Biomedical and environmental sciences : BES最新文献_第4页

Predicting Postoperative Circulatory Complications in Older Patients: A Machine Learning Approach. 预测老年患者术后循环系统并发症：机器学习方法。

Biomedical and environmental sciences : BES Pub Date : 2025-03-20 DOI: 10.3967/bes2025.005

Xiao Yun Hu, Wei Xuan Sheng, Kang Yu, Jie Tai Duo, Peng Fei Liu, Ya Wei Li, Dong Xin Wang, Hui Hui Miao

{"title":"Predicting Postoperative Circulatory Complications in Older Patients: A Machine Learning Approach.","authors":"Xiao Yun Hu, Wei Xuan Sheng, Kang Yu, Jie Tai Duo, Peng Fei Liu, Ya Wei Li, Dong Xin Wang, Hui Hui Miao","doi":"10.3967/bes2025.005","DOIUrl":"https://doi.org/10.3967/bes2025.005","url":null,"abstract":"Objective: This study examines utilizes the advantages of machine learning algorithms to discern key determinants in prognosticate postoperative circulatory complications (PCCs) for older patients.Methods: This secondary analysis of data from a randomized controlled trial involved 1,720 elderly participants in five tertiary hospitals in Beijing, China. Participants aged 60-90 years undergoing major non-cardiac surgery under general anesthesia. The primary outcome metric of the study was the occurrence of PCCs, according to the European Society of Cardiology and the European Society of Anaesthesiology diagnostic criteria. The analysis metrics contained 67 candidate variables, including baseline characteristics, laboratory tests, and scale assessments.Results: Our feature selection process identified key variables that significantly impact patient outcomes, including the duration of ICU stay, surgery, and anesthesia; APACHE-II score; intraoperative average heart rate and blood loss; cumulative opioid use during surgery; patient age; VAS-Move-Median score on the 1st to 3rd day; Charlson comorbidity score; volumes of intraoperative plasma, crystalloid, and colloid fluids; cumulative red blood cell transfusion during surgery; and endotracheal intubation duration. Notably, our Random Forest model demonstrated exceptional performance with an accuracy of 0.9872.Conclusion: We have developed and validated an algorithm for predicting PCCs in elderly patients by identifying key risk factors.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"38 3","pages":"328-340"},"PeriodicalIF":0.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Environmental Temperature and the Risk of Hand, Foot, and Mouth Disease Transmission in the Yangtze River Region of China. 长江地区环境温度与手足口病传播风险

Biomedical and environmental sciences : BES Pub Date : 2025-03-20 DOI: 10.3967/bes2025.011

Yan Qing Yang, Min Chen, Jin Li, Kai Qi Liu, Xue Yan Guo, Xin Xu, Qian Liang, Xing Lu Wu, Su Wen Lei, Jing Li

{"title":"Environmental Temperature and the Risk of Hand, Foot, and Mouth Disease Transmission in the Yangtze River Region of China.","authors":"Yan Qing Yang, Min Chen, Jin Li, Kai Qi Liu, Xue Yan Guo, Xin Xu, Qian Liang, Xing Lu Wu, Su Wen Lei, Jing Li","doi":"10.3967/bes2025.011","DOIUrl":"https://doi.org/10.3967/bes2025.011","url":null,"abstract":"Objective: To assess health equity in the Yangtze River region to improve understanding of the correlation between hand, foot, and mouth disease (HFMD) and socioeconomic factors.Methods: From 2014-2016, data on HFMD incidence, population statistics, economic indicators, and meteorology from 26 cities along the Yangtze River were analyzed. A multi-city random-effects meta-analysis was performed to study the relationship between temperature and HFMD transmission, and health equity was assessed with respect to socio-economic impact.Results: Over the study period, 919,458 HFMD cases were reported, with Shanghai (162,303) having the highest incidence and Tongling (5,513) having the lowest. Males were more commonly affected (male-to-female ratio, 1.49:1). The exposure-response relationship had an M-shaped curve, with two HFMD peaks occurring at 4 °C and 26 °C. The relative risk had two peaks at 1.30 °C (1.834, 95% CI: 1.204-2.794) and 31.4 °C (1.143, 95% CI: 0.901-1.451), forming an M shape, with the first peak higher than the second. The most significant impact of temperature on HFMD was observed between -2 °C and 18.1 °C. The concentration index (0.2463) indicated moderate concentration differences, whereas the Theil index (0.0418) showed low inequality in distribution.Conclusion: The incidence of HFMD varied across cities, particularly with changes in temperature. Economically prosperous areas showed higher risks, indicating disparities. Targeted interventions in these areas are crucial for mitigating the risk of HFMD.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"38 3","pages":"290-302"},"PeriodicalIF":0.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The First Imported Case of Lassa Fever in China - Implications for Global Health Surveillance. 中国首例输入性拉沙热病例——对全球卫生监测的启示

Biomedical and environmental sciences : BES Pub Date : 2025-03-20 DOI: 10.3967/bes2025.029

Qi Yong Liu

引用次数: 0

Laboratory Diagnosis and Molecular Epidemiological Characterization of the First Imported Case of Lassa Fever in China. 中国首例输入性拉沙热的实验室诊断和分子流行病学特征

Biomedical and environmental sciences : BES Pub Date : 2025-03-20 DOI: 10.3967/bes2025.014

Yu Liang Feng, Wei Li, Ming Feng Jiang, Hong Rong Zhong, Wei Wu, Lyu Bo Tian, Guo Chen, Zhen Hua Chen, Can Luo, Rong Mei Yuan, Xing Yu Zhou, Jian Dong Li, Xiao Rong Yang, Ming Pan

{"title":"Laboratory Diagnosis and Molecular Epidemiological Characterization of the First Imported Case of Lassa Fever in China.","authors":"Yu Liang Feng, Wei Li, Ming Feng Jiang, Hong Rong Zhong, Wei Wu, Lyu Bo Tian, Guo Chen, Zhen Hua Chen, Can Luo, Rong Mei Yuan, Xing Yu Zhou, Jian Dong Li, Xiao Rong Yang, Ming Pan","doi":"10.3967/bes2025.014","DOIUrl":"https://doi.org/10.3967/bes2025.014","url":null,"abstract":"Objective: This study reports the first imported case of Lassa fever (LF) in China. Laboratory detection and molecular epidemiological analysis of the Lassa virus (LASV) from this case offer valuable insights for the prevention and control of LF.Methods: Samples of cerebrospinal fluid (CSF), blood, urine, saliva, and environmental materials were collected from the patient and their close contacts for LASV nucleotide detection. Whole-genome sequencing was performed on positive samples to analyze the genetic characteristics of the virus.Results: LASV was detected in the patient's CSF, blood, and urine, while all samples from close contacts and the environment tested negative. The virus belongs to the lineage IV strain and shares the highest homology with strains from Sierra Leone. The variability in the glycoprotein complex (GPC) among different strains ranged from 3.9% to 15.1%, higher than previously reported for the seven known lineages. Amino acid mutation analysis revealed multiple mutations within the GPC immunogenic epitopes, increasing strain diversity and potentially impacting immune response.Conclusion: The case was confirmed through nucleotide detection, with no evidence of secondary transmission or viral spread. The LASV strain identified belongs to lineage IV, with broader GPC variability than previously reported. Mutations in the immune-related sites of GPC may affect immune responses, necessitating heightened vigilance regarding the virus.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"38 3","pages":"279-289"},"PeriodicalIF":0.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Laboratory Analytical Indicators on Positive Blood Culture Detection Rates: A Single Center Study. 实验室分析指标对阳性血培养检出率的影响：单中心研究。

Biomedical and environmental sciences : BES Pub Date : 2025-03-20 DOI: 10.3967/bes2024.157

Di Wang, Ling Li Liu, Rui Rui Ma, Li Jun Du, Gui Xue Cheng, Ya Li Liu, Qiao Lian Yi, Ying Chun Xu

{"title":"Impact of Laboratory Analytical Indicators on Positive Blood Culture Detection Rates: A Single Center Study.","authors":"Di Wang, Ling Li Liu, Rui Rui Ma, Li Jun Du, Gui Xue Cheng, Ya Li Liu, Qiao Lian Yi, Ying Chun Xu","doi":"10.3967/bes2024.157","DOIUrl":"https://doi.org/10.3967/bes2024.157","url":null,"abstract":"Objective: Blood culture remains the gold standard for diagnosing bloodstream infections. Clinical laboratories must ensure the quality of blood culture processes from receipt to obtaining definitive results. We examined laboratory analytical indicators associated with positive blood culture results.Methods: Blood cultures collected from Peking Union Medical College Hospital between January 1, 2020, and December 31, 2022, were retrospectively analyzed. The mode of transportation (piping logistics delivery vs. staff), source of blood cultures (outpatient/emergency department vs. inpatient department), rotation of personnel, and time of reception (8:00-19:59 vs. 20:00-07:59) were compared between blood culture-positive and -negative results.Results: Between 2020 and 2022, the total positive rate of blood culture was 8.07%. The positive rate of blood cultures in the outpatient/emergency department was significantly higher than that in the inpatient department (12.46% vs. 5.83%; P < 0.0001). The time-to-detection of blood cultures was significantly affected by the delivery mode and personnel rotation. The blood culture positive rate of the total pre-analytical time within 1 h was significantly higher than that within 1-2 h or > 2 h ( P < 0.0170).Conclusion: Laboratory analytical indicators such as patient source, transportation mode, and personnel rotation significantly impacted the positive detection rate or time of blood culture.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"38 3","pages":"303-312"},"PeriodicalIF":0.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144038105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of VSD in Enhancing the Biological Environment of Scarred Skin Incisions in Valve Replacement: A Clinical Study on Postoperative Outcomes in Patients with Extensive Burns and Cardiac Valve Neoplasms. 瓣膜置换术中VSD在改善瘢痕皮肤切口生物环境中的作用：广泛烧伤合并心脏瓣膜肿瘤患者术后预后的临床研究

Biomedical and environmental sciences : BES Pub Date : 2025-03-20 DOI: 10.3967/bes2025.023

Wei Liu, Ting He, Yang Chang, Long Long Yang, Chuan-An Shen

引用次数: 0

A New Classification System for Childhood and Adolescent Obesity: Definition of the BCAMS Classification. 一种新的儿童青少年肥胖分类体系：BCAMS分类的定义。

Biomedical and environmental sciences : BES Pub Date : 2025-03-20 DOI: 10.3967/bes2025.006

Ming Li, Shan Gao

引用次数: 0

Trends of Disease Burden of Pancreatic Cancer Attributed to High Fasting Plasma Glucose in China,1990-2021: Insights from the Global Burden of Disease Study 2021. 1990-2021年中国高空腹血糖导致的胰腺癌疾病负担趋势：来自2021年全球疾病负担研究的见解

Biomedical and environmental sciences : BES Pub Date : 2025-03-20 DOI: 10.3967/bes2025.027

Xiao Chen Chen, Fei Fei Zhong, Juan Li

引用次数: 0

Short-term Effects of Fine Particulate Matter and its Constituents on Acute Exacerbations of Chronic Bronchitis: A Time-stratified Case-crossover Study. 细颗粒物及其成分对慢性支气管炎急性加重的短期影响：一项时间分层病例交叉研究。

Biomedical and environmental sciences : BES Pub Date : 2025-03-20 DOI: 10.3967/bes2025.026

Jing Wei Zhang, Jian Zhang, Peng Fei Li, Yan Dan Xu, Xue Song Zhou, Xiu Li Tang, Jia Qiu, Zhong Ao Ding, Ming Jia Xu, Chong Jian Wang

引用次数: 0

Comprehensive Analysis of Oncogenic, Prognostic, and Immunological Roles of FANCD2 in Hepatocellular Carcinoma: A Potential Predictor for Survival and Immunotherapy. FANCD2在肝细胞癌中的致癌、预后和免疫学作用的综合分析：生存和免疫治疗的潜在预测因子。

Biomedical and environmental sciences : BES Pub Date : 2025-03-20 DOI: 10.3967/bes2024.182

Meng Jiao Xu, Wen Deng, Ting Ting Jiang, Shi Yu Wang, Ru Yu Liu, Min Chang, Shu Ling Wu, Ge Shen, Xiao Xue Chen, Yuan Jiao Gao, Hongxiao Hao, Lei Ping Hu, Lu Zhang, Yao Lu, Wei Yi, Yao Xie, Ming Hui Li

{"title":"Comprehensive Analysis of Oncogenic, Prognostic, and Immunological Roles of FANCD2 in Hepatocellular Carcinoma: A Potential Predictor for Survival and Immunotherapy.","authors":"Meng Jiao Xu, Wen Deng, Ting Ting Jiang, Shi Yu Wang, Ru Yu Liu, Min Chang, Shu Ling Wu, Ge Shen, Xiao Xue Chen, Yuan Jiao Gao, Hongxiao Hao, Lei Ping Hu, Lu Zhang, Yao Lu, Wei Yi, Yao Xie, Ming Hui Li","doi":"10.3967/bes2024.182","DOIUrl":"https://doi.org/10.3967/bes2024.182","url":null,"abstract":"Objective: Hepatocellular carcinoma (HCC) is sensitive to ferroptosis, a new form of programmed cell death that occurs in most tumor types. However, the mechanism through which ferroptosis modulates HCC remains unclear. This study aimed to investigate the oncogenic role and prognostic value of FANCD2 and provide novel insights into the prognostic assessment and prediction of immunotherapy.Methods: Using clinicopathological parameters and bioinformatic techniques, we comprehensively examined the expression of FANCD2 macroscopically and microcosmically. We conducted univariate and multivariate Cox regression analyses to identify the prognostic value of FANCD2 in HCC and elucidated the detailed molecular mechanisms underlying the involvement of FANCD2 in oncogenesis by promoting iron-related death.Results: FANCD2 was significantly upregulated in digestive system cancers with abundant immune infiltration. As an independent risk factor for HCC, a high FANCD2 expression level was associated with poor clinical outcomes and response to immune checkpoint blockade. Gene set enrichment analysis revealed that FANCD2 was mainly involved in the cell cycle and CYP450 metabolism.Conclusion: To the best of our knowledge, this is the first study to comprehensively elucidate the oncogenic role of FANCD2. FANCD2 has a tumor-promoting aspect in the digestive system and acts as an independent risk factor in HCC; hence, it has recognized value for predicting tumor aggressiveness and prognosis and may be a potential biomarker for poor responsiveness to immunotherapy.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"38 3","pages":"313-327"},"PeriodicalIF":0.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144059695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0