Biomedical and environmental sciences : BES最新文献_第2页

Global Burden of Clostridium difficile Infection-Related Diarrhea Mortality from 1990 to 2021: A Study Based on the 2021 Global Burden of Disease Database. 1990 - 2021年艰难梭菌感染相关腹泻死亡率的全球负担：基于2021年全球疾病负担数据库的研究

Biomedical and environmental sciences : BES Pub Date : 2025-05-20 DOI: 10.3967/bes2025.039

Ying Li, Jie Li, He Sheng Chang, Yue Hua Hu, Cheng Dong Xu

引用次数: 0

Synaptic Vesicle Glycoprotein 2A Slows down Amyloidogenic Processing of Amyloid Precursor Protein via Regulating Its Intracellular Trafficking. 突触囊泡糖蛋白2A通过调节淀粉样前体蛋白的细胞内运输减缓淀粉样蛋白的淀粉样变性加工。

Biomedical and environmental sciences : BES Pub Date : 2025-05-20 DOI: 10.3967/bes2025.049

Qian Zhang, Xiao Ling Wang, Yu Li Hou, Jing Jing Zhang, Cong Cong Liu, Xiao Min Zhang, Ya Qi Wang, Yu Jian Fan, Jun Ting Liu, Jing Liu, Qiao Song, Pei Chang Wang

{"title":"Synaptic Vesicle Glycoprotein 2A Slows down Amyloidogenic Processing of Amyloid Precursor Protein via Regulating Its Intracellular Trafficking.","authors":"Qian Zhang, Xiao Ling Wang, Yu Li Hou, Jing Jing Zhang, Cong Cong Liu, Xiao Min Zhang, Ya Qi Wang, Yu Jian Fan, Jun Ting Liu, Jing Liu, Qiao Song, Pei Chang Wang","doi":"10.3967/bes2025.049","DOIUrl":"https://doi.org/10.3967/bes2025.049","url":null,"abstract":"Objective: To reveal the effects and potential mechanisms by which synaptic vesicle glycoprotein 2A (SV2A) influences the distribution of amyloid precursor protein (APP) in the trans-Golgi network (TGN), endolysosomal system, and cell membranes and to reveal the effects of SV2A on APP amyloid degradation.Methods: Colocalization analysis of APP with specific tagged proteins in the TGN, ensolysosomal system, and cell membrane was performed to explore the effects of SV2A on the intracellular transport of APP. APP, β-site amyloid precursor protein cleaving enzyme 1 (BACE1) expressions, and APP cleavage products levels were investigated to observe the effects of SV2A on APP amyloidogenic processing.Results: APP localization was reduced in the TGN, early endosomes, late endosomes, and lysosomes, whereas it was increased in the recycling endosomes and cell membrane of SV2A-overexpressed neurons. Moreover, Arl5b (ADP-ribosylation factor 5b), a protein responsible for transporting APP from the TGN to early endosomes, was upregulated by SV2A. SV2A overexpression also decreased APP transport from the cell membrane to early endosomes by downregulating APP endocytosis. In addition, products of APP amyloid degradation, including sAPPβ, Aβ 1-42, and Aβ 1-40, were decreased in SV2A-overexpressed cells.Conclusion: These results demonstrated that SV2A promotes APP transport from the TGN to early endosomes by upregulating Arl5b and promoting APP transport from early endosomes to recycling endosomes-cell membrane pathway, which slows APP amyloid degradation.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"38 5","pages":"607-624"},"PeriodicalIF":0.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changes in Esophageal Cancer Survival: A Global Review of Survival Analysis from Cancer Registration Data over the Past Three Decades. 食管癌生存期的变化：过去30年癌症登记数据的全球生存分析综述

Biomedical and environmental sciences : BES Pub Date : 2025-05-20 DOI: 10.3967/bes2025.018

Zhuo Jun Ye, Dan Ni Yang, Yu Jiang, Yu Xuan Xiao, Zhuo Ying Li, Yu Ting Tan, Hui Yun Yuan, Yong Bing Xiang

{"title":"Changes in Esophageal Cancer Survival: A Global Review of Survival Analysis from Cancer Registration Data over the Past Three Decades.","authors":"Zhuo Jun Ye, Dan Ni Yang, Yu Jiang, Yu Xuan Xiao, Zhuo Ying Li, Yu Ting Tan, Hui Yun Yuan, Yong Bing Xiang","doi":"10.3967/bes2025.018","DOIUrl":"https://doi.org/10.3967/bes2025.018","url":null,"abstract":"Objective: To describe survival trends and global patterns of esophageal cancer (EC) using survival data from population-based cancer registries.Methods: We systematically searched PubMed, EMBASE, Web of Science, SEER, and SinoMed databases for articles published up to 31 December 2023. Eligible EC survival estimates were evaluated according to country or region, period, sex, age group, pathology, and disease stage.Results: After 2010, Jordan exhibited the highest age-standardized 5-year relative survival rates (RSRs)/net survival rates (NSRs) at 41.1% between 2010 and 2014, while India had the lowest, at 4.1%. Survival rates generally improved with diagnostic age across most countries, with significant increases in South Korea and China, of 12.7% and 10.5% between 2000 and 2017, respectively. Survival was higher among women compared to men, ranging from 0.4%-10.9%. Survival rates for adenocarcinoma and squamous cell carcinoma were similar, differing by about 4%. In China, the highest age-standardized RSRs/NSRs was 33.4% between 2015 and 2017. Meanwhile, the lowest was 5.3%, in Qidong (Jiangsu province) between 1992-1996.Conclusion: Global EC survival rates have improved significantly in recent decades, but substantial geographical, sex, and age disparities still exist. In Asia, squamous cell carcinoma demonstrated superior survival rates compared to adenocarcinoma, while the opposite trend was observed in Western countries. Future research should clarify the prognostic factors influencing EC survival and tailor prevention and screening strategies to the changing EC survival patterns.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"38 5","pages":"571-584"},"PeriodicalIF":0.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Forecast of the Burden of Lower Respiratory Infections in the Elderly Aged 70 and above in China from 1990 to 2050, GBD2021. 1990 - 2050年中国70岁及以上老年人下呼吸道感染负担预测，GBD2021。

Biomedical and environmental sciences : BES Pub Date : 2025-05-20 DOI: 10.3967/bes2025.036

Miao Miao Zhang, Rui Yi Zhang, Yu Chang Zhou, Mai Geng Zhou

{"title":"Forecast of the Burden of Lower Respiratory Infections in the Elderly Aged 70 and above in China from 1990 to 2050, GBD2021.","authors":"Miao Miao Zhang, Rui Yi Zhang, Yu Chang Zhou, Mai Geng Zhou","doi":"10.3967/bes2025.036","DOIUrl":"https://doi.org/10.3967/bes2025.036","url":null,"abstract":"Objective: This study aims to analyze the burden of lower respiratory infections in Chinese elderly people aged 70 and above.Methods: This study utilized Global Burden of Disease (GBD) 1990-2050 prediction data to analyze changes in mortality rates and disability-adjusted life year (DALY) rates for lower respiratory infections in the elderly population (aged 70 and above) in China from 1990 to 2050. It also discusses future trends in the burden of lower respiratory infections (LRI) in China under different scenarios.Results: According to GBD predictions, the burden of lower respiratory infections in the elderly aged 70 years and above in China is lower than the global average. The burden has been decreasing from 1990 to 2020, but is projected to increase from 2020 to 2050. Scenario-based predictions suggest that, under scenarios involving improvements in nutrition and vaccination, the burden of lower respiratory infections in the elderly in China is expected to be the lowest in 2050.Conclusion: This study indicates that the burden of lower respiratory infections in elderly people aged 70 years and above in China remains a significant public health issue and may worsen. The government should consider strengthening the preventive measures and management strategies for respiratory infections in the elderly population.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"38 5","pages":"539-546"},"PeriodicalIF":0.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lumbar Spondylolysis in Chinese Adults: Prevalence and Musculoskeletal Conditions. 中国成人腰椎峡部裂：患病率和肌肉骨骼状况。

Biomedical and environmental sciences : BES Pub Date : 2025-05-20 DOI: 10.3967/bes2025.043

Dong Yan, Yan Dong Liu, Ling Wang, Kai Li, Wen Shuang Zhang, Yi Yuan, Jian Geng, Kang Kang Ma, Feng Yun Zhou, Zi Tong Cheng, Xiao Guang Cheng

{"title":"Lumbar Spondylolysis in Chinese Adults: Prevalence and Musculoskeletal Conditions.","authors":"Dong Yan, Yan Dong Liu, Ling Wang, Kai Li, Wen Shuang Zhang, Yi Yuan, Jian Geng, Kang Kang Ma, Feng Yun Zhou, Zi Tong Cheng, Xiao Guang Cheng","doi":"10.3967/bes2025.043","DOIUrl":"https://doi.org/10.3967/bes2025.043","url":null,"abstract":"Objective: To determine the prevalence of lumbar spondylolysis (LS) and the proportion of spondylolytic spondylolisthesis (SS) in China, and to evaluate the musculoskeletal status of patients with LS and SS.Methods: Spine Computed Tomography (CT) images were collected from community populations aged 40 and above in a nationwide multi-center project. LS was diagnosed, and SS was graded by an experienced radiologist. Bone mineral density (BMD) and paraspinal muscle parameters were quantified based on CT images.Results: One hundred and seventeen patients of a total of 3,317 individuals were diagnosed with LS, corresponding to a prevalence rate of 3.53%. 63 of the 1,214 males (5.18%) and 54 of the 2,103 females (2.57%) were diagnosed with LS. SS occurred in 64/121 vertebrae (52.89%). BMD was not associated with LS ( P = 0.341). The L5 extensor paraspinal muscle density was higher in the LS group than in the non-LS group. In the LS group, patients with SS had a smaller L5 paraspinal extensor muscle cross-sectional area than those without SS ( P = 0.003).Conclusion: The prevalence of LS in Chinese adults was 3.53%, with prevalence rates of 5.18% in males and 2.57% in females. Patients with LS have higher muscle density, whereas those with SS have smaller muscle cross-sectional areas at the L5 level.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"38 5","pages":"598-606"},"PeriodicalIF":0.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction. 修正。

Biomedical and environmental sciences : BES Pub Date : 2025-04-20

引用次数: 0

Antibiotic-Depleted Lung Microbiota Modulates Surfactant Proteins Expression and Reduces Experimental Silicosis. 抗生素耗竭的肺微生物群调节表面活性蛋白表达并减少实验性矽肺。

Biomedical and environmental sciences : BES Pub Date : 2025-04-20 DOI: 10.3967/bes2025.012

Qiang Zhou, Mei Yu Chang, Ning Li, Yi Guan, San Qiao Yao

{"title":"Antibiotic-Depleted Lung Microbiota Modulates Surfactant Proteins Expression and Reduces Experimental Silicosis.","authors":"Qiang Zhou, Mei Yu Chang, Ning Li, Yi Guan, San Qiao Yao","doi":"10.3967/bes2025.012","DOIUrl":"https://doi.org/10.3967/bes2025.012","url":null,"abstract":"Objective: Recent studies have overturned the traditional concept of the lung as a \"sterile organ\" revealing that pulmonary microbiota dysbiosis and abnormal surfactant proteins (SPs) expression are involved in the progression of silicosis. This study aimed to investigate the relationship between abnormal SPs expression and dysbiosis of lung microbiota in silica-induced lung fibrosis, providing insights into mechanisms of silicosis.Methods: Lung pathology, SPs expression, and microbiota composition were evaluated in silica-exposed mice. A mouse model of antibiotic-induced microbiota depletion was established, and alveolar structure and SPs expression were assessed. The roles of the lung microbiota and SPs in silicosis progression were further evaluated in mice with antibiotic-induced microbiota depletion, both with and without silica exposure.Results: Silica exposure induced lung inflammation and fibrosis, along with increased expression of SP-A expression. Antibiotics (Abx)-induced microbiota depletion elevated SP-A and SP-D expression. Furthermore, silica exposure altered lung microbiota composition, enriching potentially pathogenic taxa. However, antibiotic-induced microbiota depletion prior to silica exposure reduced silica-mediated lung fibrosis and inflammation.Conclusion: Lung microbiota is associated with silica-induced lung injury. Overproduction of SP-A and SP-D, induced by Abx-induced microbiota depletion, may enhance the resistance of mouse lung tissue to silica-induced injury.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"38 4","pages":"469-483"},"PeriodicalIF":0.0,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144031681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of High-Risk Populations: The Cornerstone of Effective and Cost-Efficient Cancer Screening. 高危人群的识别：有效和成本效益的癌症筛查的基石。

Biomedical and environmental sciences : BES Pub Date : 2025-04-20 DOI: 10.3967/bes2025.044

Wei Cao, Fei Wang, Ni Li

引用次数: 0

Construction of a Prognostic Model for Lysosome-dependent Cell Death in Gastric Cancer Based on Single-cell RNA-seq and Bulk RNA-seq Data. 基于单细胞RNA-seq和整体RNA-seq数据构建胃癌溶酶体依赖性细胞死亡预后模型

Biomedical and environmental sciences : BES Pub Date : 2025-04-20 DOI: 10.3967/bes2024.159

Peng Ni, Kai Xin Guo, Tian Yi Liang, Xin Shuang Fan, Yan Qiao Hua, Yang Ye Gao, Shuai Yin Chen, Guang Cai Duan, Rong Guang Zhang

{"title":"Construction of a Prognostic Model for Lysosome-dependent Cell Death in Gastric Cancer Based on Single-cell RNA-seq and Bulk RNA-seq Data.","authors":"Peng Ni, Kai Xin Guo, Tian Yi Liang, Xin Shuang Fan, Yan Qiao Hua, Yang Ye Gao, Shuai Yin Chen, Guang Cai Duan, Rong Guang Zhang","doi":"10.3967/bes2024.159","DOIUrl":"https://doi.org/10.3967/bes2024.159","url":null,"abstract":"Objective: To identify prognostic genes associated with lysosome-dependent cell death (LDCD) in patients with gastric cancer (GC).Methods: Differentially expressed genes (DEGs) were identified using The Cancer Genome Atlas - Stomach Adenocarcinoma. Weighted gene co-expression network analysis was performed to identify the key module genes associated with LDCD score. Candidate genes were identified by DEGs and key module genes. Univariate Cox regression analysis, and least absolute shrinkage and selection operator regression and multivariate Cox regression analyses were performed for the selection of prognostic genes, and risk module was established. Subsequently, key cells were identified in the single-cell dataset (GSE183904), and prognostic gene expression was analyzed. Cell proliferation and migration were assessed using the Cell Counting Kit-8 assay and the wound healing assay.Results: A total of 4,465 DEGs, 95 candidate genes, and 4 prognostic genes, including C19orf59, BATF2, TNFAIP2, and TNFSF18, were identified in the analysis. Receiver operating characteristic curves indicated the excellent predictive power of the risk model. Three key cell types (B cells, chief cells, and endothelial/pericyte cells) were identified in the GSE183904 dataset. C19orf59 and TNFAIP2 exhibited predominant expression in macrophage species, whereas TNFAIP2 evolved over time in endothelial/pericyte cells and chief cells. Functional experiments confirmed that interfering with C19orf59 inhibited proliferation and migration in GC cells.Conclusion: C19orf59, BATF2, TNFAIP2, and TNFSF18 are prognostic genes associated with LDCD in GC. Furthermore, the risk model established in this study showed robust predictive power.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"38 4","pages":"416-432"},"PeriodicalIF":0.0,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144046246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk Factors and Predictive Model for Acute Mountain Sickness among Han Chinese Travelers to Xizang Autonomous Region. 西藏汉族旅行者急性高山病危险因素及预测模型

Biomedical and environmental sciences : BES Pub Date : 2025-04-20 DOI: 10.3967/bes2025.030

Qian Hui Gong, Qiong Li, Zhi Chao Xu, Xiao Wei Chen, Xiao Bing Shen

引用次数: 0