Biomedical and environmental sciences : BES最新文献

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Whole-Genome Phylogeny of Brucella melitensis Isolates from Gansu Province, China. 甘肃省梅利特布鲁氏菌分离株的全基因组系统发育
IF 4.1
Biomedical and environmental sciences : BES Pub Date : 2025-07-20 DOI: 10.3967/bes2025.084
Xiao Yan Zhou, Ping Gui Wang, Qing Qing Xu, Yu Feng, Ding Sheng Wang, Qi Zhao, Li Xia Niu, Ming Hui Ma, Ai Wei He, Hai Jiang
{"title":"Whole-Genome Phylogeny of <i>Brucella melitensis</i> Isolates from Gansu Province, China.","authors":"Xiao Yan Zhou, Ping Gui Wang, Qing Qing Xu, Yu Feng, Ding Sheng Wang, Qi Zhao, Li Xia Niu, Ming Hui Ma, Ai Wei He, Hai Jiang","doi":"10.3967/bes2025.084","DOIUrl":"10.3967/bes2025.084","url":null,"abstract":"","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"38 7","pages":"873-876"},"PeriodicalIF":4.1,"publicationDate":"2025-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144877267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Seasonal Effects of Air Pollutants on Stroke Deaths in Qingdao from 2014 to 2019. 2014 - 2019年青岛市空气污染物对脑卒中死亡的季节性影响
IF 4.1
Biomedical and environmental sciences : BES Pub Date : 2025-07-20 DOI: 10.3967/bes2025.073
Jing Kai Zhang, Bing Ling Wang, Lu Pan, Nan Ge, Jing Ya Yin, Yuan Fang, Hua Zhang, Jian Jun Zhang, Xiu Tao Cao, Yan Ma, Li Cheng, Hai Ping Duan
{"title":"Seasonal Effects of Air Pollutants on Stroke Deaths in Qingdao from 2014 to 2019.","authors":"Jing Kai Zhang, Bing Ling Wang, Lu Pan, Nan Ge, Jing Ya Yin, Yuan Fang, Hua Zhang, Jian Jun Zhang, Xiu Tao Cao, Yan Ma, Li Cheng, Hai Ping Duan","doi":"10.3967/bes2025.073","DOIUrl":"10.3967/bes2025.073","url":null,"abstract":"","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"38 7","pages":"885-890"},"PeriodicalIF":4.1,"publicationDate":"2025-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144877262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Retrospective Study of Pregnancy and Fetal Outcomes in Mothers with Hepatitis C Viremia. 丙型肝炎病毒血症母亲妊娠和胎儿结局的回顾性研究。
IF 4.1
Biomedical and environmental sciences : BES Pub Date : 2025-07-20 DOI: 10.3967/bes2025.079
Wen Deng, Zi Yu Zhang, Xin Xin Li, Ya Qin Zhang, Wei Hua Cao, Shi Yu Wang, Xin Wei, Zi Xuan Gao, Shuo Jie Wang, Lin Mei Yao, Lu Zhang, Hong Xiao Hao, Xiao Xue Chen, Yuan Jiao Gao, Wei Yi, Yao Xie, Ming Hui Li
{"title":"A Retrospective Study of Pregnancy and Fetal Outcomes in Mothers with Hepatitis C Viremia.","authors":"Wen Deng, Zi Yu Zhang, Xin Xin Li, Ya Qin Zhang, Wei Hua Cao, Shi Yu Wang, Xin Wei, Zi Xuan Gao, Shuo Jie Wang, Lin Mei Yao, Lu Zhang, Hong Xiao Hao, Xiao Xue Chen, Yuan Jiao Gao, Wei Yi, Yao Xie, Ming Hui Li","doi":"10.3967/bes2025.079","DOIUrl":"10.3967/bes2025.079","url":null,"abstract":"<p><strong>Objective: </strong>To investigate chronic hepatitis C virus (HCV) infection's effect on gestational liver function, pregnancy and delivery complications, and neonatal development.</p><p><strong>Methods: </strong>A total of 157 HCV antibody-positive (anti-HCV[+]) and HCV RNA(+) patients (Group C) and 121 anti-HCV(+) and HCV RNA(-) patients (Group B) were included as study participants, while 142 anti-HCV(-) and HCV RNA(-) patients (Group A) were the control group. Data on biochemical indices during pregnancy, pregnancy complications, delivery-related information, and neonatal complications were also collected.</p><p><strong>Results: </strong>Elevated alanine aminotransferase (ALT) rates in Group C during early, middle, and late pregnancy were 59.87%, 43.95%, and 42.04%, respectively-significantly higher than Groups B (26.45%, 15.70%, 10.74%) and A (23.94%, 19.01%, 6.34%) ( <i>P</i> < 0.05). Median ALT levels in Group C were significantly higher than in Groups A and B at all pregnancy stages ( <i>P</i> < 0.05). No significant differences were found in neonatal malformation rates across groups ( <i>P</i> > 0.05). However, neonatal jaundice incidence was significantly greater in Group C (75.16%) compared to Groups A (42.25%) and B (57.02%) ( <i>χ</i> <sup>2</sup> = 33.552, <i>P</i> < 0.001). HCV RNA positivity during pregnancy was an independent risk factor for neonatal jaundice ( <i>OR</i> = 2.111, 95% <i>CI</i> 1.242-3.588, <i>P</i> = 0.006).</p><p><strong>Conclusions: </strong>Chronic HCV infection can affect the liver function of pregnant women, but does not increase the pregnancy or delivery complication risks. HCV RNA(+) is an independent risk factor for neonatal jaundice.</p>","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"38 7","pages":"829-839"},"PeriodicalIF":4.1,"publicationDate":"2025-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144877242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Independent and Interactive Effects of Air Pollutants, Meteorological Factors, and Green Space on Tuberculosis Incidence in Shanghai. 上海市大气污染物、气象因子和绿地对结核病发病率的独立与交互影响
IF 4.1
Biomedical and environmental sciences : BES Pub Date : 2025-07-20 DOI: 10.3967/bes2025.041
Qi Ye, Jing Chen, Ya Ting Ji, Xiao Yu Lu, Jia le Deng, Nan Li, Wei Wei, Ren Jie Hou, Zhi Yuan Li, Jian Bang Xiang, Xu Gao, Xin Shen, Chong Guang Yang
{"title":"Independent and Interactive Effects of Air Pollutants, Meteorological Factors, and Green Space on Tuberculosis Incidence in Shanghai.","authors":"Qi Ye, Jing Chen, Ya Ting Ji, Xiao Yu Lu, Jia le Deng, Nan Li, Wei Wei, Ren Jie Hou, Zhi Yuan Li, Jian Bang Xiang, Xu Gao, Xin Shen, Chong Guang Yang","doi":"10.3967/bes2025.041","DOIUrl":"10.3967/bes2025.041","url":null,"abstract":"<p><strong>Objective: </strong>To assess the independent and combined effects of air pollutants, meteorological factors, and greenspace exposure on new tuberculosis (TB) cases.</p><p><strong>Methods: </strong>TB case data from Shanghai (2013-2018) were obtained from the Shanghai Center for Disease Control and Prevention. Environmental data on air pollutants, meteorological variables, and greenspace exposure were obtained from the National Tibetan Plateau Data Center. We employed a distributed-lag nonlinear model to assess the effects of these environmental factors on TB cases.</p><p><strong>Results: </strong>Increased TB risk was linked to PM <sub>2.5</sub>, PM <sub>10</sub>, and rainfall, whereas NO <sub>2</sub>, SO <sub>2</sub>, and air pressure were associated with a reduced risk. Specifically, the strongest cumulative effects occurred at various lags: PM <sub>2.5</sub> ( <i>RR</i> = 1.166, 95% <i>CI</i>: 1.026-1.325) at 0-19 weeks; PM <sub>10</sub> ( <i>RR</i> = 1.167, 95% <i>CI</i>: 1.028-1.324) at 0-18 weeks; NO <sub>2</sub> ( <i>RR</i> = 0.968, 95% <i>CI</i>: 0.938-0.999) at 0-1 weeks; SO <sub>2</sub> ( <i>RR</i> = 0.945, 95% <i>CI</i>: 0.894-0.999) at 0-2 weeks; air pressure ( <i>RR</i> = 0.604, 95% <i>CI</i>: 0.447-0.816) at 0-8 weeks; and rainfall ( <i>RR</i> = 1.404, 95% <i>CI</i>: 1.076-1.833) at 0-22 weeks. Green space exposure did not significantly impact TB cases. Additionally, low temperatures amplified the effect of PM <sub>2.5</sub> on TB.</p><p><strong>Conclusion: </strong>Exposure to PM <sub>2.5</sub>, PM <sub>10</sub>, and rainfall increased the risk of TB, highlighting the need to address air pollutants for the prevention of TB in Shanghai.</p>","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"38 7","pages":"792-809"},"PeriodicalIF":4.1,"publicationDate":"2025-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144877261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Job Preferences of Centers for Disease Control and Prevention Workers: A Discrete Choice Experiment in China. 疾病预防控制中心工作人员的职业偏好:中国的离散选择实验。
Biomedical and environmental sciences : BES Pub Date : 2025-06-20 DOI: 10.3967/bes2025.070
Yan Guo, Han Lin Nie, Hao Chen, Stephen Nicholas, Elizabeth Maitland, Si Si Chen, Lie Yu Huang, Xiu Min Zhang, Xue Feng Shi
{"title":"Job Preferences of Centers for Disease Control and Prevention Workers: A Discrete Choice Experiment in China.","authors":"Yan Guo, Han Lin Nie, Hao Chen, Stephen Nicholas, Elizabeth Maitland, Si Si Chen, Lie Yu Huang, Xiu Min Zhang, Xue Feng Shi","doi":"10.3967/bes2025.070","DOIUrl":"https://doi.org/10.3967/bes2025.070","url":null,"abstract":"<p><strong>Objective: </strong>This study explored the job choice preferences of Center for Disease Prevention and Control (CDC) workers to provide CDC management information and recommendations for optimizing employee retention and motivation policies.</p><p><strong>Methods: </strong>A discrete choice experiment was conducted in nine provinces across China. Seven key attributes were identified to analyze the job preferences of CDC workers. Mixed logit models, latent class models, and policy simulation tools were used.</p><p><strong>Results: </strong>A valid sample of 5,944 cases was included in the analysis. All seven attributes significantly influenced the job choices of CDC workers. Heterogeneity analyses identified two main groups based on different levels of preference for attribute utility. <i>Income-prioritizers</i> were concerned with income and opportunities for career development, whereas <i>bianzhi-prioritizers</i> were concerned with <i>bianzhi</i> and welfare benefits. The policy simulation analysis revealed that <i>income-prioritizers</i> had a relatively higher sensitivity to multiple job preference incentives.</p><p><strong>Conclusion: </strong>Income and <i>bianzhi</i> were the two key attributes influencing the job choices and retention preferences of CDC workers. Heterogeneity in job preferences was also identified. Based on the preference characteristics of different subgroups, policy content should be skewed to differentiate the importance of incentives.</p>","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"38 6","pages":"740-750"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144568223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Single-Cell and Multi-Dimensional Data Analysis of the Key Role of IDH2 in Cervical Squamous Cell Carcinoma Progression. IDH2在宫颈鳞癌进展中的关键作用的单细胞和多维数据分析。
Biomedical and environmental sciences : BES Pub Date : 2025-06-20 DOI: 10.3967/bes2025.067
Xiao Juan Liu, Zhen Peng Zhu, Chen Yang Hou, Hui Ma, Xiao Yan Li, Chun Xing Ma, Li Sha Shu, Hui Ying Zhang
{"title":"Single-Cell and Multi-Dimensional Data Analysis of the Key Role of IDH2 in Cervical Squamous Cell Carcinoma Progression.","authors":"Xiao Juan Liu, Zhen Peng Zhu, Chen Yang Hou, Hui Ma, Xiao Yan Li, Chun Xing Ma, Li Sha Shu, Hui Ying Zhang","doi":"10.3967/bes2025.067","DOIUrl":"https://doi.org/10.3967/bes2025.067","url":null,"abstract":"","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"38 6","pages":"773-778"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144568227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trajectory Modelling: A Novel Approach to Dig Value of Longitudinal Cohort Studies. 轨迹建模:一种挖掘纵向队列研究价值的新方法。
Biomedical and environmental sciences : BES Pub Date : 2025-06-20 DOI: 10.3967/bes2025.068
Si Yan Zhan
{"title":"Trajectory Modelling: A Novel Approach to Dig Value of Longitudinal Cohort Studies.","authors":"Si Yan Zhan","doi":"10.3967/bes2025.068","DOIUrl":"https://doi.org/10.3967/bes2025.068","url":null,"abstract":"","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"38 6","pages":"651-652"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144568228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Occupational Hazard Factors and the Trajectory of Fasting Blood Glucose Changes in Chinese Male Steelworkers Based on Environmental Risk Scores: A Prospective Cohort Study. 基于环境风险评分的中国男性钢铁工人职业危害因素和空腹血糖变化轨迹:一项前瞻性队列研究。
Biomedical and environmental sciences : BES Pub Date : 2025-06-20 DOI: 10.3967/bes2025.058
Ming Xia Zou, Wei Du, Qin Kang, Yu Hao Xia, Nuo Yun Zhang, Liu Feng, Fei Yue Li, Tian Cheng Ma, Ya Jing Bao, Hong Min Fan
{"title":"Occupational Hazard Factors and the Trajectory of Fasting Blood Glucose Changes in Chinese Male Steelworkers Based on Environmental Risk Scores: A Prospective Cohort Study.","authors":"Ming Xia Zou, Wei Du, Qin Kang, Yu Hao Xia, Nuo Yun Zhang, Liu Feng, Fei Yue Li, Tian Cheng Ma, Ya Jing Bao, Hong Min Fan","doi":"10.3967/bes2025.058","DOIUrl":"10.3967/bes2025.058","url":null,"abstract":"<p><strong>Objective: </strong>We aimed to investigate the patterns of fasting blood glucose (FBG) trajectories and analyze the relationship between various occupational hazard factors and FBG trajectories in male steelworkers.</p><p><strong>Methods: </strong>The study cohort included 3,728 workers who met the selection criteria for the Tanggang Occupational Cohort (TGOC) between 2017 and 2022. A group-based trajectory model was used to identify the FBG trajectories. Environmental risk scores (ERS) were constructed using regression coefficients from the occupational hazard model as weights. Univariate and multivariate logistic regression analyses were performed to explore the effects of occupational hazard factors using the ERS on FBG trajectories.</p><p><strong>Results: </strong>FBG trajectories were categorized into three groups. An association was observed between high temperature, noise exposure, and FBG trajectory ( <i>P</i> < 0.05). Using the first quartile group of ERS1 as a reference, the fourth quartile group of ERS1 had an increased risk of medium and high FBG by 1.90 and 2.21 times, respectively (odds ratio [ <i>OR</i>] = 1.90, 95% confidence interval [ <i>CI</i>]: 1.17-3.10; <i>OR</i> = 2.21, 95% <i>CI</i>: 1.09-4.45).</p><p><strong>Conclusion: </strong>An association was observed between occupational hazards based on ERS and FBG trajectories. The risk of FBG trajectory levels increase with an increase in ERS.</p>","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"38 6","pages":"666-677"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144568225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between Solid Cooking Fuel Use and Frailty Trajectories: Findings from a Nationwide Cohort in China. 固体烹饪燃料使用与脆弱轨迹之间的关系:来自中国全国队列的研究结果。
Biomedical and environmental sciences : BES Pub Date : 2025-06-20 DOI: 10.3967/bes2025.022
Yang Liu, Bing Jie Wu, Bing Bing Fan, Chun Xia Li, Chang Su, Ai Dong Liu, Tao Zhang
{"title":"Association between Solid Cooking Fuel Use and Frailty Trajectories: Findings from a Nationwide Cohort in China.","authors":"Yang Liu, Bing Jie Wu, Bing Bing Fan, Chun Xia Li, Chang Su, Ai Dong Liu, Tao Zhang","doi":"10.3967/bes2025.022","DOIUrl":"https://doi.org/10.3967/bes2025.022","url":null,"abstract":"<p><strong>Objective: </strong>Burning solid cooking fuel contributes to household air pollution and is associated with frailty. However, how solid cooking fuel use contributes to the development of frailty has not been well illustrated.</p><p><strong>Methods: </strong>This study recruited 8,947 participants aged ≥ 45 years from the China Health and Retirement Longitudinal Study, 2011-2018. Group-based trajectory modeling was employed to identify frailty trajectories. Multinomial logistic regression was used to assess the association between solid cooking fuel use and frailty trajectories. Population-attributable fractions were used to estimate the frailty burden from solid fuel use.</p><p><strong>Results: </strong>We identified three frailty trajectories: low-stable ( <i>n</i> = 5,789), moderate-increasing ( <i>n</i> = 2,603), and fast-increasing ( <i>n</i> = 555). Solid fuel use was associated with higher odds of being in the moderate-increasing ( <i>OR</i>: 1.24, 95% <i>CI</i>: 1.08-1.42) and fast-increasing ( <i>OR</i>: 1.48, 95% <i>CI</i>: 1.14-1.92) trajectories. These associations were strengthened by longer solid fuel use ( <i>P</i> for trend < 0.001). Switching to clean fuel significantly reduced the risk of being in these trajectories compared with persistent solid fuel users. Without solid fuel, 8% of moderate- and 19% of fast-increasing trajectories demonstrated frailty development like the low-stable group.</p><p><strong>Conclusion: </strong>Solid cooking fuel use is associated with frailty trajectories in middle-aged and older Chinese populations.</p>","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"38 6","pages":"653-665"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144568217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Life-Course Trajectories of Body Mass Index, Insulin Resistance, and Incident Diabetes in Chinese Adults. 中国成人体重指数、胰岛素抵抗和糖尿病发病率的生命轨迹
Biomedical and environmental sciences : BES Pub Date : 2025-06-20 DOI: 10.3967/bes2025.072
Zhi Yuan Ning, Jing Lan Zhang, Bing Bing Fan, Yan Lin Qu, Chang Su, Tao Zhang
{"title":"Life-Course Trajectories of Body Mass Index, Insulin Resistance, and Incident Diabetes in Chinese Adults.","authors":"Zhi Yuan Ning, Jing Lan Zhang, Bing Bing Fan, Yan Lin Qu, Chang Su, Tao Zhang","doi":"10.3967/bes2025.072","DOIUrl":"10.3967/bes2025.072","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to explore the interplay between the life-course body mass index (BMI) trajectories and insulin resistance (IR) on incident diabetes.</p><p><strong>Methods: </strong>This longitudinal cohort included 2,336 participants who had BMI repeatedly measured 3-8 times between 1989 and 2009, as well as glucose and insulin measured in 2009. BMI trajectories were identified using a latent class growth mixed model. The interplay between BMI trajectories and IR on diabetes was explored using the four-way effect decomposition method. Logistic regression and mediation models were used to estimate the interaction and mediation effects, respectively.</p><p><strong>Results: </strong>Three distinct BMI trajectory groups were identified: low-stable ( <i>n</i> = 1,625), medium-increasing ( <i>n</i> = 613), and high-increasing ( <i>n</i> = 98). Both interaction and mediation effects of BMI trajectories and IR on incident diabetes were significant ( <i>P</i> < 0.05). The proportion of incident diabetes was higher in the IR-obesity than in the insulin-sensitivity (IS) obesity group (18.9% <i>vs.</i> 5.8%, <i>P</i> < 0.001). After adjusting for covariates, the odds ratios (95% confidence intervals) of the IR, IS-obesity, and IR-obesity groups <i>vs.</i> the normal group were 3.22 (2.05, 5.16), 2.05 (1.00, 3.97), and 7.98 (5.19, 12.62), respectively. IR mediated 10.7% of the total effect of BMI trajectories on incident diabetes ( <i>P</i> < 0.001).</p><p><strong>Conclusion: </strong>We found strong interactions and weak mediation effects of IR on the relationship between life-course BMI trajectories and incident diabetes. IS-obesity is associated with a lower risk of incident diabetes than IR-obesity.</p>","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"38 6","pages":"706-715"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144568224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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