Biomedical and environmental sciences : BES最新文献

{"title":"Association between Non-high-density Lipoprotein Cholesterol to High-density Lipoprotein Cholesterol Ratio (NHHR) and Stroke among Adults in the USA: A Cross-Sectional NHANES Study.","authors":"Hai Xia Ma, Hua Qiu Chen, Pei Chang Wang","doi":"10.3967/bes2025.001","DOIUrl":"10.3967/bes2025.001","url":null,"abstract":"<p><strong>Objective: </strong>The relationship between non-high-density lipoprotein (NHDL) cholesterol to high-density lipoprotein cholesterol (HDL-C) ratio (NHHR) and stoke remains unknown. This study aimed to evaluate the association between the adult NHHR and stroke occurrence in the United States of America (USA).</p><p><strong>Methods: </strong>To clarify the relationship between the NHHR and stroke risk, this study used a multivariable logistic regression model and a restricted cubic spline (RCS) model to investigate the association between the NHHR and stroke, and data from the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2018. Subgroup and sensitivity analyses were conducted to test the robustness of the results.</p><p><strong>Results: </strong>This study included 29,928 adult participants, of which 1,165 participants had a history of stroke. Logistic regression analysis of variables demonstrated a positive association between NHHR and stroke ( <i>OR</i> 1.24, 95% <i>CI</i>: 1.03-1.50, <i>P</i> = 0.026). Compared with the lowest reference group of NHHR, participants in the second, third, and fourth quartile had a significantly increased risk of stroke after full adjustments ( <i>OR</i>: 1.35, 95% <i>CI</i>: 1.08-1.69) ( <i>OR</i>: 1.83, 95% <i>CI:</i> 1.42-2.36) ( <i>OR</i>: 2.04, 95% <i>CI</i>: 1.50-2.79). In the total population, a nonlinear dose-response relationship was observed between the NHHR and stroke risk ( <i>P</i> non-linearity = 0.002). This association remained significant in several subgroup analyses. Further investigation of the NHHR may enhance our understanding of stroke prevention and treatment.</p><p><strong>Conclusion: </strong>Our findings suggest a positive correlation between the NHHR and an increased prevalence of stroke, potentially serving as a novel predictive factor for stroke. Timely intervention and management of the NHHR may effectively mitigate stroke occurrence. Prospective studies are required to validate this association and further explore the underlying biological mechanisms.</p>","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"38 1","pages":"37-46"},"PeriodicalIF":0.0,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"W ₁₈O ₄₉ Crystal and ICG Labeled Macrophage: An Efficient Targeting Vector for Fluorescence Imaging-guided Photothermal Therapy.","authors":"Yang Bai, Guo Qing Feng, Muskan Saif Khan, Qing Bin Yang, Ting Ting Hua, Hao Lin Guo, Yuan Liu, Bo Wen Li, Yi Wen Wu, Bin Zheng, Nian Song Qian, Qing Yuan","doi":"10.3967/bes2024.171","DOIUrl":"https://doi.org/10.3967/bes2024.171","url":null,"abstract":"","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"38 1","pages":"100-105"},"PeriodicalIF":0.0,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Fish Consumption and Stroke Incidence Across Different Predicted Risk Populations: A Prospective Cohort Study from China.","authors":"Hong Yue Hu, Fang Chao Liu, Ke Yong Huang, Chong Shen, Jian Liao, Jian Xin Li, Chen Xi Yuan, Ying Li, Xue Li Yang, Ji Chun Chen, Jie Cao, Shu Feng Chen, Dong Sheng Hu, Jian Feng Huang, Xiang Feng Lu, Dong Feng Gu","doi":"10.3967/bes2025.003","DOIUrl":"10.3967/bes2025.003","url":null,"abstract":"<p><strong>Objective: </strong>The relationship between fish consumption and stroke is inconsistent, and it is uncertain whether this association varies across predicted stroke risks.</p><p><strong>Methods: </strong>A cohort study comprising 95,800 participants from the Prediction for Atherosclerotic Cardiovascular Disease Risk in China project was conducted. A standardized questionnaire was used to collect data on fish consumption. Participants were stratified into low- and moderate-to-high-risk categories based on their 10-year stroke risk prediction scores. Hazard ratios ( <i>HRs</i>) and 95% confidence intervals ( <i>CIs</i>) were estimated using Cox proportional hazard models and additive interaction by relative excess risk due to interaction (RERI), attributable proportion (AP), and synergy index (SI).</p><p><strong>Results: </strong>During 703,869 person-years of follow-up, 2,773 incident stroke events were identified. Higher fish consumption was associated with a lower risk of stroke, particularly among moderate-to-high-risk individuals ( <i>HR</i> = 0.53, 95% <i>CI</i>: 0.47-0.60) than among low-risk individuals ( <i>HR</i> = 0.64, 95% <i>CI</i>: 0.49-0.85). A significant additive interaction between fish consumption and predicted stroke risk was observed (RERI = 4.08, 95% <i>CI</i>: 2.80-5.36; SI = 1.64, 95% <i>CI</i>: 1.42-1.89; AP = 0.36, 95% <i>CI</i>: 0.28-0.43).</p><p><strong>Conclusion: </strong>Higher fish consumption was associated with a lower risk of stroke, and this beneficial association was more pronounced in individuals with moderate-to-high stroke risk.</p>","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"38 1","pages":"15-26"},"PeriodicalIF":0.0,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Sequential Mediating Roles of Body Pain and Self-Reported Health Status in the Relationship between Sleep Duration and Life Satisfaction.","authors":"Jia Feng Li, Xue Wei Fu, Dan Yang, Ye Wang, Ting Chen, Yang Peng, Feng Hao Yang, Yu Chen Zhan, Yu Wang, Xiang Dong Tang","doi":"10.3967/bes2024.185","DOIUrl":"10.3967/bes2024.185","url":null,"abstract":"<p><strong>Objective: </strong>This study examines the sequential mediating roles of body pain and self-reported health in the association between sleep duration and self-reported life satisfaction among elderly Chinese adults.</p><p><strong>Methods: </strong>Data from the fifth wave of the China Health and Retirement Longitudinal Survey (CHARLS) were used to analyse the relationships between sleep duration and body pain, self-reported health, and life satisfaction through logistic regression and Restricted Cubic Spline (RCS) analyses. The sequential mediation effects of body pain and self-reported health status were examined <i>via</i> chain mediation analysis.</p><p><strong>Results: </strong>Logistic regression analysis showed that sleeping fewer than 6 hours or 6-7 hours was linked to higher risks of body pain, poor health, and dissatisfaction with life compared to sleeping 7-8 hours (all <i>P</i> < 0.05). Additionally, those sleeping more than 9 hours also had increased risks of poor health and dissatisfaction with life compared to those sleeping 7-8 hours (all <i>P</i> < 0.05). Chain mediation analysis showed that body pain and self-reported health status sequentially mediated 46.15% of the association between sleep duration and life satisfaction.</p><p><strong>Conclusion: </strong>Body pain and self-reported health may shape the relationship between sleep duration and life satisfaction in elderly Chinese adults.</p>","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"38 1","pages":"47-55"},"PeriodicalIF":0.0,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammatory Bowel Disease and Dementia: Evidence Triangulation from a Meta-Analysis of Observational Studies and Mendelian Randomization Study.","authors":"Di Liu, Mei Ling Cao, Shan Shan Wu, Bing Li Li, Yi Wen Jiang, Teng Fei Lin, Fu Xiao Li, Wei Jie Cao, Jin Qiu Yuan, Feng Sha, Zhi Rong Yang, Jin Ling Tang","doi":"10.3967/bes2024.149","DOIUrl":"10.3967/bes2024.149","url":null,"abstract":"<p><strong>Objective: </strong>Observational studies have found associations between inflammatory bowel disease (IBD) and the risk of dementia, including Alzheimer's dementia (AD) and vascular dementia (VD); however, these findings are inconsistent. It remains unclear whether these associations are causal.</p><p><strong>Methods: </strong>We conducted a meta-analysis by systematically searching for observational studies on the association between IBD and dementia. Mendelian randomization (MR) analysis based on summary genome-wide association studies (GWASs) was performed. Genetic correlation and Bayesian co-localization analyses were used to provide robust genetic evidence.</p><p><strong>Results: </strong>Ten observational studies involving 80,565,688 participants were included in this meta-analysis. IBD was significantly associated with dementia (risk ratio [ <i>RR</i>] =1.36, 95% <i>CI</i> = 1.04-1.78; <i>I</i> ² = 84.8%) and VD ( <i>RR</i> = 2.60, 95% <i>CI</i> = 1.18-5.70; only one study), but not with AD ( <i>RR</i> = 2.00, 95% <i>CI</i> = 0.96-4.13; <i>I</i> ² = 99.8%). MR analyses did not supported significant causal associations of IBD with dementia (dementia: odds ratio [ <i>OR</i>] = 1.01, 95% <i>CI</i> = 0.98-1.03; AD: <i>OR</i> = 0.98, 95% <i>CI</i> = 0.95-1.01; VD: <i>OR</i> = 1.02, 95% <i>CI</i> = 0.97-1.07). In addition, genetic correlation and co-localization analyses did not reveal any genetic associations between IBD and dementia.</p><p><strong>Conclusion: </strong>Our study did not provide genetic evidence for a causal association between IBD and dementia risk. The increased risk of dementia observed in observational studies may be attributed to unobserved confounding factors or detection bias.</p>","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"38 1","pages":"56-66"},"PeriodicalIF":0.0,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting Diabetic Retinopathy Using a Machine Learning Approach Informed by Whole-Exome Sequencing Studies.","authors":"Chong Yang She, Wen Ying Fan, Yun Yun Li, Yong Tao, Zu Fei Li","doi":"10.3967/bes2025.002","DOIUrl":"10.3967/bes2025.002","url":null,"abstract":"<p><strong>Objective: </strong>To establish and validate a novel diabetic retinopathy (DR) risk-prediction model using a whole-exome sequencing (WES)-based machine learning (ML) method.</p><p><strong>Methods: </strong>WES was performed to identify potential single nucleotide polymorphism (SNP) or mutation sites in a DR pedigree comprising 10 members. A prediction model was established and validated in a cohort of 420 type 2 diabetic patients based on both genetic and demographic features. The contribution of each feature was assessed using Shapley Additive explanation analysis. The efficacies of the models with and without SNP were compared.</p><p><strong>Results: </strong>WES revealed that seven SNPs/mutations ( <i>rs116911833 in TRIM7, 1997T>C in LRBA, 1643T>C in PRMT10,</i> rs117858678 in <i>C9orf152</i>, <i>rs201922794 in CLDN25</i>, <i>rs146694895 in SH3GLB2</i>, and <i>rs201407189 in FANCC</i>) were associated with DR. Notably, the model including <i>rs146694895</i> <i>and rs201407189</i> achieved better performance in predicting DR (accuracy: 80.2%; sensitivity: 83.3%; specificity: 76.7%; area under the receiver operating characteristic curve [AUC]: 80.0%) than the model without these SNPs (accuracy: 79.4%; sensitivity: 80.3%; specificity: 78.3%; AUC: 79.3%).</p><p><strong>Conclusion: </strong>Novel SNP sites associated with DR were identified in the DR pedigree. Inclusion of <i>rs146694895</i> and <i>rs201407189</i> significantly enhanced the performance of the ML-based DR prediction model.</p>","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"38 1","pages":"67-78"},"PeriodicalIF":0.0,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolomic Changes in Mice Induced by Copper Exposure: Systematic Analysis and Exploration of Toxicity Mechanisms.","authors":"Shuai Xiao, Lin Qiang Gong, Shi Yuan Zhao, Xue Chu, Feng Feng Li, Ya Zhou Zhang, Fang Qiang Song, Pei Jiang","doi":"10.3967/bes2024.179","DOIUrl":"https://doi.org/10.3967/bes2024.179","url":null,"abstract":"","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"38 1","pages":"106-111"},"PeriodicalIF":0.0,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glycemic Control and Diabetes Duration in Relation to Subsequent Myocardial Infarction among Patients with Coronary Heart Disease and Type 2 Diabetes.","authors":"Fu Rong Li, Yan Dou, Chun Bao Mo, Shuang Wang, Jing Zheng, Dong Feng Gu, Feng Chao Liang","doi":"10.3967/bes2024.187","DOIUrl":"10.3967/bes2024.187","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the impact of glycemic control and diabetes duration on subsequent myocardial infarction (MI) in patients with both coronary heart disease (CHD) and type 2 diabetes (T2D).</p><p><strong>Methods: </strong>We conducted a retrospective cohort study of 33,238 patients with both CHD and T2D in Shenzhen, China. Patients were categorized into 6 groups based on baseline fasting plasma glucose (FPG) levels and diabetes duration (from the date of diabetes diagnosis to the baseline date) to examine their combined effects on subsequent MI. Cox proportional hazards regression models were used, with further stratification by age, sex, and comorbidities to assess potential interactions.</p><p><strong>Results: </strong>Over a median follow-up of 2.4 years, 2,110 patients experienced MI. Compared to those with optimal glycemic control (FPG < 6.1 mmol/L) and shorter diabetes duration (< 10 years), the fully-adjusted hazard ratio ( <i>HR</i>) (95% Confidence Interval [95% <i>CI</i>]) for those with a diabetes duration of ≥ 10 years and FPG > 8.0 mmol/L was 1.93 (95% <i>CI</i>: 1.59, 2.36). The combined effects of FPG and diabetes duration on MI were largely similar across different age, sex, and comorbidity groups, although the excess risk of MI associated with long-term diabetes appeared to be more pronounced among those with atrial fibrillation.</p><p><strong>Conclusion: </strong>Our study indicates that glycemic control and diabetes duration significant influence the subsequent occurrence of MI in patients with both CHD and T2D. Tailored management strategies emphasizing strict glycemic control may be particularly beneficial for patients with longer diabetes duration and atrial fibrillation.</p>","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"38 1","pages":"27-36"},"PeriodicalIF":0.0,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nogo-A Protein Mediates Oxidative Stress and Synaptic Damage Induced by High-Altitude Hypoxia in the Rat Hippocampus.","authors":"Jin Yu Fang, Huai Cun Liu, Yan Fei Zhang, Quan Cheng Cheng, Zi Yuan Wang, Xuan Fang, Hui Ru Ding, Wei Guang Zhang, Chun Hua Chen","doi":"10.3967/bes2024.112","DOIUrl":"10.3967/bes2024.112","url":null,"abstract":"<p><strong>Objective: </strong>High-altitude hypoxia exposure often damages hippocampus-dependent learning and memory. Nogo-A is an important axonal growth inhibitory factor. However, its function in high-altitude hypoxia and its mechanism of action remain unclear.</p><p><strong>Methods: </strong>In an <i>in vivo</i> study, a low-pressure oxygen chamber was used to simulate high-altitude hypoxia, and genetic or pharmacological intervention was used to block the Nogo-A/NgR1 signaling pathway. Contextual fear conditioning and Morris water maze behavioral tests were used to assess learning and memory in rats, and synaptic damage in the hippocampus and changes in oxidative stress levels were observed. <i>In vitro</i>, SH-SY5Y cells were used to assess oxidative stress and mitochondrial function with or without Nogo-A knockdown in Oxygen Glucose-Deprivation/Reperfusion (OGD/R) models.</p><p><strong>Results: </strong>Exposure to acute high-altitude hypoxia for 3 or 7 days impaired learning and memory in rats, triggered oxidative stress in the hippocampal tissue, and reduced the dendritic spine density of hippocampal neurons. Blocking the Nogo-A/NgR1 pathway ameliorated oxidative stress, synaptic damage, and the learning and memory impairment induced by high-altitude exposure.</p><p><strong>Conclusion: </strong>Our results demonstrate the detrimental role of Nogo-A protein in mediating learning and memory impairment under high-altitude hypoxia and suggest the potential of the Nogo-A/NgR1 signaling pathway as a crucial therapeutic target for alleviating learning and memory dysfunction induced by high-altitude exposure.</p><p><strong>Graphical abstract: </strong>available in www.besjournal.com.</p>","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"38 1","pages":"79-93"},"PeriodicalIF":0.0,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of Associated Factors and Microbiota of Different Oral Niches in Early Childhood Caries.","authors":"Shuai Tang, Ze Jun Zheng, Ze Kun Li, Qing Wang, Shuang Zhu, Tong Yang, Gang Ding","doi":"10.3967/bes2024.186","DOIUrl":"https://doi.org/10.3967/bes2024.186","url":null,"abstract":"","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"38 1","pages":"112-118"},"PeriodicalIF":0.0,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}