基于中国健康体检数据的代谢综合征与骨质疏松的相关性研究。

Hongyu Chen, Mingyang Zheng, Qingli Cheng, Jiahui Zhao, Yansong Zheng
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引用次数: 0

摘要

目的:由于研究数量有限,样本量小,代谢综合征(metabolic syndrome, MS)是否导致骨质疏松症的发生、发展及其可能的机制有待进一步研究。本研究旨在探讨多发性硬化症与骨质疏松症的关系及其影响因素。方法:本观察性横断面研究纳入了2014年9月至2022年3月期间接受健康检查的139,470名年龄≥18岁的个体。根据骨密度(BMD)筛查结果,参与者被分为疑似骨质疏松症组和非骨质疏松症组(对照组)。参与者进一步分为满足0个MS标准、1个MS标准、2个MS标准和≥3个MS标准(MS组)。接受过至少两次健康检查的参与者组成随访队列;随访期≥5年且MS组不变的患者进行自匹配分析。结果:疑似骨质疏松组多项检查指标与对照组比较,差异有统计学意义。与0 MS标准组相比,MS组疑似骨质疏松的比例显著增加(优势比[OR]: 1.215, Z = 29.11, P < 0.001, 95%可信区间:1.199 ~ 1.231)。在调整了年龄、性别、吸烟和饮酒等因素后,2 MS标准组和MS组的OR值仍为bbb1 (P < 0.001)。在随访队列中,随着基线和每次随访时满足MS标准的次数的增加,疑似骨质疏松的比例逐渐增加(P < 0.05),其中MS组比例最高。然而,不同MS组中疑似骨质疏松的比例并没有随着时间的推移而显著增加(P < 0.05)。在随访队列中,随访≥5年后,MS组从正常骨密度过渡到疑似骨质疏松症的个体比例高于满足0 MS标准的组(0.08%比1.15%,χ 2 = 10.76, P = 0.001)。0 MS标准组5年后骨密度值差异无统计学意义(P < 0.05),而其他3组5年后骨密度值显著降低(P < 0.05)。结论:MS是骨质疏松的独立危险因素,与MS相关的危险因素对骨质疏松的影响可能超过单纯的衰老。具体机制值得进一步调查。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
An Investigation of the Association between Metabolic Syndrome and Osteoporosis Based on Chinese Health Examination Data.

Objective: Because of the limited number of studies and small sample sizes, whether metabolic syndrome (MS) leads to the occurrence and progression of osteoporosis and the possible underlying mechanisms require further investigation. This study aimed to investigate the association between MS and osteoporosis, along with its influencing factors.

Methods: This observational cross-sectional study included 139,470 individuals aged ≥ 18 years who underwent health examinations from September 2014 to March 2022. Based on bone mineral density (BMD) screening results, the participants were categorized into a suspected osteoporosis or non-osteoporosis group (control). Participants were further divided into those who met 0 MS criteria, 1 MS criterion, 2 MS criteria, and ≥ 3 MS criteria (MS group). Participants who had undergone health examinations at least twice formed the follow-up cohort; a self-matched analysis was performed on those with follow-up periods ≥ 5 years and unchanged MS grouping.

Results: Several examination indicators in the suspected osteoporosis group showed statistically significant differences compared with the control group. The proportion of suspected osteoporosis in the MS group was significantly increased compared with that in the 0 MS criteria group (odds ratio [ OR]: 1.215, Z = 29.11, P < 0.001, 95% confidence interval: 1.199-1.231). After adjusting for age, sex, smoking, and alcohol consumption, the 2 MS criteria group and MS group still had OR values > 1 ( P < 0.001). In the follow-up cohort, the proportion of suspected osteoporosis increased gradually with an increase in the number of MS criteria met at baseline and during each follow-up visit ( P < 0.05), with the highest proportion observed in the MS group. However, the proportion of suspected osteoporosis did not increase significantly over time in the different MS groups ( P > 0.05). In the follow-up cohort, the proportion of individuals transitioning from normal BMD to suspected osteoporosis was higher in the MS group after ≥ 5 years of follow-up compared with the group meeting 0 MS criteria (0.08% versus 1.15%, χ 2 = 10.76, P = 0.001). There was no significant difference in BMD values for the 0 MS criteria group after 5 years ( P > 0.05), whereas the other three groups experienced a significant decrease in BMD values after 5 years ( P < 0.05).

Conclusion: MS is an independent risk factor for osteoporosis, and the effect of risk factors related to MS on osteoporosis may exceed that of aging alone. The specific mechanisms warrant further investigation.

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