Biomedical and environmental sciences : BES最新文献_第5页

Activation of IP10/CXCR3 Signaling is Highly Coincidental with PrP ^Sc Deposition in the Brains of Scrapie-Infected Mice. IP10/CXCR3信号的激活与刮伤病感染小鼠脑内的PrP Sc沉积高度吻合。

Biomedical and environmental sciences : BES Pub Date : 2024-11-20 DOI: 10.3967/bes2024.158

Chen Jia, Chen Cao, Hu Chao, Yang Wei, Wang Lin, Chen Dongdong, Wu Yuezhang, Shi Qi, Dong Xiaoping

{"title":"Activation of IP10/CXCR3 Signaling is Highly Coincidental with PrP Sc Deposition in the Brains of Scrapie-Infected Mice.","authors":"Chen Jia, Chen Cao, Hu Chao, Yang Wei, Wang Lin, Chen Dongdong, Wu Yuezhang, Shi Qi, Dong Xiaoping","doi":"10.3967/bes2024.158","DOIUrl":"https://doi.org/10.3967/bes2024.158","url":null,"abstract":"Objective: To analyze the relationship between Chemokine IP10 and its receptor CXCR3 during prion infection.Methods: We investigated the increases in IP10 signals, primarily localized in neurons within the brains of scrapie-infected mice, using western blotting, ELISA, co-immunoprecipitation, immunohistochemistry, immunofluorescence assays, and RT-PCR.Results: Both CXCR3 levels and activation were significantly higher in the brains of scrapie-infected mice and prion-infected SMB-S15 cells. Enhanced CXCR3 expression was predominantly observed in neurons and activated microglia. Morphological colocalization of PrP C/PrP Sc with IP10/CXCR3 was observed in scrapie-infected mouse brains using immunohistochemistry and immunofluorescence. immunohistochemistry (IHC) analysis of whole brain sections further revealed increased accumulation of IP10/CXCR3 specifically in brain regions with higher levels of PrP Sc deposits. Co-immunoprecipitation and biomolecular interaction assays revealed the molecular interactions between PrP and IP10/CXCR3. Notably, a significantly larger amount of IP10 accumulated within prion-infected SMB-S15 cells than in the normal partner cell line, SMB-PS. Importantly, resveratrol treatment effectively suppressed prion replication in SMB-S15 cells, thereby restoring the accumulation and secretion pattern of cellular IP10 similar to that observed in SMB-PS cells.Conclusion: Our data demonstrate that the activation of IP10/CXCR3 signaling in prion-infected brain tissues coincides with PrP Sc deposition. Modulation of IP10/CXCR3 signaling in the brain represents a potential therapeutic target for mitigating the progression of prion diseases.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"37 11","pages":"1235-1251"},"PeriodicalIF":0.0,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142820358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High Diversity in Genotypes of Human Rhinovirus Contributes to High Prevalence in Beijing, 2018-2022: A Retrospective Multiple-Center Epidemiological Study. 北京2018-2022年人类鼻病毒基因型多样性高流行率的多中心回顾性流行病学研究

Biomedical and environmental sciences : BES Pub Date : 2024-11-20 DOI: 10.3967/bes2024.126

Qing Wang, Qi Huang, Qin Luo, Xiaofeng Wei, Xue Wang, Maozhong Li, Cheng Gong, Fang Huang

{"title":"High Diversity in Genotypes of Human Rhinovirus Contributes to High Prevalence in Beijing, 2018-2022: A Retrospective Multiple-Center Epidemiological Study.","authors":"Qing Wang, Qi Huang, Qin Luo, Xiaofeng Wei, Xue Wang, Maozhong Li, Cheng Gong, Fang Huang","doi":"10.3967/bes2024.126","DOIUrl":"https://doi.org/10.3967/bes2024.126","url":null,"abstract":"Objective: To comprehensively examine the molecular epidemiological characteristics of human rhinovirus (HRV) in Beijing.Methods: A total of 7,151 children and adults with acute respiratory tract infections (ARTIs) were recruited from 35 sentinel hospitals in Beijing between 2018 and 2022. Their respiratory samples were obtained, and epidemiological and clinical data were collected. Nucleic acid testing for 11 respiratory pathogens, including HRV, was performed on the specimens. We sequenced VP4/VP2 or 5'UTR of HRV isolates to identify their genotypes using phylogenetic analyses.Results: HRV was detected in 462 (6.5%) cases. A total of 105 HRV genotypes were successfully identified in 359 (77.7%) specimens, comprising 247 (68.8%) with HRV-A, 42 (11.7%) with HRV-B, and 70 (19.5%) with HRV-C. No predominant genotype was observed. HRV was prevalent year-round with two weak peaks in spring and autumn. HRV detection declined gradually between 2018 and 2022, with seven genotypes disappearing and five genotypes emerging. HRV detection rate decreased by age without resurge among old people. HRV-C was more common among children aged less than 5 years with severe community-acquired pneumonia compared to HRV-A and HRV-B. Adults infected with HRV-B had higher rates of hospitalization, intensive care unit admission, and complications than those infected with HRV-A and HRV-C.Conclusion: HRV epidemics in Beijing were highly dispersed in genotypes, which probably resulted in a high prevalence of HRV infection, attenuated its seasonality, and made it more difficult to establish effective population immunity.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"37 11","pages":"1262-1272"},"PeriodicalIF":0.0,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142820397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endometrial Cancer Research Based on Gut Microbiomics and Metabolomics: An Analysis of Correlation and Differences. 基于肠道微生物组学和代谢组学的子宫内膜癌研究：相关性和差异分析。

Biomedical and environmental sciences : BES Pub Date : 2024-10-20 DOI: 10.3967/bes2024.145

Dan Xu, Fengqin Xue, Ruifang Zhai, Sanyuan Zhang, Zhe Wang, Peiyue Yu

引用次数: 0

Simulated Microgravity can Promote the Apoptosis and Change Inflammatory State of Kupffer Cells. 模拟微重力可促进Kupffer细胞凋亡，改变炎症状态。

Biomedical and environmental sciences : BES Pub Date : 2024-10-20 DOI: 10.3967/bes2024.141

Jun Ge, Fei Liu, Hongyun Nie, Yuan Yue, Kaige Liu, Haiguan Lin, Hao Li, Tao Zhang, Hongfeng Yan, Bingxin Xu, Hongwei Sun, Jianwu Yang, Shaoyan Si, Jinlian Zhou, Yan Cui

{"title":"Simulated Microgravity can Promote the Apoptosis and Change Inflammatory State of Kupffer Cells.","authors":"Jun Ge, Fei Liu, Hongyun Nie, Yuan Yue, Kaige Liu, Haiguan Lin, Hao Li, Tao Zhang, Hongfeng Yan, Bingxin Xu, Hongwei Sun, Jianwu Yang, Shaoyan Si, Jinlian Zhou, Yan Cui","doi":"10.3967/bes2024.141","DOIUrl":"https://doi.org/10.3967/bes2024.141","url":null,"abstract":"Objective: In this study, we analyzed the transcriptome sequences of Kupffer cells exposed to simulated microgravity for 3 d and conducted biological experiments to determine how microgravity initiates apoptosis in Kupffer cells.Methods: Rotary cell culture system was used to construct a simulated microgravity model. GO and KEGG analyses were conducted using the DAVID database. GSEA was performed using the R language. The STRING database was used to conduct PPI analysis. qPCR was used to measure the IL1B, TNFA, CASP3, CASP9, and BCL2L11 mRNA expressions . Western Blotting was performed to detect the level of proteins CASP3 and CASP 9. Flow cytometry was used to detect apoptosis and mitochondrial membrane cells. Transmission electron microscopy was used to detect changes in the ultrastructure of Kupffer cells.Results: Transcriptome Sequencing indicated that simulated microgravity affected apoptosis and the inflammatory state of Kupffer cells. Simulated microgravity improved the CASP3, CASP9, and BCL2L11 expressions in Kupffer cells. Annexin-V/ PI and JC-1 assays showed that simulated microgravity promoted apoptosis in Kupffer cells. Simulated microgravity causes M1 polarization in Kupffer cells.Conclusion: Our study found that simulated microgravity facilitated the apoptosis of Kupffer cells through the mitochondrial pathway and activated Kupffer cells into M1 polarization, which can secrete TNFA to promote apoptosis.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"37 10","pages":"1117-1127"},"PeriodicalIF":0.0,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatial Heterogeneity and Risk Factors of Dental Caries in 12-Year-Old Children in Shanxi Province, China. 山西省12岁儿童龋病空间异质性及危险因素分析

Biomedical and environmental sciences : BES Pub Date : 2024-10-20 DOI: 10.3967/bes2024.102

Ruxia Hou, Tingting Yang, Jiajia Liu, Hao Chen, Wen Kang, Junming Li, Xiaotong Shi, Yi Liang, Junyu Liu, Bin Zhao, Xiangyu Wang

{"title":"Spatial Heterogeneity and Risk Factors of Dental Caries in 12-Year-Old Children in Shanxi Province, China.","authors":"Ruxia Hou, Tingting Yang, Jiajia Liu, Hao Chen, Wen Kang, Junming Li, Xiaotong Shi, Yi Liang, Junyu Liu, Bin Zhao, Xiangyu Wang","doi":"10.3967/bes2024.102","DOIUrl":"https://doi.org/10.3967/bes2024.102","url":null,"abstract":"Objective: This study aimed to explore the spatial heterogeneity and risk factors for dental caries in 12-year-old children in Shanxi province, China.Methods: The data encompassed 3,721 participants from the two most recent oral health surveys conducted across 16 districts in Shanxi Province in 2015 and 2018. Eighteen specific variables were analyzed to examine the interplay between socioeconomic factors, medical resources and environmental conditions. The Geo-detector model was employed to assess the impacts and interactions of these ecological factors.Results: Socioeconomic factors ( Q = 0.30, P < 0.05) exhibited a more substantial impact compared to environmental ( Q = 0.19, P < 0.05) and medical resource factors ( Q = 0.25, P < 0.05). Notably, the urban population percentage (UPP) demonstrated the most significant explanatory power for the spatial heterogeneity in caries prevalence, as denoted by its highest q-value ( q = 0.51, P < 0.05). Additionally, the spatial distribution's heterogeneity of caries was significantly affected by SO 2 concentration ( q = 0.39, P < 0.05) and water fluoride levels ( q = 0.27, P < 0.05) among environmental factors.Conclusion: The prevalence of caries exhibited spatial heterogeneity, escalating from North to South in Shanxi Province, China, influenced by socioeconomic factors, medical resources, and environmental conditions to varying extents.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"37 10","pages":"1173-1183"},"PeriodicalIF":0.0,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of Blood Lipid Profiles on Chronic Kidney Disease in a Prospective Cohort: Based on a Regression Discontinuity Design. 前瞻性队列中血脂对慢性肾脏疾病的影响：基于非连续性回归设计

Biomedical and environmental sciences : BES Pub Date : 2024-10-20 DOI: 10.3967/bes2024.113

Kang Lyu, Shaodong Liu, Yanli Liu, Jinlong You, Xue Wang, Min Jiang, Chun Yin, Desheng Zhang, Yana Bai, Minzhen Wang, Shan Zheng

{"title":"The Effect of Blood Lipid Profiles on Chronic Kidney Disease in a Prospective Cohort: Based on a Regression Discontinuity Design.","authors":"Kang Lyu, Shaodong Liu, Yanli Liu, Jinlong You, Xue Wang, Min Jiang, Chun Yin, Desheng Zhang, Yana Bai, Minzhen Wang, Shan Zheng","doi":"10.3967/bes2024.113","DOIUrl":"https://doi.org/10.3967/bes2024.113","url":null,"abstract":"Objective: Previous studies on the association between lipid profiles and chronic kidney disease (CKD) have yielded inconsistent results and no defined thresholds for blood lipids.Methods: A prospective cohort study including 32,351 subjects who completed baseline and follow-up surveys over 5 years was conducted. Restricted cubic splines and Cox models were used to examine the association between the lipid profiles and CKD. A regression discontinuity design was used to determine the cutoff value of lipid profiles that was significantly associated with increased the risk of CKD.Results: Over a median follow-up time of 2.2 (0.5, 4.2) years, 648 (2.00%) subjects developed CKD. The lipid profiles that were significantly and linearly related to CKD included total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), TC/HDL-C, and TG/HDL-C, whereas low-density lipoprotein cholesterol (LDL-C) and LDL-C/HDL-C were nonlinearly correlated with CKD. TC, TG, TC/HDL-C, and TG/HDL-C showed an upward jump at the cutoff value, increasing the risk of CKD by 0.90%, 1.50%, 2.30%, and 1.60%, respectively, whereas HDL-C showed a downward jump at the cutoff value, reducing this risk by 1.0%. Female and participants with dyslipidemia had a higher risk of CKD, while the cutoff values for the different characteristics of the population were different.Conclusion: There was a significant association between lipid profiles and CKD in a prospective cohort from Northwest China, while TG, TC/HDL-C, and TG/HDL-C showed a stronger risk association. The specific cutoff values of lipid profiles may provide a clinical reference for screening or diagnosing CKD risk.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"37 10","pages":"1158-1172"},"PeriodicalIF":0.0,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation and Methicillin-Resistant Staphylococcus aureus Biofilm Elimination Effect of Baicalein-Loaded Hyaluronic acid/β-Cyclodextrin grafted Chitosan Nanoparticles. 黄芩素透明质酸/β-环糊精接枝壳聚糖纳米颗粒的制备及其对耐甲氧西林金黄色葡萄球菌生物膜的去除作用

Biomedical and environmental sciences : BES Pub Date : 2024-10-20 DOI: 10.3967/bes2024.160

Liting Lai, Wenyou Ding, Guoying Huang, Mengke Wang, Jinqing Chen, Liuzhen Lai, Xiuzhen Deng, Ling Tang, Xinyi Yu, Ya Huang, Thi Minh Hien Truong, Zhongbin Zhang, Wenya Ding

引用次数: 0

Effects of Seasonal and Temperature Variations on the Association between Nitrogen Dioxide Exposure and First-Aid Incidence for Neurological Diseases in Shenzhen, China. 季节和温度变化对深圳地区二氧化氮暴露与神经系统疾病急救发生率关系的影响

Biomedical and environmental sciences : BES Pub Date : 2024-10-20 DOI: 10.3967/bes2024.147

Tongyu Yang, Qingqing Wang, Yuchen Tian, Siyi Chen, Yilei Ma, Peng Wang, Suli Huang, Ji Peng, Jinquan Cheng, Jing Hu, Ping Yin

引用次数: 0

Efficacy and Safety of Combined Bedaquiline and Delamanid Use among Patients with Multidrug-Resistant Tuberculosis in Beijing, China. 北京地区贝达喹啉和德拉马尼联合应用在耐多药结核病患者中的疗效和安全性

Biomedical and environmental sciences : BES Pub Date : 2024-10-20 DOI: 10.3967/bes2024.088

Can Guo, Lihui Nie, Yanhua Song, Rongmei Liu, Xiaoguang Wu, Yuanyuan Shang, Xuxia Zhang, Yu Pang, Mengqiu Gao

{"title":"Efficacy and Safety of Combined Bedaquiline and Delamanid Use among Patients with Multidrug-Resistant Tuberculosis in Beijing, China.","authors":"Can Guo, Lihui Nie, Yanhua Song, Rongmei Liu, Xiaoguang Wu, Yuanyuan Shang, Xuxia Zhang, Yu Pang, Mengqiu Gao","doi":"10.3967/bes2024.088","DOIUrl":"https://doi.org/10.3967/bes2024.088","url":null,"abstract":"Objectives: The combined use of bedaquiline and delamanid (BDQ-DLM) is limited by an increased risk of prolonging the QTc interval. We retrospectively evaluated patients who received DLM/BDQ-containing regimens at a TB-specialized hospital. We aimed to present clinical efficacy and safety data for Chinese patients.Methods: This case-control study included patients with multidrug-resistant tuberculosis (MDR-TB) treated with BDQ alone or BDQ plus DLM.Results: A total of 96 patients were included in this analysis: 64 in the BDQ group and 32 in the BDQ + DLM group. Among the 96 patients with positive sputum culture at the initiation of BDQ alone or BDQ combined with DLM, 46 patients (71.9%) in the BDQ group and 29 (90.6%) in the BDQ-DLM group achieved sputum culture conversion during treatment. The rate of sputum culture conversion did not differ between the two groups. The time to sputum culture conversion was significantly shorter in the BDQ-DLM group than in the BDQ group. The most frequent adverse event was QTc interval prolongation; however, the frequency of adverse events did not differ between the groups.Conclusion: In conclusion, our results demonstrate that the combined use of BDQ and DLM is efficacious and tolerable in Chinese patients infected with MDR-TB. Patients in the BDQ-DLM group achieved sputum culture conversion sooner than those in the BDQ group.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"37 10","pages":"1195-1203"},"PeriodicalIF":0.0,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between Metal(loid) Exposure and Risk of Polycystic Ovary Syndrome Mediated by Anti-Müllerian Hormone among Women Undergoing In Vitro Fertilization and Embryo Transfer. 体外受精和胚胎移植妇女中抗<s:1>勒氏激素介导的金属暴露与多囊卵巢综合征风险的关系

Biomedical and environmental sciences : BES Pub Date : 2024-10-20 DOI: 10.3967/bes2024.154

Shu Su, Mengyuan Ren, Yanqiu Feng, Changxin Lan, Lailai Yan, Qun Lu, Jia Xu, Bin Han, Lili Zhuang, Mingliang Fang, Bin Wang, Hongchu Bao, Bo Pan

{"title":"Association between Metal(loid) Exposure and Risk of Polycystic Ovary Syndrome Mediated by Anti-Müllerian Hormone among Women Undergoing In Vitro Fertilization and Embryo Transfer.","authors":"Shu Su, Mengyuan Ren, Yanqiu Feng, Changxin Lan, Lailai Yan, Qun Lu, Jia Xu, Bin Han, Lili Zhuang, Mingliang Fang, Bin Wang, Hongchu Bao, Bo Pan","doi":"10.3967/bes2024.154","DOIUrl":"https://doi.org/10.3967/bes2024.154","url":null,"abstract":"Objective: To investigate the relationship and potential pathways between metal(loid) exposure and the risk of polycystic ovary syndrome (PCOS) in women of childbearing age.Methods: This case-control study included 200 patients with PCOS (cases) and 896 non-PCOS controls with the age of 25-37 years. The concentrations of 29 metal(loid)s in the follicular fluid (FF) and clinical indicators in the serum were measured in all participants. Logistic regression analysis and mediation analysis were conducted to evaluate the associations between metal(loid) exposure and PCOS risk and investigate the possible roles of clinical indicators, respectively.Results: Logistic regression analysis revealed an association between high copper levels in FF and increased PCOS risk (highest vs. lowest quartile: adjusted odds ratio = 2.94, 95% confidence interval: 1.83-4.72). A high luteinizing hormone/follicle-stimulating hormone ratio and elevated levels of testosterone and anti-Müllerian hormone (AMH) were strongly associated with increased PCOS risk induced by high copper exposure. The mediation analysis indicated a mediating effect of AMH in the association between copper exposure and PCOS risk.Conclusion: Copper may affect PCOS risk through the hypothalamic-pituitary-ovarian axis, mediated by AMH. Copper exposure and internal AMH levels are important indicators for early warning of PCOS development.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"37 10","pages":"1107-1116"},"PeriodicalIF":0.0,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0