Biomedical and environmental sciences : BES最新文献_第2页

Integrating Internet Search Data and Surveillance Data to Construct Influenza Epidemic Thresholds in Hubei Province: A Moving Epidemic Method Approach. 整合互联网搜索数据和监测数据构建湖北省流感流行阈值：一种移动流行病方法

IF 4.1

Biomedical and environmental sciences : BES Pub Date : 2025-09-20 DOI: 10.3967/bes2025.109

Cai Xia Dang, Feng Liu, Heng Liang Lyu, Zi Qian Zhao, Si Jin Zhu, Yang Wang, Yuan Yong Xu, Ye Qing Tong, Hui Chen

引用次数: 0

Pathogenicity and Transcriptomic Profiling Revealed Activation of Apoptosis and Pyroptosis in Brain of Mice Infected with the Beta Variant of SARS-CoV-2. 致病性和转录组学分析揭示了感染SARS-CoV-2 β变体的小鼠脑内细胞凋亡和焦亡的激活。

IF 4.1

Biomedical and environmental sciences : BES Pub Date : 2025-09-20 DOI: 10.3967/bes2025.106

Han Li, Bao Ying Huang, Gao Qian Zhang, Fei Ye, Li Zhao, Wei Bang Huo, Zhong Xian Zhang, Wen Wang, Wen Ling Wang, Xiao Ling Shen, Chang Cheng Wu, Wen Jie Tan

{"title":"Pathogenicity and Transcriptomic Profiling Revealed Activation of Apoptosis and Pyroptosis in Brain of Mice Infected with the Beta Variant of SARS-CoV-2.","authors":"Han Li, Bao Ying Huang, Gao Qian Zhang, Fei Ye, Li Zhao, Wei Bang Huo, Zhong Xian Zhang, Wen Wang, Wen Ling Wang, Xiao Ling Shen, Chang Cheng Wu, Wen Jie Tan","doi":"10.3967/bes2025.106","DOIUrl":"https://doi.org/10.3967/bes2025.106","url":null,"abstract":"Objective: Patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection frequently develop central nervous system damage, yet the mechanisms driving this pathology remain unclear. This study investigated the primary pathways and key factors underlying brain tissue damage induced by the SARS-CoV-2 beta variant (lineage B.1.351).Methods: K18-hACE2 and C57BL/6 mice were intranasally infected with the SARS-CoV-2 beta variant. Viral replication, pathological phenotypes, and brain transcriptomes were analyzed. Gene Ontology (GO) analysis was performed to identify altered pathways. Expression changes of host genes were verified using reverse transcription-quantitative polymerase chain reaction and Western blot.Results: Pathological alterations were observed in the lungs of both mouse strains. However, only K18-hACE2 mice exhibited elevated viral RNA loads and infectious titers in the brain at 3 days post-infection, accompanied by neuropathological injury and weight loss. GO analysis of infected K18-hACE2 brain tissue revealed significant dysregulation of genes associated with innate immunity and antiviral defense responses, including type I interferons, pro-inflammatory cytokines, Toll-like receptor signaling components, and interferon-stimulated genes. Neuroinflammation was evident, alongside activation of apoptotic and pyroptotic pathways. Furthermore, altered neural cell marker expression suggested viral-induced neuroglial activation, resulting in caspase 4 and lipocalin 2 release and disruption of neuronal molecular networks.Conclusion: These findings elucidate mechanisms of neuropathogenicity associated with the SARS-CoV-2 beta variant and highlight therapeutic targets to mitigate COVID-19-related neurological dysfunction.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"38 9","pages":"1082-1094"},"PeriodicalIF":4.1,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145294731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness of Pentavalent Rotavirus Vaccine - a Propensity Score Matched Test Negative Design Case-Control Study Using Medical Big Data in Three Provinces of China. 五价轮状病毒疫苗的有效性——中国三省医学大数据的倾向评分匹配阴性设计病例对照研究

IF 4.1

Biomedical and environmental sciences : BES Pub Date : 2025-09-20 DOI: 10.3967/bes2025.056

Yue Xin Xiu, Lin Tang, Fu Zhen Wang, Lei Wang, Zhen Li, Jun Liu, Dan Li, Xue Yan Li, Yao Yi, Fan Zhang, Lei Yu, Jing Feng Wu, Zun Dong Yin

{"title":"Effectiveness of Pentavalent Rotavirus Vaccine - a Propensity Score Matched Test Negative Design Case-Control Study Using Medical Big Data in Three Provinces of China.","authors":"Yue Xin Xiu, Lin Tang, Fu Zhen Wang, Lei Wang, Zhen Li, Jun Liu, Dan Li, Xue Yan Li, Yao Yi, Fan Zhang, Lei Yu, Jing Feng Wu, Zun Dong Yin","doi":"10.3967/bes2025.056","DOIUrl":"https://doi.org/10.3967/bes2025.056","url":null,"abstract":"Objective: The objective of our study was to evaluate the vaccine effectiveness (VE) of the pentavalent rotavirus vaccine (RV5) among < 5-year-old children in three provinces of China during 2020-2024 via a propensity score-matched test-negative case-control study.Methods: Electronic health records and immunization information systems were used to obtain data on acute gastroenteritis (AGE) cases tested for rotavirus (RV) infection. RV-positive cases were propensity score matched with RV-negative controls for age, visit month, and province.Results: The study included 27,472 children with AGE aged 8 weeks to 4 years at the time of AGE diagnosis; 7.98% (2,192) were RV-positive. The VE (95% confidence interval, CI) of 1-2 and 3 doses of RV5 against any medically attended RV infection (inpatient or outpatient) was 57.6% (39.8%, 70.2%) and 67.2% (60.3%, 72.9%), respectively. Among children who received the 3rd dose before turning 5 months of age, 3-dose VE decreased from 70.4% (53.9%, 81.1%) (< 5 months since the 3rd dose) to 63.0% (49.1%, 73.0%) (≥ 1 year since the 3rd dose). The three-dose VE rate was 69.4% (41.3%, 84.0%) for RVGE hospitalization and 57.5% (38.9%, 70.5%) for outpatient-only medically attended RVGE.Conclusion: Three-dose RV5 VE against rotavirus gastroenteritis (RVGE) in children aged < 5 years was higher than 1-2-dose VE. Three-dose VE decreased with time since the 3rd dose in children who received the 3rd dose before turning five months of age, but remained above 60% for at least one year. VE was higher for RVGE hospitalizations than for medically attended outpatient visits.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"38 9","pages":"1032-1043"},"PeriodicalIF":4.1,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145294762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transcriptomics: from Technological Breakthrough to Disease Control Empowerment. 转录组学：从技术突破到疾病控制授权。

IF 4.1

Biomedical and environmental sciences : BES Pub Date : 2025-09-20 DOI: 10.3967/bes2025.116

Yong Zhang

引用次数: 0

Analysis of Serum Metabolic Biomarkers in Adult Patients with Kashin-Beck Disease and Degenerative Osteoarthritis in Qinghai Province. 青海省成人大骨节病和退行性骨关节炎患者血清代谢标志物分析

IF 4.1

Biomedical and environmental sciences : BES Pub Date : 2025-09-20 DOI: 10.3967/bes2025.111

Jia le Xu, Qiang Li, Chuan Lu, Xin Zhou, Yan Mei Zhao, Jian Ling Wang, Ji Quan Li, Li Ma, Zhi Jun Zhao, Ke Wen Li

引用次数: 0

Sirtuin 3 Attenuates Acute Lung Injury by Decreasing Ferroptosis and Inflammation through Inhibiting Aerobic Glycolysis. Sirtuin 3通过抑制有氧糖酵解减少铁下垂和炎症减轻急性肺损伤。

IF 4.1

Biomedical and environmental sciences : BES Pub Date : 2025-09-20 DOI: 10.3967/bes2025.110

Ke Wei Qin, Qing Qing Ji, Wei Jun Luo, Wen Qian Li, Bing Bing Hao, Hai Yan Zheng, Chao Feng Han, Jian Lou, Li Ming Zhao, Xing Ying He

引用次数: 0

Interpretation of Annual Report on Cardiovascular Health and Diseases in China 2024. 《中国心血管健康与疾病年度报告2024》解读

IF 4.1

Biomedical and environmental sciences : BES Pub Date : 2025-08-20 DOI: 10.3967/bes2025.099

Ming Bo Liu, Xin Ye He, Xiao Hong Yang, Zeng Wu Wang

引用次数: 0

Chromosome 8 Open Reading Frame 76 (C8orf76) Co-Expressed with Cyclin-Dependent Kinase 4 (CDK4) as a Prognostic Indicator of Colorectal Cancer. 8号染色体开放阅读框76 （C8orf76）与细胞周期蛋白依赖性激酶4 （CDK4）共表达作为结直肠癌的预后指标

IF 4.1

Biomedical and environmental sciences : BES Pub Date : 2025-08-20 DOI: 10.3967/bes2024.177

Shang Guo, Cheng Cheng Liu, Zi Feng Zhao, Zhong Xin Li, Xia Jiang, Zeng Ren Zhao

{"title":"Chromosome 8 Open Reading Frame 76 (C8orf76) Co-Expressed with Cyclin-Dependent Kinase 4 (CDK4) as a Prognostic Indicator of Colorectal Cancer.","authors":"Shang Guo, Cheng Cheng Liu, Zi Feng Zhao, Zhong Xin Li, Xia Jiang, Zeng Ren Zhao","doi":"10.3967/bes2024.177","DOIUrl":"https://doi.org/10.3967/bes2024.177","url":null,"abstract":"Objective: To explore the correlation between chromosome 8 open reading frame 76 (C8orf76) and cyclin-dependent kinase 4 (CDK4) and the potential predictive effect of C8orf76 and CDK4 on the prognosis of colorectal cancer (CRC).Methods: We constructed a protein-protein interaction network of C8orf76-related genes and analyzed the prognostic signatures of C8orf76 and CDK4. Clinicopathological features of C8orf76 and CDK4 were visualized using a nomogram.Results: C8orf76 and CDK4 levels were positively correlated in two independent human CRC cohorts ( n = 83 and n = 597). A consistent positive correlation was observed between C8orf76 and CDK4 expression in the CRC cell lines. The nomogram included prognostic genes (C8orf76 and CDK4) and pathological N and M stages. The concordance index (C-index) in our cohort was 0.776, which suggests that the ability of the indicators to predict the overall survival of patients with CRC in our cohort was strong.Conclusion: We found that C8orf76 was positively correlated with CDK4 in both the cohorts as well as in CRC cell lines. Therefore, C8orf76 and CDK4 can be used as potential biomarkers to predict the prognosis of CRC.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"38 8","pages":"977-987"},"PeriodicalIF":4.1,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum Lipidomics Profiling to Identify Potential Biomarkers of Ischemic Stroke: A Pilot Study in Chinese Adults. 血清脂质组学分析鉴定缺血性脑卒中的潜在生物标志物：一项在中国成年人中的初步研究。

IF 4.1

Biomedical and environmental sciences : BES Pub Date : 2025-08-20 DOI: 10.3967/bes2025.095

Ji Jun Shi, Zu Jiao Nie, Shu Yao Wang, Hao Zhang, Xin Wei Li, Jia Ling Yao, Yi Bing Jin, Xiang Dong Yang, Xue Yang Zhang, Ming Zhi Zhang, Hao Peng

{"title":"Serum Lipidomics Profiling to Identify Potential Biomarkers of Ischemic Stroke: A Pilot Study in Chinese Adults.","authors":"Ji Jun Shi, Zu Jiao Nie, Shu Yao Wang, Hao Zhang, Xin Wei Li, Jia Ling Yao, Yi Bing Jin, Xiang Dong Yang, Xue Yang Zhang, Ming Zhi Zhang, Hao Peng","doi":"10.3967/bes2025.095","DOIUrl":"10.3967/bes2025.095","url":null,"abstract":"Objective: Lipid oxidation is involved in the pathogenesis of atherosclerosis and may be contribute to the development of Ischemic stroke (IS). However, the lipid profiles associated with IS have been poorly studied. We conducted a pilot study to identify potential IS-related lipid molecules and pathways using lipidomic profiling.Methods: Serum lipidomic profiling was performed using LC-MS in 20 patients with IS and 20 age- and sex-matched healthy controls. Univariate and multivariate analyses were simultaneously performed to identify the differential lipids. Multiple testing was controlled for using a false discovery rate (FDR) approach. Enrichment analysis was performed using MetaboAnalyst software.Results: Based on the 294 lipids assayed, principal component analysis (PCA) and orthogonal partial least squares discriminant analysis (OPLS-DA) models were used to distinguish patients with IS from healthy controls. Fifty-six differential lipids were identified with an FDR-adjusted P less than 0.05 and variable influences in projection (VIP) greater than 1.0. These lipids were significantly enriched in glycerophospholipid metabolism (FDR-adjusted P = 0.009, impact score = 0.216).Conclusions: Serum lipid profiles differed significantly between patients with IS and healthy controls. Thus, glycerophospholipid metabolism may be involved in the development of IS. These results provide initial evidence that lipid molecules and their related metabolites may serve as new biomarkers and potential therapeutic targets for IS.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"38 8","pages":"918-925"},"PeriodicalIF":4.1,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Generalized Functional Linear Models: Efficient Modeling for High-dimensional Correlated Mixture Exposures. 广义泛函线性模型：高维相关混合暴露的有效建模。

IF 4.1

Biomedical and environmental sciences : BES Pub Date : 2025-08-20 DOI: 10.3967/bes2025.024

Bing Song Zhang, Hai Bin Yu, Xin Peng, Hai Yi Yan, Si Ran Li, Shutong Luo, Hui Zi WeiRen, Zhu Jiang Zhou, Ya Lin Kuang, Yi Huan Zheng, Chu Lan Ou, Lin Hua Liu, Yuehua Hu, Jin Dong Ni

{"title":"Generalized Functional Linear Models: Efficient Modeling for High-dimensional Correlated Mixture Exposures.","authors":"Bing Song Zhang, Hai Bin Yu, Xin Peng, Hai Yi Yan, Si Ran Li, Shutong Luo, Hui Zi WeiRen, Zhu Jiang Zhou, Ya Lin Kuang, Yi Huan Zheng, Chu Lan Ou, Lin Hua Liu, Yuehua Hu, Jin Dong Ni","doi":"10.3967/bes2025.024","DOIUrl":"https://doi.org/10.3967/bes2025.024","url":null,"abstract":"Objective: Humans are exposed to complex mixtures of environmental chemicals and other factors that can affect their health. Analysis of these mixture exposures presents several key challenges for environmental epidemiology and risk assessment, including high dimensionality, correlated exposure, and subtle individual effects.Methods: We proposed a novel statistical approach, the generalized functional linear model (GFLM), to analyze the health effects of exposure mixtures. GFLM treats the effect of mixture exposures as a smooth function by reordering exposures based on specific mechanisms and capturing internal correlations to provide a meaningful estimation and interpretation. The robustness and efficiency was evaluated under various scenarios through extensive simulation studies.Results: We applied the GFLM to two datasets from the National Health and Nutrition Examination Survey (NHANES). In the first application, we examined the effects of 37 nutrients on BMI (2011-2016 cycles). The GFLM identified a significant mixture effect, with fiber and fat emerging as the nutrients with the greatest negative and positive effects on BMI, respectively. For the second application, we investigated the association between four pre- and perfluoroalkyl substances (PFAS) and gout risk (2007-2018 cycles). Unlike traditional methods, the GFLM indicated no significant association, demonstrating its robustness to multicollinearity.Conclusion: GFLM framework is a powerful tool for mixture exposure analysis, offering improved handling of correlated exposures and interpretable results. It demonstrates robust performance across various scenarios and real-world applications, advancing our understanding of complex environmental exposures and their health impacts on environmental epidemiology and toxicology.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"38 8","pages":"961-976"},"PeriodicalIF":4.1,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0