Biomedical and environmental sciences : BES最新文献_第2页

Epidemic Characteristics and Spatio-Temporal Patterns of HFRS in Qingdao City, China, 2010-2022. 2010-2022 年中国青岛市 HFRS 的流行特征和时空模式。

Biomedical and environmental sciences : BES Pub Date : 2024-09-20 DOI: 10.3967/bes2024.092

Ying Li, Run Ze Lu, Li Yan Dong, Li Tao Sun, Zong Yi Zhang, Ya Ting Zhao, Qing Duan, Li Jie Zhang, Fa Chun Jiang, Jing Jia, Hui Lai Ma

{"title":"Epidemic Characteristics and Spatio-Temporal Patterns of HFRS in Qingdao City, China, 2010-2022.","authors":"Ying Li, Run Ze Lu, Li Yan Dong, Li Tao Sun, Zong Yi Zhang, Ya Ting Zhao, Qing Duan, Li Jie Zhang, Fa Chun Jiang, Jing Jia, Hui Lai Ma","doi":"10.3967/bes2024.092","DOIUrl":"https://doi.org/10.3967/bes2024.092","url":null,"abstract":"Objective: This study investigated the epidemic characteristics and spatio-temporal dynamics of hemorrhagic fever with renal syndrome (HFRS) in Qingdao City, China.Methods: Information was collected on HFRS cases in Qingdao City from 2010 to 2022. Descriptive epidemiologic, seasonal decomposition, spatial autocorrelation, and spatio-temporal cluster analyses were performed.Results: A total of 2,220 patients with HFRS were reported over the study period, with an average annual incidence of 1.89/100,000 and a case fatality rate of 2.52%. The male:female ratio was 2.8:1. 75.3% of patients were aged between 16 and 60 years old, 75.3% of patients were farmers, and 11.6% had both \"three red\" and \"three pain\" symptoms. The HFRS epidemic showed two-peak seasonality: the primary fall-winter peak and the minor spring peak. The HFRS epidemic presented highly spatially heterogeneous, street/township-level hot spots that were mostly distributed in Huangdao, Pingdu, and Jiaozhou. The spatio-temporal cluster analysis revealed three cluster areas in Qingdao City that were located in the south of Huangdao District during the fall-winter peak.Conclusion: The distribution of HFRS in Qingdao exhibited periodic, seasonal, and regional characteristics, with high spatial clustering heterogeneity. The typical symptoms of \"three red\" and \"three pain\" in patients with HFRS were not obvious.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142482974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prospective Cohort Investigation on Physical Activity of Osteoporosis Outcomes (PAOPO) in Jidong: Objectives, Study Design, and Baseline Characteristics. 冀东地区骨质疏松症结果的体育锻炼前瞻性队列调查（PAOPO）：目标、研究设计和基线特征。

Biomedical and environmental sciences : BES Pub Date : 2024-09-20 DOI: 10.3967/bes2024.117

Jing Zhi Yang, Hao Shen, Si Cheng Wang, Long Bai, Zhen Geng, Ying Ying Jing, Ke Xu, Yu He Liu, Wen Qian Wu, Hao Zhang, Yuan Wei Zhang, Zuhao Li, Chuan Dong Wang, Guang Chao Wang, Xiao Chen, Jia Can Su

{"title":"Prospective Cohort Investigation on Physical Activity of Osteoporosis Outcomes (PAOPO) in Jidong: Objectives, Study Design, and Baseline Characteristics.","authors":"Jing Zhi Yang, Hao Shen, Si Cheng Wang, Long Bai, Zhen Geng, Ying Ying Jing, Ke Xu, Yu He Liu, Wen Qian Wu, Hao Zhang, Yuan Wei Zhang, Zuhao Li, Chuan Dong Wang, Guang Chao Wang, Xiao Chen, Jia Can Su","doi":"10.3967/bes2024.117","DOIUrl":"https://doi.org/10.3967/bes2024.117","url":null,"abstract":"Objective: The aim of this study was to investigate the prospective association between physical activity (PA), independently or in conjunction with other contributing factors, and osteoporosis (OP) outcomes.Methods: The Physical Activity in Osteoporosis Outcomes (PAOPO) study was a community-based cohort investigation. A structured questionnaire was used to gather the participants' sociodemographic characteristics. Bone mineral density (BMD) measurements were performed to assess OP outcomes, and the relationship between BMD and OP was evaluated within this cohort.Results: From 2013 to 2014, 8,471 participants aged 18 years and older were recruited from Tangshan, China's Jidong community. Based on their PA level, participants were categorized as inactive, moderately active, or very active. Men showed higher physical exercise levels than women across the activity groups. BMD was significantly higher in the very active group than in the moderately active and inactive groups. Individuals aged > 50 years are at a higher risk of developing OP and osteopenia.Conclusion: The PAOPO study offers promising insights into the relationship between PA and OP outcomes, encouraging the implementation of PA in preventing and managing OP.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142482979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of Temperature and Humidity on the Incidence of Pulmonary Tuberculosis in Hainan, China, 2004-2018. 2004-2018年温湿度对中国海南肺结核发病率的影响

Biomedical and environmental sciences : BES Pub Date : 2024-09-20 DOI: 10.3967/bes2024.144

Wei Xia Li, Xiao Dan Wang, Bo Bi, Jing Jing Lu, Zheng Yuan Li, Li Cao, Hao Zhang

引用次数: 0

ATM Activation is Key in Vasculogenic Mimicry Formation by Glioma Stem-like Cells. ATM激活是胶质瘤干样细胞形成血管生成模拟的关键。

Biomedical and environmental sciences : BES Pub Date : 2024-08-20 DOI: 10.3967/bes2024.127

Jing Xie, Jia Xin Tang, Yuan Li, Xue Kong, Wei Wang, Haibo Wu

{"title":"ATM Activation is Key in Vasculogenic Mimicry Formation by Glioma Stem-like Cells.","authors":"Jing Xie, Jia Xin Tang, Yuan Li, Xue Kong, Wei Wang, Haibo Wu","doi":"10.3967/bes2024.127","DOIUrl":"https://doi.org/10.3967/bes2024.127","url":null,"abstract":"Objective: Vasculogenic mimicry (VM) is a novel vasculogenic process integral to glioma stem cells (GSCs) in glioblastoma (GBM). However, the relationship between VM and ataxia-telangiectasia mutated (ATM) serine/threonine kinase activation, which confers chemoradiotherapy resistance, remains unclear.Methods: We investigated VM formation and phosphorylated ATM (pATM) levels by CD31/GFAP-periodic acid-Schiff dual staining and immunohistochemical staining in 145 GBM specimens. Glioma stem-like cells (GSLCs) derived from the formatted spheres of U87 and U251 cell lines and their pATM level and VM formation ability were examined using western blot and three-dimensional culture. For the examination of the function of pATM in VM formation by GSLCs, ATM knockdown by shRNAs and deactivated via ATM phosphorylation inhibitor KU55933 were studied.Results: VM and high pATM expression occurred in 38.5% and 41.8% of tumors, respectively, and were significantly associated with reduced progression-free and overall survival. Patients with VM-positive GBMs exhibited higher pATM levels ( r s = 0.425, P = 0.01). The multivariate analysis established VM as an independent negative prognostic factor ( P = 0.002). Furthermore, GSLCs expressed high levels of pATM and formed vascular-like networks in vitro. ATM inactivation or knockdown hindered VM-like network formation concomitant with the downregulation of pVEGFR-2, VE-cadherin, and laminin B2.Conclusion: VM may predict a poor GBM prognosis and is associated with pATM expression. We propose that pATM promotes VM through extracellular matrix modulation and VE-Cadherin / pVEGFR-2 activation, thereby highlighting ATM activation as a potential target for enhancing anti-angiogenesis therapies for GBM.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142094319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multivariate Analysis of Female Stress Urinary Incontinence and Establishment of a Prediction Model. 女性压力性尿失禁的多变量分析及预测模型的建立。

Biomedical and environmental sciences : BES Pub Date : 2024-08-20 DOI: 10.3967/bes2024.114

Lei Li, Lin Luo, Jun Nai Wang, Ying Hong, Jian Fang Geng

引用次数: 0

Secreted Frizzled-Related Protein 5 Mediates Wnt5a Expression in Microcystin-Leucine-Arginine-Induced Liver Lipid Metabolism Disorder in Mice. 分泌型Frizzled相关蛋白5在微囊藻-亮氨酸-精氨酸诱导的小鼠肝脂代谢紊乱中介导Wnt5a的表达

Biomedical and environmental sciences : BES Pub Date : 2024-08-20 DOI: 10.3967/bes2024.081

Mei Yan Yang, Fu Rong Yu, Qian Qian Ji, Hui Ying Zhang, Jia Xiang Zhang, Dao Jun Chen

{"title":"Secreted Frizzled-Related Protein 5 Mediates Wnt5a Expression in Microcystin-Leucine-Arginine-Induced Liver Lipid Metabolism Disorder in Mice.","authors":"Mei Yan Yang, Fu Rong Yu, Qian Qian Ji, Hui Ying Zhang, Jia Xiang Zhang, Dao Jun Chen","doi":"10.3967/bes2024.081","DOIUrl":"10.3967/bes2024.081","url":null,"abstract":"Objective: Microcystin-leucine-arginine (MC-LR) exposure induces lipid metabolism disorders in the liver. Secreted frizzled-related protein 5 (SFRP5) is a natural antagonist of winglesstype MMTV integration site family, member 5A (Wnt5a) and an anti-inflammatory adipocytokine. In this study, we aimed to investigate whether MC-LR can induce lipid metabolism disorders in hepatocytes and whether SFRP5, which has anti-inflammatory effects, can alleviate the effects of hepatic lipid metabolism by inhibiting the Wnt5a/Jun N-terminal kinase (JNK) pathway.Methods: We exposed mice to MC-LR in vivo to induce liver lipid metabolism disorders. Subsequently, mouse hepatocytes that overexpressed SFRP5 or did not express SFRP5 were exposed to MC-LR, and the effects of SFRP5 overexpression on inflammation and Wnt5a/JNK activation by MC-LR were observed.Results: MC-LR exposure induced liver lipid metabolism disorders in mice and significantly decreased SFRP5 mRNA and protein levels in a concentration-dependent manner. SFRP5 overexpression in AML12 cells suppressed MC-LR-induced inflammation. Overexpression of SFRP5 also inhibited Wnt5a and phosphorylation of JNK.Conclusion: MC-LR can induce lipid metabolism disorders in mice, and SFRP5 can attenuate lipid metabolism disorders in the mouse liver by inhibiting Wnt5a/JNK signaling.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142094328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TIPE2 is Essential for Apocynin-mediated Protection against Intestinal Ischemia/Reperfusion-induced Acute Lung Injury. TIPE2对阿朴霉素介导的肠缺血/再灌注诱导的急性肺损伤的保护作用至关重要

Biomedical and environmental sciences : BES Pub Date : 2024-08-20 DOI: 10.3967/bes2024.124

Hui Rong Jing, Wen Yan Jia, Xue Wen Tang

引用次数: 0

Synaptic Transmission of Primary Hippocampal Neurons was Enhanced after Terahertz Waves Exposure. 原发性海马神经元的突触传递在太赫兹波暴露后得到增强

Biomedical and environmental sciences : BES Pub Date : 2024-08-20 DOI: 10.3967/bes2024.099

Le Quan Song, Zhi Wei He, Jun Miao Pan, Ji Dong, Hao Yu Wang, Jing Zhang, Bin Wei Yao, Xin Ping Xu, Hui Wang, Li Zhao, Rui Yun Peng

引用次数: 0

Predicting Acute Mountain Sickness Using Regional Sea-Level Cerebral Blood Flow. 利用区域海平面脑血流量预测急性晕山症

Biomedical and environmental sciences : BES Pub Date : 2024-08-20 DOI: 10.3967/bes2024.100

Hao Zhang, Jie Feng, Shi Yu Zhang, Wen Jia Liu, Lin Ma

{"title":"Predicting Acute Mountain Sickness Using Regional Sea-Level Cerebral Blood Flow.","authors":"Hao Zhang, Jie Feng, Shi Yu Zhang, Wen Jia Liu, Lin Ma","doi":"10.3967/bes2024.100","DOIUrl":"https://doi.org/10.3967/bes2024.100","url":null,"abstract":"Objective: To investigate the role of sea-level cerebral blood flow (CBF) in predicting acute mountain sickness (AMS) using three-dimensional pseudo-continuous arterial spin labeling (3D-pCASL).Methods: Forty-eight healthy volunteers reached an altitude of 3,650 m by air after undergoing a head magnetic resonance imaging (MRI) including 3D-pCASL at sea level. The CBF values of the bilateral anterior cerebral artery (ACA), middle cerebral artery (MCA), posterior cerebral artery (PCA), and posterior inferior cerebellar artery (PICA) territories and the laterality index (LI) of CBF were compared between the AMS and non-AMS groups. Statistical analyses were performed to determine the relationship between CBF and AMS, and the predictive performance was assessed using receiver operating characteristic (ROC) curves.Results: The mean cortical CBF in women (81.65 ± 2.69 mL/100 g/min) was higher than that in men (74.35 ± 2.12 mL/100 g/min) ( P < 0.05). In men, the cortical CBF values in the bilateral ACA, PCA, PICA, and right MCA were higher in patients with AMS than in those without. Cortical CBF in the right PCA best predicted AMS (AUC = 0.818). In women, the LI of CBF in the ACA was different between the AMS and non-AMS groups and predicted AMS with an AUC of 0.753.Conclusion: Although the mechanism and prediction of AMS are quite complicated, higher cortical CBF at sea level, especially the CBF of the posterior circulatory system, may be used for prediction in male volunteers using non-invasive 3D-pCASL.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142094327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Health Risk Assessment of Employees Exposed to Chlorination By-products of Recreational Water in Large Amusement Parks in Shanghai. 上海大型游乐园员工接触娱乐用水氯化副产物的健康风险评估。

Biomedical and environmental sciences : BES Pub Date : 2024-08-20 DOI: 10.3967/bes2024.082

Wei Zhao Cao, Yi Ming Zheng, Wen Xuan Zhao, Li Sha Shi, Yun Hui Zhang, Li Jun Zhang, Jian Chen

{"title":"Health Risk Assessment of Employees Exposed to Chlorination By-products of Recreational Water in Large Amusement Parks in Shanghai.","authors":"Wei Zhao Cao, Yi Ming Zheng, Wen Xuan Zhao, Li Sha Shi, Yun Hui Zhang, Li Jun Zhang, Jian Chen","doi":"10.3967/bes2024.082","DOIUrl":"https://doi.org/10.3967/bes2024.082","url":null,"abstract":"Objective: Chlorination is often used to disinfect recreational water in large amusement parks; however, the health hazards of chlorination disinfection by-products (DBPs) to occupational populations are unknown. This study aimed to assess the exposure status of chlorinated DBPs in recreational water and the health risks to employees of large amusement parks.Methods: Exposure parameters of employees of three large amusement parks in Shanghai were investigated using a questionnaire. Seven typical chlorinated DBPs in recreational water and spray samples were quantified by gas chromatography, and the health risks to amusement park employees exposed to chlorinated DBPs were evaluated according to the WHO's risk assessment framework.Results: Trichloroacetic acid, dibromochloromethane, bromodichloromethane, and dichloroacetic acid were detected predominantly in recreational water. The carcinogenic and non-carcinogenic risks of the five DBPs did not exceed the risk thresholds. In addition, the carcinogenic and non-carcinogenic risks of mixed exposure to DBPs were within the acceptable risk limits.Conclusion: Typical DBPs were widely detected in recreational water collected from three large amusement parks in Shanghai; however, the health risks of DBPs and their mixtures were within acceptable limits.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142094322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0