Biomedical and environmental sciences : BES最新文献_第8页

Secreted Frizzled-Related Protein 5 Mediates Wnt5a Expression in Microcystin-Leucine-Arginine-Induced Liver Lipid Metabolism Disorder in Mice. 分泌型Frizzled相关蛋白5在微囊藻-亮氨酸-精氨酸诱导的小鼠肝脂代谢紊乱中介导Wnt5a的表达

Biomedical and environmental sciences : BES Pub Date : 2024-08-20 DOI: 10.3967/bes2024.081

Mei Yan Yang, Fu Rong Yu, Qian Qian Ji, Hui Ying Zhang, Jia Xiang Zhang, Dao Jun Chen

{"title":"Secreted Frizzled-Related Protein 5 Mediates Wnt5a Expression in Microcystin-Leucine-Arginine-Induced Liver Lipid Metabolism Disorder in Mice.","authors":"Mei Yan Yang, Fu Rong Yu, Qian Qian Ji, Hui Ying Zhang, Jia Xiang Zhang, Dao Jun Chen","doi":"10.3967/bes2024.081","DOIUrl":"10.3967/bes2024.081","url":null,"abstract":"Objective: Microcystin-leucine-arginine (MC-LR) exposure induces lipid metabolism disorders in the liver. Secreted frizzled-related protein 5 (SFRP5) is a natural antagonist of winglesstype MMTV integration site family, member 5A (Wnt5a) and an anti-inflammatory adipocytokine. In this study, we aimed to investigate whether MC-LR can induce lipid metabolism disorders in hepatocytes and whether SFRP5, which has anti-inflammatory effects, can alleviate the effects of hepatic lipid metabolism by inhibiting the Wnt5a/Jun N-terminal kinase (JNK) pathway.Methods: We exposed mice to MC-LR in vivo to induce liver lipid metabolism disorders. Subsequently, mouse hepatocytes that overexpressed SFRP5 or did not express SFRP5 were exposed to MC-LR, and the effects of SFRP5 overexpression on inflammation and Wnt5a/JNK activation by MC-LR were observed.Results: MC-LR exposure induced liver lipid metabolism disorders in mice and significantly decreased SFRP5 mRNA and protein levels in a concentration-dependent manner. SFRP5 overexpression in AML12 cells suppressed MC-LR-induced inflammation. Overexpression of SFRP5 also inhibited Wnt5a and phosphorylation of JNK.Conclusion: MC-LR can induce lipid metabolism disorders in mice, and SFRP5 can attenuate lipid metabolism disorders in the mouse liver by inhibiting Wnt5a/JNK signaling.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"37 8","pages":"850-864"},"PeriodicalIF":0.0,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142094328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TIPE2 is Essential for Apocynin-mediated Protection against Intestinal Ischemia/Reperfusion-induced Acute Lung Injury. TIPE2对阿朴霉素介导的肠缺血/再灌注诱导的急性肺损伤的保护作用至关重要

Biomedical and environmental sciences : BES Pub Date : 2024-08-20 DOI: 10.3967/bes2024.124

Hui Rong Jing, Wen Yan Jia, Xue Wen Tang

引用次数: 0

Synaptic Transmission of Primary Hippocampal Neurons was Enhanced after Terahertz Waves Exposure. 原发性海马神经元的突触传递在太赫兹波暴露后得到增强

Biomedical and environmental sciences : BES Pub Date : 2024-08-20 DOI: 10.3967/bes2024.099

Le Quan Song, Zhi Wei He, Jun Miao Pan, Ji Dong, Hao Yu Wang, Jing Zhang, Bin Wei Yao, Xin Ping Xu, Hui Wang, Li Zhao, Rui Yun Peng

引用次数: 0

Predicting Acute Mountain Sickness Using Regional Sea-Level Cerebral Blood Flow. 利用区域海平面脑血流量预测急性晕山症

Biomedical and environmental sciences : BES Pub Date : 2024-08-20 DOI: 10.3967/bes2024.100

Hao Zhang, Jie Feng, Shi Yu Zhang, Wen Jia Liu, Lin Ma

{"title":"Predicting Acute Mountain Sickness Using Regional Sea-Level Cerebral Blood Flow.","authors":"Hao Zhang, Jie Feng, Shi Yu Zhang, Wen Jia Liu, Lin Ma","doi":"10.3967/bes2024.100","DOIUrl":"https://doi.org/10.3967/bes2024.100","url":null,"abstract":"Objective: To investigate the role of sea-level cerebral blood flow (CBF) in predicting acute mountain sickness (AMS) using three-dimensional pseudo-continuous arterial spin labeling (3D-pCASL).Methods: Forty-eight healthy volunteers reached an altitude of 3,650 m by air after undergoing a head magnetic resonance imaging (MRI) including 3D-pCASL at sea level. The CBF values of the bilateral anterior cerebral artery (ACA), middle cerebral artery (MCA), posterior cerebral artery (PCA), and posterior inferior cerebellar artery (PICA) territories and the laterality index (LI) of CBF were compared between the AMS and non-AMS groups. Statistical analyses were performed to determine the relationship between CBF and AMS, and the predictive performance was assessed using receiver operating characteristic (ROC) curves.Results: The mean cortical CBF in women (81.65 ± 2.69 mL/100 g/min) was higher than that in men (74.35 ± 2.12 mL/100 g/min) ( P < 0.05). In men, the cortical CBF values in the bilateral ACA, PCA, PICA, and right MCA were higher in patients with AMS than in those without. Cortical CBF in the right PCA best predicted AMS (AUC = 0.818). In women, the LI of CBF in the ACA was different between the AMS and non-AMS groups and predicted AMS with an AUC of 0.753.Conclusion: Although the mechanism and prediction of AMS are quite complicated, higher cortical CBF at sea level, especially the CBF of the posterior circulatory system, may be used for prediction in male volunteers using non-invasive 3D-pCASL.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"37 8","pages":"887-896"},"PeriodicalIF":0.0,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142094327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Health Risk Assessment of Employees Exposed to Chlorination By-products of Recreational Water in Large Amusement Parks in Shanghai. 上海大型游乐园员工接触娱乐用水氯化副产物的健康风险评估。

Biomedical and environmental sciences : BES Pub Date : 2024-08-20 DOI: 10.3967/bes2024.082

Wei Zhao Cao, Yi Ming Zheng, Wen Xuan Zhao, Li Sha Shi, Yun Hui Zhang, Li Jun Zhang, Jian Chen

{"title":"Health Risk Assessment of Employees Exposed to Chlorination By-products of Recreational Water in Large Amusement Parks in Shanghai.","authors":"Wei Zhao Cao, Yi Ming Zheng, Wen Xuan Zhao, Li Sha Shi, Yun Hui Zhang, Li Jun Zhang, Jian Chen","doi":"10.3967/bes2024.082","DOIUrl":"https://doi.org/10.3967/bes2024.082","url":null,"abstract":"Objective: Chlorination is often used to disinfect recreational water in large amusement parks; however, the health hazards of chlorination disinfection by-products (DBPs) to occupational populations are unknown. This study aimed to assess the exposure status of chlorinated DBPs in recreational water and the health risks to employees of large amusement parks.Methods: Exposure parameters of employees of three large amusement parks in Shanghai were investigated using a questionnaire. Seven typical chlorinated DBPs in recreational water and spray samples were quantified by gas chromatography, and the health risks to amusement park employees exposed to chlorinated DBPs were evaluated according to the WHO's risk assessment framework.Results: Trichloroacetic acid, dibromochloromethane, bromodichloromethane, and dichloroacetic acid were detected predominantly in recreational water. The carcinogenic and non-carcinogenic risks of the five DBPs did not exceed the risk thresholds. In addition, the carcinogenic and non-carcinogenic risks of mixed exposure to DBPs were within the acceptable risk limits.Conclusion: Typical DBPs were widely detected in recreational water collected from three large amusement parks in Shanghai; however, the health risks of DBPs and their mixtures were within acceptable limits.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"37 8","pages":"865-875"},"PeriodicalIF":0.0,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142094322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-Term Survival Trend of Gynecological Cancer: A Systematic Review of Population-Based Cancer Registration Data. 妇科癌症的长期生存趋势：基于人口的癌症登记数据的系统性回顾。

Biomedical and environmental sciences : BES Pub Date : 2024-08-20 DOI: 10.3967/bes2024.133

Xiao Hui Zhou, Dan Ni Yang, Yi Xin Zou, Dan Dan Tang, Jun Chen, Zhuo Ying Li, Qiu Ming Shen, Qun Xu, Yong Bing Xiang

{"title":"Long-Term Survival Trend of Gynecological Cancer: A Systematic Review of Population-Based Cancer Registration Data.","authors":"Xiao Hui Zhou, Dan Ni Yang, Yi Xin Zou, Dan Dan Tang, Jun Chen, Zhuo Ying Li, Qiu Ming Shen, Qun Xu, Yong Bing Xiang","doi":"10.3967/bes2024.133","DOIUrl":"https://doi.org/10.3967/bes2024.133","url":null,"abstract":"Gynecological cancer significantly affect the health of women. This review aimed to describe the global patterns and trends in the survival of patients with gynecological cancers. We searched PubMed, Embase, Web of Science, SinoMed, and SEER for survival analyses of cancer registration data of cervical, endometrial, and ovarian cancers published between 1980 and 2022. Globally, the highest 5-year observed survival rate for cervical cancer was 76.5% in Anshan, Liaoning, China (2008-2017). The 5-year observed survival rates of endometrial and ovarian cancers were higher in Finland (1995-1999, 82.5%) and Singapore (1988-1992, 62.0%). The 5-year relative survival rate of cervical cancer patients was higher in Haining, Zhejiang, China (2011-2014, 85.8%). Korea ranked first at 89.0% and 64.5% for endometrial and ovarian cancers, respectively. Survival rates have improved for cervical, endometrial, and ovarian cancers. Patients aged ≥ 75 years and those with advanced-stage disease had the worst 5-year survival rates. Survival rates were better for squamous cell carcinoma in cervical cancer, for endometrial carcinoma and mucinous adenocarcinoma in endometrial cancer, and for germ cell and sex-cord stromal tumors in ovarian cancer. Over the past four decades, the survival rates of gynecological cancers have increased globally, with notable increases in cervical and endometrial cancers. Survival rates are higher in developed countries, with a slow-growing trend. Future studies should focus on improving survival, especially in ovarian cancer patients.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"37 8","pages":"897-921"},"PeriodicalIF":0.0,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142094324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Curcumin on Neuroinflammation and the Nrf2/HO-1 Pathway in Rat Brains Following Gas Explosion. 姜黄素对毒气爆炸后大鼠大脑神经炎症和 Nrf2/HO-1 通路的影响

Biomedical and environmental sciences : BES Pub Date : 2024-08-20 DOI: 10.3967/bes2024.116

Xin Wen Dong, Ya Guang Su, Zheng Luo, Lyu Fei Deng, Xiao Feng Han, Yi Fang Liang, San Qiao Yao, Wei Dong Wu, Jia Cao, Lin Qiang Tian, Yi Chun Bai, Wen Jie Ren

引用次数: 0

Molecular Investigation of Theileria in Ixodid Ticks from Changzhi, Shanxi Province, China. 中国山西省长治市蜱虫中忒伊勒氏菌的分子研究

Biomedical and environmental sciences : BES Pub Date : 2024-08-20 DOI: 10.3967/bes2024.098

Jia Cui, Hua Xiang Rao, Yi Ping Liu, Dong Mei Li, Juan Yu

引用次数: 0

Changes on Stroke Burden Attributable to Ambient Fine Particulate Matter in China. 中国环境细颗粒物对脑卒中负担的影响变化。

Biomedical and environmental sciences : BES Pub Date : 2024-08-20 DOI: 10.3967/bes2024.083

Jing Yu Wang, Yan Wang, Xiao Hua Liang, Ke Yong Huang, Fang Chao Liu, Shu Feng Chen, Xiang Feng Lu, Jian Xin Li

{"title":"Changes on Stroke Burden Attributable to Ambient Fine Particulate Matter in China.","authors":"Jing Yu Wang, Yan Wang, Xiao Hua Liang, Ke Yong Huang, Fang Chao Liu, Shu Feng Chen, Xiang Feng Lu, Jian Xin Li","doi":"10.3967/bes2024.083","DOIUrl":"https://doi.org/10.3967/bes2024.083","url":null,"abstract":"Objective: In recent decades, China has implemented a series of policies to address air pollution. We aimed to assess the health effects of these policies on stroke burden attributable to ambient fine particulate matter (PM 2.5).Methods: Joinpoint regression was applied to explore the temporal tendency of stroke burden based on data from the Global Burden of Disease 2019 study.Results: The age-standardized rates of disability-adjusted life year (DALY) for stroke attributable to ambient PM 2.5 in China, increased dramatically during 1990-2012, subsequently decreased at an annual percentage change (APC) of -1.98 [95% confidence interval ( CI): -2.26, -1.71] during 2012-2019. For ischemic stroke (IS), the age-standardized DALY rates doubled from 1990 to 2014, and decreased at an APC of -0.83 (95% CI: -1.33, -0.33) during 2014-2019. Intracerebral hemorrhage (ICH) showed a substantial increase in age-standardized DALY rates from 1990 to 2003, followed by declining trends, with APCs of -1.46 (95% CI: -2.74, -0.16) during 2003-2007 and -3.33 (95% CI: -3.61, -3.06) during 2011-2019, respectively. Conversely, the age-standardized DALY rates for subarachnoid hemorrhage (SAH) generally declined during 1990-2019.Conclusion: Our results clarified the dynamic changes of the ambient PM 2.5-attributable stroke burden in China during 1990-2019, highlighting the health effects of air quality improvement policies.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"37 8","pages":"823-833"},"PeriodicalIF":0.0,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142094320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Air Pollutants on Lung Function and Inflammatory Response in Asthma in Shanghai. 空气污染物对上海哮喘患者肺功能和炎症反应的影响

Biomedical and environmental sciences : BES Pub Date : 2024-08-20 DOI: 10.3967/bes2024.125

Gui Fang Wang, You Zhi Zhang, Hai Yan Yang, Yi Yang, Liang Dong, Peng Zhang, Jie Liu, Xiao Dong Chen, Yi Gong

{"title":"Impact of Air Pollutants on Lung Function and Inflammatory Response in Asthma in Shanghai.","authors":"Gui Fang Wang, You Zhi Zhang, Hai Yan Yang, Yi Yang, Liang Dong, Peng Zhang, Jie Liu, Xiao Dong Chen, Yi Gong","doi":"10.3967/bes2024.125","DOIUrl":"https://doi.org/10.3967/bes2024.125","url":null,"abstract":"Objective: Air pollution is a leading public health issue. This study investigated the effect of air quality and pollutants on pulmonary function and inflammation in patients with asthma in Shanghai.Methods: The study monitored 27 asthma outpatients for a year, collecting data on weather, patient self-management [daily asthma diary, peak expiratory flow (PEF) monitoring, medication usage], spirometry and serum markers. To explore the potential mechanisms of any effects, asthmatic mice induced by ovalbumin (OVA) were exposed to PM 2.5.Results: Statistical and correlational analyses revealed that air pollutants have both acute and chronic effects on asthma. Acute exposure showed a correlation between PEF and levels of ozone (O 3) and nitrogen dioxide (NO 2). Chronic exposure indicated that interleukin-5 (IL-5) and interleukin-13 (IL-13) levels correlated with PM 2.5 and PM 10 concentrations. In asthmatic mouse models, exposure to PM 2.5 increased cytokine levels and worsened lung function. Additionally, PM 2.5 exposure inhibited cell proliferation by blocking the NF-κB and ERK phosphorylation pathways.Conclusion: Ambient air pollutants exacerbate asthma by worsening lung function and enhancing Th2-mediated inflammation. Specifically, PM 2.5 significantly contributes to these adverse effects. Further research is needed to elucidate the mechanisms by which PM 2.5 impacts asthma.","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"37 8","pages":"811-822"},"PeriodicalIF":0.0,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142094323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0