Biomedical and environmental sciences : BES最新文献

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A Case Study on Garbage Code Redistribution Methods for Heart Failure at City Level by Two Approaches. 基于两种方法的城市级心力衰竭垃圾代码再分配方法研究
Biomedical and environmental sciences : BES Pub Date : 2025-01-20 DOI: 10.3967/bes2024.173
Li Qun Liu, Ze Min Cai, Xue Wei Wang, Chun Ping Wang, Xiang Yun Ma, Xian Feng Meng, Bo Fu Ning, Ning Li, Xia Wan
{"title":"A Case Study on Garbage Code Redistribution Methods for Heart Failure at City Level by Two Approaches.","authors":"Li Qun Liu, Ze Min Cai, Xue Wei Wang, Chun Ping Wang, Xiang Yun Ma, Xian Feng Meng, Bo Fu Ning, Ning Li, Xia Wan","doi":"10.3967/bes2024.173","DOIUrl":"https://doi.org/10.3967/bes2024.173","url":null,"abstract":"","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"38 1","pages":"119-125"},"PeriodicalIF":0.0,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trend of Relationship Models between Public and Private Hospitals in China Using Coopetition Theory. 基于合作理论的中国公立医院与民营医院关系模式发展趋势
Biomedical and environmental sciences : BES Pub Date : 2024-12-20 DOI: 10.3967/bes2024.138
Peiqiang Yu, Zhan Shu, Yuanyuan Xu, Bo Sun
{"title":"Trend of Relationship Models between Public and Private Hospitals in China Using Coopetition Theory.","authors":"Peiqiang Yu, Zhan Shu, Yuanyuan Xu, Bo Sun","doi":"10.3967/bes2024.138","DOIUrl":"https://doi.org/10.3967/bes2024.138","url":null,"abstract":"","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"37 12","pages":"1458-1462"},"PeriodicalIF":0.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-Term Exposure to Low-Level Ambient Air Pollution and Mortality among 0.3 Million Chinese Older Adults. 中国30万老年人长期暴露于低水平环境空气污染与死亡率
Biomedical and environmental sciences : BES Pub Date : 2024-12-20 DOI: 10.3967/bes2024.183
Likun Liu, Xueli Yuan, Wenqing Ni, Jing Wei, Tingting Liu, Ruijun Xu, Yingxin Li, Zihua Zhong, Yi Zheng, Sihan Liang, Rui Wang, Jian Xu, Yuewei Liu
{"title":"Long-Term Exposure to Low-Level Ambient Air Pollution and Mortality among 0.3 Million Chinese Older Adults.","authors":"Likun Liu, Xueli Yuan, Wenqing Ni, Jing Wei, Tingting Liu, Ruijun Xu, Yingxin Li, Zihua Zhong, Yi Zheng, Sihan Liang, Rui Wang, Jian Xu, Yuewei Liu","doi":"10.3967/bes2024.183","DOIUrl":"https://doi.org/10.3967/bes2024.183","url":null,"abstract":"<p><strong>Objective: </strong>Evidence that long-term exposure to ambient air pollution increases mortality among older adults, particularly those residing in low-level air pollution locations, remains scarce. This study investigated the potential links between long-term low-level air pollution exposure and mortality among Chinese older adults.</p><p><strong>Methods: </strong>A population-based study with 317,464 individuals aged ≥ 65 years was conducted in Shenzhen, China during 2018 and 2020. Logistic regression models were used to analyze the associations between long-term exposure to air pollution and all-cause mortality, as the primary outcome, as well as non-accidental, cancer and cardiovascular mortality.</p><p><strong>Results: </strong>Significant associations of PM <sub>1</sub>, PM <sub>2.5</sub>, PM <sub>10</sub>, SO <sub>2</sub>, CO, and O <sub>3</sub> exposures with a higher risk of all-cause mortality were found. Adjusted odds ratio ( <i>OR</i>) for each 1 µg/m <sup>3</sup> increment was 1.49 [95% confidence interval ( <i>CI</i>): 1.46, 1.53] for PM <sub>1</sub>, 1.30 (1.27, 1.32) for PM <sub>2.5</sub>, 1.05 (1.04, 1.06) for PM <sub>10</sub>, 5.84 (5.39, 6.32) for SO <sub>2</sub>, 1.04 (1.04, 1.05) for CO, and 1.02 (1.00, 1.03) for O <sub>3</sub>, respectively. Long-term PM <sub>1</sub>, PM <sub>2.5</sub>, PM <sub>10</sub>, SO <sub>2</sub>, and CO exposures also elevated the risks of non-accidental, cancer and cardiovascular mortality.</p><p><strong>Conclusion: </strong>Long-term low-level air pollution exposure was associated with an increased mortality risk among Chinese older adults.</p>","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"37 12","pages":"1362-1372"},"PeriodicalIF":0.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Genetic Association between CDKN1A and Heart Failure: Genome-Wide Exploration of m 6A-SNPs and Mendelian Randomization. CDKN1A与心力衰竭之间的遗传关联:m 6A-SNPs的全基因组探索和孟德尔随机化。
Biomedical and environmental sciences : BES Pub Date : 2024-12-20 DOI: 10.3967/bes2024.172
Ziyi Yang, Zhennan Lin, Xiaotong Ning, Xingbo Mo, Laiyuan Wang, Xiangfeng Lu, Shufeng Chen
{"title":"The Genetic Association between CDKN1A and Heart Failure: Genome-Wide Exploration of m <sup>6</sup>A-SNPs and Mendelian Randomization.","authors":"Ziyi Yang, Zhennan Lin, Xiaotong Ning, Xingbo Mo, Laiyuan Wang, Xiangfeng Lu, Shufeng Chen","doi":"10.3967/bes2024.172","DOIUrl":"https://doi.org/10.3967/bes2024.172","url":null,"abstract":"<p><strong>Objective: </strong>N6-methyladenosine (m <sup>6</sup>A) is a common epigenetic modification in eukaryotes. In this study, we explore the potential impact of m <sup>6</sup>A-associated single nucleotide polymorphisms (m <sup>6</sup>A-SNPs) on heart failure (HF).</p><p><strong>Methods: </strong>Data from genome-wide association studies (GWAS) investigating HF in humans and from m <sup>6</sup>A-SNPs datasets were used to identify HF-associated m <sup>6</sup>A-SNPs. Their functions were explored using expression quantitative trait locus (eQTL), gene expression, and gene enrichment analyses. Mediation protein quantitative trait locus (pQTL)-Mendelian randomization (MR) was used to investigate the potential mechanism between critical protein levels and risk factors for HF.</p><p><strong>Results: </strong>We screened 44 HF-associated m <sup>6</sup>A-SNPs, including 10 m <sup>6</sup>A-SNPs that showed eQTL signals and differential expressions in HF. The SNP rs1801270 in CDKN1A showed the strongest association with HF ( <i>P =</i> 7.75 × 10 <sup>-6</sup>). Additionally, MR verified the genetic association between the CDKN1A protein and HF, as well as the mediating effect of blood pressure (BP) in this pathway. Higher circulating level of CDKN1A was associated with a lower risk of HF (odds ratio [ <i>OR</i>] = 0.82, 95% confidence interval [ <i>CI</i>]: 0.69 to 0.99). The proportions of hypertension, systolic BP, and diastolic BP were 48.10%, 28.94%, and 18.02%, respectively. Associations of PDIA6 ( <i>P</i> = 1.30 × 10 <sup>-2</sup>) and SMAD3 ( <i>P</i> = 4.80 × 10 <sup>-2</sup>) with HF were also detected.</p><p><strong>Conclusion: </strong>Multiple HF-related m <sup>6</sup>A-SNPs were identified in this study. Genetic associations of CDKN1A and other proteins with HF and its risk factors were demonstrated, providing new ideas for further exploration of the molecular mechanisms of HF.</p>","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"37 12","pages":"1397-1413"},"PeriodicalIF":0.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relationship of Ambient Humidity with Cardiovascular Diseases: A Prospective Study of 24,510 Adults in a General Population. 环境湿度与心血管疾病的关系:一项24510名普通人群成年人的前瞻性研究
Biomedical and environmental sciences : BES Pub Date : 2024-12-20 DOI: 10.3967/bes2024.156
Congyi Zheng, Jiamin Wu, Haosu Tang, Xin Wang, Ye Tian, Xue Cao, Yixin Tian, Runqing Gu, Yuxin Song, Xuyan Pei, Jiayuan Qiu, Zujiao Nie, Minmei He, Gang Huang, Zengwu Wang
{"title":"Relationship of Ambient Humidity with Cardiovascular Diseases: A Prospective Study of 24,510 Adults in a General Population.","authors":"Congyi Zheng, Jiamin Wu, Haosu Tang, Xin Wang, Ye Tian, Xue Cao, Yixin Tian, Runqing Gu, Yuxin Song, Xuyan Pei, Jiayuan Qiu, Zujiao Nie, Minmei He, Gang Huang, Zengwu Wang","doi":"10.3967/bes2024.156","DOIUrl":"https://doi.org/10.3967/bes2024.156","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to explore the association between humidity exposure and the risk of cardiovascular disease (CVD), utilizing follow-up data and relative humidity (RH) metric assessments.</p><p><strong>Methods: </strong>We extracted the baseline data from the China Hypertension Survey (CHS) of 24,510 enrolled participants aged ≥ 35 years without a history of CVD between 2012 and 2015 and followed them up from 2018 to 2019. The National Meteorological Information Center (NMIC) of the China Meteorological Administration (CMA) provided the quality-controlled relative humidity (RH) datasets. Cox proportional hazards models were used to estimate hazard ratios ( <i>HR</i>s) for CVD in relation to RH.</p><p><strong>Results: </strong>During the follow-up period (2018-2019), 973 patients with CVD were identified. The <i>HR</i> of CVD risk was 1.17 (95% <i>CI</i>: 1.04-1.31) per 10% increase in summer mean RH. Compared with participants in the 3 <sup>rd</sup> quintile group, those in the 1 <sup>st</sup> and 5 <sup>th</sup> quintiles of RH had a higher risk of CVD. For summer mean RH, the <i>HRs</i> (95% <i>CIs</i>) for the 1 <sup>st</sup> and 5 <sup>th</sup> quintiles were 1.34 (1.04-1.71) and 1.44 (1.14-1.83), respectively. The relationship (\"U\" shape) between summer mean RH and the risk of CVD was nonlinear. Stratified analyses indicated that the risk of CVD was substantially influenced by the summer mean RH in female, older individuals, and those in southern China.</p><p><strong>Conclusion: </strong>Unsuitable (too high or low) humidity environments affect the risk of CVD. Our study highlights those future policies for adapting to climate change should consider the humidity-CVD relationship.</p>","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"37 12","pages":"1352-1361"},"PeriodicalIF":0.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PM 2.5-Metabolic Syndrome Causal Association: A Mendelian Randomization Study. PM 2.5-代谢综合征因果关系:孟德尔随机研究。
Biomedical and environmental sciences : BES Pub Date : 2024-12-20 DOI: 10.3967/bes2024.153
Fan Ding, Ning Ma, Shi Zhao, Qingan Wang, Zhanbing Ma, Yuhong Zhang, Yi Zhao, Yu Zhao
{"title":"PM <sub>2.5</sub>-Metabolic Syndrome Causal Association: A Mendelian Randomization Study.","authors":"Fan Ding, Ning Ma, Shi Zhao, Qingan Wang, Zhanbing Ma, Yuhong Zhang, Yi Zhao, Yu Zhao","doi":"10.3967/bes2024.153","DOIUrl":"https://doi.org/10.3967/bes2024.153","url":null,"abstract":"","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"37 12","pages":"1421-1426"},"PeriodicalIF":0.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An Investigation of the Association between Metabolic Syndrome and Osteoporosis Based on Chinese Health Examination Data. 基于中国健康体检数据的代谢综合征与骨质疏松的相关性研究。
Biomedical and environmental sciences : BES Pub Date : 2024-12-20 DOI: 10.3967/bes2024.097
Hongyu Chen, Mingyang Zheng, Qingli Cheng, Jiahui Zhao, Yansong Zheng
{"title":"An Investigation of the Association between Metabolic Syndrome and Osteoporosis Based on Chinese Health Examination Data.","authors":"Hongyu Chen, Mingyang Zheng, Qingli Cheng, Jiahui Zhao, Yansong Zheng","doi":"10.3967/bes2024.097","DOIUrl":"10.3967/bes2024.097","url":null,"abstract":"<p><strong>Objective: </strong>Because of the limited number of studies and small sample sizes, whether metabolic syndrome (MS) leads to the occurrence and progression of osteoporosis and the possible underlying mechanisms require further investigation. This study aimed to investigate the association between MS and osteoporosis, along with its influencing factors.</p><p><strong>Methods: </strong>This observational cross-sectional study included 139,470 individuals aged ≥ 18 years who underwent health examinations from September 2014 to March 2022. Based on bone mineral density (BMD) screening results, the participants were categorized into a suspected osteoporosis or non-osteoporosis group (control). Participants were further divided into those who met 0 MS criteria, 1 MS criterion, 2 MS criteria, and ≥ 3 MS criteria (MS group). Participants who had undergone health examinations at least twice formed the follow-up cohort; a self-matched analysis was performed on those with follow-up periods ≥ 5 years and unchanged MS grouping.</p><p><strong>Results: </strong>Several examination indicators in the suspected osteoporosis group showed statistically significant differences compared with the control group. The proportion of suspected osteoporosis in the MS group was significantly increased compared with that in the 0 MS criteria group (odds ratio [ <i>OR</i>]: 1.215, Z = 29.11, <i>P</i> < 0.001, 95% confidence interval: 1.199-1.231). After adjusting for age, sex, smoking, and alcohol consumption, the 2 MS criteria group and MS group still had <i>OR</i> values > 1 ( <i>P</i> < 0.001). In the follow-up cohort, the proportion of suspected osteoporosis increased gradually with an increase in the number of MS criteria met at baseline and during each follow-up visit ( <i>P</i> < 0.05), with the highest proportion observed in the MS group. However, the proportion of suspected osteoporosis did not increase significantly over time in the different MS groups ( <i>P</i> > 0.05). In the follow-up cohort, the proportion of individuals transitioning from normal BMD to suspected osteoporosis was higher in the MS group after ≥ 5 years of follow-up compared with the group meeting 0 MS criteria (0.08% versus 1.15%, <i>χ</i> <sup>2</sup> = 10.76, <i>P</i> = 0.001). There was no significant difference in BMD values for the 0 MS criteria group after 5 years ( <i>P</i> > 0.05), whereas the other three groups experienced a significant decrease in BMD values after 5 years ( <i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>MS is an independent risk factor for osteoporosis, and the effect of risk factors related to MS on osteoporosis may exceed that of aging alone. The specific mechanisms warrant further investigation.</p>","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"37 12","pages":"1385-1396"},"PeriodicalIF":0.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Impact of Environmental Factors on Cardiopulmonary Health. 环境因素对心肺健康的影响。
Biomedical and environmental sciences : BES Pub Date : 2024-12-20 DOI: 10.3967/bes2024.188
Shufeng Chen, Xiangfeng Lu
{"title":"The Impact of Environmental Factors on Cardiopulmonary Health.","authors":"Shufeng Chen, Xiangfeng Lu","doi":"10.3967/bes2024.188","DOIUrl":"https://doi.org/10.3967/bes2024.188","url":null,"abstract":"","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"37 12","pages":"1349-1351"},"PeriodicalIF":0.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect and Mechanism of Action of BMSC-derived Exosomes on Gas Explosion-induced Blast Lung Injury. 骨髓间充质干细胞衍生外泌体对气体爆炸致肺损伤的作用及机制。
Biomedical and environmental sciences : BES Pub Date : 2024-12-20 DOI: 10.3967/bes2024.161
Xiaoying Li, Jing He, Meng Deng, Hui Fan, Xiaofei Jin, Xuedan Deng, Wenjie Ren, Sanqiao Yao, Wu Yao, Changfu Hao
{"title":"Effect and Mechanism of Action of BMSC-derived Exosomes on Gas Explosion-induced Blast Lung Injury.","authors":"Xiaoying Li, Jing He, Meng Deng, Hui Fan, Xiaofei Jin, Xuedan Deng, Wenjie Ren, Sanqiao Yao, Wu Yao, Changfu Hao","doi":"10.3967/bes2024.161","DOIUrl":"https://doi.org/10.3967/bes2024.161","url":null,"abstract":"","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"37 12","pages":"1441-1446"},"PeriodicalIF":0.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between Polyaromatic Hydrocarbons and Allergy among the US General Population. 美国普通人群中多芳烃与过敏的关系。
Biomedical and environmental sciences : BES Pub Date : 2024-12-20 DOI: 10.3967/bes2024.184
Chaochao Wen, Hui Chen, Guodong Ding, Angela Vinturache, Yongjun Zhang
{"title":"Association between Polyaromatic Hydrocarbons and Allergy among the US General Population.","authors":"Chaochao Wen, Hui Chen, Guodong Ding, Angela Vinturache, Yongjun Zhang","doi":"10.3967/bes2024.184","DOIUrl":"https://doi.org/10.3967/bes2024.184","url":null,"abstract":"","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"37 12","pages":"1427-1434"},"PeriodicalIF":0.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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