Biomedical and environmental sciences : BES最新文献_第4页

Inhibition of the NF-κB Signaling Pathway Improves Cigarette Mainstream Smoke-Induced Lung Injury and Gut Microbiota Disturbance. 抑制 NF-κB 信号通路可改善卷烟主流烟雾诱发的肺损伤和肠道微生物群紊乱。

Biomedical and environmental sciences : BES Pub Date : 2024-06-20 DOI: 10.3967/bes2024.075

Hong Huang, Sheng Jie Li, Li Fang Zeng, Yan Zhang, Ying Chen, Yan Bing Ma, Jing Wei, Chang Wei Zou, Ting Tao Chen

引用次数: 0

SiO ₂ Induces Iron Overload and Ferroptosis in Cardiomyocytes in a Silicosis Mouse Model. SiO 2 在硅肺病小鼠模型中诱导心肌细胞铁超载和铁突变。

Biomedical and environmental sciences : BES Pub Date : 2024-06-20 DOI: 10.3967/bes2024.087

Yong Heng Wang, Ning Li, Yi Guan, Tong Li, Yuxiu Zhang, Hong Cao, Zhi Hua Yu, Zhi Heng Li, Shuo Yan Li, Jia Hao Hu, Wen Xin Zhou, Si Si Qin, Shuang Li, San Qiao Yao

{"title":"SiO 2 Induces Iron Overload and Ferroptosis in Cardiomyocytes in a Silicosis Mouse Model.","authors":"Yong Heng Wang, Ning Li, Yi Guan, Tong Li, Yuxiu Zhang, Hong Cao, Zhi Hua Yu, Zhi Heng Li, Shuo Yan Li, Jia Hao Hu, Wen Xin Zhou, Si Si Qin, Shuang Li, San Qiao Yao","doi":"10.3967/bes2024.087","DOIUrl":"https://doi.org/10.3967/bes2024.087","url":null,"abstract":"Objective: The aim of this study was to explore the role and mechanism of ferroptosis in SiO 2-induced cardiac injury using a mouse model.Methods: Male C57BL/6 mice were intratracheally instilled with SiO 2 to create a silicosis model. Ferrostatin-1 (Fer-1) and deferoxamine (DFO) were used to suppress ferroptosis. Serum biomarkers, oxidative stress markers, histopathology, iron content, and the expression of ferroptosis-related proteins were assessed.Results: SiO 2 altered serum cardiac injury biomarkers, oxidative stress, iron accumulation, and ferroptosis markers in myocardial tissue. Fer-1 and DFO reduced lipid peroxidation and iron overload, and alleviated SiO 2-induced mitochondrial damage and myocardial injury. SiO 2 inhibited Nuclear factor erythroid 2-related factor 2 (Nrf2) and its downstream antioxidant genes, while Fer-1 more potently reactivated Nrf2 compared to DFO.Conclusion: Iron overload-induced ferroptosis contributes to SiO 2-induced cardiac injury. Targeting ferroptosis by reducing iron accumulation or inhibiting lipid peroxidation protects against SiO 2 cardiotoxicity, potentially via modulation of the Nrf2 pathway.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141581834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research Progress on the Association between Schizophrenia and Toxoplasma gondii Infection. 精神分裂症与弓形虫感染关系的研究进展。

Biomedical and environmental sciences : BES Pub Date : 2024-06-20 DOI: 10.3967/bes2024.071

Yi Ting Zhu, Xiao Hui Yang, Miao Ru Chen, Yu Hu, Yun Feng Chang, Xiang Wu

引用次数: 0

Message from the New Editor-in-Chief. 新主编的致辞

Biomedical and environmental sciences : BES Pub Date : 2024-06-20 DOI: 10.3967/bes2024.108

Xiao Ming Shi

引用次数: 0

Genetically Predicted Plasma Levels of Amino Acids and Endometriosis: A Mendelian Randomization Study. 基因预测的血浆氨基酸水平与子宫内膜异位症：孟德尔随机研究

Biomedical and environmental sciences : BES Pub Date : 2024-06-20 DOI: 10.3967/bes2024.074

Juan Mei Li, Yao Ni, Ning Wang, Yu Liao, Yi Wei Yu, Wen Liang Lyu, Rui Hua Zhao

引用次数: 0

Knockout of C6orf120 in Rats Alleviates Concanavalin A-induced Autoimmune Hepatitis by Regulating Macrophage Polarization. 敲除大鼠体内的 C6orf120 可通过调节巨噬细胞的极化缓解由康卡伐林 A 引起的自身免疫性肝炎

Biomedical and environmental sciences : BES Pub Date : 2024-06-20 DOI: 10.3967/bes2024.066

Xin Wang, Yu Qi Wang, Hui Liu, Ying Ying Lin, Peng Wang, Yun Yun Yi, Xin Li

{"title":"Knockout of C6orf120 in Rats Alleviates Concanavalin A-induced Autoimmune Hepatitis by Regulating Macrophage Polarization.","authors":"Xin Wang, Yu Qi Wang, Hui Liu, Ying Ying Lin, Peng Wang, Yun Yun Yi, Xin Li","doi":"10.3967/bes2024.066","DOIUrl":"10.3967/bes2024.066","url":null,"abstract":"Objective: The effect of the functionally unknown gene C6orf120 on autoimmune hepatitis was investigated on C6orf120 knockout rats ( C6orf120 -/- ) and THP-1 cells.Method: Six-eight-week-old C6orf120 -/- and wild-type (WT) SD rats were injected with Con A (16 mg/kg), and euthanized after 24 h. The sera, livers, and spleens were collected. THP-1 cells and the recombinant protein (rC6ORF120) were used to explore the mechanism in vitro. The frequency of M1 and M2 macrophages was analyzed using flow cytometry. Western blotting and PCR were used to detect macrophage polarization-associated factors.Results: C6orf120 knockout attenuated Con A-induced autoimmune hepatitis. Flow cytometry indicated that the proportion of CD68 +CD86 +M1 macrophages from the liver and spleen in the C6orf120 -/- rats decreased. C6orf120 knockout induced downregulation of CD86 protein and the mRNA levels of related inflammatory factors TNF-α, IL-1β, and IL-6 in the liver. C6orf120 knockout did not affect the polarization of THP-1 cells. However, rC6ORF120 promoted the THP-1 cells toward CD68 +CD80 +M1 macrophages and inhibited the CD68 +CD206 +M2 phenotype.Conclusion: C6orf120 knockout alleviates Con A-induced autoimmune hepatitis by inhibiting macrophage polarization toward M1 macrophages and reducing the expression of related inflammatory factors in C6orf120 -/- rats.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141581829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations of Perchlorate, Nitrate, and Thiocyanate with Sex Hormones among Children: A Nationally Representative Cross-sectional Study in U.S. 全氯酸盐、硝酸盐和硫氰酸盐与儿童性激素的关系：美国一项具有全国代表性的横断面研究

Biomedical and environmental sciences : BES Pub Date : 2024-06-20 DOI: 10.3967/bes2024.073

Yi Wen Wang, Guo Dong Ding, Pei Pei Hu, Yong Jun Zhang

引用次数: 0

Health Effects of Extreme Low Temperatures and Cold Waves on Respiratory Diseases. 极端低温和寒潮对呼吸道疾病的健康影响。

Biomedical and environmental sciences : BES Pub Date : 2024-06-20 DOI: 10.3967/bes2024.076

Zong Rui Liu, Yu Xia Ma, Yu Han Zhao, Wan Ci Wang, Peng Peng Qin, Jie Yang, Bo Wen Cheng

引用次数: 0

Uphold the Original Intention and Work together for Future Development - Speech at the 35 ^th Anniversary Symposium of BES. 坚守初心，共谋发展 - 在 BES 35 周年研讨会上的发言。

Biomedical and environmental sciences : BES Pub Date : 2024-06-20 DOI: 10.3967/bes2024.107

Jun Shi Chen

引用次数: 0

Development of an Integrated Disposable Device for SARS-CoV-2 Nucleic Acid Extraction and Detection. 开发用于 SARS-CoV-2 核酸提取和检测的一次性集成装置。

Biomedical and environmental sciences : BES Pub Date : 2024-06-20 DOI: 10.3967/bes2024.070

Jing Ma, Yan Zhe Hao, Mei Ling Hou, Xiao Shan Zhang, Jing Duan Liu, Hao di Meng, Jiang Bo Chang, Xue Jun Ma, Ji Hua Liu, Qing Jie Ying, Xian Hua Wang, Hong Xia Li, Yu Xi Cao, Xiao Guang Zhang

{"title":"Development of an Integrated Disposable Device for SARS-CoV-2 Nucleic Acid Extraction and Detection.","authors":"Jing Ma, Yan Zhe Hao, Mei Ling Hou, Xiao Shan Zhang, Jing Duan Liu, Hao di Meng, Jiang Bo Chang, Xue Jun Ma, Ji Hua Liu, Qing Jie Ying, Xian Hua Wang, Hong Xia Li, Yu Xi Cao, Xiao Guang Zhang","doi":"10.3967/bes2024.070","DOIUrl":"https://doi.org/10.3967/bes2024.070","url":null,"abstract":"Objective: To develop a highly sensitive and rapid nucleic acid detection method for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).Methods: We designed, developed, and manufactured an integrated disposable device for SARS-CoV-2 nucleic acid extraction and detection. The precision of the liquid transfer and temperature control was tested. A comparison between our device and a commercial kit for SARS-Cov-2 nucleic acid extraction was performed using real-time fluorescence reverse transcription polymerase chain reaction (RT-PCR). The entire process, from SARS-CoV-2 nucleic acid extraction to amplification, was evaluated.Results: The precision of the syringe transfer volume was 19.2 ± 1.9 μL (set value was 20), 32.2 ± 1.6 (set value was 30), and 57.2 ± 3.5 (set value was 60). Temperature control in the amplification tube was measured at 60.0 ± 0.0 °C (set value was 60) and 95.1 ± 0.2 °C (set value was 95) respectively. SARS-Cov-2 nucleic acid extraction yield through the device was 7.10 × 10 6 copies/mL, while a commercial kit yielded 2.98 × 10 6 copies/mL. The mean time to complete the entire assay, from SARS-CoV-2 nucleic acid extraction to amplification detection, was 36 min and 45 s. The detection limit for SARS-CoV-2 nucleic acid was 250 copies/mL.Conclusion: The integrated disposable devices may be used for SARS-CoV-2 Point-of-Care test (POCT).","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141581824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0