Biomaterials research最新文献

{"title":"Icariin-Releasing 3-Dimensionally Printed Scaffolds for Alveolar Cleft Reconstruction.","authors":"Soomin Park, Alexander B Pascal, Sidney B Eisig, Meng Feng, Hun Jin Jeong, Elen Zhu, Emily Zhang, Chang Hun Lee","doi":"10.34133/bmr.0199","DOIUrl":"https://doi.org/10.34133/bmr.0199","url":null,"abstract":"<p><p>Each year, 1 in every 700 babies is born with an orofacial cleft in the USA. Despite a well-established protocol for early cleft repair, the alveolar cleft persists during craniofacial growth. Current surgical treatments with bone grafts for alveolar cleft often provide inadequate nasal base support and insufficient alveolar bone volume for permanent tooth eruption. Here, we developed 3-dimensionally printed polycaprolactone scaffolds with controlled delivery of icariin (ICA) to facilitate bone reconstruction. After establishing a reliable fabrication process, we determined the optimal loading dose and release kinetics of ICA for induced osteogenic differentiation of bone marrow mesenchymal stem/progenitor cells and mineralized tissue formation in vitro. Then, the ICA-releasing polycaprolactone scaffolds with the preoptimized dose were implanted into rats with full-thickness maxillary defects. Up to 8 weeks, micro-computed tomography analyses demonstrated significantly accelerated bone healing and defect closure with an ICA-releasing scaffold compared to scaffold alone and defect controls. Histology consistently confirmed the formation of dense woven bone with ICA-releasing scaffolds in contrast to unclosed gaps and soft tissue infiltration in controls. Our findings suggest the significant potential of ICA-releasing 3-dimensionally printed scaffolds to serve as a patient-focused and custom-built bone graft to improve the clinical outcome of alveolar cleft reconstruction.</p>","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"29 ","pages":"0199"},"PeriodicalIF":8.1,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12123084/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144201046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomimetic Microchannel Integrated Silk Fibroin Scaffold for Regeneration of Intervertebral Disc Degeneration.","authors":"Tongxing Zhang, Zhaojun Cheng, Zhen Zhang, Lilong Du, Zhenhua Li, Zhuyan Jiang, Zhaomin Zheng, Deling Kong, Meifeng Zhu, Wen Li, Baoshan Xu","doi":"10.34133/bmr.0203","DOIUrl":"10.34133/bmr.0203","url":null,"abstract":"<p><p>Intervertebral disc degeneration (IVDD) is the primary cause of low back pain, and patients with severe degeneration usually require lumbar fusion or total disc arthroplasty. Lumbar fusion carries the risk of accelerated degeneration of the adjacent intervertebral disc (IVD), and total disc arthroplasty could reduce the risk. However, the clinical application of artificial IVD whose nondegradable properties make it difficult to restore the biological function of the IVD. Therefore, we intend to fabricate a novel biomimetic microchannel integrated silk fibroin scaffold (BMI-SF scaffold) containing annulus fibrosus with oriented cross-microchannels and nucleus pulposus with interconnected porous structure. The BMI-SF scaffold exhibits controllable microchannels as well as excellent biocompatibility and biodegradability. In vitro and in vivo studies have demonstrated that microchannels can direct cells into the BMI-SF scaffold and enhance neovascularization, supplying adequate nutritional support for tissue regeneration. The IVD replacement model showed that the BMI-SF scaffold has superior regenerative effects, such as restoring IVD height and providing motion segments with dynamic mechanical properties akin to the natural IVD. In this study, the BMI-SF scaffold developed using controlled microchannels provides a new strategy for patients with severe IVDD and has broad clinical application prospects.</p>","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"29 ","pages":"0203"},"PeriodicalIF":8.1,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12117185/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Label-Free Prediction of Fluorescently Labeled Fibrin Networks.","authors":"Sarah Eldeen, Andres Felipe Guerrero Ramirez, Bora Keresteci, Peter D Chang, Elliot L Botvinick","doi":"10.34133/bmr.0211","DOIUrl":"10.34133/bmr.0211","url":null,"abstract":"<p><p>While fluorescent labeling has been the standard for visualizing fibers within fibrillar scaffold models of the extracellular matrix (ECM), the use of fluorescent dyes can compromise cell viability and photobleach prematurely. The intricate fibrillar composition of ECM is crucial for its viscoelastic properties, which regulate intracellular signaling and provide structural support for cells. Naturally derived biomaterials such as fibrin and collagen replicate these fibrillar structures, but longitudinal confocal imaging of fibers using fluorescent dyes may impact cell function and photobleach the sample long before termination of the experiment. An alternative technique is reflection confocal microscopy (RCM) that provides high-resolution images of fibers. However, RCM is sensitive to fiber orientation relative to the optical axis, and consequently, many fibers are not detected. We aim to recover these fibers. Here, we propose a deep learning tool for predicting fluorescently labeled optical sections from unlabeled image stacks. Specifically, our model is conditioned to reproduce fluorescent labeling using RCM images at 3 laser wavelengths and a single laser transmission image. The model is implemented using a fully convolutional image-to-image mapping architecture with a hybrid loss function that includes both low-dimensional statistical and high-dimensional structural components. Upon convergence, the proposed method accurately recovers 3-dimensional fibrous architecture without substantial differences in fiber length or fiber count. However, the predicted fibers were slightly wider than original fluorescent labels (0.213 ± 0.009 μm). The model can be implemented on any commercial laser scanning microscope, providing wide use in the study of ECM biology.</p>","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"29 ","pages":"0211"},"PeriodicalIF":8.1,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12117218/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing the Surface Functionalization of Peptide-MXene Nanoplatforms to Amplify Tumor-Targeting Efficiency and Photothermal Therapy.","authors":"Sujin Kim, Sathiyamoorthy Padmanaban, Aravindkumar Sundaram, Gul Karima, In-Kyu Park, Hwan D Kim","doi":"10.34133/bmr.0198","DOIUrl":"10.34133/bmr.0198","url":null,"abstract":"<p><p>Energy storage and conversion extensively use MXenes, a class of 2-dimensional transition metals. Research is currently exploring MXenes in areas such as biomedical imaging, positioning them as a substantial contender in biomedical applications. Even though these biocompatible MXenes have many uses, it is challenging to make nanoparticles that are all the same size. This has made it harder to use them in the biomedical field. Herein, we meticulously crafted nano-sized MXene particles, achieving exceptional uniformity and amplified photothermal conversion efficiency compared to those of their bulkier micro-sized counterparts. To make these nanoparticles better at finding tumors, we added ARGD peptides to their surfaces. These are biomolecules that are known to bind to integrin α_vβ₃, a protein that is highly expressed in cancerous cells. Our research showed that these RGD-MXene nanoconjugates have excellent targeting accuracy and can eradicate tumors very effectively. This targeted photothermal therapy platform promises to redefine cancer treatment by selectively eradicating malignant cells while safeguarding healthy tissue. Also, MXene's natural ability to change surfaces opens up a world of possibilities for a wide range of uses in nanomedicine, bringing about a new era of sophisticated therapeutic interventions.</p>","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"29 ","pages":"0198"},"PeriodicalIF":8.1,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12104560/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144153106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Automated and Enclosed Three-Dimensional Biofabrication System for Mesenchymal Stem Cell Culture to Enhance Diabetic Wound Healing.","authors":"Yanmei Chen, Yang Xu, Jiawei Cai, Marianne Lauwers, Liwei Xiang, Yali Zheng, Hua Chu, Xianglong Chen, Dai Fei Elmer Ker, Cheng Zhang, Dan Michelle Wang, Zhiyong Zhang","doi":"10.34133/bmr.0205","DOIUrl":"10.34133/bmr.0205","url":null,"abstract":"<p><p>The industrialization of mesenchymal stem cells for regenerative medicine faces substantial challenges, particularly in large-scale production. Conventional 2-dimensional (2D) culture systems demonstrate limitations in meeting clinical requirements, such as inadequate cell yield, and poor cell-cell and cell-matrix interactions. These challenges can potentially be addressed by employing a 3D culture platform, which offers higher cell yields and enhanced efficacy. Moreover, it is essential to conduct a systematic and rigorous evaluation of cells produced in 3D culture systems to ensure their successful clinical translation. In this study, we cultured human umbilical cord mesenchymal stem cells (hUCMSCs) using an automated, scalable, and enclosed 3D microcarrier-bioreactor system, and comprehensively investigated their biological characteristics and potential therapeutic effects for diabetic wound repair. Our findings revealed that hUCMSCs harvested from this 3D microcarrier-bioreactor system are genetically stable and maintain the trilineage differentiation potential. Compared to hUCMSCs expanded under 2D conditions, those cultured in 3D exhibited reduced senescence and enhanced capabilities in migration, angiogenesis, and anti-inflammatory responses across different passages in vitro. RNA-sequencing analysis showed higher expression levels of genes related to angiogenesis and anti-inflammatory pathways in hUCMSCs cultured in 3D compared to those in 2D, which was further validated using quantitative real-time polymerase chain reaction and Western blot analysis. Additionally, 3D-cultured hUCMSCs demonstrated superior therapeutic effects for diabetic wound repair in mice, potentially due to their enhanced angiogenetic and anti-inflammatory effects. Collectively, our finding showcases the high quality of hUCMSCs cultured using an automated and enclosed 3D microcarrier-bioreactor system and their promising potential for diabetic wound repair.</p>","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"29 ","pages":"0205"},"PeriodicalIF":8.1,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12104559/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144153103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Hemostasis to Angiogenesis: A Self-Healing Hydrogel Loaded with Copper Sulfide-Based Nanoenzyme for Whole-Process Management of Diabetic Wounds.","authors":"Chuankai Zhang, Peirong Zhou, Shoucheng Li, Xuancheng Zhang, Zhaoxin Xia, Zihan Rao, Xuemin Ma, Yajuan Hu, Yongcen Chen, Junliang Chen, Yun He, Gang Tao, Rui Cai","doi":"10.34133/bmr.0208","DOIUrl":"10.34133/bmr.0208","url":null,"abstract":"<p><p>Diabetic wounds pose considerable healing challenges due to factors such as impaired angiogenesis, persistent inflammation, elevated levels of reactive oxygen species, and bacterial infections. In this study, we synthesized copper sulfide nanoparticles (NPs) using sericin as a biotemplate and functionalized them with tannic acid-Fe (TA-Fe) metal-phenolic network coatings to create CuS-based nanoenzymes (CuS-Se@TA-Fe NPs). These NPs were integrated into a composite hydrogel formed from polyvinyl alcohol, carboxymethyl chitosan, and borax. The hydrogen bonding between polyvinyl alcohol and carboxymethyl chitosan, combined with the borate ester bonds from borax and the electrostatic interactions with CuS-Se@TA-Fe NPs, resulted in a hydrogel with remarkable adhesion, self-healing capabilities, and shape retention (PCCuT hydrogel). Additionally, the PCCuT hydrogel demonstrated superoxide dismutase and catalase mimetic activities to eliminate excess free radicals, along with excellent photothermal conversion and antimicrobial properties due to the photothermal effect. Both in vitro and in vivo investigations indicated that the PCCuT hydrogel could enhance angiogenesis and promote the transformation of macrophages into the M2 anti-inflammatory phenotype. Notably, in a rat model of diabetic wound infection, the hydrogel exhibited substantial wound-healing benefits. In summary, the PCCuT hydrogel holds promise for advancing the treatment of diabetic wounds complicated by infection.</p>","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"29 ","pages":"0208"},"PeriodicalIF":8.1,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12099055/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Mechanical Environment Alterations in 3D Stem Cell Culture on the Therapeutic Potential of Extracellular Vesicles.","authors":"Wu Young Kang, Sunyoung Jung, Hyundoo Jeong, Hyun-Myung Woo, Min-Ho Kang, Hojae Bae, Jae Min Cha","doi":"10.34133/bmr.0189","DOIUrl":"10.34133/bmr.0189","url":null,"abstract":"<p><p>Stem-cell-derived extracellular vesicles (EVs) have emerged as a promising therapeutic option, addressing the limitations of conventional stem cell therapies. However, the variability and poorly defined therapeutic contents of EVs produced under standard 2-dimensional culture conditions present challenges for their clinical application. In this study, we investigated how the therapeutic properties of mesenchymal stem cell (MSC)-derived EVs can be enhanced by culturing MSCs within 3-dimensional hydrogels that have tunable mechanical properties. Our results demonstrate that different mechanical cues from the culture environment can induce specific gene expression changes in MSCs without compromising their inherent characteristics. Furthermore, EVs derived from these MSCs exhibited distinct angiogenic and immunomodulatory activities, which were dependent on the mechanical properties of the hydrogels used. A comprehensive analysis of the cytokines and microRNAs present in the EVs provided additional validation of these findings. By utilizing a noninvasive culture method that eliminates the need for genetic modification or exogenous biochemical supplementation, our approach presents a novel platform for the tailored production of EVs, thereby enhancing their therapeutic potential in regenerative medicine.</p>","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"29 ","pages":"0189"},"PeriodicalIF":8.1,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12099057/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engineered Macrophage Membrane-Coated Nanoparticles for Hepatic Ischemia-Reperfusion Injury Therapeutics.","authors":"Long Yang, Weiwei Li, Zhen Huang, Yinping Zhao, Zhenwen Sun, Haoyu Wang, Longpo Cao, Jiao Lu, Ruirui Sun, Xiang Ma, Tianxin Shao, Xixi Wu, Siqi He, Zuojin Liu","doi":"10.34133/bmr.0212","DOIUrl":"10.34133/bmr.0212","url":null,"abstract":"<p><p>Hepatic ischemia-reperfusion injury (HIRI) is a common perioperative complication occurring after liver transplantation and can lead to further problems such as early allograft dysfunction (EAD). Currently, the treatment options for HIRI are extremely limited. In this study, we used bioinformatics analysis to elucidate the critical role of neutrophil chemokines (CXC chemokines) in HIRI. By analyzing sequencing data from the hepatic tissue of posttransplant patients with EAD and the reperfused animal model, we discovered that hepatocytes and macrophages are the primary cells secreting CXC chemokines, and the activation of the nuclear factor kappa B (NF-κB) signaling pathway is the main driver of their secretion. Melatonin (MT) can protect cells from oxidative harm while also inhibiting NF-κB signaling, suggesting its potential to ameliorate HIRI. Accordingly, we designed a nanoparticle platform coated with genetically engineered macrophage membranes-called CXCR2-MM@PLGA/MT-to target the cells secreting CXC chemokines. CXCR2 overexpression on the macrophage membranes not only enhanced the targeting capacity of the nanoparticles but also prevented neutrophil infiltration via the scavenging of CXC chemokines. Meanwhile, the MT delivered to the site of injury successfully attenuated CXC chemokine release after macrophage polarization and hepatocyte necrosis by inhibiting NF-κB phosphorylation and inducing antioxidant effects. Through the synergistic effects of MT and the CXCL/CXCR axis-blocking function of the engineered nanoparticles, CXCR2-MM@PLGA/MT attenuated the aggregation of neutrophils at the site of injury, markedly reducing local inflammation and cellular damage following HIRI. This engineered cellular nanoparticle-based therapy could thus serve as a safe, effective, and cost-efficient strategy for treating HIRI.</p>","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"29 ","pages":"0212"},"PeriodicalIF":8.1,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12099054/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Potential of Photoacoustic Imaging in Detecting and Managing Complex Wounds.","authors":"Haifeng Hu, Ruiyin Zeng, Longyu Du, Weixian Hu, Chuanlu Lin, Jiewen Liao, Chong Ding, Xudong Xie, Bobin Mi, Wu Zhou, Yun Sun, Faqi Cao, Guohui Liu","doi":"10.34133/bmr.0206","DOIUrl":"10.34133/bmr.0206","url":null,"abstract":"<p><p>Photoacoustic imaging (PAI) is a promising emerging technology in biomedical imaging, particularly in wound healing. This review summarizes the applications of PAI in the detection and management of complex wounds, emphasizing its advantages in providing high-contrast, high-resolution deep tissue imaging. PAI integrates optical imaging's high contrast with ultrasound's deep penetration, facilitating the monitoring of vital physiological parameters like blood flow, oxygen saturation, and tissue regeneration in wounds. The review details the applications of PAI in monitoring wound pH, nerve repair, drug absorption, burn imaging, and infection-related wound assessment. It also explores the role of novel materials like carbon-based materials, nanorobots, and inorganic nanoparticles in enhancing PAI capabilities. Despite the technical challenges and limitations in clinical applications, PAI holds tremendous potential for wound healing monitoring. The review concludes by addressing the challenges and solutions for PAI, along with future development directions, to facilitate the transition of PAI technologies from experimental stages to clinical application.</p>","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"29 ","pages":"0206"},"PeriodicalIF":8.1,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12092969/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanozymes Empower Periodontitis Treatment: New Strategies and Clinical Application Prospects.","authors":"Yurong Xu, Jingyu Yan, Chenying Cui, Lihong Zhou, Kaifang Zhang, Meijun Du, Yajuan Gong, Zhuowei Zhang, Xiuping Wu, Bing Li","doi":"10.34133/bmr.0210","DOIUrl":"10.34133/bmr.0210","url":null,"abstract":"<p><p>Periodontitis is a chronic inflammatory disease mediated by the immune system. Its pathogenesis involves the interaction of multiple factors, among which the accumulation of dental plaque is considered the initial key factor in the onset of the disease. As the pathogenic bacteria in plaque proliferate and metabolites are released, the host's immune system produces a strong response, leading to an inflammatory response and structural destruction of local tissues. Traditional treatment relies on mechanical scraping and antibiotics but suffers from tissue damage, difficulty in removing deep-seated bacteria, development of drug resistance, and insufficient modulation of complex pathomechanisms. Nanozymes, as a novel therapeutic tool with high efficiency, stability, and multifunctionality, can remove pathogenic bacteria, modulate inflammation, and promote tissue repair, as well as have better environmental stability and biocompatibility, which provides a new way for precise treatment of periodontal disease and tissue regeneration. In this paper, the pathophysiology of periodontitis was first elucidated, and the design strategy of nanozymes and their application classification for the treatment of periodontitis were also discussed. Then, the recent advances in treating periodontitis with nanozymes are summarized in terms of antibacterial, anti-inflammatory, and tissue regeneration. Finally, the problems and prospects for the development of nanozymes for the treatment of periodontitis are discussed in terms of current challenges in the treatment of periodontitis and the stimulation of innovative research on nanozymes drugs, with a view to the clinical translation of novel enzyme mimicry strategies and efficient nanozymes for periodontitis drugs.</p>","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"29 ","pages":"0210"},"PeriodicalIF":8.1,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12089970/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144113043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}