Biomaterials research最新文献_第6页

Perfluorocarbon Nanoparticles Loaded with Oxygen Alleviate Acute Kidney Injury via Ameliorating Renal Oxygenation Level. 载氧的全氟碳纳米颗粒通过改善肾氧合水平减轻急性肾损伤。

IF 8.1

Biomaterials research Pub Date : 2025-04-10 eCollection Date: 2025-01-01 DOI: 10.34133/bmr.0181

Dasheng Li, Yisong Ju, Qingsong Ye, Yuanyuan Chang, Chaoli An, Beibei Liu, Li Lu, Jinhui Wu, Xiaozhi Zhao

{"title":"Perfluorocarbon Nanoparticles Loaded with Oxygen Alleviate Acute Kidney Injury via Ameliorating Renal Oxygenation Level.","authors":"Dasheng Li, Yisong Ju, Qingsong Ye, Yuanyuan Chang, Chaoli An, Beibei Liu, Li Lu, Jinhui Wu, Xiaozhi Zhao","doi":"10.34133/bmr.0181","DOIUrl":"https://doi.org/10.34133/bmr.0181","url":null,"abstract":"Renal microcirculatory disturbances and tissue hypoxia play a pivotal role in acute kidney injury (AKI) initiation and progression, and addressing renal hypoxia during the acute phase presents a promising therapeutic strategy for preventing AKI or protecting kidney function. In this study, we explored the renal protective potential of perfluorocarbon nanoparticles (PFPs), engineered for superior oxygen-carrying and delivery capacities, in an AKI mouse. Specifically, PFP-treated mice exhibited significant reductions in tubular dilation, necrosis, and brush border loss in renal tubules. Additionally, PFP pretreatment reduced tissue inflammation and fibrosis, as indicated by decreased nuclear factor-kappa B, α-smooth muscle actin, fibronectin, and collagen I expression. Serum creatinine and blood urea nitrogen levels improved, decreasing by 26.9% and 41.7%, respectively. Flow cytometry further showed controlled levels of f4/80+ macrophages and CD45+ inflammatory markers, with f4/80+ macrophages reduced by approximately 31.2% and CD45+ inflammatory factors reduced by 40.5%. Metabolomic analyses highlighted PFP's modulation of key metabolic pathways linked to renal recovery, notably up-regulating slc22a19 by 48.3%, a gene encoding a short-chain fatty acid transporter, and down-regulating hyaluronic acid synthesis in renal tissue. These findings are the first to demonstrate that PFPs, as an oxygen carrier, can enhance renal resilience against IR (ischemia-reperfusion)-induced AKI, offering compelling evidence of PFP's clinical potential in AKI management.","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"29 ","pages":"0181"},"PeriodicalIF":8.1,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11982615/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144031923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Near-Infrared Light-Controlled Dynamic Hydrogel for Modulating Mechanosensitive Ion Channels in 3-Dimensional Environment. 近红外光控制动态水凝胶在三维环境中调节机械敏感离子通道。

IF 8.1

Biomaterials research Pub Date : 2025-04-09 eCollection Date: 2025-01-01 DOI: 10.34133/bmr.0182

Xiaoning Liu, Zimeng Zhang, Zhanshuo Cao, Hongbo Yuan, Chengfen Xing

{"title":"Near-Infrared Light-Controlled Dynamic Hydrogel for Modulating Mechanosensitive Ion Channels in 3-Dimensional Environment.","authors":"Xiaoning Liu, Zimeng Zhang, Zhanshuo Cao, Hongbo Yuan, Chengfen Xing","doi":"10.34133/bmr.0182","DOIUrl":"https://doi.org/10.34133/bmr.0182","url":null,"abstract":"The extracellular matrix (ECM) creates a dynamic mechanical environment for cellular functions, continuously influencing cellular activities via the mechanotransduction pathway. Mechanosensitive ion channels, recently identified as key mechanotransducers, convert mechanical stimuli into electrical or chemical signals when they detect membrane deformation. This process facilitates extracellular Ca2+ influx, cytoskeletal reorganization, and transcriptional regulation, all of which are essential for cellular physiological functions. In this study, we developed a fibrous hydrogel composite (PIC/OEG-NPs) with near-infrared (NIR) light-controlled dynamic mechanical properties to modulate mechanosensitive ion channels in cells, by using oligo-ethylene glycol (OEG)-assembled polyisocyanide (PIC) polymer and OEG-grafted conjugated polymer nanoparticles (OEG-NPs). PIC and OEG-NPs assemble into PIC/OEG-NPs composites through OEG-mediated hydrophobic interactions when heated. Under NIR stimulation, the PIC/OEG-NPs composites exhibit increased mechanical tension and form tighter fibrous networks due to their thermoresponsive behavior. These changes are reversible and allow for the dynamic regulation of mechanosensitive ion channels, including Piezo1 in transfected HEK-293T cells and the endogenous TRPV4 in human umbilical vein endothelial cells (HUVECs), by switching NIR on and off. Furthermore, this process enhances the angiogenic potential of HUVECs. In summary, we present a simple and effective platform for in situ modulation of mechanosensitive ion channels in 3 dimensions.","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"29 ","pages":"0182"},"PeriodicalIF":8.1,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11979339/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144000093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanotension Relief Agent Enhances Tissue Penetration by Reducing Solid Stress in Pancreatic Ductal Adenocarcinoma via Rho/ROCK Pathway Inhibition. 纳米张力缓解剂通过抑制Rho/ROCK通路减少固体应力，增强胰腺导管腺癌组织穿透性。

IF 8.1

Biomaterials research Pub Date : 2025-04-09 eCollection Date: 2025-01-01 DOI: 10.34133/bmr.0173

Feiran Yu, Gaorui Zhang, Jintang Sun, Yuxuan Zhao, Yafei Qi, Xiaoyu Han, Chen Ai, Weikai Sun, Jiazhi Duan, Dexin Yu

{"title":"Nanotension Relief Agent Enhances Tissue Penetration by Reducing Solid Stress in Pancreatic Ductal Adenocarcinoma via Rho/ROCK Pathway Inhibition.","authors":"Feiran Yu, Gaorui Zhang, Jintang Sun, Yuxuan Zhao, Yafei Qi, Xiaoyu Han, Chen Ai, Weikai Sun, Jiazhi Duan, Dexin Yu","doi":"10.34133/bmr.0173","DOIUrl":"https://doi.org/10.34133/bmr.0173","url":null,"abstract":"The formidable contractile tension exerted by cancer-associated fibroblasts (CAFs) in pancreatic ductal adenocarcinoma (PDAC) tissue is crucial for maintaining high tissue solid stress (TSS), which impedes the delivery and penetration of chemotherapeutic drugs. To address this obstacle, we constructed a pH-responsive nanotension relief agent (FS@MMS), in which fasudil (FS) was ingeniously conjugated to mesoporous silica encapsulated with magnetic iron oxide (MMS). The nanotension relief agent was demonstrated to inhibit the synthesis of phosphorylated myosin light chain by blocking the Rho/Rho-associated serine/threonine kinase (ROCK) pathway, triggering the swift transformation of high-tension CAFs into low-tension CAFs in PDAC tissue, which relieves TSS and enhances drug penetration in Panc02/NIH-3T3 multicellular tumor spheroids. When the nanotension relief agent was further loaded with the chemotherapeutic drug gemcitabine (GEM), as FS@MMS-GEM, the enhanced permeation of GEM progressively killed tumor cells and amplified their TSS-relief properties, thereby maximizing the anticancer efficacy of chemotherapeutic agents in Panc02/NIH-3T3 coplanted model mice. The magnetic resonance imaging results revealed that the synergistic effect substantially improved drug delivery and penetration efficiency. The developed approach holds great potential for improving chemotherapy efficacy in PDAC and provides a novel therapeutic approach for the treatment of related stroma-rich tumors.","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"29 ","pages":"0173"},"PeriodicalIF":8.1,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11979343/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144055189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current Trends in Messenger RNA Technology for Cancer Therapeutics. 信使RNA技术用于癌症治疗的最新趋势。

IF 8.1

Biomaterials research Pub Date : 2025-04-09 eCollection Date: 2025-01-01 DOI: 10.34133/bmr.0178

Ali Afzal, Muddasir Hassan Abbasi, Shaaf Ahmad, Nadeem Sheikh, Muhammad Babar Khawar

引用次数: 0

MXene/Doxorubicin Complex-Loaded Supramolecular Hydrogels for Near Infrared-Triggered Synergistic Cancer Therapy. MXene/阿霉素复合物负载超分子水凝胶用于近红外触发的协同癌症治疗。

IF 8.1

Biomaterials research Pub Date : 2025-04-09 eCollection Date: 2025-01-01 DOI: 10.34133/bmr.0163

Seung Min Yang, Hanseo Bae, Seong-Jong Kim, Mungu Kim, Sang Hoon Hong, Hyunsik Choi, Sei Kwang Hahn

{"title":"MXene/Doxorubicin Complex-Loaded Supramolecular Hydrogels for Near Infrared-Triggered Synergistic Cancer Therapy.","authors":"Seung Min Yang, Hanseo Bae, Seong-Jong Kim, Mungu Kim, Sang Hoon Hong, Hyunsik Choi, Sei Kwang Hahn","doi":"10.34133/bmr.0163","DOIUrl":"https://doi.org/10.34133/bmr.0163","url":null,"abstract":"Photothermal therapy (PTT) has attracted great interest due to the high spatial precision and reduced general toxicity compared to conventional cancer therapies. However, PTT often faces challenges such as incomplete tumor eradication and collateral damage to healthy tissues. Here, we report an injectable MXene-doxorubicin (MD) complex-loaded supramolecular hydrogel (MDGel) for dual synergistic cancer therapy of near-infrared (NIR) PTT and chemotherapy. MDGel is prepared by the host-guest interaction between gelatin-cyclodextrin (GE-CD) and hyaluronic acid-adamantane (HA-AD), facilitating the efficient dispersion of MD complexes in the hydrogel. NIR irradiation triggers the PTT and the release of doxorubicin with increasing temperature. In vitro therapeutic effect is confirmed by achieving nearly 80% cancer cell death via the synergistic effect, compared to the single-modality treatment. In vivo tumor inhibition (68.9% volume reduction) is further validated in skin cancer-bearing model mice with no substantial negative side effect. With its prolonged retention, NIR light-controlled release, and localized therapeutic effect, the MDGel system would provide a notable paradigm as a versatile platform for dual synergistic cancer therapy.","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"29 ","pages":"0163"},"PeriodicalIF":8.1,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11979340/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fabrication of 3-Dimensional-Printed Bilayered Scaffold Carboxymethyl Chitosan/Oxidized Xanthan Gum, Biphasic Calcium Phosphate for Osteochondral Regeneration. 羧甲基壳聚糖/氧化黄原胶/双相磷酸钙三维打印骨软骨再生双层支架的制备。

IF 8.1

Biomaterials research Pub Date : 2025-04-09 eCollection Date: 2025-01-01 DOI: 10.34133/bmr.0186

My N-H Nguyen, Binh T Vu, Dung M Truong, Thanh D Le, Thanh-Tuyen T Vo, Toi V Vo, Thi-Hiep Nguyen

{"title":"Fabrication of 3-Dimensional-Printed Bilayered Scaffold Carboxymethyl Chitosan/Oxidized Xanthan Gum, Biphasic Calcium Phosphate for Osteochondral Regeneration.","authors":"My N-H Nguyen, Binh T Vu, Dung M Truong, Thanh D Le, Thanh-Tuyen T Vo, Toi V Vo, Thi-Hiep Nguyen","doi":"10.34133/bmr.0186","DOIUrl":"https://doi.org/10.34133/bmr.0186","url":null,"abstract":"Cartilage tissue regeneration remains challenging due to the tissue's poor self-healing capacity, attributed to its hypocellular and avascular nature, which limits nutrient delivery to the defect site and complicates healing. Traditional methods often utilize the subchondral tissue layer to improve nutrient exchange through its vascular network, although these approaches have limitations. To address these issues, 3-dimensional (3D) printing has been employed to create the bilayered scaffold that mimics the complex structure of osteochondral tissue. In this study, the N,O-carboxymethyl chitosan (NOCC) and oxidized xanthan gum (OXG) hydrogel was fabricated for the cartilage layer due to its similarity to the native cartilage structure, while the biphasic calcium phosphate (BCP) incorporation enhanced the osteoconductivity to promote new bone growth for osteochondral tissue regeneration. Various characterization tests, including compression strength, scanning electron microscopy analysis, and biological properties, were conducted to evaluate and balanced to achieve the highest regenerative capacity for implantation. No cytotoxicity was caused, while the in vitro testing highlighted that the addition of BCP considerably supported cellular behavior on the scaffold and improved the regeneration rate. With 60% BCP content, the 3D scaffold demonstrated a high osteochondral tissue regeneration rate, as evidenced by visual inspection, x-ray imaging, and histological analysis, outperforming other experimental models.","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"29 ","pages":"0186"},"PeriodicalIF":8.1,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11979342/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144048688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Janus-Structured Micro/Nanomotors: Self-Propelled Mechanisms and Biomedical Applications. 双结构微/纳米马达：自推进机制和生物医学应用。

IF 8.1

Biomaterials research Pub Date : 2025-04-05 eCollection Date: 2025-01-01 DOI: 10.34133/bmr.0155

Haoyan Cheng, Beng Ma, Anqi Ji, Haonan Yao, Pan Chen, Wenyang Zhai, Shegan Gao, Linlin Shi, Hao Hu

{"title":"Janus-Structured Micro/Nanomotors: Self-Propelled Mechanisms and Biomedical Applications.","authors":"Haoyan Cheng, Beng Ma, Anqi Ji, Haonan Yao, Pan Chen, Wenyang Zhai, Shegan Gao, Linlin Shi, Hao Hu","doi":"10.34133/bmr.0155","DOIUrl":"10.34133/bmr.0155","url":null,"abstract":"Self-propelled micro/nanomotors (MNMs), which can convert other energy into mechanical motion, have attracted considerable attention due to their potential applications in diverse fields. Due to the asymmetric structures and 2 or more chemically discrepant composites constructed in the Janus nanoparticles, asymmetrical forces can be created in the physical environment. Thus, MNMs with Janus structures have been widely studied for revealing possible driving mechanisms. This tutorial review covers the most representative examples of Janus-structured MNMs developed so far, which are self-propelled by different mechanisms. We focus on Janus MNMs that exhibit self-propelled motion in liquid environments and their potential applications in biomedicine, including drug delivery, cancer therapy, bioimaging, and biosensing. The driving mechanisms and challenges associated with constructing asymmetric fields are deeply discussed, along with future opportunities for these versatile and promising MNMs. This review provides an overview of the rapidly evolving field of MNMs and their potential applications, serving as a valuable resource for researchers and others interested in this field.","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"29 ","pages":"0155"},"PeriodicalIF":8.1,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11971528/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Label-Free Enrichment of Highly Metastatic Tumor-Initiating Cells up to a Monoclonal State. 无标记富集高度转移的肿瘤启动细胞，使其达到单克隆状态。

IF 8.1

Biomaterials research Pub Date : 2025-04-02 eCollection Date: 2025-01-01 DOI: 10.34133/bmr.0168

Larissa M Ciaramicoli, Haw-Young Kwon, Chun Y Im, Namhui Kim, Yoojin Oh, Young-Tae Chang, Nam-Young Kang

引用次数: 0

Molecular Targeting of Intracellular Bacteria by Homotypic Recognizing Nanovesicles for Infected Pneumonia Treatment. 利用同型识别纳米囊泡对细胞内细菌的分子靶向治疗感染性肺炎。

IF 8.1

Biomaterials research Pub Date : 2025-04-02 eCollection Date: 2025-01-01 DOI: 10.34133/bmr.0172

Xu Wang, Hao Zhou, Dan Li, Zhe Zhao, Ke Peng, Xiang Xu, Jia-Jia Wang, Yang Wang, Jun Wang, Jing-Jing Zhang, Shuang-Shuang Wan, Mai-Qing Shi, Jun Chen, Xian-Guang Ding, Fu-Hai Ji

{"title":"Molecular Targeting of Intracellular Bacteria by Homotypic Recognizing Nanovesicles for Infected Pneumonia Treatment.","authors":"Xu Wang, Hao Zhou, Dan Li, Zhe Zhao, Ke Peng, Xiang Xu, Jia-Jia Wang, Yang Wang, Jun Wang, Jing-Jing Zhang, Shuang-Shuang Wan, Mai-Qing Shi, Jun Chen, Xian-Guang Ding, Fu-Hai Ji","doi":"10.34133/bmr.0172","DOIUrl":"10.34133/bmr.0172","url":null,"abstract":"Although extensive antibiotic regimens have been implemented to address pathogen-infected pneumonia, existing strategies are constrained in their efficacy against intracellular bacteria, a prominent contributor to antibiotic resistance. In addition, the concurrent occurrence of a cytokine storm during antibiotic therapy presents a formidable obstacle in the management of pneumonia caused by pathogens. In the present study, an infection-targeting system that leverages M2-macrophage-derived vesicles [exosomes (Exos)] as vehicles to convey antibiotics (antibiotics@Exos) was developed for effective pneumonia management. The proposed system can enable antibiotics to be specifically delivered to infected macrophages in pneumonia through homotypic recognition and was found to exhibit an exceptional intracellular bactericidal effect. Moreover, M2-type vesicles exhibit a high degree of efficiency in reprogramming inflammatory macrophages toward an anti-inflammatory phenotype. As a result, the administration of antibiotics@Exos was found to substantical decrease the level of the infiltrated inflammatory cells and alleviate the inflammatory factor storm in the lungs of acute lung injury mice. This intervention resulted in the alleviation of reactive-oxygen-species-induced damage, reduction of pulmonary edema, and successful pneumonia treatment. This bioactive vesicle delivery system effectively compensates for the limitations of traditional antibiotic therapy regimens with pluralism effects, paving a new strategy for serious infectious diseases, especially acute pneumonia treatment.","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"29 ","pages":"0172"},"PeriodicalIF":8.1,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11964281/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143775150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Layered Double Hydroxide Reshapes the Immune Microenvironment of Rheumatoid Arthritis through Small Mothers against Decapentaplegic 5. 层状双氢氧化物重塑类风湿关节炎免疫微环境通过小母亲对抗十四肢瘫痪5。

IF 8.1

Biomaterials research Pub Date : 2025-03-28 eCollection Date: 2025-01-01 DOI: 10.34133/bmr.0176

Dengju Li, Yawei Sun, Guangxian Liu, Changxing Liu, Guojiang Zhang, Haojue Wang, Shui Sun, Senbo An

{"title":"Layered Double Hydroxide Reshapes the Immune Microenvironment of Rheumatoid Arthritis through Small Mothers against Decapentaplegic 5.","authors":"Dengju Li, Yawei Sun, Guangxian Liu, Changxing Liu, Guojiang Zhang, Haojue Wang, Shui Sun, Senbo An","doi":"10.34133/bmr.0176","DOIUrl":"10.34133/bmr.0176","url":null,"abstract":"Persistent synovitis is a pivotal pathological feature of rheumatoid arthritis (RA). However, the current rheumatoid drugs are accompanied by severe side effects and have limited anti-inflammatory capabilities. In this work, we designed a bioactive material-folic acid modified layered double hydroxides (FA-LDH), aiming at targeting M1 macrophages and modulating macrophage repolarization. The in vitro experiment showed that FA-LDH mitigated the release of proinflammatory cytokines and promoted the expression of M2 macrophage markers. In terms of the action mechanism, FA-LDH modulated the nucleocytoplasmic transport of the small mothers against decapentaplegic 5 (Smad5) protein by adjusting the pH within the immune microenvironment. Subsequently, relying on the interaction between phospho-Smad5 (pSmad5) and p65, the nuclear factor kappa B signaling pathway was down-regulated through inhibiting nuclear transport of p65. Additionally, FA-LDH exhibited excellent targeting capability toward M1 macrophages and strong accumulation capacity in inflamed joints. In vivo experiment showed that FA-LDH could relieve swelling of limbs, reduce the infiltration of inflammatory cells, and protect joint cartilage and subchondral bone structure in collagen-induced arthritis mice. In summary, this work introduces a strategy for utilizing bioactive FA-LDH in the treatment of RA, highlighting the potential of FA-LDH to alleviate inflammation and reshape the immune microenvironment through the pSmad5/p65 axis.","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"29 ","pages":"0176"},"PeriodicalIF":8.1,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951257/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0