Biomaterials research最新文献

{"title":"Recent Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Engineering Strategies for Precise Strike Therapy against Tumor.","authors":"Chae Eun Lee, Kyung Mu Noh, Sungjun Kim, Jiyeon Hong, Kyobum Kim","doi":"10.34133/bmr.0170","DOIUrl":"https://doi.org/10.34133/bmr.0170","url":null,"abstract":"<p><p>Effective drug delivery relies on the selection of suitable carriers, which is crucial for protein-based therapeutics such as tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). One of the key advantages of TRAIL is its ability to selectively induce apoptosis in cancer cells excluding healthy tissues by binding to death receptors DR4 and DR5, which are highly expressed in various cancer cells. Despite this promise, the clinical application of TRAIL has been limited by its short half-life, limited stability, and inefficient delivery to tumor sites. To overcome currently available clinical and engineering approaches, a series of sophisticated strategies is required: (a) the design of biomaterial-mediated carriers for enhanced targeting efficacy, particularly via optimizing selected materials, composition, formulation, and surface modulation. Moreover, (b) development of genetically modified cellular products for augmented TRAIL secretion toward tumor microenvironments and (c) cell surface engineering techniques for TRAIL immobilization onto infusible cell populations are also discussed in the present review. Among these approaches, living cell-based carriers offer the distinct advantage of systemically administered TRAIL-functionalized cells capturing circulating tumor cells in the bloodstream, thereby preventing secondary tumor formation. This review provides insight into the development of novel TRAIL delivery platforms, discusses considerations for clinical translation, and suggests future directions and complementary strategies to advance the field of TRAIL-based cancer therapeutics.</p>","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"29 ","pages":"0170"},"PeriodicalIF":8.1,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11922527/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Extracellular Matrix Promotes Diabetic Oral Wound Healing by Modulating the Microenvironment.","authors":"Zhongke Wang, Li Wang, Sihan Wang, Hongmei Chen, Danni Wang, Aodi Li, Ying Huang, Yifan Pu, Xinlei Xiong, Xiangrui Lui, Yuwen Huang, Ling Guo","doi":"10.34133/bmr.0169","DOIUrl":"https://doi.org/10.34133/bmr.0169","url":null,"abstract":"<p><p>Oral wounds in diabetes mellitus (DM) often delay healing due to reduced angiogenesis and increased inflammatory response in the local microenvironment, even leading to graft necrosis and implant failure. Therefore, developing an effective program to promote healing is of great clinical value. Much of the current research is focused on promoting wound healing through surface adhesive materials that exert a pro-angiogenic, anti-inflammatory effect. However, the application of surface bonding materials in the oral cavity is very limited due to the humid and friction-prone environment. Decellularized extracellular adipose tissue (DAT) is an easily accessible and biocompatible material derived from adipose tissue. To further explore the potential of DAT, we used multi-omics to analyze its composition and possible mechanisms. Proteomic studies revealed that DAT contains anti-inflammatory, pro-angiogenic proteins that promote DM tissue regeneration. To adapt to the moist and chewing friction environment of the mouth, we modified DAT into a temperature-sensitive hydrogel material that can be injected intramucosally. DAT hydrogel has been verified to promote angiogenesis and exert anti-inflammatory effects through macrophage phenotypic transformation. Meanwhile, transcriptome analysis suggested that the inhibitory effect of DAT on the interleukin 17 signaling pathway might be a key factor in promoting DM oral wound healing. In conclusion, after multi-omic analysis, DAT hydrogel can exert good pro-angiogenic and anti-inflammatory effects through the interleukin 17 signaling pathway and can be adapted to the specific environment of the oral cavity. This provides a potential way to promote DM oral wound healing in a clinical setting.</p>","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"29 ","pages":"0169"},"PeriodicalIF":8.1,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11922533/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polydopamine-based Nanoadjuvants Promote a Positive Feedback Loop for Cancer Immunotherapy via Overcoming Photothermally Boosted T Cell Exhaustion.","authors":"Xiao-Kai Chi, Hai-Rui Zhang, Jing-Jing Gao, Jin Su, Yong-Zhong Du, Xiao-Ling Xu","doi":"10.34133/bmr.0166","DOIUrl":"https://doi.org/10.34133/bmr.0166","url":null,"abstract":"<p><p>Immunogenic cell death, triggered by photothermal therapy or specific chemotherapy, strives to establish a positive feedback loop in cancer immunotherapy. This loop is characterized by the rapid release of antigens and adenosine triphosphate (ATP), ultimately leading to accelerated T cell infiltration. However, this loop is hindered by T cell exhaustion caused by adenosine originating from ATP and glucose deprivation in the immunosuppressive microenvironment. To overcome this challenge, we developed a pH-low insertion peptide-functionalized mesoporous-polydopamine-based nanoadjuvant that incorporates adenosine deaminase and doxorubicin (termed as PPMAD). PPMAD aimed to overcome T cell exhaustion by reducing adenosine consumption and providing an alternative carbon source for CD8⁺ T cell function during glucose starvation. First, PPMAD triggered the burst release of antigens and ATP through photothermal therapy and doxorubicin-induced immunogenic cell death, culminating in the expedited infiltration of T cells. Second, adenosine deaminase depleted adenosine, reducing immunosuppressive agents and generating abundant inosine, which served as an alternative carbon source for CD8⁺ T cells. By implementing this \"reducing suppression and broadening sources\" strategy, we successfully overcome T cell exhaustion, greatly enhancing the effectiveness of cancer immunotherapy both in vitro and in vivo. Our findings highlighted the positive feedback loop between on-demand photothermal therapy, chemotherapy immunotherapy, and achieving complete tumor response.</p>","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"29 ","pages":"0166"},"PeriodicalIF":8.1,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11922554/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Natural Polyphenol-Mediated Inhibition of Ferroptosis Alleviates Oxidative Damage and Inflammation in Acute Liver Injury.","authors":"Yangjing Su, Yunong Zeng, Minjie Zhou, Meihui Liao, Ping Qin, Rong Wu, Jiaochan Han, Xiaoqi Liang, Ze Wang, Jingjing Jiang, Zhichao Yu, Xintao Huang, Kaixin Ding, Peiheng Guo, Yi He, Ying Du, Tingting Duan, Haitao Yuan, Yuewei Ge, Ali Chen, Wei Xiao","doi":"10.34133/bmr.0167","DOIUrl":"10.34133/bmr.0167","url":null,"abstract":"<p><p>Acetaminophen (APAP) overdose has long been recognized as the main cause of drug-induced liver injury (DILI), characterized by glutathione (GSH) depletion and reactive oxygen species (ROS) accumulation, leading to ferroptosis and inflammatory responses. There is an urgent need for liver-protective agents to combat ferroptosis, modulate oxidative stress, and ameliorate inflammation. Catechin, a well-known polyphenol compound, has been shown to have antioxidant potential. However, its protective role on APAP-induced liver injury (AILI) has not been elucidated. In this study, we evaluated the modulating effects of catechin on AILI and observed that catechin attenuated liver injury by reducing inflammation. Mechanistically, catechin alleviated hepatic oxidative stress by inhibiting ROS accumulation, malondialdehyde (MDA) production, and GSH depletion. Furthermore, catechin, as a hepatic injury reparative agent, could counteract APAP-induced hepatocyte ferroptosis by activating the xCT/GPX4 pathway, and is expected to be a novel natural inhibitor of ferroptosis. Additionally, the transcriptomic results indicated that the inhibition of <i>Stat1</i> by catechin is important for the management of AILI. Inhibition of signal transducer and activator of transcription 1 (STAT1) expression, achieved through the use of the STAT1 inhibitor fludarabine in vivo and small interfering RNA (siRNA) in vitro, was confirmed to attenuate APAP-induced ferroptosis. In conclusion, the present study identified a novel natural drug inhibitor of ferroptosis and revealed its mechanism of action to inhibit ferroptosis, regulate oxidative stress, and ameliorate inflammation in AILI. This further provides new insights into the novel natural ferroptosis inhibitors for the treatment of ROS-related inflammatory diseases.</p>","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"29 ","pages":"0167"},"PeriodicalIF":8.1,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11913781/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143660125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Image-Guided Monitoring of Mitochondria and Blood-Brain Barrier Dysfunction in Amyotrophic Lateral Sclerosis Mice.","authors":"Do Won Hwang, Jinhui Ser, Konstantyn Ziabrev, G Kate Park, Min Joo Jo, Shinya Yokomizo, Kai Bao, Atsushi Yamashita, Hoonsung Cho, Maged Henary, Satoshi Kashiwagi, Hak Soo Choi","doi":"10.34133/bmr.0162","DOIUrl":"10.34133/bmr.0162","url":null,"abstract":"<p><p>Early detection of amyotrophic lateral sclerosis (ALS) progression is critical for improving disease management and therapeutic outcomes. However, the clinical heterogeneity and variability in ALS symptoms often lead to delayed diagnosis and suboptimal therapeutic interventions. Since mitochondrial dysfunction is a hallmark of ALS, we hypothesized that monitoring mitochondrial function could serve as a reliable strategy for early diagnosis and therapeutic monitoring of ALS. To address this, we synthesized and characterized 2 novel near-infrared fluorophores, ALS04 and ALS05, designed to target mitochondria and lysosomes. Their physicochemical properties, serum protein binding, fluorescence characteristics, photostability, and pharmacokinetics were systematically evaluated. We found that benzothiazole-based fluorophores exhibit excellent mitochondrial targeting, optimal optical properties, biocompatibility, and favorable biodistribution in vivo. Interestingly, ALS04 showed superior mitochondrial accumulation compared to ALS05, despite their similar physicochemical properties. This enhanced accumulation can be attributed to the lower molecular weight and higher lipophilicity of ALS04. Real-time fluorescence imaging revealed a substantial reduction in ALS04 signals in mitochondrial-rich tissues such as brown fat, highlighting its potential for monitoring mitochondrial dysfunction in early-stage ALS. Furthermore, the detection of ALS04 in the mouse brain suggests its ability to monitor blood-brain barrier hyperpermeability, another key feature of ALS pathology. These findings establish ALS04 as a promising noninvasive imaging tool for monitoring biomarkers associated with ALS progression. Its ability to detect early-stage pathophysiological changes in an ALS mouse model highlights its potential for advancing our understanding of ALS mechanisms and facilitating the identification of novel therapeutic targets.</p>","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"29 ","pages":"0162"},"PeriodicalIF":8.1,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11912748/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydrogen Peroxide-Releasing Hydrogel-Mediated Cellular Senescence Model for Aging Research.","authors":"Shibo Wei, Phuong Le Thi, Yan Zhang, Moon-Young Park, Khanh Do, Thi Thai Thanh Hoang, Nyssa Morgan, Tam Dao, Jimin Heo, Yunju Jo, You Jung Kang, Hansang Cho, Chang-Myung Oh, Young C Jang, Ki-Dong Park, Dongryeol Ryu","doi":"10.34133/bmr.0161","DOIUrl":"https://doi.org/10.34133/bmr.0161","url":null,"abstract":"<p><p>Cellular senescence, a process that induces irreversible cell cycle arrest in response to diverse stressors, is a primary contributor to aging and age-related diseases. Currently, exposure to hydrogen peroxide is a widely used technique for establishing in vitro cellular senescence models; however, this traditional method is inconsistent, laborious, and ineffective in vivo. To overcome these limitations, we have developed a hydrogen peroxide-releasing hydrogel that can readily and controllably induce senescence in conventional 2-dimensional cell cultures as well as advanced 3-dimensional microphysiological systems. Notably, we have established 2 platforms using our hydrogen peroxide-releasing hydrogel for investigating senolytics, which is a promising innovation in anti-geronic therapy. Conclusively, our advanced model presents a highly promising tool that offers a simple, versatile, convenient, effective, and highly adaptable technique for inducing cellular senescence. This innovation not only lays a crucial foundation for future research on aging but also markedly accelerates the development of novel therapeutic strategies targeting age-related diseases.</p>","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"29 ","pages":"0161"},"PeriodicalIF":8.1,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11907071/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical-Loaded Thermo-responsive Liposome for Synergistic Treatment of Methicillin-Resistant <i>Staphylococcus aureus</i> Infection.","authors":"Sidi Zheng, Xinshu Zou, Yanru Wei, Xilong Cui, Shuang Cai, Xiubo Li, Zhiyun Zhang, Yanhua Li","doi":"10.34133/bmr.0159","DOIUrl":"10.34133/bmr.0159","url":null,"abstract":"<p><p>The ever-increasing emergence and prevalence of multidrug-resistant bacteria accelerate the desire for the development of new antibacterial strategies. Although antibacterial phytochemicals are a promising approach for long-term treatment of resistant bacteria, their low antibacterial activity and poor solubility hinder their practical applications. Here, the natural antibacterial compound sanguinarine (SG) together with gallic acid-ferrous coordination nanoparticles (GA-Fe(II) NPs) was encapsulated in a near-infrared (NIR)-activated thermo-responsive liposome. By virtue of the photothermal effect of GA-Fe(II) NPs, the nanoplatform released SG on demand upon NIR irradiation. Additionally, the heat can boost the Fenton reaction triggered by GA-Fe(II) NPs to generate hydroxyl radicals and perform sterilization. By coupling with photothermal therapy, chemodynamic therapy, and SG-based pharmacotherapy, the platform showed enhanced antibacterial efficiency and an antibiofilm effect toward methicillin-resistant <i>Staphylococcus aureus</i> and reduced the risk of developing new bacterial resistance. This antibacterial system displayed excellent antibacterial activity in a methicillin-resistant <i>S. aureus</i>-caused skin abscess, demonstrating its potential clinical application. Moreover, transcription analysis clarified that the platform achieved a synergistic antibacterial effect by attacking the cell membrane, inducing energy metabolism disorder, inhibiting nucleic acid synthesis, etc. The developed NIR-controlled phytochemical-loaded platform offers new possibilities for killing antibiotic-resistant bacteria and avoiding bacterial resistance, making it contributory in the fields of anti-infective therapy and precision medicine.</p>","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"29 ","pages":"0159"},"PeriodicalIF":8.1,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11906118/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143627102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"pH-Activated Nanoplatform Derived from M1 Macrophages' Exosomes for Photodynamic and Ferroptosis Synergistic Therapy to Augment Cancer Immunotherapy.","authors":"Yawen Guo, Ruijie Qian, Xin Wei, Chunwang Yang, Jing Cao, Xiaoming Hou, Xiaokuan Zhang, Tingting Lv, Lu Bai, Daoyu Wei, Rumeng Bi, Baoen Shan, Zhiyu Wang","doi":"10.34133/bmr.0153","DOIUrl":"10.34133/bmr.0153","url":null,"abstract":"<p><p>Combining nanomedicine with immunotherapy offers a promising and potent cancer treatment strategy; however, improving the effectiveness of the antitumor immune response remains challenging. A \"cold\" tumor microenvironment (TME) is a marked factor affecting the efficacy of immunotherapy. Herein, intracellular-acidity-activatable dynamic nanoparticles (NPs) were designed for precision photodynamic immunotherapy and ferroptosis in cancer. M1 macrophage-derived exosomes (Mex) were constructed to coassemble the photosensitizer SR780, Fe³⁺, and the antioxidant enzyme catalase (CAT). By further modifying the RS17 peptides on the NPs, we increased their tumor-targeting capability and blocked the CD47-signal regulatory protein checkpoint, enabling macrophages to effectively phagocytose tumor cells. With proper particle size and dual targeting, including homologous targeting and RS17 targeting, FeSR780@CAT@Mex-RS17 NPs were able to accumulate effectively at the tumor site. These NPs can deliver exogenous CAT to relieve the hypoxic TME and enhance the therapeutic effects of photodynamic therapy. SR780 triggered photodynamic therapy to produce reactive oxygen species and induced immunogenic cell death to release danger-associated molecular patterns. In combination with Fe²⁺-induced ferroptosis, long-term immunotherapeutic effects can be obtained by reprogramming \"cold\" TMEs into \"hot\" TMEs. Upon laser irradiation, the designed FeSR780@CAT@Mex-RS17 NPs exert potent antitumor efficacy against both the Lewis lung carcinoma subcutaneous xenograft tumor model and lung orthotopic and liver metastasis models. The NPs suppressed the growth of the primary tumor while inhibiting liver metastasis, thereby exhibiting great potential for antitumor immunotherapy.</p>","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"29 ","pages":"0153"},"PeriodicalIF":8.1,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11883086/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to \"Harnessing Nanotechnology for Gout Therapy: Colchicine-Loaded Nanoparticles Regulate Macrophage Polarization and Reduce Inflammation\".","authors":"Yu Chen, Lanqing Zhao, Jinwei Li, Hongxi Li, Ning Zhang","doi":"10.34133/bmr.0141","DOIUrl":"10.34133/bmr.0141","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.34133/bmr.0089.].</p>","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"29 ","pages":"0141"},"PeriodicalIF":8.1,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11880572/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A New Light-Sensor System Affecting Cancer Cell Fate.","authors":"Silvia Buonvino, Ilaria Arciero, Stefano Moretti, Egidio Iorio, Sonia Melino","doi":"10.34133/bmr.0157","DOIUrl":"10.34133/bmr.0157","url":null,"abstract":"<p><p>A new physiological photopolymerizing system with relevant effects on proteins and able to affect cancer cell fate was discovered here. The riboflavin-phosphocholine-light (RPL) system induces lysozyme (LYZ) photopolymerization in vitro, affecting the cell viability of cancer cells, in both 2-dimensional and 3-dimensional cell cultures. The RPL treatment of nontumoral, mesenchymal stem cells, or cancer cells shows a distinct behavior, depending on the ectopic presence of LYZ. Morphological changes and cellular aggregation of the cancer cells were induced by the treatment. The presence of both phosphocholine and high levels of LYZ expression at the breast cancer cell-cell interface seems to create a vulnerability for this new photodynamic system under visible light exposure. Further, we generated 2 new riboflavin-phosphocholine hydrogels (RPHy and RPHy-LYZ) by light-emitting diode exposure. A transdifferentiation into osteoblast-like cells of a triple-negative breast cancer cell line, embedded into RPHy, was detected, while cell death was observed using RPHy-LYZ<i>.</i> Our results reveal new properties of phosphocholine and LYZ with potential translational implications linked to the study of the transdifferentiation process of breast cancer cells and to therapeutical applications. The results highlight new aspects of the molecular mechanism by which riboflavin acts on cancer cells, paving the way for the use of the physiological expression levels of both phosphocholine and LYZ in selective therapies using the RPL system.</p>","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"29 ","pages":"0157"},"PeriodicalIF":8.1,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11880576/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}