBV) assays between January 1, 2020, and August 31, 2023, were included. The chi-square test was used for categorical data analysis, and R software was used to analyze the differences in EBV DNA load levels and the diagnostic capabilities of WBEBV.Results: Positive rates were 10.2% and 25.4% for healthy controls (HC) and patients, respectively. The positivity rate for EBV-associated neoplasms (EN) was the highest at 7.53%, followed by leukemia (Le) at 5.49%. The subgroup analysis showed that the positivity rate for abnormal proliferation or hyperplasia (APH) was 31.9%, followed by 30.5% for Le. The WBEBV of patients with transplants (TP), especially living-related transplants (LT), was the highest among all subgroups. WBEBV at diagnosis was used to differentiate between infectious mononucleosis (IM) and chronic active Epstein-Barr virus (CAEBV), with a sensitivity of 67.4% (95% confidence interval [ CI]: 57.6-75.8) and specificity of 72% (95% CI: 63.3-79.3). We conclude that the prevalence of EBV infection is low in the healthy population in this region and that a high EBV load at baseline is more common in LT, IM, and Lymphocyte Leukemia (LL).Conclusion: This study used a large-sample survey to characterize the prevalence of whole-blood EBV levels in various diseases, including the stages and subtypes. The EBV detection rate was higher in patients with malignant disease than in those with benign disease. Our study provides clinicians with baseline information regarding EBV-associated diseases.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142482962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MicroRNA-451 from Human Umbilical Cord-Derived Mesenchymal Stem Cell Exosomes Inhibits Alveolar Macrophage Autophagy via Tuberous Sclerosis Complex 1/Mammalian Target of Rapamycin Pathway to Attenuate Burn-Induced Acute Lung Injury in Rats. 人脐带间充质干细胞外泌体中的 MicroRNA-451 通过结节性硬化症复合物 1/哺乳动物雷帕霉素靶途径抑制肺泡巨噬细胞自噬，从而减轻大鼠烧伤诱发的急性肺损伤。

Biomedical and environmental sciences : BES Pub Date : 2024-09-20 DOI: 10.3967/bes2024.128

Zhi Gang Jia, Lin Li, Peng Zhao, Guo Fei, Shuang Ru Li, Qin Qin Song, Guang Peng Liu, Ji Song Liu

{"title":"MicroRNA-451 from Human Umbilical Cord-Derived Mesenchymal Stem Cell Exosomes Inhibits Alveolar Macrophage Autophagy via Tuberous Sclerosis Complex 1/Mammalian Target of Rapamycin Pathway to Attenuate Burn-Induced Acute Lung Injury in Rats.","authors":"Zhi Gang Jia, Lin Li, Peng Zhao, Guo Fei, Shuang Ru Li, Qin Qin Song, Guang Peng Liu, Ji Song Liu","doi":"10.3967/bes2024.128","DOIUrl":"https://doi.org/10.3967/bes2024.128","url":null,"abstract":"Objective: Our previous studies established that microRNA (miR)-451 from human umbilical cord mesenchymal stem cell-derived exosomes (hUC-MSC-Exos) alleviates acute lung injury (ALI). This study aims to elucidate the mechanisms by which miR-451 in hUC-MSC-Exos reduces ALI by modulating macrophage autophagy.Methods: Exosomes were isolated from hUC-MSCs. Severe burn-induced ALI rat models were treated with hUC-MSC-Exos carrying the miR-451 inhibitor. Hematoxylin-eosin staining evaluated inflammatory injury. Enzyme-linked immunosorbnent assay measured lipopolysaccharide (LPS), tumor necrosis factor-α, and interleukin-1β levels. qRT-PCR detected miR-451 and tuberous sclerosis complex 1 (TSC1) expressions. The regulatory role of miR-451 on TSC1 was determined using a dual-luciferase reporter system. Western blotting determined TSC1 and proteins related to the mammalian target of rapamycin (mTOR) pathway and autophagy. Immunofluorescence analysis was conducted to examine exosomes phagocytosis in alveolar macrophages and autophagy level.Results: hUC-MSC-Exos with miR-451 inhibitor reduced burn-induced ALI and promoted macrophage autophagy. MiR-451 could be transferred from hUC-MSCs to alveolar macrophages via exosomes and directly targeted TSC1. Inhibiting miR-451 in hUC-MSC-Exos elevated TSC1 expression and inactivated the mTOR pathway in alveolar macrophages. Silencing TSC1 activated mTOR signaling and inhibited autophagy, while TSC1 knockdown reversed the autophagy from the miR-451 inhibitor-induced.Conclusion: miR-451 from hUC-MSC exosomes improves ALI by suppressing alveolar macrophage autophagy through modulation of the TSC1/mTOR pathway, providing a potential therapeutic strategy for ALI.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142482977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

What Mice Can Teach Us about How to Stop Drug-Resistant Tuberculosis: Correct Chemotherapy Regimen and Patient Compliance are the Key. 小鼠能告诉我们如何阻止耐药性结核病：正确的化疗方案和患者的依从性是关键。

Biomedical and environmental sciences : BES Pub Date : 2024-09-20 DOI: 10.3967/bes2024.084

Igor Mokrousov, Tatiana Vinogradova, Marine Dogonadze, Maria Vitovskaya, Natalia Zabolotnykh, Sergei Chekrygin, Anna Vyazovaya

引用次数: 0

Estimation of Incidence of Herpes Zoster in Three Cities of China, 2019-2020. 2019-2020 年中国三大城市带状疱疹发病率估计。

Biomedical and environmental sciences : BES Pub Date : 2024-09-20 DOI: 10.3967/bes2024.115

Qian Zhang, Wei Qin, Zhen Shui Huang, Li Lin Liang, Qian Qian Hu, Yao Wang, Fan Pan, Feng Cui, Xin Li Liu, Lin Tang, Xiao Qi Wang, Chao Ma, Fu Zhen Wang, Zun Dong Yin

引用次数: 0

Effective Nucleic Acid Contamination Disinfection in Laboratory Settings using Ozone Gas. 在实验室环境中使用臭氧气体进行有效的核酸污染消毒。

Biomedical and environmental sciences : BES Pub Date : 2024-09-20 DOI: 10.3967/bes2024.086

Ying Yi Long, Lin Lin Liang, Xing Yan Zhou, Fei Ren, Lu Wang, Peng Zhang, Jing Wang

引用次数: 0

Quantifying the Temperature Effects on the Morbidity of Digestive Diseases In an Inland Plateau-Valley City. 内陆高原河谷城市气温对消化道疾病发病率影响的量化研究

Biomedical and environmental sciences : BES Pub Date : 2024-09-20 DOI: 10.3967/bes2024.140

Pan Ma, Yang Yang, Ning Zhou, Xin Zi Wang, Yu Lu Wang, Wen Juan Feng, Zhaoqin Bai, Shi Gong Wang

引用次数: 0

Summary Analysis of National Surveillance on Kashin-Beck Disease from 1990 to 2023. 1990 年至 2023 年全国卡欣贝克病监测情况汇总分析。

Biomedical and environmental sciences : BES Pub Date : 2024-09-20 DOI: 10.3967/bes2024.109

Si Lu Cui, Hui Liu, Jun Rui Pei, Jia Xin Li, Zhe Jiao, Qing Deng, Ning Liu, Yan Hong Cao, Jun Yu

{"title":"Summary Analysis of National Surveillance on Kashin-Beck Disease from 1990 to 2023.","authors":"Si Lu Cui, Hui Liu, Jun Rui Pei, Jia Xin Li, Zhe Jiao, Qing Deng, Ning Liu, Yan Hong Cao, Jun Yu","doi":"10.3967/bes2024.109","DOIUrl":"https://doi.org/10.3967/bes2024.109","url":null,"abstract":"Objective: To analyze the epidemiological characteristics and epidemic situation of children with Kashin-Beck disease (KBD) in China, and provide the basis for formulating prevention and control measures.Methods: Fixed-point monitoring, moving-point monitoring, and full coverage of monitoring were promoted successively from 1990 to 2023. Some children (7-12 years old) underwent clinical and right-hand X-ray examinations every year. According to the KBD diagnosis criteria, clinical and X-ray assessments were used to confirm the diagnosis.Results: In 1990, the national KBD detectable rate was 21.01%. X-ray detection decreased to below 10% in 2003 and below 5% in 2007. Between 2010 and 2018, the prevalence of KBD in children was less than 0.4%, which fluctuated at a low level, and has decreased to 0% since 2019. Spatial epidemiological analysis indicated a spatial clustering of adult patients prevalence rate in the KBD areas.Conclusion: The evaluation results of the elimination of KBD in China over the last 5 years showed that all villages in the monitored areas have reached the elimination standard. While the adult KBD patients still need for policy consideration and care.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142482982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0