{"title":"Cardiovascular Health and Disease Report in China: Two Decades of Progress.","authors":"Shu Yao Su, Fang Chao Liu","doi":"10.3967/bes2025.098","DOIUrl":"https://doi.org/10.3967/bes2025.098","url":null,"abstract":"","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"38 8","pages":"891-892"},"PeriodicalIF":4.1,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ze Lin Xu, Si Qi Liu, Xiao Yu, Si Yi Wang, Bing Bing Li, Xin Yu Wang, Si Yuan Shan, Hong Xu, Bo Nan Zhang, Yi Wei Shi, Xue Min Gao
{"title":"MicroRNA-411-3p Attenuates Cell Senescence in SiO <sub>2</sub>-Induced Pulmonary Fibrosis.","authors":"Ze Lin Xu, Si Qi Liu, Xiao Yu, Si Yi Wang, Bing Bing Li, Xin Yu Wang, Si Yuan Shan, Hong Xu, Bo Nan Zhang, Yi Wei Shi, Xue Min Gao","doi":"10.3967/bes2025.097","DOIUrl":"https://doi.org/10.3967/bes2025.097","url":null,"abstract":"","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"38 8","pages":"1023-1028"},"PeriodicalIF":4.1,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wen Bin Fang, Ying Tang, Ya Ning Sun, Yan Lan Tang, Yin Yin Chen, Ya Wen Cao, Ji Qi Fang, Kun Jing He, Yu Shan Li, Ya Ning Dai, Shuang Shuang Bao, Peng Zhu, Shan Shan Shao, Fang Biao Tao, Gui Xia Pan
{"title":"Influence of Outdoor Light at Night on Early Reproductive Outcomes of <i>In Vitro</i> Fertilization and Its Threshold Effect: Evidence from a Couple-Based Preconception Cohort Study.","authors":"Wen Bin Fang, Ying Tang, Ya Ning Sun, Yan Lan Tang, Yin Yin Chen, Ya Wen Cao, Ji Qi Fang, Kun Jing He, Yu Shan Li, Ya Ning Dai, Shuang Shuang Bao, Peng Zhu, Shan Shan Shao, Fang Biao Tao, Gui Xia Pan","doi":"10.3967/bes2025.101","DOIUrl":"https://doi.org/10.3967/bes2025.101","url":null,"abstract":"","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"38 8","pages":"1009-1015"},"PeriodicalIF":4.1,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ya Long Wang, Pan Pan Sun, Xin Ying Wang, Jun Xi Zhang, Xiang Yu Yu, Jian Chai, Ruo Du, Wen Yi Liu, Fang Fang Yu, Yue Ba, Guo Yu Zhou
{"title":"Association between PM <sub>2.5</sub> Chemical Constituents and Preterm Birth: The Undeniable Role of Preconception <i>H19</i> Gene Variation.","authors":"Ya Long Wang, Pan Pan Sun, Xin Ying Wang, Jun Xi Zhang, Xiang Yu Yu, Jian Chai, Ruo Du, Wen Yi Liu, Fang Fang Yu, Yue Ba, Guo Yu Zhou","doi":"10.3967/bes2025.076","DOIUrl":"https://doi.org/10.3967/bes2025.076","url":null,"abstract":"","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"38 8","pages":"1016-1022"},"PeriodicalIF":4.1,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bao Xi Wang, Yue Ting Zhou, Yi Pin Zhao, Yong Cheng, Jun Ren, Guan Chang Tan, Xiao Hu Wang
{"title":"Hypertrophic Cardiomyopathy: Mechanisms of Pathogenicity.","authors":"Bao Xi Wang, Yue Ting Zhou, Yi Pin Zhao, Yong Cheng, Jun Ren, Guan Chang Tan, Xiao Hu Wang","doi":"10.3967/bes2025.096","DOIUrl":"10.3967/bes2025.096","url":null,"abstract":"<p><p>Hypertrophic cardiomyopathy (HCM) is a major contributor to cardiovascular diseases (CVD), the leading cause of death globally. HCM can precipitate heart failure (HF) by causing the cardiac tissue to weaken and stretch, thereby impairing its pumping efficiency. Moreover, HCM increases the risk of atrial fibrillation, which in turn elevates the likelihood of thrombus formation and stroke. Given these significant clinical ramifications, research into the etiology and pathogenesis of HCM is intensifying at multiple levels. In this review, we discuss and synthesize the latest findings on HCM pathogenesis, drawing on key experimental studies conducted both <i>in vitro</i> and <i>in vivo</i>. We also offer our insights and perspectives on these mechanisms, while highlighting the limitations of current research. Advancing fundamental research in this area is essential for developing effective therapeutic interventions and enhancing the clinical management of HCM.</p>","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"38 8","pages":"988-1000"},"PeriodicalIF":4.1,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xiao Juan Liu, Hui Ma, Xiao Yan Li, Chun Xing Ma, Li Sha Shu, Hui Ying Zhang
{"title":"MYCN-Mediated Transcriptional Activation of IDH2 Enhances Proliferation, Migration, and Invasion in Cervical Squamous Cell Carcinoma through the HIF1-α Pathway.","authors":"Xiao Juan Liu, Hui Ma, Xiao Yan Li, Chun Xing Ma, Li Sha Shu, Hui Ying Zhang","doi":"10.3967/bes2025.075","DOIUrl":"https://doi.org/10.3967/bes2025.075","url":null,"abstract":"","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"38 8","pages":"1003-1008"},"PeriodicalIF":4.1,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xiao Bing Liu, Jun Wang, Ya Jie Li, Hong Xing Tan, De Qian Mao, Yan Yan Liu, Wei Dong Li, Wei Yu, Jun An Yan, Jian Hua Piao, Chong Zheng Guo, Xiao Li Liu, Xiao Guang Yang
{"title":"Re-Exploration for Dietary Iodine Intake in Chinese Adults using the Obligatory Iodine Loss Hypothesis.","authors":"Xiao Bing Liu, Jun Wang, Ya Jie Li, Hong Xing Tan, De Qian Mao, Yan Yan Liu, Wei Dong Li, Wei Yu, Jun An Yan, Jian Hua Piao, Chong Zheng Guo, Xiao Li Liu, Xiao Guang Yang","doi":"10.3967/bes2025.017","DOIUrl":"10.3967/bes2025.017","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to reexplore minimum iodine excretion and to build a dietary iodine recommendation for Chinese adults using the obligatory iodine loss hypothesis.</p><p><strong>Methods: </strong>Data from 171 Chinese adults (19-21 years old) were collected and analyzed based on three balance studies in Shenzhen, Yinchuan, and Changzhi. The single exponential equation was accordingly used to simulate the trajectory of 24 h urinary iodine excretion as the low iodine experimental diets offered (iodine intake: 11-26 μg/day) and to further deduce the dietary reference intakes (DRIs) for iodine, including estimated average requirement (EAR) and recommended nutrient intake (RNI).</p><p><strong>Results: </strong>The minimum iodine excretion was estimated as 57, 58, and 51 μg/day in three balance studies, respectively. Moreover, it was further suggested as 57, 58, and 51 μg/day for iodine EAR, and 80, 81, and 71 μg/day for iodine RNI or expressed as 1.42, 1.41, and 1.20 μg/(day·kg) of body weight.</p><p><strong>Conclusion: </strong>The iodine DRIs for Chinese adults were established based on the obligatory iodine loss hypothesis, which provides scientific support for the amendment of nutrient requirements.</p>","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"38 8","pages":"952-960"},"PeriodicalIF":4.1,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jing Xuan Fu, Wei Ping Wang, Yi Dan Wang, Pei Chang Wang
{"title":"Beams of Hope: Shedding New Light on Alzheimer's Treatment with Low-Dose Radiation Therapy.","authors":"Jing Xuan Fu, Wei Ping Wang, Yi Dan Wang, Pei Chang Wang","doi":"10.3967/bes2025.100","DOIUrl":"https://doi.org/10.3967/bes2025.100","url":null,"abstract":"","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"38 8","pages":"1001-1002"},"PeriodicalIF":4.1,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tai Yang Luo, Xuan Deng, Xue Yu Chen, Yu He Liu, Shuo Hua Chen, Hao Ran Sun, Zi Wei Yin, Shou Ling Wu, Yong Zhou, Xing Dong Zheng
{"title":"Association of Longitudinal Change in Fasting Blood Glucose with Risk of Cerebral Infarction in a Patients with Diabetes.","authors":"Tai Yang Luo, Xuan Deng, Xue Yu Chen, Yu He Liu, Shuo Hua Chen, Hao Ran Sun, Zi Wei Yin, Shou Ling Wu, Yong Zhou, Xing Dong Zheng","doi":"10.3967/bes2025.052","DOIUrl":"https://doi.org/10.3967/bes2025.052","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the association between long-term glycemic control and cerebral infarction risk in patients with diabetes through a large-scale cohort study.</p><p><strong>Methods: </strong>This prospective, community-based cohort study included 12,054 patients with diabetes. From 2006 to 2012, 38,272 fasting blood glucose (FBG) measurements were obtained from these participants. FBG trajectory patterns were generated using latent mixture modelling. Cox proportional hazards models were applied to assess the subsequent risk of cerebral infarction associated with different FBG trajectory patterns.</p><p><strong>Results: </strong>At baseline, the mean age of the participants was 55.2 years. Four distinct FBG trajectories were identified based on FBG concentrations and their changes over the 6-year follow-up period. After a median follow-up of 6.9 years, 786 cerebral infarction events were recorded. Different trajectory patterns were associated with significantly varied outcome risks (Log-Rank <i>P</i> < 0.001). Compared with the low-stability group, Hazard Ratio ( <i>HR</i>) adjusted for potential confounders were 1.37 for the moderate-increasing group, 1.23 for the elevated-decreasing group, and 2.08 for the elevated-stable group.</p><p><strong>Conclusion: </strong>Sustained high FBG levels were found to play a critical role in the development of ischemic stroke among patients with diabetes. Controlling FBG levels may reduce the risk of cerebral infarction.</p>","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"38 8","pages":"926-934"},"PeriodicalIF":4.1,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hong Yuan Fu, Yi Chun, Ya Han Zhang, Yu Wang, Yu Lin Shi, Tao Jiang, Xiao Juan Hu, Li Ping Tu, Yong Zhi Li, Jia Tuo Xu
{"title":"Analysis of Tongue and Face Image Features of Anemic Women and Construction of Risk-Screening Model.","authors":"Hong Yuan Fu, Yi Chun, Ya Han Zhang, Yu Wang, Yu Lin Shi, Tao Jiang, Xiao Juan Hu, Li Ping Tu, Yong Zhi Li, Jia Tuo Xu","doi":"10.3967/bes2025.047","DOIUrl":"https://doi.org/10.3967/bes2025.047","url":null,"abstract":"<p><strong>Objective: </strong>To identify the key features of facial and tongue images associated with anemia in female populations, establish anemia risk-screening models, and evaluate their performance.</p><p><strong>Methods: </strong>A total of 533 female participants (anemic and healthy) were recruited from Shuguang Hospital. Facial and tongue images were collected using the TFDA-1 tongue and face diagnosis instrument. Color and texture features from various parts of facial and tongue images were extracted using Face Diagnosis Analysis System (FDAS) and Tongue Diagnosis Analysis System version 2.0 (TDAS v2.0). Least Absolute Shrinkage and Selection Operator (LASSO) regression was used for feature selection. Ten machine learning models and one deep learning model (ResNet50V2 + Conv1D) were developed and evaluated.</p><p><strong>Results: </strong>Anemic women showed lower a-values, higher L- and b-values across all age groups. Texture features analysis showed that women aged 30-39 with anemia had higher angular second moment (ASM)and lower entropy (ENT) values in facial images, while those aged 40-49 had lower contrast (CON), ENT, and MEAN values in tongue images but higher ASM. Anemic women exhibited age-related trends similar to healthy women, with decreasing L-values and increasing a-, b-, and ASM-values. LASSO identified 19 key features from 62. Among classifiers, the Artificial Neural Network (ANN) model achieved the best performance [area under the curve (AUC): 0.849, accuracy: 0.781]. The ResNet50V2 model achieved comparable results [AUC: 0.846, accuracy: 0.818].</p><p><strong>Conclusion: </strong>Differences in facial and tongue images suggest that color and texture features can serve as potential TCM phenotype and auxiliary diagnostic indicators for female anemia.</p>","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"38 8","pages":"935-951"},"PeriodicalIF":4.1,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}