Biomaterials research最新文献_第2页

Hydrogen Peroxide-Releasing Hydrogel-Mediated Cellular Senescence Model for Aging Research. 过氧化氢释放水凝胶介导的细胞衰老模型的衰老研究。

IF 8.1

Biomaterials research Pub Date : 2025-03-14 eCollection Date: 2025-01-01 DOI: 10.34133/bmr.0161

Shibo Wei, Phuong Le Thi, Yan Zhang, Moon-Young Park, Khanh Do, Thi Thai Thanh Hoang, Nyssa Morgan, Tam Dao, Jimin Heo, Yunju Jo, You Jung Kang, Hansang Cho, Chang-Myung Oh, Young C Jang, Ki-Dong Park, Dongryeol Ryu

{"title":"Hydrogen Peroxide-Releasing Hydrogel-Mediated Cellular Senescence Model for Aging Research.","authors":"Shibo Wei, Phuong Le Thi, Yan Zhang, Moon-Young Park, Khanh Do, Thi Thai Thanh Hoang, Nyssa Morgan, Tam Dao, Jimin Heo, Yunju Jo, You Jung Kang, Hansang Cho, Chang-Myung Oh, Young C Jang, Ki-Dong Park, Dongryeol Ryu","doi":"10.34133/bmr.0161","DOIUrl":"https://doi.org/10.34133/bmr.0161","url":null,"abstract":"Cellular senescence, a process that induces irreversible cell cycle arrest in response to diverse stressors, is a primary contributor to aging and age-related diseases. Currently, exposure to hydrogen peroxide is a widely used technique for establishing in vitro cellular senescence models; however, this traditional method is inconsistent, laborious, and ineffective in vivo. To overcome these limitations, we have developed a hydrogen peroxide-releasing hydrogel that can readily and controllably induce senescence in conventional 2-dimensional cell cultures as well as advanced 3-dimensional microphysiological systems. Notably, we have established 2 platforms using our hydrogen peroxide-releasing hydrogel for investigating senolytics, which is a promising innovation in anti-geronic therapy. Conclusively, our advanced model presents a highly promising tool that offers a simple, versatile, convenient, effective, and highly adaptable technique for inducing cellular senescence. This innovation not only lays a crucial foundation for future research on aging but also markedly accelerates the development of novel therapeutic strategies targeting age-related diseases.","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"29 ","pages":"0161"},"PeriodicalIF":8.1,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11907071/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phytochemical-Loaded Thermo-responsive Liposome for Synergistic Treatment of Methicillin-Resistant Staphylococcus aureus Infection. 植物化学负载热响应脂质体协同治疗耐甲氧西林金黄色葡萄球菌感染。

IF 8.1

Biomaterials research Pub Date : 2025-03-13 eCollection Date: 2025-01-01 DOI: 10.34133/bmr.0159

Sidi Zheng, Xinshu Zou, Yanru Wei, Xilong Cui, Shuang Cai, Xiubo Li, Zhiyun Zhang, Yanhua Li

{"title":"Phytochemical-Loaded Thermo-responsive Liposome for Synergistic Treatment of Methicillin-Resistant Staphylococcus aureus Infection.","authors":"Sidi Zheng, Xinshu Zou, Yanru Wei, Xilong Cui, Shuang Cai, Xiubo Li, Zhiyun Zhang, Yanhua Li","doi":"10.34133/bmr.0159","DOIUrl":"10.34133/bmr.0159","url":null,"abstract":"The ever-increasing emergence and prevalence of multidrug-resistant bacteria accelerate the desire for the development of new antibacterial strategies. Although antibacterial phytochemicals are a promising approach for long-term treatment of resistant bacteria, their low antibacterial activity and poor solubility hinder their practical applications. Here, the natural antibacterial compound sanguinarine (SG) together with gallic acid-ferrous coordination nanoparticles (GA-Fe(II) NPs) was encapsulated in a near-infrared (NIR)-activated thermo-responsive liposome. By virtue of the photothermal effect of GA-Fe(II) NPs, the nanoplatform released SG on demand upon NIR irradiation. Additionally, the heat can boost the Fenton reaction triggered by GA-Fe(II) NPs to generate hydroxyl radicals and perform sterilization. By coupling with photothermal therapy, chemodynamic therapy, and SG-based pharmacotherapy, the platform showed enhanced antibacterial efficiency and an antibiofilm effect toward methicillin-resistant Staphylococcus aureus and reduced the risk of developing new bacterial resistance. This antibacterial system displayed excellent antibacterial activity in a methicillin-resistant S. aureus-caused skin abscess, demonstrating its potential clinical application. Moreover, transcription analysis clarified that the platform achieved a synergistic antibacterial effect by attacking the cell membrane, inducing energy metabolism disorder, inhibiting nucleic acid synthesis, etc. The developed NIR-controlled phytochemical-loaded platform offers new possibilities for killing antibiotic-resistant bacteria and avoiding bacterial resistance, making it contributory in the fields of anti-infective therapy and precision medicine.","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"29 ","pages":"0159"},"PeriodicalIF":8.1,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11906118/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143627102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

pH-Activated Nanoplatform Derived from M1 Macrophages' Exosomes for Photodynamic and Ferroptosis Synergistic Therapy to Augment Cancer Immunotherapy. 来自M1巨噬细胞外泌体的ph活化纳米平台用于光动力和铁凋亡协同治疗以增强癌症免疫治疗。

IF 8.1

Biomaterials research Pub Date : 2025-03-06 eCollection Date: 2025-01-01 DOI: 10.34133/bmr.0153

Yawen Guo, Ruijie Qian, Xin Wei, Chunwang Yang, Jing Cao, Xiaoming Hou, Xiaokuan Zhang, Tingting Lv, Lu Bai, Daoyu Wei, Rumeng Bi, Baoen Shan, Zhiyu Wang

{"title":"pH-Activated Nanoplatform Derived from M1 Macrophages' Exosomes for Photodynamic and Ferroptosis Synergistic Therapy to Augment Cancer Immunotherapy.","authors":"Yawen Guo, Ruijie Qian, Xin Wei, Chunwang Yang, Jing Cao, Xiaoming Hou, Xiaokuan Zhang, Tingting Lv, Lu Bai, Daoyu Wei, Rumeng Bi, Baoen Shan, Zhiyu Wang","doi":"10.34133/bmr.0153","DOIUrl":"10.34133/bmr.0153","url":null,"abstract":"Combining nanomedicine with immunotherapy offers a promising and potent cancer treatment strategy; however, improving the effectiveness of the antitumor immune response remains challenging. A \"cold\" tumor microenvironment (TME) is a marked factor affecting the efficacy of immunotherapy. Herein, intracellular-acidity-activatable dynamic nanoparticles (NPs) were designed for precision photodynamic immunotherapy and ferroptosis in cancer. M1 macrophage-derived exosomes (Mex) were constructed to coassemble the photosensitizer SR780, Fe3+, and the antioxidant enzyme catalase (CAT). By further modifying the RS17 peptides on the NPs, we increased their tumor-targeting capability and blocked the CD47-signal regulatory protein checkpoint, enabling macrophages to effectively phagocytose tumor cells. With proper particle size and dual targeting, including homologous targeting and RS17 targeting, FeSR780@CAT@Mex-RS17 NPs were able to accumulate effectively at the tumor site. These NPs can deliver exogenous CAT to relieve the hypoxic TME and enhance the therapeutic effects of photodynamic therapy. SR780 triggered photodynamic therapy to produce reactive oxygen species and induced immunogenic cell death to release danger-associated molecular patterns. In combination with Fe2+-induced ferroptosis, long-term immunotherapeutic effects can be obtained by reprogramming \"cold\" TMEs into \"hot\" TMEs. Upon laser irradiation, the designed FeSR780@CAT@Mex-RS17 NPs exert potent antitumor efficacy against both the Lewis lung carcinoma subcutaneous xenograft tumor model and lung orthotopic and liver metastasis models. The NPs suppressed the growth of the primary tumor while inhibiting liver metastasis, thereby exhibiting great potential for antitumor immunotherapy.","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"29 ","pages":"0153"},"PeriodicalIF":8.1,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11883086/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erratum to "Harnessing Nanotechnology for Gout Therapy: Colchicine-Loaded Nanoparticles Regulate Macrophage Polarization and Reduce Inflammation". “利用纳米技术治疗痛风：秋水仙碱负载纳米颗粒调节巨噬细胞极化和减少炎症”的勘误。

IF 8.1

Biomaterials research Pub Date : 2025-03-05 eCollection Date: 2025-01-01 DOI: 10.34133/bmr.0141

Yu Chen, Lanqing Zhao, Jinwei Li, Hongxi Li, Ning Zhang

引用次数: 0

A New Light-Sensor System Affecting Cancer Cell Fate. 一种影响癌细胞命运的新型光传感器系统。

IF 8.1

Biomaterials research Pub Date : 2025-03-05 eCollection Date: 2025-01-01 DOI: 10.34133/bmr.0157

Silvia Buonvino, Ilaria Arciero, Stefano Moretti, Egidio Iorio, Sonia Melino

{"title":"A New Light-Sensor System Affecting Cancer Cell Fate.","authors":"Silvia Buonvino, Ilaria Arciero, Stefano Moretti, Egidio Iorio, Sonia Melino","doi":"10.34133/bmr.0157","DOIUrl":"10.34133/bmr.0157","url":null,"abstract":"A new physiological photopolymerizing system with relevant effects on proteins and able to affect cancer cell fate was discovered here. The riboflavin-phosphocholine-light (RPL) system induces lysozyme (LYZ) photopolymerization in vitro, affecting the cell viability of cancer cells, in both 2-dimensional and 3-dimensional cell cultures. The RPL treatment of nontumoral, mesenchymal stem cells, or cancer cells shows a distinct behavior, depending on the ectopic presence of LYZ. Morphological changes and cellular aggregation of the cancer cells were induced by the treatment. The presence of both phosphocholine and high levels of LYZ expression at the breast cancer cell-cell interface seems to create a vulnerability for this new photodynamic system under visible light exposure. Further, we generated 2 new riboflavin-phosphocholine hydrogels (RPHy and RPHy-LYZ) by light-emitting diode exposure. A transdifferentiation into osteoblast-like cells of a triple-negative breast cancer cell line, embedded into RPHy, was detected, while cell death was observed using RPHy-LYZ. Our results reveal new properties of phosphocholine and LYZ with potential translational implications linked to the study of the transdifferentiation process of breast cancer cells and to therapeutical applications. The results highlight new aspects of the molecular mechanism by which riboflavin acts on cancer cells, paving the way for the use of the physiological expression levels of both phosphocholine and LYZ in selective therapies using the RPL system.","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"29 ","pages":"0157"},"PeriodicalIF":8.1,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11880576/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biomimetic Atorvastatin Self-Assembled Nanomedicine Inhibits the Cyclooxygenase-2/Prostaglandin E2 Pathway Enhanced Photothermal and Antitumor Immunity. 仿生阿托伐他汀自组装纳米药物抑制环氧化酶-2/前列腺素E2途径增强光热和抗肿瘤免疫。

IF 8.1

Biomaterials research Pub Date : 2025-03-04 eCollection Date: 2025-01-01 DOI: 10.34133/bmr.0149

Min Zhou, Ruyue Han, Wenjie Xu, Xinyan Hao, Yanjin Peng, Yucheng Tang, Pengcheng Sun, Tiantian Tang, Junyong Wu, Daxiong Xiang

{"title":"Biomimetic Atorvastatin Self-Assembled Nanomedicine Inhibits the Cyclooxygenase-2/Prostaglandin E2 Pathway Enhanced Photothermal and Antitumor Immunity.","authors":"Min Zhou, Ruyue Han, Wenjie Xu, Xinyan Hao, Yanjin Peng, Yucheng Tang, Pengcheng Sun, Tiantian Tang, Junyong Wu, Daxiong Xiang","doi":"10.34133/bmr.0149","DOIUrl":"10.34133/bmr.0149","url":null,"abstract":"Cancer continues to pose remarkable medical challenges worldwide. While current cancer therapies can lead to initial clinical improvement, they are often followed by recurrence, metastasis, and drug resistance, underscoring the urgent need for innovative treatment strategies. Atorvastatin calcium (AC), a widely used lipid-lowering and anti-inflammation drug in the clinic, has shown antitumor potential. To further improve the antitumor efficacy, we developed self-assembled AC and polydopamine (PDA) nanoparticles whose surface was coated with macrophage membranes (CM) as a biomimetic drug delivery system [AC@PDA@CM (APM)]. APM showed high drug-loading capacity, excellent stability, excellent bioavailability, and tumor-targeting ability, ultimately achieving photothermal synergistic cancer immunotherapy. Our findings indicate that APM efficiently delivers AC to tumor sites while leveraging photothermal therapy (PTT) to enhance local tumor ablation and antitumor immune effect. Notably, APM mitigates tumor immunosuppression triggered by PTT through AC, suppressing the COX-2/PGE2 pathway and immune evasion signal CD47. Furthermore, APM notably reduced nonspecific distribution and side effects, which is conducive to ensuring the safety level of medication. This integrated approach boosts therapeutic efficacy and highlights the potential of APM as a multifunctional agent for cancer therapy, paving the way for future clinical applications.","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"29 ","pages":"0149"},"PeriodicalIF":8.1,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11876541/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143560372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photothermally Responsive Hydrogel Releases Basic Fibroblast Growth Factor to Promote the Healing of Infected Wounds. 光热反应性水凝胶释放碱性成纤维细胞生长因子促进感染伤口愈合。

IF 8.1

Biomaterials research Pub Date : 2025-03-04 eCollection Date: 2025-01-01 DOI: 10.34133/bmr.0156

Shengnan Ma, Chengzhi Zhang, Xiaofeng Ren, Lei Song, Jiheng Shan, Yiming Liu, Siyuan Weng, Yang Wang, Dechao Jiao, Kewei Ren, Zhen Li, Xinwei Han, Yanan Zhao

{"title":"Photothermally Responsive Hydrogel Releases Basic Fibroblast Growth Factor to Promote the Healing of Infected Wounds.","authors":"Shengnan Ma, Chengzhi Zhang, Xiaofeng Ren, Lei Song, Jiheng Shan, Yiming Liu, Siyuan Weng, Yang Wang, Dechao Jiao, Kewei Ren, Zhen Li, Xinwei Han, Yanan Zhao","doi":"10.34133/bmr.0156","DOIUrl":"10.34133/bmr.0156","url":null,"abstract":"The treatment of infected wounds is often complicated by bacterial infection and impaired scar healing. Antibiotics and growth factors are typically utilized to address these clinical challenges and expedite wound healing. However, the use of hydrogels containing these therapeutic agents is often restricted to complex cases and increases treatment costs considerably. In this study, we developed a quaternized-chitosan-based hybrid hydrogel dressing (SQFB) with intrinsic antibacterial properties to address these limitations. The hybrid hydrogel contained interpenetrating polymer networks of basic fibroblast growth factor and black phosphorus nanosheets, facilitating a photothermal response that triggers the release of basic fibroblast growth factor upon near-infrared irradiation. In vitro experiments demonstrated that SQFB exhibits superior antibacterial, hemostatic, enhanced cell proliferation, and angiogenesis functions. Importantly, the results showed that SQFB can promote the healing of infected wounds by accelerating all 4 stages of wound repair while preventing scarring formation. RNA sequencing analysis revealed that combined treatment with SQFB and near-infrared irradiation can effectively modulate genes primarily associated with epithelial regeneration pathways and metabolic processes. Collectively, our findings suggest that this hybrid hydrogel holds great promise for the effective management of infected wounds.","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"29 ","pages":"0156"},"PeriodicalIF":8.1,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11876544/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143560376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biomimetic-Nanoparticle-Enhanced Photothermal Immunotherapy: Targeted Delivery of Near-Infrared Region II Agents and Immunoadjuvants for Tumor Immunogenicity. 仿生-纳米颗粒增强光热免疫疗法：靶向递送近红外区II药物和免疫佐剂的肿瘤免疫原性。

IF 8.1

Biomaterials research Pub Date : 2025-03-04 eCollection Date: 2025-01-01 DOI: 10.34133/bmr.0151

Yanlu Yu, Wen Li, Qiqi Yu, Jingtao Ye, Hu Wang, Yang Li, Shouchun Yin

{"title":"Biomimetic-Nanoparticle-Enhanced Photothermal Immunotherapy: Targeted Delivery of Near-Infrared Region II Agents and Immunoadjuvants for Tumor Immunogenicity.","authors":"Yanlu Yu, Wen Li, Qiqi Yu, Jingtao Ye, Hu Wang, Yang Li, Shouchun Yin","doi":"10.34133/bmr.0151","DOIUrl":"10.34133/bmr.0151","url":null,"abstract":"Advancing at the cutting edge of oncology, the synergistic application of photothermal therapy coupled with immunotherapy is rapidly establishing itself as an innovative and potent strategy against cancer. A critical challenge in this domain is the precise and efficient targeting of tumor tissues with photothermal agents and immunoadjuvants while minimizing interference with healthy tissues. In this paper, we introduce an ingenious biomimetic nanoparticle platform, cancer cell membrane coated F127/(R837 and IR1048) (CFRI) nanoparticles encapsulating a near-infrared region II photothermal agent, IR1048, and an immunostimulatory molecule, R837, with their surface modified using membranes derived from tumor cells, conferring exceptional specificity for tumor targeting. CFRI nanoparticles demonstrated an extraordinary photothermal conversion efficiency of 49%, adeptly eradicating in situ tumors. This process also triggered the release of damage-associated molecular patterns, thereby activating dendritic cells and catalyzing the maturation and differentiation of T cells, initiating a robust immune response. In vivo animal models substantiated that the CFRI-mediated synergistic photothermal and immunotherapeutic strategy markedly suppressed the proliferation of in situ tumors and provoked a vigorous systemic immune response, effectively curtailing the metastasis and recurrence of distant tumors. The successful development of the CFRI nanoparticle system offers a promising horizon for future clinical translations and pioneering research in oncology.","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"29 ","pages":"0151"},"PeriodicalIF":8.1,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11876542/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143560374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Viscoelastic Hydrogel Promotes Disc Mechanical Homeostasis Repair and Delays Intervertebral Disc Degeneration via the Yes-Associated Protein Pathway. 粘弹性水凝胶通过yes相关蛋白途径促进椎间盘机械稳态修复并延缓椎间盘退变。

IF 8.1

Biomaterials research Pub Date : 2025-03-04 eCollection Date: 2025-01-01 DOI: 10.34133/bmr.0150

Zilin Yu, Kang Wu, Chunyang Fan, Jiale Wang, Fengcheng Chu, Wei He, Zhongwei Ji, Yongkang Deng, Di Hua, Yao Zhang, Dechun Geng, Xiexing Wu, Haiqing Mao

{"title":"Viscoelastic Hydrogel Promotes Disc Mechanical Homeostasis Repair and Delays Intervertebral Disc Degeneration via the Yes-Associated Protein Pathway.","authors":"Zilin Yu, Kang Wu, Chunyang Fan, Jiale Wang, Fengcheng Chu, Wei He, Zhongwei Ji, Yongkang Deng, Di Hua, Yao Zhang, Dechun Geng, Xiexing Wu, Haiqing Mao","doi":"10.34133/bmr.0150","DOIUrl":"10.34133/bmr.0150","url":null,"abstract":"Intervertebral disc degeneration (IDD) process is accompanied by overactive inflammation and mechanical instability of the nucleus pulposus (NP). Current treatments do not fully restore the biomechanical environment of discs, limiting their therapeutic efficacy. Thus, novel strategies are required to combat IDD. Hydrogels have outstanding biocompatibility and mechanical properties, most importantly, absorbing and retaining water similar to human NP tissue, showing a unique superiority in the treatment of IDD. In this study, we employed a viscoelastic ionic hydrogel (VIG) composed of polyvinyl alcohol and magnesium ions to investigate the therapeutic effect for IDD. VIG demonstrated an optimal degradation rate and NP-biomimetic swelling behavior in vitro. In the rat model of IDD, VIG-injected discs demonstrated mechanical properties approximating those of native discs, including stiffness, relaxation, and dissipation capacity. Furthermore, finite element analysis demonstrated that VIG improved biomechanical function of degenerated discs. VIG effectively inhibited the progression of IDD in the rat model by increasing extracellular matrix synthesis and decreasing matrix metalloproteinase-13 (MMP-13) expression. Moreover, VIG promoted proliferation and differentiation of NP cells in response to extracellular mechanical changes through the integrin-YAP signaling pathway. These findings suggest that VIG has the potential to modulate the NP inflammatory microenvironment and restore mechanical stability in IDD. This work represents a straightforward and promising strategy for IDD treatment.","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"29 ","pages":"0150"},"PeriodicalIF":8.1,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11876543/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143560378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanisms and Applications of Manganese-Based Nanomaterials in Tumor Diagnosis and Therapy. 锰基纳米材料在肿瘤诊断和治疗中的作用机制及应用。

IF 8.1

Biomaterials research Pub Date : 2025-02-28 eCollection Date: 2025-01-01 DOI: 10.34133/bmr.0158

Xiaowen Ma, Chuan He, Yang Wang, Xingrui Cao, Zikai Jin, Yi Ge, Zhipeng Cao, Mingxin An, Liang Hao

{"title":"Mechanisms and Applications of Manganese-Based Nanomaterials in Tumor Diagnosis and Therapy.","authors":"Xiaowen Ma, Chuan He, Yang Wang, Xingrui Cao, Zikai Jin, Yi Ge, Zhipeng Cao, Mingxin An, Liang Hao","doi":"10.34133/bmr.0158","DOIUrl":"https://doi.org/10.34133/bmr.0158","url":null,"abstract":"Tumors are the second most common cause of mortality globally, ranking just below heart disease. With continuous advances in diagnostic technology and treatment approaches, the survival rates of some cancers have increased. Nevertheless, due to the complexity of the mechanisms underlying tumors, cancer remains a serious public health issue that threatens the health of the population globally. Manganese (Mn) is an essential trace element for the human body. Its regulatory role in tumor biology has received much attention in recent years. Developments in nanotechnology have led to the emergence of Mn-based nanoparticles that have great potential for use in the diagnosis and treatment of cancers. Mn-based nanomaterials can be integrated with conventional techniques, including chemotherapy, radiation therapy, and gene therapy, to augment their therapeutic effectiveness. Further, Mn-based nanomaterials can play a synergistic role in emerging treatment strategies for tumors, such as immunotherapy, photothermal and photodynamic therapy, electromagnetic hyperthermia, sonodynamic therapy, chemodynamic therapy, and intervention therapy. Moreover, Mn-based nanomaterials can enhance both the precision of tumor diagnostics and the capability for combined diagnosis and treatment. This article examines the roles and associated mechanisms of Mn in the field of physiology and tumor biology, with a focus on the application prospects of Mn-based nanomaterials in tumor diagnosis and treatment.","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"29 ","pages":"0158"},"PeriodicalIF":8.1,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11868662/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143545157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0