Biomaterials research最新文献

{"title":"Acid-Responsive Zeolitic Imidazolate Framework-8 Core-Shell Nanovesicles Loaded with Interleukin-2 Nanoplatforms Selectively Expand Regulatory T Cells to Reconstruct Immunometabolic Homeostasis in Diabetic Neuropathy.","authors":"Yangjie Li, Yanqing Liu, Fei Gong, Kangling Xie, Ling Zhang, Taolin Fan, Cui Li, Jiahao Li, Fan Hu, Ying Cai","doi":"10.34133/bmr.0407","DOIUrl":"https://doi.org/10.34133/bmr.0407","url":null,"abstract":"<p><p>This study presents a nanotherapeutic strategy for diabetic peripheral neuropathy (DPN) by developing polyimide-coated zeolitic imidazolate framework-8 core-shell nanovesicles loaded with interleukin-2 (MOF@PI-IL2) for inflammation-microenvironment-responsive delivery of IL-2 and relatively preferential activation of regulatory T cells (Treg cells). Given that DPN is characterized by chronic neuroinflammation and immune dysregulation with impaired Treg cell numbers and activity, the engineered nanoparticles promote Treg cell expansion and immunometabolic reprogramming while suppressing CD8⁺ T cell cytotoxicity. Through comprehensive evaluation using multiomics integration, biomineralization synthesis, inflammatory models, and DPN mouse experiments, the system demonstrated favorable physicochemical properties and biodistribution. Treatment with MOF@PI-IL2 significantly improved both electrophysiological parameters and structural nerve function. Forkhead box P3 knockdown experiments confirmed that the therapeutic effects were Treg cell dependent. Multiomics analysis further suggested that the treatment partly corrected short-chain fatty acid and tryptophan metabolic dysregulation and was associated with reconstruction of correlations within a \"metabolism-IL-2 response-Treg cell module\". This work provides an inflammation-microenvironment-responsive and translatable Treg-cell-targeted nanoimmunotherapeutic strategy for DPN while broadening the conceptual framework for treating chronic inflammatory diseases through immunometabolic modulation.</p>","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"30 ","pages":"0407"},"PeriodicalIF":9.8,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13542432/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148898591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Female Reproductive Tract Modeling through Advanced 3D Biomimetic Platforms.","authors":"Chaeyoun Lee, Yoonseo Choi, Hyejin Lee, Seunghee Kim, Jeong Su Park, Young Min Shin, Dae Hyeok Yang, Gun-Jae Jeong, Dong Nyoung Heo, Jeong-Kee Yoon, Junhyeong Yim, Jongmin Kim, Yonghwan Kim, Kyung Hyun Yoo, Jung Bok Lee, Byung-Chul Lee","doi":"10.34133/bmr.0413","DOIUrl":"10.34133/bmr.0413","url":null,"abstract":"<p><p>The female reproductive tract (FRT) is an intricate and highly regulated network comprising the ovaries, fallopian tubes, uterus, cervix, and placenta, which work in concert to govern complex reproductive functions. Dysfunction within any of these organs can lead to serious pathological conditions, including infertility, pregnancy complications, and gynecological cancers. Although conventional 2-dimensional (2D) cultures and animal models have provided foundational insights, they are limited in their ability to recapitulate human-specific 3D tissue architecture and dynamic biochemical microenvironments. To address these limitations, organoid and organ-on-a-chip (OoC) technologies have emerged as a powerful 3D biomimetic platform. Organoids preserve epithelial identity, cellular heterogeneity, and patient-specific phenotypes, whereas OoC systems incorporate microfluidic flow, mechanical stimulation, and multicompartmental interfaces to model organ-level physiology. This review provides an organ-specific overview of recent advances in organoid and OoC systems across the FRT, discusses their advantages and current limitations relative to traditional models, and highlights their potential to transform reproductive biology research, disease modeling, and translational applications.</p>","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"30 ","pages":"0413"},"PeriodicalIF":9.8,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13538936/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148889725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surface Calcium Enrichment of Biogenic Hydroxyapatite Regulates Macrophage Inflammation via Toll-Like Receptor 4 Signaling.","authors":"Meihua Mai, Mengxi Su, Shudan Deng, Tianze Lin, Junming Feng, Chunhsin Hsu, Chuangji Li, Zefeng Guo, Xinyi Yang, Shiyu Wu, Zhuofan Chen","doi":"10.34133/bmr.0409","DOIUrl":"10.34133/bmr.0409","url":null,"abstract":"<p><p>Biogenic hydroxyapatite (BHA) is widely used for oral bone defect regeneration, yet its osteogenic efficacy is limited by slow osteogenesis and insufficient bone volume, which may be attributed to early inflammatory responses. The investigation of granular biomaterials is further challenged by conventional in vitro models that fail to ensure adequate cell-material interactions and efficient RNA extraction, limiting experimental reliability. Here, we developed an improved direct coculture system together with an optimized RNA extraction strategy to address these limitations. Using this platform, we characterized BHA-induced inflammatory responses at the gene, protein, and transcriptomic levels. Our results showed that the inflammatory activity of BHA is associated with its calcium-enriched surface, which activates the Toll-like receptor 4 signaling pathway. Furthermore, a calcium pre-adsorption strategy was introduced to modulate surface ion activity, which reduced calcium enrichment and attenuated inflammatory signaling. These findings suggest that modulating calcium enrichment capacity may offer a promising strategy to regulate the immune response of hydroxyapatite-based bone substitutes and improve their biological performance.</p>","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"30 ","pages":"0409"},"PeriodicalIF":9.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13530371/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148876932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioactive Mineralized Cell-Derived Extracellular Matrix via Polymer-Induced Liquid Precursor Enhances Osteogenesis and Bone Regeneration.","authors":"Jae Won Kwon, Jin Jeon, Seung Won Yang, Youngdoo Chung, Jin Hee Park, Yoon Ki Joung, Hee Seok Yang, Kwideok Park","doi":"10.34133/bmr.0410","DOIUrl":"10.34133/bmr.0410","url":null,"abstract":"<p><p>Effective bone regeneration requires biomaterials that exhibit appropriate bioactive functions, particularly osteoconductive and osteoinductive properties. Here, we engineered a cell-derived, decellularized extracellular matrix (cdECM) into a novel mineralized ECM scaffold by harnessing the polymer-induced liquid precursor (PILP) process, an effective strategy for generating calcium phosphate (CaP) mineralized constructs. Mineral deposition within cdECM was successfully achieved through the PILP mineralization, which stabilizes the amorphous precursor phase and promotes matrix-associated mineralization. The resulting mineralized ECM (mECM) exhibited osteoconductive properties, as evidenced by excellent cytocompatibility and enhanced cell proliferation of osteogenic cells. The mECM also demonstrated osteoinductive potential, as confirmed by enhanced alkaline phosphatase activity, increased calcification, and up-regulated osteogenic gene expression in mouse preosteoblasts and human mesenchymal stem cells. Moreover, mECM promoted M2-like macrophage polarization and enhanced tubular formation of endothelial cells. To enable localized in vivo delivery of both ECM-derived biological cues and minerals, a sheet-type mECM scaffold was fabricated using hyaluronic acid as a supporting matrix and further stabilized by glutaraldehyde vapor crosslinking. In a mouse calvarial defect model, the mECM sheet facilitated new bone formation and supported advanced bone maturation, accompanied by enhanced angiogenesis and an M2-dominant anti-inflammatory milieu at an early time point. Collectively, our findings demonstrate that PILP mineralization can be successfully applied to cdECM for generating a bioactive mECM scaffold with enhanced regenerative capacity, representing a promising biomaterial platform for bone tissue regeneration.</p>","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"30 ","pages":"0410"},"PeriodicalIF":9.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13530373/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148876942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multifunctional Metal Polyphenol Nanoparticles Based on Photothermal Therapy for Bacterial Eradication and Wound Healing.","authors":"Haitao Yuan, Mengyun Hou, Min Zou, Shiyan He, Yunmeng Bai, Wenzhe Chen, Junhui Chen, Xiaoxian Wang, Jingbo Ma, Jinyue He, Centing Wang, Xinmiao Liu, Lihong Jiang, Li Song, Wei Xiao, Jigang Wang","doi":"10.34133/bmr.0387","DOIUrl":"10.34133/bmr.0387","url":null,"abstract":"<p><p>Balancing short-term antibacterial needs with long-term anti-inflammatory effects remains a major challenge in wound healing. Multifunctional bioactive materials capable of both efficient antibacterial action and inflammation modulation represent a promising solution. However, the majority of traditional antibacterial biomaterials possess only a single antibacterial effect, and their synthesis and preparation are intricate, which might restrict their clinical transformation. Chlorogenic acid is a natural compound endowed with anti-inflammatory properties. However, it is beset by certain inherent drawbacks, including poor water solubility and limited bioavailability. To overcome these difficulties, we have fabricated multifunctional nanoparticles (chlorogenic acid-iron nanoparticles, CA-Fe NPs) through the co-assembly of chlorogenic acid and iron ions in a straightforward manner. We found that CA-Fe NPs exhibit excellent photothermal conversion performance in vitro. Upon near-infrared (NIR) irradiation, they exhibit potent broad-spectrum antimicrobial activity against <i>Staphylococcus aureus</i>, <i>Escherichia coli</i>, <i>Candida albicans</i>, <i>Klebsiella pneumoniae</i>, and <i>Pseudomonas aeruginosa</i>. The CA-Fe NPs markedly reduced H₂O₂-induced reactive oxygen species levels and apoptosis in epithelial cells and suppressed lipopolysaccharide-induced M1 macrophage polarization in RAW 264.7 cells. Transmission electron microscopy results revealed enhanced bacterial membrane disruption by CA-Fe NPs under NIR irradiation, causing pronounced protein leakage. Transcriptomic analysis indicates that CA-Fe NPs combined with NIR disrupt the tricarboxylic acid cycle, cell-wall organization, and other metabolic processes. In vivo, within a methicillin-resistant <i>Staphylococcus aureus</i>-infected skin wound model, CA-Fe NPs maintained photothermal efficacy, effectively reduced serum levels of interleukin-1 beta, interleukin-6, and tumor necrosis factor alpha, and accelerated wound healing. These findings suggest that CA-Fe NPs are multifunctional materials with broad-spectrum bactericidal ability, antioxidant, anti-inflammatory, and wound-healing-promotion properties. These nanoparticles possess promising prospects for biomedical applications.</p>","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"30 ","pages":"0387"},"PeriodicalIF":9.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13530372/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148876897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regenerative Nano-scaffolds for Tissue Engineering: From Bench to Clinical Translation.","authors":"Woochan Kim, Sangbae Park, Sang Won Beom, Selin Choi, Hye-Won Yang, Dream Kim, Shinyull Lee, Harshita Sharma, Chaeyeon Park, Won-Pyo Lee, Jangho Kim","doi":"10.34133/bmr.0414","DOIUrl":"10.34133/bmr.0414","url":null,"abstract":"<p><p>Biomedical membranes are among the most widely used biomaterials in clinical regenerative medicine due to their ease of application, biocompatibility, and versatility across multiple tissues. However, conventional membranes have been limited to passive roles serving as physical barriers or wound coverings without an intrinsic capability to initiate or orchestrate true tissue regeneration. Here, we report the design, development, and clinical validation of an active tissue-regenerative biomedical membrane patch, aiming to advance biomedical membranes from passive protection toward active human tissue regeneration. In this study, we developed a multifunctional, collagen-coated polylactic-<i>co</i>-glycolic acid nanotopographical scaffold (Col-NS) that mimics the native extracellular matrix to enhance soft- and hard-tissue regeneration. In a clinical trial for laser-induced human skin injury, Col-NS substantially improved healing outcomes, achieving accelerated wound contraction, dermal volume restoration, reduced surface roughness, and decreased transepidermal water loss relative to standard care. In human dental procedures, including alveolar ridge preservation and guided bone regeneration, Col-NS enabled robust bone formation, stable implant osseointegration, and complication-free recovery. These findings demonstrate the translational feasibility of an extracellular-matrix-mimetic nanoengineered scaffold across soft- and hard-tissue applications and support its potential as a clinically relevant platform for regenerative medicine. This work may contribute to broadening the clinical role of biomedical patches from passive coverings toward active regenerative platforms.</p>","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"30 ","pages":"0414"},"PeriodicalIF":9.8,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13527211/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148868542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Glucose-Responsive Hydrogel with Multifunctional Properties for Accelerated Diabetic Wound Healing.","authors":"Zhaoguo Wang, Susu Lei, Feng Lai, Chao Wang, Jing Xu, Shulan Xu","doi":"10.34133/bmr.0405","DOIUrl":"https://doi.org/10.34133/bmr.0405","url":null,"abstract":"<p><p>Diabetic wounds are characterized by oxidative stress, chronic inflammation, and impaired tissue regeneration under persistent hyperglycemic conditions. Herein, we report an injectable dual-dynamic covalent hydrogel fabricated from phenylboronic-acid-functionalized oxidized sodium alginate and gallic-acid-conjugated chitosan. Crosslinked via reversible Schiff base and boronate ester bonds, the hydrogel exhibits excellent injectability, self-healing capability, and structural stability. Under hyperglycemic conditions, competitive glucose binding modulates the boronate ester equilibrium and induces glucose-responsive release of galloyl-containing species. These glucose-responsive release behaviors contribute to the antioxidant, antibacterial, and immunoregulatory activities of the hydrogel. In vitro and in vivo results demonstrate that the hydrogel promotes macrophage polarization toward the anti-inflammatory M2 phenotype, alleviates inflammatory responses, enhances angiogenesis, and accelerates skin regeneration. Collectively, the phenylboronic-acid-functionalized oxidized sodium alginate and gallic-acid-conjugated chitosan hydrogel represents a multifunctional glucose-responsive biomaterial with considerable potential for diabetic wound therapy.</p>","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"30 ","pages":"0405"},"PeriodicalIF":9.8,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13486732/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148803066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Degradable Nanoplatform Integrating Glucose Oxidase and Copper Selenide for Near-Infrared-Enhanced Multimodal Synergistic Therapy in Lung Cancer.","authors":"Yong Zhang, Lei Xue, Lin Shi, Mengni Zhu, Jun Li, Degang Liu, Qiang Yang, Jiebai Zhou, Zilong Liu, Dawei Yang, Jiangzhou Peng","doi":"10.34133/bmr.0404","DOIUrl":"https://doi.org/10.34133/bmr.0404","url":null,"abstract":"<p><p>Lung cancer remains a leading cause of cancer-related mortality worldwide, with therapeutic outcomes frequently constrained by drug resistance, tumor heterogeneity, and systemic toxicity. Multimodal synergistic therapy has emerged as a promising strategy to address these challenges. In this study, we developed a biodegradable nanosystem, designated CSZG, which integrates glucose oxidase (GOx) and copper-rich copper selenide (Cu_2-<i>x</i> Se) within a ZIF-8 nanocarrier for lung cancer therapy. CSZG exhibited pH-responsive GOx release, favorable colloidal stability, and retained glucose-responsive catalytic activity of GOx. GOx supplied hydrogen peroxide (H₂O₂) through glucose oxidation, while Cu⁺ catalyzed the conversion of H₂O₂ into cytotoxic hydroxyl radicals (•OH) under near-infrared (NIR) irradiation, thereby enhancing chemodynamic therapy. Electron spin resonance analysis directly confirmed NIR-enhanced •OH generation, particularly under acidic conditions. In addition, CSZG + NIR induced copper-dependent mitochondrial dysfunction with cuproptosis-associated features, as evidenced by aggregation of dihydrolipoamide S-acetyltransferase, down-regulation of ferredoxin 1 , depletion of Fe-S cluster proteins, and partial reversal by tetrathiomolybdate. The Cu_2-<i>x</i> Se-containing platform also promoted macrophage polarization toward an M1-like phenotype. In vivo, CSZG + NIR achieved a tumor inhibition rate of 91.7% and demonstrated favorable short-term systemic biosafety under the tested therapeutic conditions. Collectively, these findings highlight CSZG as a promising multimodal therapeutic platform for lung cancer.</p>","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"30 ","pages":"0404"},"PeriodicalIF":9.8,"publicationDate":"2026-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13473715/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148764485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comprehensive Reactive-Oxygen-Species-Scavenging Metal-Organic Framework Orchestrates the AMPK-DOT1L-H3K79me3 Cascade to Alleviate Osteoarthritis.","authors":"Yu Jin, Cheng Zhu, Tiancheng Li, Ruomei Li, Chengxiao Liu, Yixin Li, Bing Fang, Lunguo Xia","doi":"10.34133/bmr.0402","DOIUrl":"10.34133/bmr.0402","url":null,"abstract":"<p><p>Osteoarthritis (OA) is a complex pathological condition characterized by oxidative stress and progressive cartilage breakdown. The reciprocal relationship between the inflammatory joint milieu and impaired chondrocyte function drives the progressive deterioration of OA. Inspired by natural metalloenzymes that utilize metal ions as catalytic centers, stable metal-organic frameworks (MOFs) assembled from natural polyphenols and metal ions have emerged as promising candidates for mitigating inflammatory diseases. Nonetheless, numerous nanozymes are limited to restricted antioxidant capacity, failing to eliminate various kinds of reactive oxygen species (ROS). To address these limitations, we engineered the MnO₂@UiO-66(Ce) (abbreviated as MCU) system, which was fabricated through the integration of MnO₂ into nanoscale mesoporous UiO-66 MOFs for OA therapy. Within the MOF architecture, MnO₂ coupled with Ce clusters establishes a continuous superoxide dismutase/catalase cascade reaction platform that enables efficient ROS scavenging. In vitro and in vivo experiments reveal that the MCU system significantly reduces intracellular ROS accumulation and ameliorates the inflammatory microenvironment, consequently attenuating cartilage matrix destruction. Further mechanistic investigations indicates that MCU alleviates OA progression through the epigenetic activation of Wnt/β-catenin via adenosine monophosphate-activated protein kinase-disruptor of telomeric silencing 1-like-mediated H3K79 methylation. In summary, this study suggests that this highly efficient cascade catalytic system may represent a promising strategic avenue for combating oxidative stress in chronic inflammatory diseases.</p>","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"30 ","pages":"0402"},"PeriodicalIF":9.8,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13457904/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148714916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Near-Infrared-Triggered \"Bridge-and-Attack\" Strategy via a Bioinspired Copper-Polyphenol Nanoarchitectonics Platform for Vascular Normalization-Enhanced Cuproptosis-Immunotherapy of Triple-Negative Breast Cancer.","authors":"Xinru Shen, Ying Zhang, Mengyan Shan, Yiqing Kou, Xintao Jia, Mengru Yang, Changxiang Yu, Jingbai Li, Pan Guo, Jiawei Li, Zhidong Liu","doi":"10.34133/bmr.0398","DOIUrl":"10.34133/bmr.0398","url":null,"abstract":"<p><p>Triple-negative breast cancer (TNBC) presents formidable treatment barriers due to dysfunctional vasculature and an immunosuppressive microenvironment. To address these challenges, we engineered a bioinspired near-infrared (NIR)-responsive copper-polyphenol nanoplatform, SCP, to implement a NIR-triggered \"bridge-and-attack\" therapeutic strategy. This nanoassembly was constructed through the coordination of salvianolic acid B (SAB) with copper ions and further stabilized by a polydopamine (PDA) shell. Upon NIR irradiation, SAB and Cu²⁺ were co-released from SCP, enabling simultaneous vascular remodeling and tumor cell killing. The released SAB promoted vascular normalization, increasing pericyte coverage to 51.6% and alleviating tumor hypoxia, thereby facilitating intratumoral penetration and immune-cell infiltration. Meanwhile, released Cu²⁺, together with PDA-mediated photothermal activation, induced cuproptosis and immunogenic cell death (ICD). This combined remodeling of the tumor microenvironment enhanced CD8⁺ T cell infiltration and achieved a tumor inhibition rate of 88.5% in 4T1 tumor-bearing mice with favorable systemic biosafety. Overall, this interfacial nanomaterial design integrates vascular normalization, photothermal-enhanced cuproptosis, and immunotherapy, providing a promising materials-based strategy for TNBC treatment.</p>","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"30 ","pages":"0398"},"PeriodicalIF":9.8,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13429914/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148671527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}