The Impact of Reproductive Traits on Psoriasis Risk is Mediated by Education Attainment and Body Mass Index: A Mendelian Randomization Study.

Biomedical and environmental sciences : BES Pub Date : 2025-03-20 DOI:10.3967/bes2024.122

Ya Jia Li, Qiang Xiang Li, Zi Qin Cao, Jian Huang Wu

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Abstract

Objective: To explore the causality between reproductive traits and risk of psoriasis by using a large Mendelian randomization (MR) study.

Methods: A two-sample MR study was performed using summarized statistics from the genome-wide association studies (GWAS) conducted in reproductive traits, as well as GWAS data on overall psoriasis, psoriatic arthritis (PsA), and psoriasis vulgaris (PV). Besides univariable MR (UVMR), multivariable MR and two-step MR was used to calculate the independent effects and quantify the proportion mediated by education or body mass index (BMI).

Results: Genetically predicted early age at first sexual intercourse (AFS) led to an increased risk of overall psoriasis [odds ratio ( OR) _UVMR: 0.54]; 36.13% of this effect was mediated through BMI and 47.79% through educational attainment. The direct negative casual association between age at first birth (AFB)-PsA was dominant ( OR _UVMR: 0.76), with 49.61% proportion of the mediation due to BMI. The mediating effect was found for BMI on the AFS-PV relationship, which accounted for 26.27% of the proportion. AFS was inversely associated with the risk of overall psoriasis and PV, with considerable mediation by BMI and educational attainment.

Conclusion: Early AFB may cause a higher risk of PsA, while the AFS-PsA association was fully mediated by BMI.

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生殖性状对银屑病风险的影响受教育程度和体重指数的调节：一项孟德尔随机研究。

目的：通过大型孟德尔随机化（MR）研究，探讨生殖性状与银屑病发病风险之间的因果关系。方法：利用生殖性状全基因组关联研究（GWAS）的汇总统计数据，以及整体银屑病、银屑病关节炎（PsA）和寻常型银屑病（PV）的GWAS数据，进行两样本MR研究。除了单变量磁共振（UVMR）外，我们还使用多变量磁共振和两步磁共振来计算独立效应，并量化受教育程度或体重指数（BMI）介导的比例。结果：基因预测的第一次性交年龄（AFS）会导致整体牛皮癣风险增加[比值比（OR） UVMR: 0.54]；其中36.13%的影响是由BMI介导的，47.79%是由受教育程度介导的。第一胎年龄(AFB)-PsA之间的直接负相关是显性的（OR UVMR: 0.76），其中由BMI介导的比例为49.61%。BMI对AFS-PV关系有中介作用，占26.27%的比例。AFS与整体牛皮癣和PV的风险呈负相关，BMI和受教育程度有相当大的中介作用。结论：早期AFB可能导致PsA发生风险增高，而AFS-PsA之间的关联完全由BMI介导。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Biomedical and environmental sciences : BES

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