Biomedical and environmental sciences : BES最新文献_第3页

Co-Circulation of Respiratory Pathogens that Cause Severe Acute Respiratory Infections during the Autumn and Winter of 2023 in Beijing, China. 2023年秋冬季北京地区引起严重急性呼吸道感染的呼吸道病原体共循环

Biomedical and environmental sciences : BES Pub Date : 2025-05-20 DOI: 10.3967/bes2025.050

Jing Zhi Li, Da Huo, Dai Tao Zhang, Jia Chen Zhao, Chun Na Ma, Dan Wu, Peng Yang, Quan Yi Wang, Zhao Min Feng

引用次数: 0

Building China's Burden of Disease Research System: Priorities and Pathways. 构建中国疾病负担研究体系：重点和途径。

Biomedical and environmental sciences : BES Pub Date : 2025-05-20 DOI: 10.3967/bes2025.055

Peng Yin, Mai Geng Zhou

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Perioperative Cardiac Arrest in Mechanically Ventilated Older Patients Undergoing Thoracic Surgery. 胸外科机械通气老年患者围手术期心脏骤停的研究。

Biomedical and environmental sciences : BES Pub Date : 2025-05-20 DOI: 10.3967/bes2025.035

Wen Jun Liu, Shu Yu Zhang, Sheng Wang

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Factors in Work-Related Musculoskeletal Disorders in Dentists: A Structural Equation Model. 牙医中与工作相关的肌肉骨骼疾病的因素：一个结构方程模型。

Biomedical and environmental sciences : BES Pub Date : 2025-05-20 DOI: 10.3967/bes2025.037

Shun Hang Li, Jian Li, Xin Xu, Yu Shan Huang, Yi Lin Zhang, Xiao Shuang Xu, Wei Zhen Guan, Xiao Ping Liu, Jing Li

引用次数: 0

Global Burden of Clostridium difficile Infection-Related Diarrhea Mortality from 1990 to 2021: A Study Based on the 2021 Global Burden of Disease Database. 1990 - 2021年艰难梭菌感染相关腹泻死亡率的全球负担：基于2021年全球疾病负担数据库的研究

Biomedical and environmental sciences : BES Pub Date : 2025-05-20 DOI: 10.3967/bes2025.039

Ying Li, Jie Li, He Sheng Chang, Yue Hua Hu, Cheng Dong Xu

引用次数: 0

Synaptic Vesicle Glycoprotein 2A Slows down Amyloidogenic Processing of Amyloid Precursor Protein via Regulating Its Intracellular Trafficking. 突触囊泡糖蛋白2A通过调节淀粉样前体蛋白的细胞内运输减缓淀粉样蛋白的淀粉样变性加工。

Biomedical and environmental sciences : BES Pub Date : 2025-05-20 DOI: 10.3967/bes2025.049

Qian Zhang, Xiao Ling Wang, Yu Li Hou, Jing Jing Zhang, Cong Cong Liu, Xiao Min Zhang, Ya Qi Wang, Yu Jian Fan, Jun Ting Liu, Jing Liu, Qiao Song, Pei Chang Wang

{"title":"Synaptic Vesicle Glycoprotein 2A Slows down Amyloidogenic Processing of Amyloid Precursor Protein via Regulating Its Intracellular Trafficking.","authors":"Qian Zhang, Xiao Ling Wang, Yu Li Hou, Jing Jing Zhang, Cong Cong Liu, Xiao Min Zhang, Ya Qi Wang, Yu Jian Fan, Jun Ting Liu, Jing Liu, Qiao Song, Pei Chang Wang","doi":"10.3967/bes2025.049","DOIUrl":"https://doi.org/10.3967/bes2025.049","url":null,"abstract":"Objective: To reveal the effects and potential mechanisms by which synaptic vesicle glycoprotein 2A (SV2A) influences the distribution of amyloid precursor protein (APP) in the trans-Golgi network (TGN), endolysosomal system, and cell membranes and to reveal the effects of SV2A on APP amyloid degradation.Methods: Colocalization analysis of APP with specific tagged proteins in the TGN, ensolysosomal system, and cell membrane was performed to explore the effects of SV2A on the intracellular transport of APP. APP, β-site amyloid precursor protein cleaving enzyme 1 (BACE1) expressions, and APP cleavage products levels were investigated to observe the effects of SV2A on APP amyloidogenic processing.Results: APP localization was reduced in the TGN, early endosomes, late endosomes, and lysosomes, whereas it was increased in the recycling endosomes and cell membrane of SV2A-overexpressed neurons. Moreover, Arl5b (ADP-ribosylation factor 5b), a protein responsible for transporting APP from the TGN to early endosomes, was upregulated by SV2A. SV2A overexpression also decreased APP transport from the cell membrane to early endosomes by downregulating APP endocytosis. In addition, products of APP amyloid degradation, including sAPPβ, Aβ 1-42, and Aβ 1-40, were decreased in SV2A-overexpressed cells.Conclusion: These results demonstrated that SV2A promotes APP transport from the TGN to early endosomes by upregulating Arl5b and promoting APP transport from early endosomes to recycling endosomes-cell membrane pathway, which slows APP amyloid degradation.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"38 5","pages":"607-624"},"PeriodicalIF":0.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changes in Esophageal Cancer Survival: A Global Review of Survival Analysis from Cancer Registration Data over the Past Three Decades. 食管癌生存期的变化：过去30年癌症登记数据的全球生存分析综述

Biomedical and environmental sciences : BES Pub Date : 2025-05-20 DOI: 10.3967/bes2025.018

Zhuo Jun Ye, Dan Ni Yang, Yu Jiang, Yu Xuan Xiao, Zhuo Ying Li, Yu Ting Tan, Hui Yun Yuan, Yong Bing Xiang

{"title":"Changes in Esophageal Cancer Survival: A Global Review of Survival Analysis from Cancer Registration Data over the Past Three Decades.","authors":"Zhuo Jun Ye, Dan Ni Yang, Yu Jiang, Yu Xuan Xiao, Zhuo Ying Li, Yu Ting Tan, Hui Yun Yuan, Yong Bing Xiang","doi":"10.3967/bes2025.018","DOIUrl":"https://doi.org/10.3967/bes2025.018","url":null,"abstract":"Objective: To describe survival trends and global patterns of esophageal cancer (EC) using survival data from population-based cancer registries.Methods: We systematically searched PubMed, EMBASE, Web of Science, SEER, and SinoMed databases for articles published up to 31 December 2023. Eligible EC survival estimates were evaluated according to country or region, period, sex, age group, pathology, and disease stage.Results: After 2010, Jordan exhibited the highest age-standardized 5-year relative survival rates (RSRs)/net survival rates (NSRs) at 41.1% between 2010 and 2014, while India had the lowest, at 4.1%. Survival rates generally improved with diagnostic age across most countries, with significant increases in South Korea and China, of 12.7% and 10.5% between 2000 and 2017, respectively. Survival was higher among women compared to men, ranging from 0.4%-10.9%. Survival rates for adenocarcinoma and squamous cell carcinoma were similar, differing by about 4%. In China, the highest age-standardized RSRs/NSRs was 33.4% between 2015 and 2017. Meanwhile, the lowest was 5.3%, in Qidong (Jiangsu province) between 1992-1996.Conclusion: Global EC survival rates have improved significantly in recent decades, but substantial geographical, sex, and age disparities still exist. In Asia, squamous cell carcinoma demonstrated superior survival rates compared to adenocarcinoma, while the opposite trend was observed in Western countries. Future research should clarify the prognostic factors influencing EC survival and tailor prevention and screening strategies to the changing EC survival patterns.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"38 5","pages":"571-584"},"PeriodicalIF":0.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Forecast of the Burden of Lower Respiratory Infections in the Elderly Aged 70 and above in China from 1990 to 2050, GBD2021. 1990 - 2050年中国70岁及以上老年人下呼吸道感染负担预测，GBD2021。

Biomedical and environmental sciences : BES Pub Date : 2025-05-20 DOI: 10.3967/bes2025.036

Miao Miao Zhang, Rui Yi Zhang, Yu Chang Zhou, Mai Geng Zhou

{"title":"Forecast of the Burden of Lower Respiratory Infections in the Elderly Aged 70 and above in China from 1990 to 2050, GBD2021.","authors":"Miao Miao Zhang, Rui Yi Zhang, Yu Chang Zhou, Mai Geng Zhou","doi":"10.3967/bes2025.036","DOIUrl":"https://doi.org/10.3967/bes2025.036","url":null,"abstract":"Objective: This study aims to analyze the burden of lower respiratory infections in Chinese elderly people aged 70 and above.Methods: This study utilized Global Burden of Disease (GBD) 1990-2050 prediction data to analyze changes in mortality rates and disability-adjusted life year (DALY) rates for lower respiratory infections in the elderly population (aged 70 and above) in China from 1990 to 2050. It also discusses future trends in the burden of lower respiratory infections (LRI) in China under different scenarios.Results: According to GBD predictions, the burden of lower respiratory infections in the elderly aged 70 years and above in China is lower than the global average. The burden has been decreasing from 1990 to 2020, but is projected to increase from 2020 to 2050. Scenario-based predictions suggest that, under scenarios involving improvements in nutrition and vaccination, the burden of lower respiratory infections in the elderly in China is expected to be the lowest in 2050.Conclusion: This study indicates that the burden of lower respiratory infections in elderly people aged 70 years and above in China remains a significant public health issue and may worsen. The government should consider strengthening the preventive measures and management strategies for respiratory infections in the elderly population.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"38 5","pages":"539-546"},"PeriodicalIF":0.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lumbar Spondylolysis in Chinese Adults: Prevalence and Musculoskeletal Conditions. 中国成人腰椎峡部裂：患病率和肌肉骨骼状况。

Biomedical and environmental sciences : BES Pub Date : 2025-05-20 DOI: 10.3967/bes2025.043

Dong Yan, Yan Dong Liu, Ling Wang, Kai Li, Wen Shuang Zhang, Yi Yuan, Jian Geng, Kang Kang Ma, Feng Yun Zhou, Zi Tong Cheng, Xiao Guang Cheng

{"title":"Lumbar Spondylolysis in Chinese Adults: Prevalence and Musculoskeletal Conditions.","authors":"Dong Yan, Yan Dong Liu, Ling Wang, Kai Li, Wen Shuang Zhang, Yi Yuan, Jian Geng, Kang Kang Ma, Feng Yun Zhou, Zi Tong Cheng, Xiao Guang Cheng","doi":"10.3967/bes2025.043","DOIUrl":"https://doi.org/10.3967/bes2025.043","url":null,"abstract":"Objective: To determine the prevalence of lumbar spondylolysis (LS) and the proportion of spondylolytic spondylolisthesis (SS) in China, and to evaluate the musculoskeletal status of patients with LS and SS.Methods: Spine Computed Tomography (CT) images were collected from community populations aged 40 and above in a nationwide multi-center project. LS was diagnosed, and SS was graded by an experienced radiologist. Bone mineral density (BMD) and paraspinal muscle parameters were quantified based on CT images.Results: One hundred and seventeen patients of a total of 3,317 individuals were diagnosed with LS, corresponding to a prevalence rate of 3.53%. 63 of the 1,214 males (5.18%) and 54 of the 2,103 females (2.57%) were diagnosed with LS. SS occurred in 64/121 vertebrae (52.89%). BMD was not associated with LS ( P = 0.341). The L5 extensor paraspinal muscle density was higher in the LS group than in the non-LS group. In the LS group, patients with SS had a smaller L5 paraspinal extensor muscle cross-sectional area than those without SS ( P = 0.003).Conclusion: The prevalence of LS in Chinese adults was 3.53%, with prevalence rates of 5.18% in males and 2.57% in females. Patients with LS have higher muscle density, whereas those with SS have smaller muscle cross-sectional areas at the L5 level.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"38 5","pages":"598-606"},"PeriodicalIF":0.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction. 修正。

Biomedical and environmental sciences : BES Pub Date : 2025-04-20

引用次数: 0