Biomedical and environmental sciences : BES最新文献_第3页

The Role of VSD in Enhancing the Biological Environment of Scarred Skin Incisions in Valve Replacement: A Clinical Study on Postoperative Outcomes in Patients with Extensive Burns and Cardiac Valve Neoplasms. 瓣膜置换术中VSD在改善瘢痕皮肤切口生物环境中的作用：广泛烧伤合并心脏瓣膜肿瘤患者术后预后的临床研究

Biomedical and environmental sciences : BES Pub Date : 2025-03-20 DOI: 10.3967/bes2025.023

Wei Liu, Ting He, Yang Chang, Long Long Yang, Chuan-An Shen

引用次数: 0

A New Classification System for Childhood and Adolescent Obesity: Definition of the BCAMS Classification. 一种新的儿童青少年肥胖分类体系：BCAMS分类的定义。

Biomedical and environmental sciences : BES Pub Date : 2025-03-20 DOI: 10.3967/bes2025.006

Ming Li, Shan Gao

引用次数: 0

Trends of Disease Burden of Pancreatic Cancer Attributed to High Fasting Plasma Glucose in China,1990-2021: Insights from the Global Burden of Disease Study 2021. 1990-2021年中国高空腹血糖导致的胰腺癌疾病负担趋势：来自2021年全球疾病负担研究的见解

Biomedical and environmental sciences : BES Pub Date : 2025-03-20 DOI: 10.3967/bes2025.027

Xiao Chen Chen, Fei Fei Zhong, Juan Li

引用次数: 0

Short-term Effects of Fine Particulate Matter and its Constituents on Acute Exacerbations of Chronic Bronchitis: A Time-stratified Case-crossover Study. 细颗粒物及其成分对慢性支气管炎急性加重的短期影响：一项时间分层病例交叉研究。

Biomedical and environmental sciences : BES Pub Date : 2025-03-20 DOI: 10.3967/bes2025.026

Jing Wei Zhang, Jian Zhang, Peng Fei Li, Yan Dan Xu, Xue Song Zhou, Xiu Li Tang, Jia Qiu, Zhong Ao Ding, Ming Jia Xu, Chong Jian Wang

引用次数: 0

Comprehensive Analysis of Oncogenic, Prognostic, and Immunological Roles of FANCD2 in Hepatocellular Carcinoma: A Potential Predictor for Survival and Immunotherapy. FANCD2在肝细胞癌中的致癌、预后和免疫学作用的综合分析：生存和免疫治疗的潜在预测因子。

Biomedical and environmental sciences : BES Pub Date : 2025-03-20 DOI: 10.3967/bes2024.182

Meng Jiao Xu, Wen Deng, Ting Ting Jiang, Shi Yu Wang, Ru Yu Liu, Min Chang, Shu Ling Wu, Ge Shen, Xiao Xue Chen, Yuan Jiao Gao, Hongxiao Hao, Lei Ping Hu, Lu Zhang, Yao Lu, Wei Yi, Yao Xie, Ming Hui Li

{"title":"Comprehensive Analysis of Oncogenic, Prognostic, and Immunological Roles of FANCD2 in Hepatocellular Carcinoma: A Potential Predictor for Survival and Immunotherapy.","authors":"Meng Jiao Xu, Wen Deng, Ting Ting Jiang, Shi Yu Wang, Ru Yu Liu, Min Chang, Shu Ling Wu, Ge Shen, Xiao Xue Chen, Yuan Jiao Gao, Hongxiao Hao, Lei Ping Hu, Lu Zhang, Yao Lu, Wei Yi, Yao Xie, Ming Hui Li","doi":"10.3967/bes2024.182","DOIUrl":"https://doi.org/10.3967/bes2024.182","url":null,"abstract":"Objective: Hepatocellular carcinoma (HCC) is sensitive to ferroptosis, a new form of programmed cell death that occurs in most tumor types. However, the mechanism through which ferroptosis modulates HCC remains unclear. This study aimed to investigate the oncogenic role and prognostic value of FANCD2 and provide novel insights into the prognostic assessment and prediction of immunotherapy.Methods: Using clinicopathological parameters and bioinformatic techniques, we comprehensively examined the expression of FANCD2 macroscopically and microcosmically. We conducted univariate and multivariate Cox regression analyses to identify the prognostic value of FANCD2 in HCC and elucidated the detailed molecular mechanisms underlying the involvement of FANCD2 in oncogenesis by promoting iron-related death.Results: FANCD2 was significantly upregulated in digestive system cancers with abundant immune infiltration. As an independent risk factor for HCC, a high FANCD2 expression level was associated with poor clinical outcomes and response to immune checkpoint blockade. Gene set enrichment analysis revealed that FANCD2 was mainly involved in the cell cycle and CYP450 metabolism.Conclusion: To the best of our knowledge, this is the first study to comprehensively elucidate the oncogenic role of FANCD2. FANCD2 has a tumor-promoting aspect in the digestive system and acts as an independent risk factor in HCC; hence, it has recognized value for predicting tumor aggressiveness and prognosis and may be a potential biomarker for poor responsiveness to immunotherapy.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"38 3","pages":"313-327"},"PeriodicalIF":0.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144059695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Impact of Reproductive Traits on Psoriasis Risk is Mediated by Education Attainment and Body Mass Index: A Mendelian Randomization Study. 生殖性状对银屑病风险的影响受教育程度和体重指数的调节：一项孟德尔随机研究。

Biomedical and environmental sciences : BES Pub Date : 2025-03-20 DOI: 10.3967/bes2024.122

Ya Jia Li, Qiang Xiang Li, Zi Qin Cao, Jian Huang Wu

{"title":"The Impact of Reproductive Traits on Psoriasis Risk is Mediated by Education Attainment and Body Mass Index: A Mendelian Randomization Study.","authors":"Ya Jia Li, Qiang Xiang Li, Zi Qin Cao, Jian Huang Wu","doi":"10.3967/bes2024.122","DOIUrl":"https://doi.org/10.3967/bes2024.122","url":null,"abstract":"Objective: To explore the causality between reproductive traits and risk of psoriasis by using a large Mendelian randomization (MR) study.Methods: A two-sample MR study was performed using summarized statistics from the genome-wide association studies (GWAS) conducted in reproductive traits, as well as GWAS data on overall psoriasis, psoriatic arthritis (PsA), and psoriasis vulgaris (PV). Besides univariable MR (UVMR), multivariable MR and two-step MR was used to calculate the independent effects and quantify the proportion mediated by education or body mass index (BMI).Results: Genetically predicted early age at first sexual intercourse (AFS) led to an increased risk of overall psoriasis [odds ratio ( OR) UVMR: 0.54]; 36.13% of this effect was mediated through BMI and 47.79% through educational attainment. The direct negative casual association between age at first birth (AFB)-PsA was dominant ( OR UVMR: 0.76), with 49.61% proportion of the mediation due to BMI. The mediating effect was found for BMI on the AFS-PV relationship, which accounted for 26.27% of the proportion. AFS was inversely associated with the risk of overall psoriasis and PV, with considerable mediation by BMI and educational attainment.Conclusion: Early AFB may cause a higher risk of PsA, while the AFS-PsA association was fully mediated by BMI.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"38 3","pages":"365-375"},"PeriodicalIF":0.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Health Economic Evaluation of an Artificial Intelligence-assisted Prescription Review System in a Real-world Setting in China. 中国人工智能辅助处方审查系统的健康经济评价

Biomedical and environmental sciences : BES Pub Date : 2025-03-20 DOI: 10.3967/bes2025.025

Di Wu, Ying Peng Qiu, Li Wei Shi, Ke Jun Liu, Xue Qing Tian, Ping Ren, Mao You, Jun Rui Pei, Wen Qi Fu, Yue Xiao

引用次数: 0

Association of Loneliness and Social Isolation with Ischemic Heart Disease: A Bidirectional and Network Mendelian Randomization Study. 孤独和社会隔离与缺血性心脏病的关系：一项双向和网络孟德尔随机研究

Biomedical and environmental sciences : BES Pub Date : 2025-03-20 DOI: 10.3967/bes2024.170

Shu Yao Su, Wan Yue Wang, Chen Xi Yuan, Zhen Nan Lin, Xiang Feng Lu, Fang Chao Liu

{"title":"Association of Loneliness and Social Isolation with Ischemic Heart Disease: A Bidirectional and Network Mendelian Randomization Study.","authors":"Shu Yao Su, Wan Yue Wang, Chen Xi Yuan, Zhen Nan Lin, Xiang Feng Lu, Fang Chao Liu","doi":"10.3967/bes2024.170","DOIUrl":"https://doi.org/10.3967/bes2024.170","url":null,"abstract":"Objective: Observational studies have shown inconsistent associations of loneliness or social isolation (SI) with ischemic heart disease (IHD), with unknown mediators.Methods: Using data from genome-wide association studies of predominantly European ancestry, we performed a bidirectional two-sample Mendelian Randomization (MR) study to estimate causal effects of loneliness ( N = 487,647) and SI traits on IHD ( N = 184,305). SI traits included whether individuals lived alone, participated in various types of social activities, and how often they had contact with friends or family ( N = 459,830 to 461,369). A network MR study was conducted to evaluate the mediating roles of 20 candidate mediators, including metabolic, behavioral and psychological factors.Results: Loneliness increased IHD risk ( OR= 2.129; 95% confidence interval [ CI]: 1.380 to 3.285), mediated by body fat percentage, waist-hip ratio, total cholesterol, and low-density lipoprotein cholesterol. For SI traits, only fewer social activities increased IHD risk ( OR= 1.815; 95% CI: 1.189 to 2.772), mediated by hypertension, high-density lipoprotein cholesterol, triglycerides, fasting insulin, and smoking cessation. No reverse causality of IHD with loneliness and SI was found.Conclusion: These findings suggested more attention should be paid to individuals who feel lonely and have fewer social activities to prevent IHD, with several mediators as prioritized targets for intervention.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"38 3","pages":"351-364"},"PeriodicalIF":0.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144014260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Causal Association between PM _2.5 Exposure and Preterm Birth based on Mendelian Randomization Analysis. 基于孟德尔随机化分析的pm2.5暴露与早产的因果关系。

Biomedical and environmental sciences : BES Pub Date : 2025-02-20 DOI: 10.3967/bes2025.009

Hui Na Wang, Ya Zhe Du, Juan Geng, Teng Zhang, Jin Zhao Long, Hai Yan Yang, Guang Cai Duan, Shuai Yin Chen

引用次数: 0

miR-34c-3p Inhibits Nasopharyngeal Carcinoma Development via Inhibiting M2 Polarization of Macrophages. miR-34c-3p通过抑制巨噬细胞M2极化抑制鼻咽癌的发展。

Biomedical and environmental sciences : BES Pub Date : 2025-02-20 DOI: 10.3967/bes2024.136

Yu Zi Ji, Yu Jie Wang, Ji Qing Ma, Zhi Hua Yin, Fei Liu, Yan Zi Zang, Guang Ke Wang, Yong Tai

{"title":"miR-34c-3p Inhibits Nasopharyngeal Carcinoma Development via Inhibiting M2 Polarization of Macrophages.","authors":"Yu Zi Ji, Yu Jie Wang, Ji Qing Ma, Zhi Hua Yin, Fei Liu, Yan Zi Zang, Guang Ke Wang, Yong Tai","doi":"10.3967/bes2024.136","DOIUrl":"10.3967/bes2024.136","url":null,"abstract":"Objective: miR-34c-3p is down-regulated in nasopharyngeal carcinoma (NPC). The biological role of miR-34c-3p in NPC and its underlying mechanisms are unknown and were explored in this study.Methods: Flow cytometry and immunohistochemical staining were employed to detect cluster of differentiation 86 (CD86) and cluster of differentiation 206 (CD206) expression; quantitative real-time polymerase chain reaction (qRT-PCR) and western blotting were employed to examine mRNA expression and protein levels; cell counting kit-8 (CCK8) and transwell assays were employed to assess cell proliferation, migration, and invasion; and hematoxylin-eosin (HE) staining was employed to assess pathological changes in tumor tissues.Results: Our results revealed that the miR-34c-3p mimic markedly inhibited M2 polarization of macrophages by targeting SLC7A11, and M2 macrophages transfected with the miR-34c-3p mimic inhibited the proliferation, migration, and invasion of NPC cells. The in vivo experiments further confirmed that miR-34c-3p mimics blocked tumor growth and reduced inflammatory infiltration in tumor tissues.Conclusion: This study provides novel insights into the pathogenesis of NPC and a new treatment strategy.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"38 2","pages":"219-229"},"PeriodicalIF":0.0,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0