Biomedical and environmental sciences : BES最新文献_第4页

Genetic Characterization of Multidrug-resistant Aeromonas Isolates from a General Hospital in China and Identification of a New CphA Variant. 中国某综合医院多药耐药气单胞菌分离株的遗传特征及一种CphA新变体的鉴定。

IF 4.1

Biomedical and environmental sciences : BES Pub Date : 2026-07-20 DOI: 10.3967/bes2026.068

Yan Yan Zhou, Ke Yi Yu, Ming Liu, Zhen Zhou Huang, Yan Qing Che, Meng Yu Shi, Zhen Peng Li, Xiao Li Du, Duo Chun Wang, Li Yan Ma, Li Yu

引用次数: 0

Incidence of Active Tuberculosis over a Two-year Follow-up Period among Individuals with different Chest Radiographic Findings who were Excluded from Active Tuberculosis at Initial Baseline Screening. 在最初的基线筛查中被排除在活动性结核病之外的具有不同胸片表现的个体在两年随访期间的活动性结核病发病率。

IF 4.1

Biomedical and environmental sciences : BES Pub Date : 2026-07-20 DOI: 10.3967/bes2026.067

Ping Zhu, Yu Gao, Yan Qian, Wei Wang, Yu Han Wang, Jian Guo Liang, Lei Gao, Ying Du

引用次数: 0

Plasma Metal Exposures and Metabolic Dysfunction-associated Steatotic Liver Disease in Rural Chinese Adults: Exploratory Evidence for Lipid-related Pathways. 血浆金属暴露与中国农村成人代谢功能障碍相关的脂肪变性肝病：脂质相关途径的探索性证据

IF 4.1

Biomedical and environmental sciences : BES Pub Date : 2026-07-20 DOI: 10.3967/bes2026.066

Yuan Yang, Mo Qi Zhang, Chao Fan Xie, Hao Wang, Shu Zhen Liu, Chi Hua Li, You Li, Jian Sheng Cai, Xu Gao, Zhi Yong Zhang

引用次数: 0

TAP1 Expression Identifies a "Hot-but-exhausted" Glioma Subtype with Distinct Immunobiology and Targetable Dependencies. TAP1表达确定了一种具有不同免疫生物学和靶向依赖性的“热但耗尽”胶质瘤亚型。

IF 4.1

Biomedical and environmental sciences : BES Pub Date : 2026-07-20 DOI: 10.3967/bes2026.056

Jian Lei An, Hong Ru Liu, Jun Zhang, Lei Liu

引用次数: 0

Concurrent MASLD and Long-term Outcomes in HBV-infected Individuals: A Population-based Cohort Study. hbv感染者并发MASLD和长期预后：一项基于人群的队列研究

IF 4.1

Biomedical and environmental sciences : BES Pub Date : 2026-07-20 DOI: 10.3967/bes2026.064

Xiao Mo Wang, Shu Tong Wu, Chen Lu Yang, Di Zhou, Shuo Hua Chen, Bao Yu Feng, Xin Yu Zhao, Shou Ling Wu, Li Wang

{"title":"Concurrent MASLD and Long-term Outcomes in HBV-infected Individuals: A Population-based Cohort Study.","authors":"Xiao Mo Wang, Shu Tong Wu, Chen Lu Yang, Di Zhou, Shuo Hua Chen, Bao Yu Feng, Xin Yu Zhao, Shou Ling Wu, Li Wang","doi":"10.3967/bes2026.064","DOIUrl":"https://doi.org/10.3967/bes2026.064","url":null,"abstract":"Objective: To examine the influence of metabolic dysfunction-associated steatotic liver disease (MASLD) on long-term outcomes of patients with chronic hepatitis B virus (HBV) infection.Methods: A total of 3,269 participants with chronic HBV infection from the Kailuan Cohort (median follow-up: 13.7 years) were enrolled to estimate the hazard ratios ( HRs) and 95% confidence intervals ( CIs) for outcomes associated with MASLD. In addition, 120,913 individuals without HBV infection were included to assess the independent and interactive associations between steatotic liver disease (SLD), cardiometabolic risk factors (CMRFs), and HBV infection.Results: In individuals with chronic HBV infection, MASLD was not linked to primary liver cancer but was associated with an increased risk of extrahepatic cancers ( HR= 1.50, 95% CI, 1.01-2.25) and cardiovascular diseases ( HR= 1.98, 95% CI, 1.49-2.63), especially in participants with normal alanine aminotransferase, mild SLD, and persistent MASLD. The risk of cardiovascular disease remained elevated in the participants with reversed MASLD. Joint analysis indicated a significant synergistic interaction between HBV infection, CMRFs, and primary liver cancer.Conclusions: In patients with chronic HBV infection, MASLD serves as a crucial indicator of significantly elevated systemic risk, underscoring the importance of addressing both virological control and metabolic health regardless of their current hepatic steatosis and liver enzyme status.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"39 7","pages":"785-798"},"PeriodicalIF":4.1,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148681648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between Occupational High-Temperature Exposure and the Biological Aging of Workers. 职业性高温暴露与工人生物老化的关系。

IF 4.1

Biomedical and environmental sciences : BES Pub Date : 2026-07-20 DOI: 10.3967/bes2026.016

Yan Guo, Rui Zhao, Wei Chao Wu, Jin Ru Chen, Xiang Kai Zhao, Bin Yang, Zhi Guang Gu, Dong Sheng Hu, Ming Zhang, Wei Wang

{"title":"Association between Occupational High-Temperature Exposure and the Biological Aging of Workers.","authors":"Yan Guo, Rui Zhao, Wei Chao Wu, Jin Ru Chen, Xiang Kai Zhao, Bin Yang, Zhi Guang Gu, Dong Sheng Hu, Ming Zhang, Wei Wang","doi":"10.3967/bes2026.016","DOIUrl":"https://doi.org/10.3967/bes2026.016","url":null,"abstract":"Objective: To investigate the association between occupational high-temperature exposure and accelerated biological aging.Methods: A total of 140 male workers exposed to occupational high-temperatures and 207 male non-exposed control workers were selected as study subjects. Questionnaire surveys and health examinations were conducted. Biological age and organ-specific biological age were calculated using the Klemera-Doubal method. Generalized linear models were used to analyze the effects of occupational high-temperature exposure, body mass index (BMI), smoking, alcohol consumption, and sleep duration on biological age (BA) acceleration and organ-specific biological age.Results: Significant differences were observed between the exposed and control groups in length of service, systolic blood pressure, red blood cell count, albumin levels, urea, creatinine, BA acceleration, and liver-kidney BA acceleration ( P < 0.05). Compared with the control group, which showed a BA acceleration of 0.04 ± 1.34 years, the exposed group demonstrated significantly higher BA acceleration of 0.62 ± 1.31 years. After adjustment for covariates, workers exposed to high-temperatures exhibited significantly higher BA acceleration and liver-kidney BA acceleration than controls ( P < 0.001). High-temperature exposure and BMI were associated with BA acceleration, with a significant interaction between the two factors ( P < 0.05). High-temperature exposure, BMI, and smoking were identified as risk factors for BA acceleration, whereas sleep duration was a protective factor ( P < 0.05).Conclusion: Occupational high-temperature exposure may accelerate biological aging. An interaction exists between occupational high-temperature exposure and BMI in relation to BA acceleration.Graphical abstract: available in www.besjournal.com.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"39 7","pages":"809-816"},"PeriodicalIF":4.1,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148681664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations between Heavy Metals and Metalloids and Hepatic Fibrosis Risk in Chinese Adults: A Potential Modifying Effect of Thyroid Hormones. 重金属和类金属与中国成人肝纤维化风险的关系：甲状腺激素的潜在调节作用。

IF 4.1

Biomedical and environmental sciences : BES Pub Date : 2026-07-20 DOI: 10.3967/bes2026.045

Lu Yu, Zheng Li, Pei Jie Sun, Shu Yang Yan, Wan Ying Shi, Wen Qi Hao, Wan Ling Li, Ming Kun Yu, De Jin Yang, Ying Li Qu, Sai Sai Ji, Wen Li Zhang, Feng Zhao, Ya Wei Li, Hao Can Song, Jia Yi Cai, Ying Zhu, Song Tang, Feng Tan, Yue Bin Lyu, Xiao Ming Shi

{"title":"Associations between Heavy Metals and Metalloids and Hepatic Fibrosis Risk in Chinese Adults: A Potential Modifying Effect of Thyroid Hormones.","authors":"Lu Yu, Zheng Li, Pei Jie Sun, Shu Yang Yan, Wan Ying Shi, Wen Qi Hao, Wan Ling Li, Ming Kun Yu, De Jin Yang, Ying Li Qu, Sai Sai Ji, Wen Li Zhang, Feng Zhao, Ya Wei Li, Hao Can Song, Jia Yi Cai, Ying Zhu, Song Tang, Feng Tan, Yue Bin Lyu, Xiao Ming Shi","doi":"10.3967/bes2026.045","DOIUrl":"10.3967/bes2026.045","url":null,"abstract":"Objective: To investigate associations between heavy metals and metalloids (HMMs) exposure and hepatic fibrosis risk, and to explore the modifying role of thyroid hormones.Methods: Using nationally representative data from 9,543 adults in the China National Human Biomonitoring (CNHBM) program, hepatic fibrosis risk was assessed with the Fibrosis-4 index (FIB-4). Weighted logistic and linear regression models were applied to evaluate links between 13 HMMs and fibrosis outcomes. Dose-response relationships were modeled with restricted cubic splines, and subgroup analyses were used to explore potential effect modification.Results: Blood cobalt (Co) ( OR = 1.613, 95% CI: 1.126-2.310) and blood manganese (Mn) ( OR = 1.699, 95% CI: 1.238-2.331) showed nonlinear positive associations with hepatic fibrosis risk, while urinary tin (Sn) ( OR = 0.888, 95% CI: 0.797-0.990) was inversely associated. Low triiodothyronine (T3) levels increased Co-induced fibrosis risk and may enhance the protective effect of Sn, while high T3 levels exacerbated Mn-related risk. Stratified analysis by thyroxine (T4) levels showed directionally consistent associations with the main findings.Conclusion: Blood Co and Mn nonlinearly increased hepatic fibrosis risk, urinary Sn reduced it. T3 levels modulated these metal-specific risks, highlighting thyroid hormones as potential modifiers in HMMs-induced hepatotoxicity.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"39 7","pages":"817-832"},"PeriodicalIF":4.1,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148681620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictions of City-based Respiratory Hospital Visits: Developing and Validating a Machine Learning Model with a Novel Composite Air Pollution Index. 基于城市的呼吸系统医院就诊预测：开发和验证具有新型复合空气污染指数的机器学习模型。

IF 4.1

Biomedical and environmental sciences : BES Pub Date : 2026-07-20 DOI: 10.3967/bes2026.062

Wen Xuan Zhao, Yu Wang, Chang Zhen Xiang, Chen Feng Li, Chen Chen, Jiao Nan Wang, Jian Long Fang, Feng Lu, Kai Chen, Shi Lu Tong, Jie Ban, Xiao Ming Shi

{"title":"Predictions of City-based Respiratory Hospital Visits: Developing and Validating a Machine Learning Model with a Novel Composite Air Pollution Index.","authors":"Wen Xuan Zhao, Yu Wang, Chang Zhen Xiang, Chen Feng Li, Chen Chen, Jiao Nan Wang, Jian Long Fang, Feng Lu, Kai Chen, Shi Lu Tong, Jie Ban, Xiao Ming Shi","doi":"10.3967/bes2026.062","DOIUrl":"https://doi.org/10.3967/bes2026.062","url":null,"abstract":"Objective: City-specific tools for assessing and warning about respiratory disease risks are underdeveloped, limiting effective public health response. This study aimed to develop and validate a novel city-specific prediction framework (WHA air-LSTM) for forecasting daily respiratory outpatient visits by integrating a composite air pollution health index.Methods: Based on over 223.7 million hospital visits across multiple megacities, we constructed and validated a five-level morbidity-driven composite air pollution index (WHA air) for each city using city-specific exposure-response relationships. An LSTM model was built using WHA air, temperature, humidity, and historical visit data to predict next-day visits. The proposed modeling framework was developed with city-level data, and it was externally validated using datasets from other cities.Results: Higher WHA air levels were significantly associated with increased outpatient visits. The model demonstrated excellent predictive performance (Beijing: R 2 = 0.963, RMSE = 53.5) and effectively captured visit surges. Excluding WHA air degraded model accuracy (ΔRMSE = +44.1%). The framework maintained robust performance in external validation, confirming its transferability.Conclusion: The WHA air-LSTM framework provides a scalable and practical tool for city-level respiratory disease early warning by bridging environmental monitoring with clinical practice.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"39 7","pages":"758-768"},"PeriodicalIF":4.1,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148681094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From Air Quality Monitoring to Health-Oriented Early Warning. 从空气质量监测到健康预警。

IF 4.1

Biomedical and environmental sciences : BES Pub Date : 2026-07-20 DOI: 10.3967/bes2026.060

Meng Meng Jia, Lu Zhao Feng

引用次数: 0

Association between Cardiorespiratory Fitness and All-cause Mortality and Life Expectancy: Two Nationwide Cohort Studies from the United Kingdom and the United States. 心肺健康与全因死亡率和预期寿命之间的关系：来自英国和美国的两项全国性队列研究。

IF 4.1

Biomedical and environmental sciences : BES Pub Date : 2026-06-20 DOI: 10.3967/bes2026.051

Tong Guo, Hui Min Lu, Mei Ling Cao, Hao Tian Wang, Jing Yu Wang, You Xin Wang

引用次数: 0