Biomedical and environmental sciences : BES最新文献

{"title":"Antibody Levels and Infection Status of Pertussis in the Population under Pertussis Resurgence in Guangxi in 2018: A Cross-Sectional Survey.","authors":"Liang Liang, Qiu Yun Deng, Li Li Deng, Jing Hang Wei, Shi Yi Chen, Yi Zhi Wei, Yu Yan Ma, Yue Qin, Wei Liu","doi":"10.3967/bes2024.069","DOIUrl":"10.3967/bes2024.069","url":null,"abstract":"<p><strong>Objective: </strong>Pertussis cases have increased markedly since 2018 in Guangxi. The aim of this study was to evaluate antibody levels and the infection status of pertussis in the resident population.</p><p><strong>Method: </strong>A total of 10,215 serum samples from residents were collected from August-November 2018 and tested for anti-pertussis IgG and toxin IgG using the enzyme-linked immunosorbent assay (ELISA).</p><p><strong>Results: </strong>Of the collected samples, 1,833 (17.94%) tested positive for anti-pertussis IgG, with the median concentration of 16.06 IU/mL. Antibody level < 10 IU/mL accounted for more than 60% in children under 4 years of age, but declined with age, whereas the percentages of the other three levels (10-40, 40-50, and ≥ 50 IU/mL) increased almost with age ( <i>P</i> < 0.001). Moreover, 7,924 samples were selected for anti-pertussis toxin IgG, of which 653 (8.24%) tested positive (≥ 40 IU/mL) with the median concentration of 5.89 IU/mL, and 204 participants (2.56%) had recent pertussis infection (≥ 100 IU/mL). Among the different age groups, the highest rates of positivity and recent infection were observed at 11-20 years of age, the lowest positivity rate at 5 years of age, and the lowest recent infection rate at 4 years of age ( <i>P</i> < 0.001, <i>P</i> = 0.005, respectively).</p><p><strong>Conclusion: </strong>The survey results showed that all age groups in Guangxi lacked immunity against pertussis, which was one of the main factors contributing to the resurgence of pertussis in 2018. In addition, the prevalence of pertussis is relatively high in Guangxi, and its incidence is seriously underestimated, especially in adolescents and adults.</p>","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141581822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying Comprehensive Genomic Alterations and Potential Neoantigens for Cervical Cancer Immunotherapy in a Cohort of Chinese Squamous Cell Carcinoma of the Cervix.","authors":"Meng Wu, Jia Lu Zhou, Zhe Zhang, Yuan Guang Meng","doi":"10.3967/bes2024.064","DOIUrl":"10.3967/bes2024.064","url":null,"abstract":"<p><strong>Objective: </strong>Genomic alterations and potential neoantigens for cervical cancer immunotherapy were identified in a cohort of Chinese patients with cervical squamous cell carcinoma (CSCC).</p><p><strong>Methods: </strong>Whole-exome sequencing was used to identify genomic alterations and potential neoantigens for CSCC immunotherapy. RNA Sequencing was performed to analyze neoantigen expression.</p><p><strong>Results: </strong>Systematic bioinformatics analysis showed that C>T/G>A transitions/transversions were dominant in CSCCs. Missense mutations were the most frequent types of somatic mutation in the coding sequence regions. Mutational signature analysis detected signature 2, signature 6, and signature 7 in CSCC samples. <i>PIK3CA</i>, <i>FBXW7</i>, and <i>BICRA</i> were identified as potential driver genes, with <i>BICRA</i> as a newly reported gene. Genomic variation profiling identified 4,960 potential neoantigens, of which 114 were listed in two neoantigen-related databases.</p><p><strong>Conclusion: </strong>The present findings contribute to our understanding of the genomic characteristics of CSCC and provide a foundation for the development of new biotechnology methods for individualized immunotherapy in CSCC.</p>","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141581827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association between GLP-1 Receptor-Based Agonists and the Incidence of Asthma in Patients with Type 2 Diabetes and/or Obesity: A Meta-Analysis.","authors":"Meng Qing Zhang, Chu Lin, Xiao Ling Cai, Ruo Yang Jiao, Shu Zhen Bai, Zong Lin Li, Sui Yuan Hu, Fang Lyu, Wen Jia Yang, Li Nong Ji","doi":"10.3967/bes2024.067","DOIUrl":"10.3967/bes2024.067","url":null,"abstract":"<p><strong>Objective: </strong>Recent studies have indicated potential anti-inflammatory effects of glucagon-like peptide-1 receptor agonists (GLP-1RAs) on asthma, which is often comorbid with type 2 diabetes mellitus (T2DM) and obesity. Therefore, we conducted a meta-analysis to assess the association between the administration of glucagon-like peptide-1 (GLP-1) receptor-based agonists and the incidence of asthma in patients with T2DM and/or obesity.</p><p><strong>Methods: </strong>PubMed, Web of Science, Embase, the Cochrane Central Register of Controlled Trials, and <i>Clinicaltrial.gov</i> were systematically searched from inception to July 2023. Randomized controlled trials (RCTs) of GLP-1 receptor-based agonists (GLP-1RA, GLP-1 based dual and triple receptor agonist) with reports of asthma events were included. Outcomes were computed as risk ratios ( <i>RR</i>) using a fixed-effects model.</p><p><strong>Results: </strong>Overall, 39 RCTs with a total of 85,755 participants were included. Compared to non-GLP-1 receptor-based agonist users, a trend of reduced risk of asthma was observed in patients with T2DM or obesity using GLP-1 receptor-based agonist treatments, although the difference was not statistically significant [ <i>RR</i> = 0.91, 95% confidence interval ( <i>CI</i>): 0.68 to 1.24]. Further Subgroup analyses indicated that the use of light-molecular-weight GLP-1RAs might be associated with a reduced the risk of asthma when compared with non-users ( <i>RR</i> = 0.65, 95% <i>CI</i>: 0.43 to 0.99, <i>P</i> = 0.043). We also performed sensitivity analyses for participant characteristics, study design, drug structure, duration of action, and drug subtypes. However, no significant associations were observed.</p><p><strong>Conclusion: </strong>Compared with non-users, a modest reduction in the incidence of asthma was observed in patients with T2DM or obesity using GLP-1 receptor-based agonist treatments. Further investigations are warranted to assess the association between GLP-1 receptor-based agonists and the risk of asthma.</p>","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141581835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inhibition of the NF-κB Signaling Pathway Improves Cigarette Mainstream Smoke-Induced Lung Injury and Gut Microbiota Disturbance.","authors":"Hong Huang, Sheng Jie Li, Li Fang Zeng, Yan Zhang, Ying Chen, Yan Bing Ma, Jing Wei, Chang Wei Zou, Ting Tao Chen","doi":"10.3967/bes2024.075","DOIUrl":"10.3967/bes2024.075","url":null,"abstract":"","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141581828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SiO ₂ Induces Iron Overload and Ferroptosis in Cardiomyocytes in a Silicosis Mouse Model.","authors":"Yong Heng Wang, Ning Li, Yi Guan, Tong Li, Yuxiu Zhang, Hong Cao, Zhi Hua Yu, Zhi Heng Li, Shuo Yan Li, Jia Hao Hu, Wen Xin Zhou, Si Si Qin, Shuang Li, San Qiao Yao","doi":"10.3967/bes2024.087","DOIUrl":"https://doi.org/10.3967/bes2024.087","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to explore the role and mechanism of ferroptosis in SiO ₂-induced cardiac injury using a mouse model.</p><p><strong>Methods: </strong>Male C57BL/6 mice were intratracheally instilled with SiO ₂ to create a silicosis model. Ferrostatin-1 (Fer-1) and deferoxamine (DFO) were used to suppress ferroptosis. Serum biomarkers, oxidative stress markers, histopathology, iron content, and the expression of ferroptosis-related proteins were assessed.</p><p><strong>Results: </strong>SiO ₂ altered serum cardiac injury biomarkers, oxidative stress, iron accumulation, and ferroptosis markers in myocardial tissue. Fer-1 and DFO reduced lipid peroxidation and iron overload, and alleviated SiO ₂-induced mitochondrial damage and myocardial injury. SiO ₂ inhibited Nuclear factor erythroid 2-related factor 2 (Nrf2) and its downstream antioxidant genes, while Fer-1 more potently reactivated Nrf2 compared to DFO.</p><p><strong>Conclusion: </strong>Iron overload-induced ferroptosis contributes to SiO ₂-induced cardiac injury. Targeting ferroptosis by reducing iron accumulation or inhibiting lipid peroxidation protects against SiO ₂ cardiotoxicity, potentially <i>via</i> modulation of the Nrf2 pathway.</p>","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141581834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research Progress on the Association between Schizophrenia and <i>Toxoplasma gondii</i> Infection.","authors":"Yi Ting Zhu, Xiao Hui Yang, Miao Ru Chen, Yu Hu, Yun Feng Chang, Xiang Wu","doi":"10.3967/bes2024.071","DOIUrl":"https://doi.org/10.3967/bes2024.071","url":null,"abstract":"<p><p><i>Toxoplasma gondii</i>( <i>T. gondii or Tg</i>), is an obligatory intracellular parasite with humans as its intermediate hosts. In recent years, significant correlations between <i>T. gondii</i> infection and schizophrenia have been reported, including the possible mediating mechanisms. Currently, mechanisms and hypotheses focus on central neurotransmitters, immunity, neuroinflammation, and epigenetics; however, the exact underlying mechanisms remain unclear. In this article, we review the studies related to <i>T. gondii</i> infection and schizophrenia, particularly the latest research progress. Research on dopamine (DA) and other neurotransmitters, the blood-brain barrier, inflammatory factors, disease heterogeneity, and other confounders is also discussed. In addition, we also summarized the results of some new epidemiological investigations.</p>","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141581832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Message from the New Editor-in-Chief.","authors":"Xiao Ming Shi","doi":"10.3967/bes2024.108","DOIUrl":"https://doi.org/10.3967/bes2024.108","url":null,"abstract":"","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141581830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetically Predicted Plasma Levels of Amino Acids and Endometriosis: A Mendelian Randomization Study.","authors":"Juan Mei Li, Yao Ni, Ning Wang, Yu Liao, Yi Wei Yu, Wen Liang Lyu, Rui Hua Zhao","doi":"10.3967/bes2024.074","DOIUrl":"https://doi.org/10.3967/bes2024.074","url":null,"abstract":"","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141581825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knockout of <i>C6orf120</i> in Rats Alleviates Concanavalin A-induced Autoimmune Hepatitis by Regulating Macrophage Polarization.","authors":"Xin Wang, Yu Qi Wang, Hui Liu, Ying Ying Lin, Peng Wang, Yun Yun Yi, Xin Li","doi":"10.3967/bes2024.066","DOIUrl":"10.3967/bes2024.066","url":null,"abstract":"<p><strong>Objective: </strong>The effect of the functionally unknown gene <i>C6orf120</i> on autoimmune hepatitis was investigated on <i>C6orf120</i> knockout rats ( <i>C6orf120</i> ^<i>-/-</i> ) and THP-1 cells.</p><p><strong>Method: </strong>Six-eight-week-old <i>C6orf120</i> ^<i>-/-</i> and wild-type (WT) SD rats were injected with Con A (16 mg/kg), and euthanized after 24 h. The sera, livers, and spleens were collected. THP-1 cells and the recombinant protein (rC6ORF120) were used to explore the mechanism <i>in vitro</i>. The frequency of M1 and M2 macrophages was analyzed using flow cytometry. Western blotting and PCR were used to detect macrophage polarization-associated factors.</p><p><strong>Results: </strong><i>C6orf120</i> knockout attenuated Con A-induced autoimmune hepatitis. Flow cytometry indicated that the proportion of CD68 ⁺CD86 ⁺M1 macrophages from the liver and spleen in the <i>C6orf120</i> ^<i>-/-</i> rats decreased. <i>C6orf120</i> knockout induced downregulation of CD86 protein and the mRNA levels of related inflammatory factors TNF-α, IL-1β, and IL-6 in the liver. <i>C6orf120</i> knockout did not affect the polarization of THP-1 cells. However, rC6ORF120 promoted the THP-1 cells toward CD68 ⁺CD80 ⁺M1 macrophages and inhibited the CD68 ⁺CD206 ⁺M2 phenotype.</p><p><strong>Conclusion: </strong><i>C6orf120</i> knockout alleviates Con A-induced autoimmune hepatitis by inhibiting macrophage polarization toward M1 macrophages and reducing the expression of related inflammatory factors in <i>C6orf120</i> ^<i>-/-</i> rats.</p>","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141581829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of Perchlorate, Nitrate, and Thiocyanate with Sex Hormones among Children: A Nationally Representative Cross-sectional Study in U.S.","authors":"Yi Wen Wang, Guo Dong Ding, Pei Pei Hu, Yong Jun Zhang","doi":"10.3967/bes2024.073","DOIUrl":"https://doi.org/10.3967/bes2024.073","url":null,"abstract":"","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141581823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}