Biomedical and environmental sciences : BES最新文献_第4页

Disparities in the Levels of Whole-Blood Epstein-Barr Virus between the Cancer and Non-Cancer Populations in Zhejiang, China. 中国浙江癌症和非癌症人群全血 Epstein-Barr 病毒水平的差异。

Biomedical and environmental sciences : BES Pub Date : 2024-09-20 DOI: 10.3967/bes2024.101

Qing Jun Jia, Meichun Zeng, Qi Chen

{"title":"Disparities in the Levels of Whole-Blood Epstein-Barr Virus between the Cancer and Non-Cancer Populations in Zhejiang, China.","authors":"Qing Jun Jia, Meichun Zeng, Qi Chen","doi":"10.3967/bes2024.101","DOIUrl":"https://doi.org/10.3967/bes2024.101","url":null,"abstract":"Objective: This study aimed to investigate the prevalence of Epstein-Barr virus (EBV) infection in patients with and without cancer.Methods: A total of 26,648 participants who underwent whole-blood EBV DNA (WBEBV) assays between January 1, 2020, and August 31, 2023, were included. The chi-square test was used for categorical data analysis, and R software was used to analyze the differences in EBV DNA load levels and the diagnostic capabilities of WBEBV.Results: Positive rates were 10.2% and 25.4% for healthy controls (HC) and patients, respectively. The positivity rate for EBV-associated neoplasms (EN) was the highest at 7.53%, followed by leukemia (Le) at 5.49%. The subgroup analysis showed that the positivity rate for abnormal proliferation or hyperplasia (APH) was 31.9%, followed by 30.5% for Le. The WBEBV of patients with transplants (TP), especially living-related transplants (LT), was the highest among all subgroups. WBEBV at diagnosis was used to differentiate between infectious mononucleosis (IM) and chronic active Epstein-Barr virus (CAEBV), with a sensitivity of 67.4% (95% confidence interval [ CI]: 57.6-75.8) and specificity of 72% (95% CI: 63.3-79.3). We conclude that the prevalence of EBV infection is low in the healthy population in this region and that a high EBV load at baseline is more common in LT, IM, and Lymphocyte Leukemia (LL).Conclusion: This study used a large-sample survey to characterize the prevalence of whole-blood EBV levels in various diseases, including the stages and subtypes. The EBV detection rate was higher in patients with malignant disease than in those with benign disease. Our study provides clinicians with baseline information regarding EBV-associated diseases.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"37 9","pages":"993-1002"},"PeriodicalIF":0.0,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142482962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MicroRNA-451 from Human Umbilical Cord-Derived Mesenchymal Stem Cell Exosomes Inhibits Alveolar Macrophage Autophagy via Tuberous Sclerosis Complex 1/Mammalian Target of Rapamycin Pathway to Attenuate Burn-Induced Acute Lung Injury in Rats. 人脐带间充质干细胞外泌体中的 MicroRNA-451 通过结节性硬化症复合物 1/哺乳动物雷帕霉素靶途径抑制肺泡巨噬细胞自噬，从而减轻大鼠烧伤诱发的急性肺损伤。

Biomedical and environmental sciences : BES Pub Date : 2024-09-20 DOI: 10.3967/bes2024.128

Zhi Gang Jia, Lin Li, Peng Zhao, Guo Fei, Shuang Ru Li, Qin Qin Song, Guang Peng Liu, Ji Song Liu

{"title":"MicroRNA-451 from Human Umbilical Cord-Derived Mesenchymal Stem Cell Exosomes Inhibits Alveolar Macrophage Autophagy via Tuberous Sclerosis Complex 1/Mammalian Target of Rapamycin Pathway to Attenuate Burn-Induced Acute Lung Injury in Rats.","authors":"Zhi Gang Jia, Lin Li, Peng Zhao, Guo Fei, Shuang Ru Li, Qin Qin Song, Guang Peng Liu, Ji Song Liu","doi":"10.3967/bes2024.128","DOIUrl":"https://doi.org/10.3967/bes2024.128","url":null,"abstract":"Objective: Our previous studies established that microRNA (miR)-451 from human umbilical cord mesenchymal stem cell-derived exosomes (hUC-MSC-Exos) alleviates acute lung injury (ALI). This study aims to elucidate the mechanisms by which miR-451 in hUC-MSC-Exos reduces ALI by modulating macrophage autophagy.Methods: Exosomes were isolated from hUC-MSCs. Severe burn-induced ALI rat models were treated with hUC-MSC-Exos carrying the miR-451 inhibitor. Hematoxylin-eosin staining evaluated inflammatory injury. Enzyme-linked immunosorbnent assay measured lipopolysaccharide (LPS), tumor necrosis factor-α, and interleukin-1β levels. qRT-PCR detected miR-451 and tuberous sclerosis complex 1 (TSC1) expressions. The regulatory role of miR-451 on TSC1 was determined using a dual-luciferase reporter system. Western blotting determined TSC1 and proteins related to the mammalian target of rapamycin (mTOR) pathway and autophagy. Immunofluorescence analysis was conducted to examine exosomes phagocytosis in alveolar macrophages and autophagy level.Results: hUC-MSC-Exos with miR-451 inhibitor reduced burn-induced ALI and promoted macrophage autophagy. MiR-451 could be transferred from hUC-MSCs to alveolar macrophages via exosomes and directly targeted TSC1. Inhibiting miR-451 in hUC-MSC-Exos elevated TSC1 expression and inactivated the mTOR pathway in alveolar macrophages. Silencing TSC1 activated mTOR signaling and inhibited autophagy, while TSC1 knockdown reversed the autophagy from the miR-451 inhibitor-induced.Conclusion: miR-451 from hUC-MSC exosomes improves ALI by suppressing alveolar macrophage autophagy through modulation of the TSC1/mTOR pathway, providing a potential therapeutic strategy for ALI.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"37 9","pages":"1030-1043"},"PeriodicalIF":0.0,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142482977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

What Mice Can Teach Us about How to Stop Drug-Resistant Tuberculosis: Correct Chemotherapy Regimen and Patient Compliance are the Key. 小鼠能告诉我们如何阻止耐药性结核病：正确的化疗方案和患者的依从性是关键。

Biomedical and environmental sciences : BES Pub Date : 2024-09-20 DOI: 10.3967/bes2024.084

Igor Mokrousov, Tatiana Vinogradova, Marine Dogonadze, Maria Vitovskaya, Natalia Zabolotnykh, Sergei Chekrygin, Anna Vyazovaya

引用次数: 0

Estimation of Incidence of Herpes Zoster in Three Cities of China, 2019-2020. 2019-2020 年中国三大城市带状疱疹发病率估计。

Biomedical and environmental sciences : BES Pub Date : 2024-09-20 DOI: 10.3967/bes2024.115

Qian Zhang, Wei Qin, Zhen Shui Huang, Li Lin Liang, Qian Qian Hu, Yao Wang, Fan Pan, Feng Cui, Xin Li Liu, Lin Tang, Xiao Qi Wang, Chao Ma, Fu Zhen Wang, Zun Dong Yin

引用次数: 0

Effective Nucleic Acid Contamination Disinfection in Laboratory Settings using Ozone Gas. 在实验室环境中使用臭氧气体进行有效的核酸污染消毒。

Biomedical and environmental sciences : BES Pub Date : 2024-09-20 DOI: 10.3967/bes2024.086

Ying Yi Long, Lin Lin Liang, Xing Yan Zhou, Fei Ren, Lu Wang, Peng Zhang, Jing Wang

引用次数: 0

Quantifying the Temperature Effects on the Morbidity of Digestive Diseases In an Inland Plateau-Valley City. 内陆高原河谷城市气温对消化道疾病发病率影响的量化研究

Biomedical and environmental sciences : BES Pub Date : 2024-09-20 DOI: 10.3967/bes2024.140

Pan Ma, Yang Yang, Ning Zhou, Xin Zi Wang, Yu Lu Wang, Wen Juan Feng, Zhaoqin Bai, Shi Gong Wang

引用次数: 0

Summary Analysis of National Surveillance on Kashin-Beck Disease from 1990 to 2023. 1990 年至 2023 年全国卡欣贝克病监测情况汇总分析。

Biomedical and environmental sciences : BES Pub Date : 2024-09-20 DOI: 10.3967/bes2024.109

Si Lu Cui, Hui Liu, Jun Rui Pei, Jia Xin Li, Zhe Jiao, Qing Deng, Ning Liu, Yan Hong Cao, Jun Yu

{"title":"Summary Analysis of National Surveillance on Kashin-Beck Disease from 1990 to 2023.","authors":"Si Lu Cui, Hui Liu, Jun Rui Pei, Jia Xin Li, Zhe Jiao, Qing Deng, Ning Liu, Yan Hong Cao, Jun Yu","doi":"10.3967/bes2024.109","DOIUrl":"https://doi.org/10.3967/bes2024.109","url":null,"abstract":"Objective: To analyze the epidemiological characteristics and epidemic situation of children with Kashin-Beck disease (KBD) in China, and provide the basis for formulating prevention and control measures.Methods: Fixed-point monitoring, moving-point monitoring, and full coverage of monitoring were promoted successively from 1990 to 2023. Some children (7-12 years old) underwent clinical and right-hand X-ray examinations every year. According to the KBD diagnosis criteria, clinical and X-ray assessments were used to confirm the diagnosis.Results: In 1990, the national KBD detectable rate was 21.01%. X-ray detection decreased to below 10% in 2003 and below 5% in 2007. Between 2010 and 2018, the prevalence of KBD in children was less than 0.4%, which fluctuated at a low level, and has decreased to 0% since 2019. Spatial epidemiological analysis indicated a spatial clustering of adult patients prevalence rate in the KBD areas.Conclusion: The evaluation results of the elimination of KBD in China over the last 5 years showed that all villages in the monitored areas have reached the elimination standard. While the adult KBD patients still need for policy consideration and care.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"37 9","pages":"1056-1066"},"PeriodicalIF":0.0,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142482982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidemic Characteristics and Spatio-Temporal Patterns of HFRS in Qingdao City, China, 2010-2022. 2010-2022 年中国青岛市 HFRS 的流行特征和时空模式。

Biomedical and environmental sciences : BES Pub Date : 2024-09-20 DOI: 10.3967/bes2024.092

Ying Li, Run Ze Lu, Li Yan Dong, Li Tao Sun, Zong Yi Zhang, Ya Ting Zhao, Qing Duan, Li Jie Zhang, Fa Chun Jiang, Jing Jia, Hui Lai Ma

{"title":"Epidemic Characteristics and Spatio-Temporal Patterns of HFRS in Qingdao City, China, 2010-2022.","authors":"Ying Li, Run Ze Lu, Li Yan Dong, Li Tao Sun, Zong Yi Zhang, Ya Ting Zhao, Qing Duan, Li Jie Zhang, Fa Chun Jiang, Jing Jia, Hui Lai Ma","doi":"10.3967/bes2024.092","DOIUrl":"https://doi.org/10.3967/bes2024.092","url":null,"abstract":"Objective: This study investigated the epidemic characteristics and spatio-temporal dynamics of hemorrhagic fever with renal syndrome (HFRS) in Qingdao City, China.Methods: Information was collected on HFRS cases in Qingdao City from 2010 to 2022. Descriptive epidemiologic, seasonal decomposition, spatial autocorrelation, and spatio-temporal cluster analyses were performed.Results: A total of 2,220 patients with HFRS were reported over the study period, with an average annual incidence of 1.89/100,000 and a case fatality rate of 2.52%. The male:female ratio was 2.8:1. 75.3% of patients were aged between 16 and 60 years old, 75.3% of patients were farmers, and 11.6% had both \"three red\" and \"three pain\" symptoms. The HFRS epidemic showed two-peak seasonality: the primary fall-winter peak and the minor spring peak. The HFRS epidemic presented highly spatially heterogeneous, street/township-level hot spots that were mostly distributed in Huangdao, Pingdu, and Jiaozhou. The spatio-temporal cluster analysis revealed three cluster areas in Qingdao City that were located in the south of Huangdao District during the fall-winter peak.Conclusion: The distribution of HFRS in Qingdao exhibited periodic, seasonal, and regional characteristics, with high spatial clustering heterogeneity. The typical symptoms of \"three red\" and \"three pain\" in patients with HFRS were not obvious.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"37 9","pages":"1015-1029"},"PeriodicalIF":0.0,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142482974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prospective Cohort Investigation on Physical Activity of Osteoporosis Outcomes (PAOPO) in Jidong: Objectives, Study Design, and Baseline Characteristics. 冀东地区骨质疏松症结果的体育锻炼前瞻性队列调查（PAOPO）：目标、研究设计和基线特征。

Biomedical and environmental sciences : BES Pub Date : 2024-09-20 DOI: 10.3967/bes2024.117

Jing Zhi Yang, Hao Shen, Si Cheng Wang, Long Bai, Zhen Geng, Ying Ying Jing, Ke Xu, Yu He Liu, Wen Qian Wu, Hao Zhang, Yuan Wei Zhang, Zuhao Li, Chuan Dong Wang, Guang Chao Wang, Xiao Chen, Jia Can Su

{"title":"Prospective Cohort Investigation on Physical Activity of Osteoporosis Outcomes (PAOPO) in Jidong: Objectives, Study Design, and Baseline Characteristics.","authors":"Jing Zhi Yang, Hao Shen, Si Cheng Wang, Long Bai, Zhen Geng, Ying Ying Jing, Ke Xu, Yu He Liu, Wen Qian Wu, Hao Zhang, Yuan Wei Zhang, Zuhao Li, Chuan Dong Wang, Guang Chao Wang, Xiao Chen, Jia Can Su","doi":"10.3967/bes2024.117","DOIUrl":"https://doi.org/10.3967/bes2024.117","url":null,"abstract":"Objective: The aim of this study was to investigate the prospective association between physical activity (PA), independently or in conjunction with other contributing factors, and osteoporosis (OP) outcomes.Methods: The Physical Activity in Osteoporosis Outcomes (PAOPO) study was a community-based cohort investigation. A structured questionnaire was used to gather the participants' sociodemographic characteristics. Bone mineral density (BMD) measurements were performed to assess OP outcomes, and the relationship between BMD and OP was evaluated within this cohort.Results: From 2013 to 2014, 8,471 participants aged 18 years and older were recruited from Tangshan, China's Jidong community. Based on their PA level, participants were categorized as inactive, moderately active, or very active. Men showed higher physical exercise levels than women across the activity groups. BMD was significantly higher in the very active group than in the moderately active and inactive groups. Individuals aged > 50 years are at a higher risk of developing OP and osteopenia.Conclusion: The PAOPO study offers promising insights into the relationship between PA and OP outcomes, encouraging the implementation of PA in preventing and managing OP.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"37 9","pages":"1067-1079"},"PeriodicalIF":0.0,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142482979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of Temperature and Humidity on the Incidence of Pulmonary Tuberculosis in Hainan, China, 2004-2018. 2004-2018年温湿度对中国海南肺结核发病率的影响

Biomedical and environmental sciences : BES Pub Date : 2024-09-20 DOI: 10.3967/bes2024.144

Wei Xia Li, Xiao Dan Wang, Bo Bi, Jing Jing Lu, Zheng Yuan Li, Li Cao, Hao Zhang

引用次数: 0