Research Advances in the Construction and Application of Intestinal Organoids.

Qing Xue Meng, Hong Yang Yi, Peng Wang, Shan Liu, Wei Quan Liang, Cui Shan Chi, Chen Yu Mao, Wei Zheng Liang, Jun Xue, Hong Zhou Lu
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Abstract

The structure of intestinal tissue is complex. In vitro simulation of intestinal structure and function is important for studying intestinal development and diseases. Recently, organoids have been successfully constructed and they have come to play an important role in biomedical research. Organoids are miniaturized three-dimensional (3D) organs, derived from stem cells, which mimic the structure, cell types, and physiological functions of an organ, making them robust models for biomedical research. Intestinal organoids are 3D micro-organs derived from intestinal stem cells or pluripotent stem cells that can successfully simulate the complex structure and function of the intestine, thereby providing a valuable platform for intestinal development and disease research. In this article, we review the latest progress in the construction and application of intestinal organoids.

肠道类器官的构建与应用研究进展。
肠道组织的结构是复杂的。体外模拟肠道结构和功能对研究肠道发育和疾病具有重要意义。近年来,类器官已被成功构建,并在生物医学研究中发挥了重要作用。类器官是源自干细胞的微型化三维(3D)器官,模仿器官的结构、细胞类型和生理功能,使其成为生物医学研究的强大模型。肠道类器官是由肠道干细胞或多能干细胞衍生的三维微器官,可以成功模拟肠道的复杂结构和功能,为肠道发育和疾病研究提供了有价值的平台。本文就肠道类器官的构建和应用的最新进展作一综述。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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