Impact of Endometrial Polyps on Pregnancy Outcomes in Patients with Endometriosis and Infertility: A Systematic Review and Meta-analysis.

Biomedical and environmental sciences : BES Pub Date : 2025-03-20 DOI:10.3967/bes2024.175

Liang Zhang, Qian Han, Mei Ru Bao, Ying Wu

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Abstract

Objective: To evaluate the impact of endometrial polyps (EP) on postoperative pregnancy outcomes in infertile women with endometriosis (EMs).

Methods: PubMed, Embase, The Cochrane Library, CNKI, VIP, SinoMed, and WanFang Data databases were searched to include clinical studies on the effect of EP on pregnancy outcomes in patients with EMs, published before August 31, 2020. A meta-analysis was performed using Rev Man 5.3 software after two investigators independently screened the literature, extracted information, and evaluated the risk of bias of the included studies.

Results: The meta-analysis included ten studies (651 and 1,040 in the combined EP and uncomplicated EP groups, respectively). The spontaneous pregnancy rate, clinical pregnancy rate, and live birth rate were significantly lower in the group with combined EPs than in the group without combined EPs [Odd's ratio ( OR) = 0.63, 95% confidence interval ( CI): 0.50-0.80, P = 0.0001; OR = 0.63, 95% CI: 0.48-0.84, P = 0.001; OR = 0.63, 95% CI: 0.42-0.96, P = 0.03], and the rate of embryonic abortion was significantly higher than that in the uncomplicated EP group [ OR = 3.10, 95% CI: 1.52-6.32, P = 0.002].

Conclusion: EP may adversely affect pregnancy outcomes in patients with infertility and EMs. Even after surgical treatment, EP can still reduce natural pregnancy, clinical pregnancy, and live birth rates in infertile women with EMs and increase the risk of embryo arrest in these women.

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子宫内膜息肉对子宫内膜异位症和不孕症患者妊娠结局的影响：系统回顾和荟萃分析。

目的：探讨子宫内膜息肉（EP）对不孕合并子宫内膜异位症（EMs）患者术后妊娠结局的影响。方法：检索PubMed、Embase、Cochrane Library、CNKI、VIP、SinoMed和万方数据库，纳入2020年8月31日前发表的关于EP对EMs患者妊娠结局影响的临床研究。在两位研究者独立筛选文献、提取信息并评估纳入研究的偏倚风险后，使用Rev Man 5.3软件进行meta分析。结果：荟萃分析包括10项研究（合并EP组和非合并EP组分别为651项和1040项）。合并EPs组的自然妊娠率、临床妊娠率、活产率均显著低于未合并EPs组[Odd’s ratio (OR) = 0.63, 95%可信区间（CI）： 0.50 ~ 0.80, P = 0.0001；Or = 0.63, 95% ci: 0.48-0.84, p = 0.001；OR = 0.63, 95% CI: 0.42 ~ 0.96, P = 0.03]，且胚胎流产率明显高于单纯EP组[OR = 3.10, 95% CI: 1.52 ~ 6.32, P = 0.002]。结论：EP可能对不孕症和EMs患者的妊娠结局产生不利影响。即使在手术治疗后，EP仍然可以降低EMs不孕妇女的自然妊娠率、临床妊娠率和活产率，并增加这些妇女胚胎骤停的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Biomedical and environmental sciences : BES

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