The Application of Stem Cells and Exosomes in Promoting Nerve Conduits for Peripheral Nerve Repair.

IF 8.1 Q1 ENGINEERING, BIOMEDICAL

Biomaterials research Pub Date : 2025-04-14 eCollection Date: 2025-01-01 DOI:10.34133/bmr.0160

Mengen Li, Ye Tang, Chengkai Zhou, Yan Geng, Chenxi Zhang, Yuwei Hsu, Le Ma, Wei Guo, Ming Li, Yanhua Wang

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Abstract

The repair of peripheral nerve injury (PNI) presents a multifaceted and protracted challenge, with current therapeutic approaches failing to achieve optimal repair outcomes, thereby not satisfying the considerable clinical demand. The advent of tissue engineering has led to a growing body of experimental evidence indicating that the synergistic application of nerve conduits, which provide structural guidance, alongside the biological signals derived from exosomes and stem cells, yields superior therapeutic results for PNI compared to isolated interventions. This combined approach holds great promise for clinical application. In this review, we present the latest advancements in the treatment of PNI through the integration of stem cells or exosomes with nerve conduits. We have addressed the inadequate efficiency of exosomes or stem cells in conjunction with nerve conduits from 3 perspectives: enhancing stem cells or exosomes, improving nerve conduits, and incorporating physical stimulation.

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干细胞和外泌体在促进神经导管修复周围神经中的应用。

周围神经损伤（PNI）的修复是一个多方面和长期的挑战，目前的治疗方法未能达到最佳的修复效果，因此不能满足相当大的临床需求。组织工程的出现导致越来越多的实验证据表明，与孤立干预相比，提供结构指导的神经导管与来自外泌体和干细胞的生物信号的协同应用，对PNI产生了更好的治疗效果。这种联合方法在临床应用中具有很大的前景。在这篇综述中，我们介绍了通过干细胞或外泌体与神经导管结合治疗PNI的最新进展。我们从增强干细胞或外泌体、改善神经导管和结合物理刺激三个方面解决了外泌体或干细胞与神经导管结合效率不足的问题。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Biomaterials research

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