Biomedical and environmental sciences : BES最新文献

{"title":"Association between Organochlorine Exposures and Lung Functions Modified by Thyroid Hormones and Mediated by Inflammatory Factors among Healthy Older Adults.","authors":"Xiao Jie Guo, Hui Min Ren, Ji Ran Zhang, Xiao Ma, Shi Lu Tong, Song Tang, Chen Mao, Xiao Ming Shi","doi":"10.3967/bes2025.015","DOIUrl":"https://doi.org/10.3967/bes2025.015","url":null,"abstract":"<p><strong>Objective: </strong>To examine the mechanistic of organochlorine-associated changes in lung function.</p><p><strong>Methods: </strong>This study investigated 76 healthy older adults in Jinan, Shandong Province, over a five-month period. Personal exposure to organochlorines was quantified using wearable passive samplers, while inflammatory factors and thyroid hormones were analyzed from blood samples. Participants' lung function was evaluated. After stratifying participants according to their thyroid hormone levels, we analyzed the differential effects of organochlorine exposure on lung function and inflammatory factors across the low and high thyroid hormone groups. Mediation analysis was further conducted to elucidate the relationships among organochlorine exposures, inflammatory factors, and lung function.</p><p><strong>Results: </strong>Bis (2-chloro-1-methylethyl) ether (BCIE), was negatively associated with forced vital capacity (FVC, -2.05%, 95% <i>CI</i>: -3.11% to -0.97%), and associated with changes in inflammatory factors such as interleukin (IL)-2, IL-7, IL-8, and IL-13 in the low thyroid hormone group. The mediation analysis indicated a mediating effect of IL-2 (15.63%, 95% <i>CI</i>: 0.91% to 44.64%) and IL-13 (13.94%, 95% <i>CI</i>: 0.52% to 41.07%) in the association between BCIE exposure and FVC.</p><p><strong>Conclusion: </strong>Lung function and inflammatory factors exhibited an increased sensitivity to organochlorine exposure at lower thyroid hormone levels, with inflammatory factors potentially mediating the adverse effects of organochlorines on lung function.</p>","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"38 2","pages":"144-153"},"PeriodicalIF":0.0,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Separate and Combained Associations of PM _2.5 Exposure and Smoking with Dementia and Cognitive Impairment.","authors":"Lu Cui, Zhi Hui Wang, Yu Hong Liu, Lin Lin Ma, Shi Ge Qi, Ran An, Xi Chen, Hao Yan Guo, Yu Xiang Yan","doi":"10.3967/bes2024.181","DOIUrl":"https://doi.org/10.3967/bes2024.181","url":null,"abstract":"<p><strong>Objective: </strong>The results of limited studies on the relationship between environmental pollution and dementia have been contradictory. We analyzed the combined effects of PM _2.5 and smoking on the prevalence of dementia and cognitive impairment in an elderly community-dwelling Chinese population.</p><p><strong>Methods: </strong>We assessed 24,117 individuals along with the annual average PM _2.5 concentrations from 2012 to 2016. Dementia was confirmed in the baseline survey at a qualified clinical facility, and newly suspected dementia was assessed in 2017, after excluding cases of suspected dementia in 2015. National census data were used to weight the sample data to reflect the entire population in China, with multiple logistic regression performed to analyze the combined effects of PM _2.5 and smoking frequency on dementia and cognitive impairment.</p><p><strong>Results: </strong>Individuals exposed to the highest PM _2.5 concentration and smoked daily were at higher risk of dementia than those in the lowest PM _2.5 concentration group ( <i>OR</i>, 1.603; 95% <i>CI</i> [1.626-1.635], <i>P</i> < 0.0001) and in the nonsmoking group ( <i>OR,</i> 1.248; 95% <i>CI</i> [1.244-1.252]; <i>P</i> < 0.0001). Moderate PM _2.5 exposure and occasional smoking together increased the short-term risk of cognitive impairment. High-level PM _2.5 exposure and smoking were associated with an increased risk of dementia, so more efforts are needed to reduce this risk through environmental protection and antismoking campaigns.</p><p><strong>Conclusion: </strong>High-level PM _2.5 exposure and smoking were associated with an increased risk of dementia. Lowering the ambient PM _2.5, and smoking cessation are recommended to promote health.</p>","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"38 2","pages":"194-205"},"PeriodicalIF":0.0,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monotropein Alleviates Sepsis-induced Spleen Injury by Inhibiting the NF-κB/NLRP3 Axis and Activating the Nrf2 Pathway.","authors":"Le Bian, Fei Biao Wang, Yue Yang, Kun Mei Xie, Ting Zhao Yun Hu, Jia Dai Tang, Lei Wang, Zi Bo Dong","doi":"10.3967/bes2025.008","DOIUrl":"https://doi.org/10.3967/bes2025.008","url":null,"abstract":"","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"38 2","pages":"270-276"},"PeriodicalIF":0.0,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Hot Night Exposure on Human Semen Quality: A Multicenter Population-Based Study.","authors":"Ting Ting Dai, Ting Xu, Qi Ling Wang, Hao Bo Ni, Chun Ying Song, Yu Shan Li, Fu Ping Li, Tian Qing Meng, Hui Qiang Sheng, Ling Xi Wang, Xiao Yan Cai, Li Na Xiao, Xiao Lin Yu, Qing Hui Zeng, Pi Guo, Xin Zong Zhang","doi":"10.3967/bes2024.131","DOIUrl":"https://doi.org/10.3967/bes2024.131","url":null,"abstract":"<p><strong>Objective: </strong>To explore and quantify the association of hot night exposure during the sperm development period (0-90 lag days) with semen quality.</p><p><strong>Methods: </strong>A total of 6,640 male sperm donors from 6 human sperm banks in China during 2014-2020 were recruited in this multicenter study. Two indices (i.e., hot night excess [HNE] and hot night duration [HND]) were used to estimate the heat intensity and duration during nighttime. Linear mixed models were used to examine the association between hot nights and semen quality parameters.</p><p><strong>Results: </strong>The exposure-response relationship revealed that HNE and HND during 0-90 days before semen collection had a significantly inverse association with sperm motility. Specifically, a 1 °C increase in HNE was associated with decreased sperm progressive motility of 0.0090 (95% confidence interval [ <i>CI</i>]: -0.0147, -0.0033) and decreased total motility of 0.0094 (95% <i>CI</i>: -0.0160, -0.0029). HND was significantly associated with reduced sperm progressive motility and total motility of 0.0021 (95% <i>CI</i>: -0.0040, -0.0003) and 0.0023 (95% <i>CI</i>: -0.0043, -0.0002), respectively. Consistent results were observed at different temperature thresholds on hot nights.</p><p><strong>Conclusion: </strong>Our findings highlight the need to mitigate nocturnal heat exposure during spermatogenesis to maintain optimal semen quality.</p>","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"38 2","pages":"178-193"},"PeriodicalIF":0.0,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Per and Polyfluoroalkyl Substance and Abdominal Fat Distribution: A Trait Spectrum Exposure Pattern and Structure-Based Investigation.","authors":"Zhi Li, Shi Lin Shan, Chen Yang Song, Cheng Zhe Tao, Hong Qian, Qin Yuan, Yan Zhang, Qiao Qiao Xu, Yu Feng Qin, Yun Fan, Chun Cheng Lu","doi":"10.3967/bes2024.176","DOIUrl":"https://doi.org/10.3967/bes2024.176","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the associations between eight serum per- and polyfluoroalkyl substances (PFASs) and regional fat depots, we analyzed the data from the National Health and Nutrition Examination Survey (NHANES) 2011-2018 cycles.</p><p><strong>Methods: </strong>Multiple linear regression models were developed to explore the associations between serum PFAS concentrations and six fat compositions along with a fat distribution score created by summing the concentrations of the six fat compositions. The associations between structurally grouped PFASs and fat distribution were assessed, and a prediction model was developed to estimate the ability of PFAS exposure to predict obesity risk.</p><p><strong>Results: </strong>Among females aged 39-59 years, trunk fat mass was positively associated with perfluorooctane sulfonate (PFOS). Higher concentrations of PFOS, perfluorohexane sulfonate (PFHxS), perfluorodecanoate (PFDeA), perfluorononanoate (PFNA), and n-perfluorooctanoate (n-PFOA) were linked to greater visceral adipose tissue in this group. In men, exposure to total perfluoroalkane sulfonates (PFSAs) and long-chain PFSAs was associated with reductions in abdominal fat, while higher abdominal fat in women aged 39-59 years was associated with short-chain PFSAs. The prediction model demonstrated high accuracy, with an area under the curve (AUC) of 0.9925 for predicting obesity risk.</p><p><strong>Conclusion: </strong>PFAS exposure is associated with regional fat distribution, with varying effects based on age, sex, and PFAS structure. The findings highlight the potential role of PFAS exposure in influencing fat depots and obesity risk, with significant implications for public health. The prediction model provides a highly accurate tool for assessing obesity risk related to PFAS exposure.</p>","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"38 1","pages":"3-14"},"PeriodicalIF":0.0,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing Nutrition to Reduce Cardiometabolic Disease Burden: Strategies for a Healthier China.","authors":"Gang Qiang Ding","doi":"10.3967/bes2025.004","DOIUrl":"https://doi.org/10.3967/bes2025.004","url":null,"abstract":"","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"38 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal Associations between Vitamin D Status and Systemic Inflammation Markers among Early Adolescents.","authors":"Ting Tang, Xin Hui Wang, Xue Wen, Min Li, Meng Yuan Yuan, Yong Han Li, Xiao Qin Zhong, Fang Biao Tao, Pu Yu Su, Xi Hua Yu, Geng Fu Wang","doi":"10.3967/bes2024.139","DOIUrl":"https://doi.org/10.3967/bes2024.139","url":null,"abstract":"","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"38 1","pages":"94-99"},"PeriodicalIF":0.0,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Non-high-density Lipoprotein Cholesterol to High-density Lipoprotein Cholesterol Ratio (NHHR) and Stroke among Adults in the USA: A Cross-Sectional NHANES Study.","authors":"Hai Xia Ma, Hua Qiu Chen, Pei Chang Wang","doi":"10.3967/bes2025.001","DOIUrl":"https://doi.org/10.3967/bes2025.001","url":null,"abstract":"<p><strong>Objective: </strong>The relationship between non-high-density lipoprotein (NHDL) cholesterol to high-density lipoprotein cholesterol (HDL-C) ratio (NHHR) and stoke remains unknown. This study aimed to evaluate the association between the adult NHHR and stroke occurrence in the United States of America (USA).</p><p><strong>Methods: </strong>To clarify the relationship between the NHHR and stroke risk, this study used a multivariable logistic regression model and a restricted cubic spline (RCS) model to investigate the association between the NHHR and stroke, and data from the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2018. Subgroup and sensitivity analyses were conducted to test the robustness of the results.</p><p><strong>Results: </strong>This study included 29,928 adult participants, of which 1,165 participants had a history of stroke. Logistic regression analysis of variables demonstrated a positive association between NHHR and stroke ( <i>OR</i> 1.24, 95% <i>CI</i>: 1.03-1.50, <i>P</i> = 0.026). Compared with the lowest reference group of NHHR, participants in the second, third, and fourth quartile had a significantly increased risk of stroke after full adjustments ( <i>OR</i>: 1.35, 95% <i>CI</i>: 1.08-1.69) ( <i>OR</i>: 1.83, 95% <i>CI:</i> 1.42-2.36) ( <i>OR</i>: 2.04, 95% <i>CI</i>: 1.50-2.79). In the total population, a nonlinear dose-response relationship was observed between the NHHR and stroke risk ( <i>P</i> non-linearity = 0.002). This association remained significant in several subgroup analyses. Further investigation of the NHHR may enhance our understanding of stroke prevention and treatment.</p><p><strong>Conclusion: </strong>Our findings suggest a positive correlation between the NHHR and an increased prevalence of stroke, potentially serving as a novel predictive factor for stroke. Timely intervention and management of the NHHR may effectively mitigate stroke occurrence. Prospective studies are required to validate this association and further explore the underlying biological mechanisms.</p>","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"38 1","pages":"37-46"},"PeriodicalIF":0.0,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammatory Bowel Disease and Dementia: Evidence Triangulation from a Meta-Analysis of Observational Studies and Mendelian Randomization Study.","authors":"Di Liu, Mei Ling Cao, Shan Shan Wu, Bing Li Li, Yi Wen Jiang, Teng Fei Lin, Fu Xiao Li, Wei Jie Cao, Jin Qiu Yuan, Feng Sha, Zhi Rong Yang, Jin Ling Tang","doi":"10.3967/bes2024.149","DOIUrl":"https://doi.org/10.3967/bes2024.149","url":null,"abstract":"<p><strong>Objective: </strong>Observational studies have found associations between inflammatory bowel disease (IBD) and the risk of dementia, including Alzheimer's dementia (AD) and vascular dementia (VD); however, these findings are inconsistent. It remains unclear whether these associations are causal.</p><p><strong>Methods: </strong>We conducted a meta-analysis by systematically searching for observational studies on the association between IBD and dementia. Mendelian randomization (MR) analysis based on summary genome-wide association studies (GWASs) was performed. Genetic correlation and Bayesian co-localization analyses were used to provide robust genetic evidence.</p><p><strong>Results: </strong>Ten observational studies involving 80,565,688 participants were included in this meta-analysis. IBD was significantly associated with dementia (risk ratio [ <i>RR</i>] =1.36, 95% <i>CI</i> = 1.04-1.78; <i>I</i> ² = 84.8%) and VD ( <i>RR</i> = 2.60, 95% <i>CI</i> = 1.18-5.70; only one study), but not with AD ( <i>RR</i> = 2.00, 95% <i>CI</i> = 0.96-4.13; <i>I</i> ² = 99.8%). MR analyses did not supported significant causal associations of IBD with dementia (dementia: odds ratio [ <i>OR</i>] = 1.01, 95% <i>CI</i> = 0.98-1.03; AD: <i>OR</i> = 0.98, 95% <i>CI</i> = 0.95-1.01; VD: <i>OR</i> = 1.02, 95% <i>CI</i> = 0.97-1.07). In addition, genetic correlation and co-localization analyses did not reveal any genetic associations between IBD and dementia.</p><p><strong>Conclusion: </strong>Our study did not provide genetic evidence for a causal association between IBD and dementia risk. The increased risk of dementia observed in observational studies may be attributed to unobserved confounding factors or detection bias.</p>","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"38 1","pages":"56-66"},"PeriodicalIF":0.0,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Fish Consumption and Stroke Incidence Across Different Predicted Risk Populations: A Prospective Cohort Study from China.","authors":"Hong Yue Hu, Fang Chao Liu, Ke Yong Huang, Chong Shen, Jian Liao, Jian Xin Li, Chen Xi Yuan, Ying Li, Xue Li Yang, Ji Chun Chen, Jie Cao, Shu Feng Chen, Dong Sheng Hu, Jian Feng Huang, Xiang Feng Lu, Dong Feng Gu","doi":"10.3967/bes2025.003","DOIUrl":"https://doi.org/10.3967/bes2025.003","url":null,"abstract":"<p><strong>Objective: </strong>The relationship between fish consumption and stroke is inconsistent, and it is uncertain whether this association varies across predicted stroke risks.</p><p><strong>Methods: </strong>A cohort study comprising 95,800 participants from the Prediction for Atherosclerotic Cardiovascular Disease Risk in China project was conducted. A standardized questionnaire was used to collect data on fish consumption. Participants were stratified into low- and moderate-to-high-risk categories based on their 10-year stroke risk prediction scores. Hazard ratios ( <i>HRs</i>) and 95% confidence intervals ( <i>CIs</i>) were estimated using Cox proportional hazard models and additive interaction by relative excess risk due to interaction (RERI), attributable proportion (AP), and synergy index (SI).</p><p><strong>Results: </strong>During 703,869 person-years of follow-up, 2,773 incident stroke events were identified. Higher fish consumption was associated with a lower risk of stroke, particularly among moderate-to-high-risk individuals ( <i>HR</i> = 0.53, 95% <i>CI</i>: 0.47-0.60) than among low-risk individuals ( <i>HR</i> = 0.64, 95% <i>CI</i>: 0.49-0.85). A significant additive interaction between fish consumption and predicted stroke risk was observed (RERI = 4.08, 95% <i>CI</i>: 2.80-5.36; SI = 1.64, 95% <i>CI</i>: 1.42-1.89; AP = 0.36, 95% <i>CI</i>: 0.28-0.43).</p><p><strong>Conclusion: </strong>Higher fish consumption was associated with a lower risk of stroke, and this beneficial association was more pronounced in individuals with moderate-to-high stroke risk.</p>","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"38 1","pages":"15-26"},"PeriodicalIF":0.0,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}