Biomaterials research最新文献_第5页

Physicochemical Properties and Efficacy of Poloxamer Bone Wax on Hemostasis at the Bone-Amputation Site. 泊洛沙姆骨蜡对截骨部位止血的理化性质及疗效观察。

IF 8.1

Biomaterials research Pub Date : 2025-04-15 eCollection Date: 2025-01-01 DOI: 10.34133/bmr.0191

Dae Hyung Lee, Miri Kim, Yeji Choi, Mi Hee Lee, Jong-Chul Park

{"title":"Physicochemical Properties and Efficacy of Poloxamer Bone Wax on Hemostasis at the Bone-Amputation Site.","authors":"Dae Hyung Lee, Miri Kim, Yeji Choi, Mi Hee Lee, Jong-Chul Park","doi":"10.34133/bmr.0191","DOIUrl":"https://doi.org/10.34133/bmr.0191","url":null,"abstract":"Bone wax, an essential material for bone hemostasis in orthopedic, thoracic, and neurological surgeries, is defined as a substance that physically controls bleeding caused by bone fractures. Absorbable bone-wax products such as poloxamer multiblock copolymers can be topically applied, form a physical barrier, are biocompatible, and can be absorbed by/excreted from the body. However, absorbable bone waxes continue to have limited physical properties, poor bone adhesion, and low hemostatic quality. When applied to the affected area, they quickly dissolve in blood and body fluids, preventing maintenance of the physical barrier over a certain period and thereby reducing the hemostatic effect. This study introduces a new type of absorbable bone wax (OSSTOP) constructed from 2 poloxamer multiblock copolymers with different molecular weight ranges. To determine whether OSSTOP overcomes the limitations of the existing products, the physicochemical properties and efficacy of OSSTOP were compared with those of 2 existing absorbable bone-wax products, OSTENE and NOVOSEAL. The adhesive strengths, yield loads, and solubilities of the products were evaluated and compared in vitro. Hemostasis at the bone-amputation site and absorption/degradation of the products were then evaluated through animal experiments in vivo. The biological safety (cytotoxicity) of the newly developed OSSTOP was also assessed. A histological analysis confirmed superior hemostasis at the bone-amputation site and a favorable biological response after treatment with OSSTOP. We expect that OSSTOP will improve the convenience, hemostatic performance, and biocompatibility of bleeding cessation at bone-amputation sites in the clinical environment.","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"29 ","pages":"0191"},"PeriodicalIF":8.1,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11997309/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144055278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Radiation-Activated Cobalt-Based Zeolite Imidazolate Frameworks for Tumor Multitherapy. 辐射激活钴基咪唑酸沸石框架用于肿瘤的综合治疗。

IF 8.1

Biomaterials research Pub Date : 2025-04-15 eCollection Date: 2025-01-01 DOI: 10.34133/bmr.0164

Qijun Du, Hongwei Jiang, Di Wu, Changlong Song, Wenqi Hu, Qinrui Lu, Chenwei Sun, Jie Liu, Guohua Wu, Shuqi Wang

{"title":"Radiation-Activated Cobalt-Based Zeolite Imidazolate Frameworks for Tumor Multitherapy.","authors":"Qijun Du, Hongwei Jiang, Di Wu, Changlong Song, Wenqi Hu, Qinrui Lu, Chenwei Sun, Jie Liu, Guohua Wu, Shuqi Wang","doi":"10.34133/bmr.0164","DOIUrl":"https://doi.org/10.34133/bmr.0164","url":null,"abstract":"Radiation dynamic therapy (RDT) is known to induce cancer apoptosis and death with minimal side effects and high accuracy. However, low efficiency of radiation sensitization and persistent hypoxic environment in tumors pose marked challenges for successful RDT. To address these challenges, a novel biodegradable drug delivery system was developed, using quercetin and sorafenib-loaded ZIF67 nanoparticles (QSZP NPs) coated with polydopamine. This system effectively controlled the tumor microenvironment (TME), overcame hypoxia, and was thus utilized for collaborative RDT and radiotherapy (RT). The QSZP NPs demonstrated great potential in x-ray sensitization and reactive oxygen species (ROS)-mediated effects in vitro. Furthermore, they continuously generated oxygen and increased ROS levels in the TME with x-ray irradiation to achieve RDT. In vivo studies showed that QSZP NPs had no apparent systemic toxicity and showed good therapeutic effect in a HepG2 tumor-bearing model. Due to its unique and outstanding combinational effect of RDT/RT/antiangiogenic cancer therapy, these synthesized NPs offer a promising method for radiation-based cancer treatment.","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"29 ","pages":"0164"},"PeriodicalIF":8.1,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11997308/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144038313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rat Sarcoma (RAS)-Protein-Targeting Synthetic Cell-Penetrating Peptide as an Anticancer Biomaterial. 大鼠肉瘤（RAS）蛋白靶向合成细胞穿透肽作为抗癌生物材料。

IF 8.1

Biomaterials research Pub Date : 2025-04-15 eCollection Date: 2025-01-01 DOI: 10.34133/bmr.0175

Gookjin Yoon, Jinsook Suh, Beom Soo Jo, Dong Woo Lee, Deogil Kim, Moonsil Choi, Eui Kyun Jeong, Hoo Cheol Lee, Hye Min Shin, Yu-Bin Kim, Sanghui Seok, Yoon Shin Park, Chong Pyung Chung, Jue-Yeon Lee, Yoon Jeong Park

{"title":"Rat Sarcoma (RAS)-Protein-Targeting Synthetic Cell-Penetrating Peptide as an Anticancer Biomaterial.","authors":"Gookjin Yoon, Jinsook Suh, Beom Soo Jo, Dong Woo Lee, Deogil Kim, Moonsil Choi, Eui Kyun Jeong, Hoo Cheol Lee, Hye Min Shin, Yu-Bin Kim, Sanghui Seok, Yoon Shin Park, Chong Pyung Chung, Jue-Yeon Lee, Yoon Jeong Park","doi":"10.34133/bmr.0175","DOIUrl":"https://doi.org/10.34133/bmr.0175","url":null,"abstract":"Various bioactive materials, including peptides, have become potential candidates for slowing cancer growth and metastasis. Among bioactive peptides, a synthetic cell-penetrating peptide referred to as rat sarcoma (RAS)-binding peptide (RBP) was suggested as a potential entity that targets RAS with high affinity in MDA-MB-231 cancer cells. This RAS binding further inhibits the RAS-rapidly accelerated fibrosarcoma (RAF) protein-protein interaction. The current study revealed that RBP effectively suppresses proliferation and extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation by disrupting the RAS-RAF interaction. This intervention not only inhibits cell migration and invasion but also has substantial potential for preventing metastasis. The RAS-RAF-ERK1/2 pathway is a key target for anticancer drug development because of frequent ERK and mitogen-activated protein kinase activation in human cancers. MDA-MB-231, a triple-negative breast cancer cell line, harbors a G13D Kirsten rat sarcoma viral oncogene homolog mutation, making it resistant to many drugs. In addition to its in vitro antitumor activity, RBP was identified as a potent antagonist that substantially arrests tumor growth and invasiveness in in vivo chicken egg and mouse xenograft tumor models. Notably, histopathological analyses revealed increased immune cell infiltration and decreased Ki-67 expression, confirming the ability of RBP to inhibit tumor cell proliferation. Taken together, these findings highlight RBP as a therapeutic anticancer biomaterial capable of impeding the progression and metastasis of RAS-mutated cancers.","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"29 ","pages":"0175"},"PeriodicalIF":8.1,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11997307/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144038101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Versatile and Marvelous Potentials of Polydeoxyribonucleotide for Tissue Engineering and Regeneration. 聚脱氧核糖核苷酸在组织工程和再生中的多用途和非凡潜力。

IF 8.1

Biomaterials research Pub Date : 2025-04-14 eCollection Date: 2025-01-01 DOI: 10.34133/bmr.0183

Nuri Oh, Juyoung Hwang, Moon Sung Kang, Chung-Yul Yoo, Minseok Kwak, Dong-Wook Han

{"title":"Versatile and Marvelous Potentials of Polydeoxyribonucleotide for Tissue Engineering and Regeneration.","authors":"Nuri Oh, Juyoung Hwang, Moon Sung Kang, Chung-Yul Yoo, Minseok Kwak, Dong-Wook Han","doi":"10.34133/bmr.0183","DOIUrl":"https://doi.org/10.34133/bmr.0183","url":null,"abstract":"Over the past decade, substantial focus has been placed on polydeoxyribonucleotide (PDRN) due to its promising pharmacological properties, making it a valuable candidate for tissue engineering applications. Accordingly, this paper aims to review and summarize the latest experimental research on PDRN in the context of tissue engineering and regeneration. The unique biochemical mechanisms of PDRN to promote cellular behavior and regeneration are summarized. We categorize commonly utilized PDRN-based tissue engineering fields as neuromuscular tissues, diabetic wound or skin, and bone regeneration. At the same time, we explore scaffold strategies for integrating PDRN into bioceramics, polymers, and cell/tissue-derived materials, along with its combination with photo/electromodulation techniques. Furthermore, we discuss potential opportunities and challenges in translating PDRN-based approaches into clinical practice. We expect future interdisciplinary research and clinical trials to evaluate the long-term efficacy and safety of PDRN while emphasizing standardization and quality control to ensure its consistency and effectiveness in regenerative applications.","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"29 ","pages":"0183"},"PeriodicalIF":8.1,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11994882/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engineered Endometrial Clear Cell Cancer-on-a-Chip Reveals Early Invasion-Metastasis Cascade of Cancer Cells. 工程子宫内膜透明细胞癌芯片揭示了癌细胞的早期侵袭-转移级联。

IF 8.1

Biomaterials research Pub Date : 2025-04-14 eCollection Date: 2025-01-01 DOI: 10.34133/bmr.0177

Chengpan Li, Jing Pan, Zhengdi Shi, Xinyan Zeng, Xiaoping Xia, Xiaogang He, Wei Wang, Bensheng Qiu, Weiping Ding, Dabing Huang

{"title":"Engineered Endometrial Clear Cell Cancer-on-a-Chip Reveals Early Invasion-Metastasis Cascade of Cancer Cells.","authors":"Chengpan Li, Jing Pan, Zhengdi Shi, Xinyan Zeng, Xiaoping Xia, Xiaogang He, Wei Wang, Bensheng Qiu, Weiping Ding, Dabing Huang","doi":"10.34133/bmr.0177","DOIUrl":"https://doi.org/10.34133/bmr.0177","url":null,"abstract":"Endometrial clear cell cancer (ECCC) is an extremely rare and highly malignant subtype of endometrial cancer. For most ECCC patients, cancer metastasis is the major cause of death. To date, due to the complexity of cancer evolution and the small number of cases, the metastasis of ECCC at the early stage remains largely unknown. Herein, we modeled the early invasion-metastasis cascade of ECCC by coculturing the ECCC patient-derived tumor cells (PDTCs) and primary human vascular endothelial cells on a microfluidic chip. With the chip, we for the first time replicated the dynamic migration of PDTCs into the surrounding stroma, including the intravasation and extravasation of PDTCs through the capillaries/microvessels, and presented the changes in the morphology and permeability of capillaries, with the decreased diameter and the increased permeability after cancer metastasis. We found that PDTCs were more invasive than the common endometrial adenocarcinoma cells. In addition, we preliminarily explored the inhibition of drugs on the early PDTC infiltration. This study provides new ideas for better understanding of ECCC evolution.","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"29 ","pages":"0177"},"PeriodicalIF":8.1,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11994883/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanomaterial-Based Autophagy Modulation: Multiple Weapons to Inflame Immune Systems and the Tumor Microenvironment. 基于纳米材料的自噬调节：多种武器炎症免疫系统和肿瘤微环境。

IF 8.1

Biomaterials research Pub Date : 2025-04-14 eCollection Date: 2025-01-01 DOI: 10.34133/bmr.0111

Min Jiang, Xinyi Zhang, Zhilei Cui, Meng Li, Huifen Qiang, Keqin Ji, Meigui Li, Xinyang Xuan Yuan, Beibei Wen, Qian Xue, Jie Gao, Zhengmao Lu, Yan Wu

{"title":"Nanomaterial-Based Autophagy Modulation: Multiple Weapons to Inflame Immune Systems and the Tumor Microenvironment.","authors":"Min Jiang, Xinyi Zhang, Zhilei Cui, Meng Li, Huifen Qiang, Keqin Ji, Meigui Li, Xinyang Xuan Yuan, Beibei Wen, Qian Xue, Jie Gao, Zhengmao Lu, Yan Wu","doi":"10.34133/bmr.0111","DOIUrl":"https://doi.org/10.34133/bmr.0111","url":null,"abstract":"Autophagy, a fundamental cellular process, is a sensitive indicator of environmental shifts and is crucial for the clearance of cellular debris, the remodeling of cellular architecture, and the facilitation of cell growth and development. The interplay between stromal, tumor, and immune cells within the tumor microenvironment is intricately linked to autophagy. Therefore, the modulation of autophagy in these cell types is essential for developing effective cancer treatment strategies. This review describes the design and optimization of nanomaterials that modulate autophagy in tumor-associated and immune cells. This review elucidates the primary mechanisms by which nanomaterials induce autophagy and discusses their application in cancer therapy, underscoring the potential of these materials to eradicate cancer cells, bolster the immune response, and elicit robust, enduring antitumor immunity, thereby advancing the frontiers of oncological treatment.","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"29 ","pages":"0111"},"PeriodicalIF":8.1,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11994884/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Application of Stem Cells and Exosomes in Promoting Nerve Conduits for Peripheral Nerve Repair. 干细胞和外泌体在促进神经导管修复周围神经中的应用。

IF 8.1

Biomaterials research Pub Date : 2025-04-14 eCollection Date: 2025-01-01 DOI: 10.34133/bmr.0160

Mengen Li, Ye Tang, Chengkai Zhou, Yan Geng, Chenxi Zhang, Yuwei Hsu, Le Ma, Wei Guo, Ming Li, Yanhua Wang

引用次数: 0

Myofibroblast-Targeting Extracellular Vesicles: A Promising Platform for Cardiac Fibrosis Drug Delivery. 肌成纤维细胞靶向细胞外囊泡：一个有前途的心脏纤维化药物递送平台。

IF 8.1

Biomaterials research Pub Date : 2025-04-11 eCollection Date: 2025-01-01 DOI: 10.34133/bmr.0179

Yi Wang, Hao Jiang, Qing Chen, Fei Guo, Bei Zhang, Lin Hu, Xuege Huang, Wenwen Shen, Jiapeng Gao, Wenwen Chen, Wei Xu, Zhijian Cai, Lin Wei, Min Li

{"title":"Myofibroblast-Targeting Extracellular Vesicles: A Promising Platform for Cardiac Fibrosis Drug Delivery.","authors":"Yi Wang, Hao Jiang, Qing Chen, Fei Guo, Bei Zhang, Lin Hu, Xuege Huang, Wenwen Shen, Jiapeng Gao, Wenwen Chen, Wei Xu, Zhijian Cai, Lin Wei, Min Li","doi":"10.34133/bmr.0179","DOIUrl":"https://doi.org/10.34133/bmr.0179","url":null,"abstract":"Current pharmacological treatments for cardiac fibrosis are often limited by their efficacy and specificity, leading to marked side effects. Fibroblast activation protein (FAP) is specifically expressed on activated myofibroblasts (myoFbs) but not on resting cardiac fibroblasts, making it a promising target for cardiac fibrosis therapy. In this study, we engineered extracellular vesicles (EVs) conjugated with an anti-FAP single-chain variable fragment, termed αFAP-EVs, which specifically target myoFbs. Our results demonstrated that αFAP-EVs successfully targeted activated myoFbs in vitro and localized to fibrotic regions in isoproterenol-induced mouse hearts in vivo. To further enhance delivery efficiency, αFAP-EVs were combined with clodronate-loaded liposomes (αFAP-EL@CLD) to reduce liver accumulation and improve cardiac fibrotic site targeting. αFAP-EL@CLD loaded with cholesterol-methylated- and phosphorothioate-modified miR-29b (Agomir-29b) or the transforming growth factor beta 1 receptor inhibitor GW788388 significantly inhibited myoFb activation and reduced fibrosis in isoproterenol-induced mouse models. Importantly, these drug-loaded αFAP-EL@CLD vesicles exhibited high therapeutic efficacy with minimal systemic toxicity, attributed to their stability and targeted delivery capabilities. These findings suggest that αFAP-EL@CLD vesicles are promising candidates for cardiac fibrosis therapy, offering a foundation for future clinical applications.","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"29 ","pages":"0179"},"PeriodicalIF":8.1,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11986206/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Novel Strategy to Enhance the Bone Healing Efficacy of Composite Scaffolds via Induction of Cell Recruitment and Vascularization. 一种通过诱导细胞募集和血管形成来增强复合支架骨愈合效果的新策略。

IF 8.1

Biomaterials research Pub Date : 2025-04-10 eCollection Date: 2025-01-01 DOI: 10.34133/bmr.0185

Jeong In Kim, Thi Thu Trang Kieu, Jeong-Chae Lee

{"title":"A Novel Strategy to Enhance the Bone Healing Efficacy of Composite Scaffolds via Induction of Cell Recruitment and Vascularization.","authors":"Jeong In Kim, Thi Thu Trang Kieu, Jeong-Chae Lee","doi":"10.34133/bmr.0185","DOIUrl":"https://doi.org/10.34133/bmr.0185","url":null,"abstract":"This study devised a novel strategy to develop a functionally improved scaffold that enhances the healing of large bone defects via synergistic activation of vascularization and cell recruitment. To this end, we fabricated round and ring-shaped silk fibroin/Broussonetia kazinoki (SFBK) composite scaffolds. The round scaffolds had a diameter of 1.5 mm, and the ring-shaped scaffolds had a 6-mm diameter with a 1.5-mm hole in the center. All scaffolds had a 3-mm thickness. A portion of round SFBKs was cross-linked with stromal cell-derived factor 1 (SDF-1), and ring-shaped scaffolds underwent in vitro angiogenic stimulation, in vivo vascularization, or both. These scaffolds were assembled by fitting a round SFBK into the center of a vascularized SFBK scaffold before implantation into a rat model with critical-sized calvarial defects. Implantation with puzzle-fitted scaffolds promoted bone regeneration, and the scaffold that underwent both SDF-1 immobilization and vascularization processes showed the greatest efficacy in the healing of defects. The bone healing efficacy of puzzle-fitted scaffolds involved their ability to stimulate microvascular network formation, collagen synthesis, and stem cell recruitment at defects. B. kazinoki-released calcium ions also participated in synergistic bone regeneration. These results suggest that the strategy of fitting SDF-1-linked SFBK into a vascularized ring-SFBK scaffold is useful in recruiting multipotent stem cells via newly formed blood vessels toward the center of scaffolds. This induces balanced and uniform bone regeneration. Overall, this study highlights the needs of calcium release, neovascularization, and stem cell recruitment for synergistic enhancement of bone regeneration.","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"29 ","pages":"0185"},"PeriodicalIF":8.1,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11982616/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144055033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Zinc Silicate-Loaded Microneedle Patch Reduces Reactive Oxygen Species Production and Enhances Collagen Synthesis for Ultraviolet B-Induced Skin Repair. 硅酸锌微针贴片减少活性氧的产生，促进胶原蛋白的合成，用于紫外线b诱导的皮肤修复。

IF 8.1

Biomaterials research Pub Date : 2025-04-10 eCollection Date: 2025-01-01 DOI: 10.34133/bmr.0180

Fang-Zhou Chen, Zhao-Wen-Bin Zhang, Qing-Feng Li, Poh-Ching Tan, Jiang Chang, Shuang-Bai Zhou

{"title":"Zinc Silicate-Loaded Microneedle Patch Reduces Reactive Oxygen Species Production and Enhances Collagen Synthesis for Ultraviolet B-Induced Skin Repair.","authors":"Fang-Zhou Chen, Zhao-Wen-Bin Zhang, Qing-Feng Li, Poh-Ching Tan, Jiang Chang, Shuang-Bai Zhou","doi":"10.34133/bmr.0180","DOIUrl":"https://doi.org/10.34133/bmr.0180","url":null,"abstract":"UVR-related skin damage is common in daily life. Excessive sunlight exposure, particularly in response to ultraviolet B (UVB) radiation, can have adverse effects on the skin and can even induce photosensitive skin diseases and skin malignancies. UVB exposure leads to the production of reactive oxygen species (ROS) in the skin, resulting in cell damage and inflammation. Furthermore, it directly inhibits the synthesis of collagen in skin fibroblasts, contributing to collagen degradation and subsequently causing skin aging, wrinkles, and erythema. To address this issue, our study introduces a biomaterial-based treatment plan for repairing UVB-induced photodamaged skin. We designed a sodium hyaluronate microneedle patch containing a hardystonite bioceramic (ZnCS/MN) with anti-ROS/inflammation/collagen degradation functions to deliver bioactive Zn2+ and SiO3 2- ions in situ to photodamaged skin areas. In addition, the cytological mechanism of ZnCS action was explored to explore the possibilities of its application in more areas. This study reveals the therapeutic potential of ZnCS for a variety of negative effects caused by photodamage. Owing to its advantages in preparation, storage, and transportation, ZnCS/MN has shown promise for clinical application in treating photodamaging.","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"29 ","pages":"0180"},"PeriodicalIF":8.1,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11982614/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144010077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0