Biomaterials research最新文献

{"title":"Application of Dual-Targeting Carbon Dot Nanozymes in Improving Hypoxia and Enhancing Small Interfering RNA-Mediated Gene Silencing for Hepatocellular Carcinoma.","authors":"Yingying Wei, Yangyi Cao, Wencheng Shao, Tao Zhang, Xiaobo Zhang, Wenhui Dong, Shizhao Zhou, Yongzhen Yang, Lin Chen, Shiping Yu","doi":"10.34133/bmr.0430","DOIUrl":"https://doi.org/10.34133/bmr.0430","url":null,"abstract":"<p><p>Hepatocellular carcinoma (HCC) is a malignant tumor with high morbidity and mortality, and current therapeutic effects remain unsatisfactory. Small interfering RNA (siRNA) therapy has attracted widespread attention owing to its strong specificity and high silencing efficiency. Golgi apparatus (GA) protein 73 (GP73) is overexpressed in HCC and promotes proliferation and invasion of HCC. However, the hypoxic microenvironment of HCC facilitates GP73 synthesis. Based on the bidirectional regulation between GP73 and the hypoxic microenvironment, this study proposes the use of carbon dot nanozyme with dual-targeting properties to deliver GP73-siRNA to the GA of HCC cells, thereby inhibiting GP73 expression and simultaneously alleviating hypoxia for synergistic HCC treatment and improved efficacy. Specifically, GA targeting manganese-doped carbon dot nanozyme (Mn-CDs) was constructed using neutral red (with a large sp² conjugated structure), L-cysteine (GA targeting agent), and manganese dioxide as raw materials via a one-step solvothermal method. Polyethyleneimine (PEI) and hyaluronic acid (HA) were modified on the surface of Mn-CDs to obtain the dual-targeting Mn-CDs-PEI-HA. Subsequently, Mn-CDs-PEI-HA was used as a carrier to load GP73-siRNA and form the Mn-CDs-PEI-HA/GP73-siRNA complex. Results demonstrated that the complex exhibited excellent catalase-like enzyme activity, which can alleviate tumor hypoxia, and could deliver GP73-siRNA to the GA of HCC cells, thereby silencing GP73 expression and synergistically inhibiting HCC progression. The therapeutic effect under hypoxic conditions was superior to that under normoxic conditions. Additionally, by simultaneously taking advantage of the favorable fluorescence and magnetic properties of Mn-CDs-PEI-HA, fluorescence/magnetic resonance dual-modality imaging of HCC was achieved, providing a new strategy for theranostics of HCC.</p>","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"30 ","pages":"0430"},"PeriodicalIF":9.8,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13678084/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149225586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-omics Profiling Reveals the Effects of Xihuangcao on Hepatic Fibrosis Attenuation through Gut Microbiota and Metabolic Reprogramming.","authors":"Weiguo Zhao, Xueling Zhang, Lifan Xu, Mianfeng Zheng, Zhuoya Li, Yuexuan Wang, Xinxiang He, Min Hong, Huiye Zhang, Junwei Li, Lei Shi, Ying Du, Haitao Yuan, Wei Zhang, Ali Chen","doi":"10.34133/bmr.0422","DOIUrl":"https://doi.org/10.34133/bmr.0422","url":null,"abstract":"<p><p>In various chronic liver diseases, hepatic fibrosis represents a frequent pathological event. This process involves the activation of hepatic stellate cells, along with the consequent excessive deposition of extracellular matrix. Emerging evidence highlights the contribution of gut microbiota dysbiosis and intestinal barrier dysfunction to its progression, underscoring the potential of targeting the liver-gut axis. Xihuangcao, a traditional Chinese medicinal herb used for acute cholecystitis and jaundice hepatitis, exhibits antifibrotic activity, but its underlying mechanisms remain unclear. In this study, hepatic fibrosis models were established to evaluate the antifibrotic effects of 3 botanical sources of Xihuangcao (<i>Isodon lophanthoides</i> (Buch.-Ham. ex D.Don) H.Hara, <i>Isodon lophanthoides</i> var. <i>graciliflorus</i> (Benth.) H.Hara, and <i>Isodon serra</i> Kudô) through integrating histopathological, transcriptomics, metabolomics, 16S ribosomal RNA (rRNA) sequencing, and network pharmacology analyses. The results indicated that all 3 botanical sources of Xihuangcao markedly alleviated hepatic fibrosis and reduced collagen deposition. Transcriptomic analysis revealed that Xihuangcao down-regulated profibrotic mediators (Toll-like receptor 5, transforming growth factor-β, and platelet-derived growth factor) and modulated mitogen-activated protein kinase, steroid biosynthesis, bile secretion, and retinol metabolism pathways, highlighting its coordinated suppression of inflammation-driven fibrogenic activation in hepatic fibrosis. Liver metabolomics revealed Xihuangcao's effect on restoration of energy metabolism, amino acid turnover, and redox homeostasis. Xihuangcao also corrected fibrosis-induced gut dysbiosis, characterized by reduced Verrucomicrobia and increased S24-7 abundance, while suppressing pathogenic genera such as <i>Clostridium</i> and <i>Prevotella</i>. Moreover, Xihuangcao decreased profibrotic metabolites (androstan-3α,17β-diol) and suppressed choline-related metabolic pathways associated with fibrogenic signaling. Network pharmacology and experimental validation further identified PI3K/Akt inhibition as a key mechanism suppressing hepatic stellate cell activation. In summary, this study, based on integrative multi-omics analyses (metabolomics, transcriptomics, and 16S rRNA sequencing), found that Xihuangcao alleviates liver fibrosis by modulating inflammatory responses, metabolic disorders, and gut microbiota dysbiosis via the gut-liver axis. Furthermore, network pharmacology combined with in vitro experiments revealed that inhibition of hepatic stellate cell activation through the PI3K/Akt pathway may be the critical mechanism underlying its therapeutic efficacy.</p>","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"30 ","pages":"0422"},"PeriodicalIF":9.8,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13678083/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149225550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatiotemporally Regulated Pro-/Anti-Inflammatory Transition via Reactive Oxygen Species-Sensitive Core-Shell Hydrogel for Diabetic Infected Wound Healing.","authors":"Jian Zhang, Yan Lin, Yan Liu, Wentao Wang, Yuanyuan Li, Ben Zhong Tang, Xin Wang","doi":"10.34133/bmr.0432","DOIUrl":"10.34133/bmr.0432","url":null,"abstract":"<p><p>Diabetic infected wounds remain difficult to heal because bacterial colonization, biofilm formation, excessive reactive oxygen species (ROS), and persistent inflammation mutually reinforce one another in the diabetic wound microenvironment. In diabetic wounds, the temporal immune switch is often impaired, resulting in oxidative stress accumulation and poor vascularized tissue repair. Therefore, an ideal wound dressing should not merely kill bacteria or suppress inflammation independently, but should coordinate antibacterial intervention and immune remodeling according to the evolving stages of wound healing. Here, we constructed a ROS-responsive core-shell hydrogel, BBT-Py⁺ NPs@SchB@CSH, to achieve spatiotemporally ordered therapy for diabetic infected wounds. The outer shell was loaded with BBT-Py⁺ nanoparticles, an aggregation-induced emission luminogen (AIEgen) with near-infrared imaging capability and synergistic photothermal-photodynamic antibacterial activity against <i>Staphylococcus aureus</i> and biofilms. The inner core encapsulated schisandrin B (Sch B), a natural antioxidant and immunomodulator that scavenges excessive ROS and promotes macrophage polarization from the pro-inflammatory M1 phenotype toward the reparative M2 phenotype. The ROS-sensitive interface enabled the infected microenvironment and laser-triggered ROS to accelerate outer-shell degradation, allowing early antibacterial action to be followed by Sch B-mediated immunoregulatory repair. In vitro and in vivo evaluations demonstrated that BBT-Py⁺ NPs@SchB@CSH effectively disrupted bacterial biofilms, reduced bacterial burden, alleviated oxidative inflammatory stress, promoted collagen deposition and angiogenesis, and accelerated diabetic infected wound closure. This study presents an \"outer-layer antibacterial, inner-core immunomodulatory repair\" strategy that matches therapeutic function to the temporal requirements of infected diabetic wound healing.</p>","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"30 ","pages":"0432"},"PeriodicalIF":9.8,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13669506/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149217365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resveratrol-Loaded Responsive Core-Shell Tecto Dendrimers Potentiate Hepatocellular Carcinoma Therapy.","authors":"Wenchao Liu, Junjie Liu, Zhenze Zheng, Wenqing Man, Xiaoyang Zhang, Xiaoyi Zheng, Yupeng Wang, Yao Shi, Qinghai Lin, Cong Song","doi":"10.34133/bmr.0428","DOIUrl":"https://doi.org/10.34133/bmr.0428","url":null,"abstract":"<p><p>Hepatocellular carcinoma (HCC) exhibits profound metabolic reprogramming, particularly enhanced glycolytic activity, which represents a therapeutic vulnerability. However, the remarkable adaptability of HCC metabolism allows tumor cells to compensate for metabolic disturbances and preserve cellular homeostasis, reducing the effectiveness of metabolism-targeted strategies. Therefore, strategies sustaining metabolic perturbation beyond tumor adaptive capacity are needed. Herein, we developed a pH-responsive zwitterion-modified core-shell tecto dendrimer nanocarrier (CSTD-PS) for resveratrol (Res) delivery to overcome these limitations and potentiate HCC therapy. CSTD-PS was constructed through dynamic boronate ester-mediated assembly and zwitterionic surface modification, enabling Res encapsulation and pH-responsive release. After Res encapsulation, Res@CSTD-PS exhibited enhanced cellular uptake and nanocarrier-associated tumor localization, resulting in superior antitumor efficacy in HCC models compared with free Res. Mechanistically, Res@CSTD-PS suppressed glycolytic regulators, including hexokinase 2, glucose transporter 1, and pyruvate kinase M2, accompanied by enhanced stress responses (glucose-regulated protein 78 and nuclear factor erythroid 2-related factor 2) and p53/caspase-3-associated apoptotic signaling. Res@CSTD-PS also reduced programmed death-ligand 1 expression, suggesting potential attenuation of immune-evasive characteristics. Collectively, this study introduces a strategy enabled by intelligent dendrimer-based nanomedicine, providing a promising approach for enhancing natural compound-based therapy against HCC.</p>","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"30 ","pages":"0428"},"PeriodicalIF":9.8,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13662274/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149198366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vulnerability and Immunogenic Cell Death under Microwave Ablation for Synergistic Treatment of Hepatocellular Carcinoma.","authors":"Zide Chen, Hongwei Xu, Yufu Peng, Mengni Zhu, Linqing Huang, Feng Fang, Kefei Chen","doi":"10.34133/bmr.0421","DOIUrl":"10.34133/bmr.0421","url":null,"abstract":"<p><p>Microwave ablation (MWA) holds great promise for hepatocellular carcinoma but is often limited by incomplete tumor eradication and recurrence. Here, we report a tumor-killing nanoimmunoreactor driven by endogenous immune cues that synergizes with MWA to eliminate residual tumors and activate systemic antitumor immunity. The 17-AAG-MnO₂PEG nanoimmunoreactor consists of a self-responsive PEGylated MnO₂ platform loaded with the HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin (17-AAG), which is designed to respond to the oxidative tumor microenvironment. 17-AAG disrupts tumor cell thermotolerance, enhancing sensitivity to microwave-induced thermal stress, thereby improving ablation efficacy and inducing immunogenic cell death. PEGylation facilitates tumor-targeted accumulation, while the degradable MnO₂ responds to hydrogen peroxide (H₂O₂) and tumor debris generated after MWA, enabling sustained local drug release. The combination treatment promotes dendritic cell maturation and T cell infiltration, effectively suppresses residual tumor regrowth, reduces the risk of metastasis, and establishes durable immune memory. By leveraging post-ablation tumor debris and microenvironmental cues, this strategy couples local tumor ablation with systemic antitumor immunity, providing a mechanistically distinct paradigm for durable cancer therapy.</p>","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"30 ","pages":"0421"},"PeriodicalIF":9.8,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13646457/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149139662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanozymes in Tumor Microenvironment Modulation for Cancer Therapy.","authors":"Xinyang Zhang, Ziqi Wang, Yangguang Niu, Jingjing Tong, Ranfeng Wang, Yulin Zhu, Pei Pei, Jie Li, Yunan Gao, Xiaoran Deng, Jundong Zhou","doi":"10.34133/bmr.0425","DOIUrl":"10.34133/bmr.0425","url":null,"abstract":"<p><p>The tumor microenvironment (TME) plays a central regulatory role in malignant tumor progression and therapeutic resistance, and its complexity and dynamic heterogeneity markedly limit the efficacy of current treatment strategies. Therefore, the development of novel functional materials capable of effectively remodeling the TME and alleviating immunosuppression and therapeutic tolerance has become an important research direction in cancer therapy. In recent years, nanozymes, as a class of nanomaterials with enzyme-mimicking catalytic activity, have shown broad potential in TME intervention and the enhancement of cancer therapy owing to their excellent physicochemical stability, tunable structural properties, and multiple biomimetic enzyme-like activities. This review systematically summarizes recent advances in nanozyme-mediated regulation of the TME. First, the basic concepts, catalytic properties, and functional classifications of nanozymes are introduced. Subsequently, the mechanisms by which nanozymes remodel the TME and enhance cancer therapy are discussed from the key dimensions of the redox microenvironment, metabolic microenvironment, and immune microenvironment. Finally, the major challenges, barriers to clinical translation, and future development directions in this field are highlighted. This review aims to provide a theoretical basis and research perspectives for the further study, rational design, and translational application of nanozymes in cancer therapy.</p>","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"30 ","pages":"0425"},"PeriodicalIF":9.8,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13643025/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149139710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intranasal Netrin-1 modRNA-Loaded Extracellular Vesicles Reduce Neuronal Apoptosis after Ischemic Stroke.","authors":"Shanshan Cao, Anmin Ren, Yanqin Geng, Hanlai Li, Yandi Qiao, Kangjie Fan, Yaohui Tang, Peng Wang, Qiang Li","doi":"10.34133/bmr.0423","DOIUrl":"10.34133/bmr.0423","url":null,"abstract":"<p><p>Ischemic stroke remains a leading cause of mortality and long-term neurological disability worldwide, while effective neuroprotective therapies remain limited. Netrin-1 is a multifunctional guidance molecule with neuroprotective properties, and chemically modified mRNA (modRNA) offers a promising platform for transient therapeutic protein expression. However, safe and efficient delivery of modRNA to the ischemic brain remains a major barrier to clinical translation. Here, we engineered Netrin-1 modRNA-loaded extracellular vesicles (EV@mNetrin-1) derived from human umbilical cord mesenchymal stem cells (hUMSCs) and administered them via a noninvasive intranasal route. EV-mediated delivery enabled intracellular translation of Netrin-1 modRNA into protein in neurons and increased Netrin-1 expression in ischemic brain tissue. In vitro, EV@mNetrin-1 significantly reduced neuronal apoptosis and improved neuronal survival following oxygen-glucose deprivation/reoxygenation (OGD/R). In vivo, intranasal administration of EV@mNetrin-1 enhanced brain Netrin-1 expression, reduced infarct volume, improved neurological outcomes, and attenuated neuronal apoptosis in transient middle cerebral artery occlusion (tMCAO) mice. Mechanistically, the neuroprotective effects of EV@mNetrin-1 were associated with DCC-dependent activation of PI3K/AKT signaling. Collectively, these findings demonstrate the therapeutic potential of intranasal EV-mediated Netrin-1 modRNA delivery for ischemic stroke and support the development of RNA therapeutics for central nervous system disorders.</p>","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"30 ","pages":"0423"},"PeriodicalIF":9.8,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13639143/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149120036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extracellular Vesicle-Mimetic Nanoplatforms for Integrated Vaccination and Targeted Antibiotic Therapy against MRSA Bacteremia: A Wolf in Sheep's Clothing.","authors":"Yu-Kuo Chung, Cheng-Yu Lin, Yu-Ting Wang, Yen-Tzu Chang, Ahmed Alalaiwe, Huang-Ping Yu, Jia-You Fang","doi":"10.34133/bmr.0411","DOIUrl":"https://doi.org/10.34133/bmr.0411","url":null,"abstract":"<p><p>Methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) remains a critical global health threat, necessitating innovative therapeutic strategies. Inspired by the multi-antigenic features and homotypic binding of MRSA extracellular vesicles (EVs), we aimed to develop a biomimetic nanoplatform cloaked with MRSA-derived EV, termed EV-NP, to integrate vaccine and antibiotic functionalities. EV-NP were efficiently internalized by macrophages and dendritic cells, promoting robust humoral and cellular immune responses, as evidenced by elevated immunoglobulin G titers and CD69 expression. When loaded with rifampicin (RF), the nanoplatform demonstrated homologous targeting to MRSA via EV-mediated adhesion, enhancing drug delivery to intracellular bacteria and biofilm. In a murine bacteremia model, EV-NP vaccination and RF-loaded EV-NP therapy each significantly reduced bacterial burden and proinflammatory cytokine expression, improving survival to 62 and 41 h, respectively. Sequential prophylaxis and therapy extended survival to 140 h. The EV-NP system also attenuated EV-associated hemolysis and showed no acute toxicity. This \"wolf-in-sheep's-clothing\" strategy offers a versatile approach for both prevention and treatment of MRSA infection.</p>","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"30 ","pages":"0411"},"PeriodicalIF":9.8,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13624486/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149120084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced Hydrogel Functionalization Strategies for Burn-Related Wound Treatment.","authors":"Md Lemon Hasan, Mohammad Faysal Al Mazid, Yeasin Khan, Al Basir, Akhmad Irhas Robby, Shihab Uddin, Khandoker Asiqur Rahaman, Yoon Ki Joung","doi":"10.34133/bmr.0406","DOIUrl":"10.34133/bmr.0406","url":null,"abstract":"<p><p>Burn injuries cause deep, extensive skin damage and are associated with high morbidity and mortality. Effective treatment goes beyond superficial wound coverage; it requires regenerative repair that progresses from deeper tissue layers to complete skin restoration. Because of extreme trauma and severity, the fastest treatment strategies play a key role in the treatment of burn injuries. Recently, hydrogel dressings have gained attention as promising wound care options because they maintain a moist environment, provide cooling and pain relief, support autolysis, and promote tissue regeneration. However, the lack of biological function and, consequently, slower tissue regeneration limit the applications of hydrogels. In recent years, collaboration between doctors, materials scientists, and biologists has substantially improved the biological functionality of hydrogels. Integrating bioactive agents, such as proteins, peptides, antimicrobial compounds, drugs, metal nanoparticles, cell-based vesicles, and extracellular matrix, enables the development of multifunctional, active burn wound dressings. This review highlights advances in the functionalization of hydrogel dressings for burn care, including fabrication methods, biological efficacy, and therapeutic mechanisms. The literature provides a comprehensive overview of the area where further advancement could be pursued.</p>","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"30 ","pages":"0406"},"PeriodicalIF":9.8,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13617242/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149077022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Piezoelectric Iron (II) Tungstate-Integrated Three-Dimensional-Printed Polycaprolactone Scaffolds for Ultrasound-Triggered Osteosarcoma Therapy and Ultrasound-Free Bone Repair.","authors":"Jiongming You, Biaotong Huang, Yinsheng Wu, Xinxing Sun, Na Liang, Hao Wang, Yong Wang","doi":"10.34133/bmr.0420","DOIUrl":"10.34133/bmr.0420","url":null,"abstract":"<p><p>The demand for effective therapeutics addressing osteosarcoma necessitates multifunctional solutions integrating both antineoplastic and osteogenic properties. This study presents a novel approach involving a 3-dimensional (3D)-printed polycaprolactone (PCL) scaffold integrated with piezoelectric iron (II) tungstate (FeWO₄) nanorods (NRs), designed to concurrently combat osteosarcoma and foster bone regeneration. Through the amalgamation of FeWO₄ NRs' piezoelectric catalytic characteristics and PCL scaffold's structural attributes, the composite scaffolds exhibit dual functionality: inducing oxidative stress in tumor cells via ultrasound-triggered piezo-sonoydnamic effects while facilitating stem cell attachment and proliferation without ultrasound. The physicochemical attributes and catalytic efficacy of the composite scaffolds are meticulously investigated. Both in vitro and in vivo tests confirm the strong ultrasound-triggered antitumor and ultrasound-free bone-forming effects of the PCL@FeWO₄ composite scaffold. This study introduces a novel class of piezoelectric nanomaterial-functionalized 3D-printing scaffolds, presenting new avenues for ultrasound-triggered osteosarcoma therapy and ultrasound-free bone regeneration.</p>","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"30 ","pages":"0420"},"PeriodicalIF":9.8,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13594697/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149027135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}