Biomaterials research最新文献

{"title":"Tryptanthrin Nanoliposomal Lotion as a Corticosteroid-Free Strategy for Safe and Effective Treatment of Atopic Dermatitis.","authors":"Yo Han Song, Young-Guk Na, Moon Sup Yoon, Da-Eun Kim, Suyeon Hwang, Samuel Lee, Young Ju Jo, Ji Hyun Bang, Gabsik Yang, Dong-Sung Lee, Hong-Ki Lee, Cheong-Weon Cho","doi":"10.34133/bmr.0384","DOIUrl":"10.34133/bmr.0384","url":null,"abstract":"<p><p>Atopic dermatitis is a chronic inflammatory skin disease characterized by dry skin, itching, and recurrent eczematous lesions. Although current therapeutic strategies are effective, their use is often limited due to adverse effects. Therefore, the development of safer and more effective alternatives is required. Tryptanthrin is a yellow-gold alkaloid compound with anti-atopic and various pharmacological activities. However, its poor aqueous solubility results in low topical bioavailability. A tryptanthrin-loaded liposomal lotion was developed using a design of experiments approach to improve topical delivery. The optimized formulation showed enhanced physicochemical stability and moisturizing properties, as well as improved drug release compared to free tryptanthrin. In human keratinocyte cells, the liposomal lotion exhibited lower cytotoxicity than the free tryptanthrin and demonstrated higher skin residual. In the DNCB-induced atopic dermatitis mouse model, the tryptanthrin-loaded liposomal lotion produced therapeutic effects comparable to or greater than those of 1.0% hydrocortisone, without inducing adverse effects such as skin atrophy. Overall, the tryptanthrin-loaded liposomal lotion is presented as a promising and safe strategy for the topical treatment of atopic dermatitis.</p>","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"30 ","pages":"0384"},"PeriodicalIF":9.8,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13396491/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148586148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plant-Derived Exosomes in Aesthetic Medicine.","authors":"Ranchen Chen, Sidun Wei, Xin Dan, Songjie Li, Han Chen, Pu Yang, Xiangjun Liu, Tong Li, Lanjie Lei, Yang Li, Xing Fan","doi":"10.34133/bmr.0397","DOIUrl":"10.34133/bmr.0397","url":null,"abstract":"<p><p>The global cosmetic surgery industry is actively seeking alternatives that can overcome the limitations of traditional animal-derived exosomes, which face clinical translation bottlenecks including high costs, immunological risks, and zoonotic disease hazards. Plant-derived exosomes (PLDEs) offer a promising attractive \"green\" nanotechnology platform owing to their inherent safety, minimal immunogenicity, and suitability for scalable manufacturing. Their core advantage lies in delivering plant-specific bioactive compounds (such as small RNAs and secondary metabolites) that target multiple key signaling pathways, including skin aging, pigmentation, inflammation, and regeneration, through cross-species regulatory mechanisms. This review critically synthesizes PLDE biological basis, isolation methods, and evidence for antiaging, skin brightening, and regenerative efficacy. It delineates how surface functionalization, targeted drug delivery, and biomaterial integration (hydrogels and microneedles) optimize PLDE targeting. Finally, it addresses current challenges in clinical translation and standardization, offering a forward-looking perspective on the development of next-generation PLDE-based therapies for minimally invasive aesthetic applications.</p>","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"30 ","pages":"0397"},"PeriodicalIF":9.8,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13392287/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148581573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting Interleukin-6 Signaling with Reactive-Oxygen-Species-Responsive Hydrogel to Promote Regeneration after Spinal Cord Injury.","authors":"Runlin Wen, Xinghui He, Kai Zhang, Wanrong Ma, Zhiquan Yang, Dingyang Liu, Ge Long, Xing Li","doi":"10.34133/bmr.0395","DOIUrl":"10.34133/bmr.0395","url":null,"abstract":"<p><p>Spinal cord injury (SCI) triggers an excessive inflammatory response, characterized by the up-regulation of various inflammatory factors that impede neural regeneration and functional recovery. Interleukin-6 (IL-6) is an early and critical inflammatory mediator observed in lesions post-SCI. Antagonizing the signaling pathway presents a promising strategy to mitigate early inflammation and secondary injury after trauma. Here, we identified specific activation of the IL-6 receptor in neurons and microglia in lesions, indicating their responsiveness to early up-regulated IL-6 signaling within the microenvironment. In vitro, neutralizing IL-6 signaling in microglia effectively alleviated their inhibitory effects on neuronal axon growth in conditioned media. Building on this, we developed a reactive-oxygen-species-responsive hydrogel for the sustained local delivery of tocilizumab, an IL-6 receptor antagonist, and implanted it in a complete transection SCI model. In vivo, sustained IL-6 receptor blockade effectively reduced early inflammatory cell infiltration, modulated microglial polarization toward an anti-inflammatory phenotype, and fostered neuronal regeneration within the lesion. Importantly, this therapeutic intervention promoted long-term hind limb functional recovery in SCI mice. This study underscores the therapeutic potential of precisely targeting early inflammatory cytokine signaling pathways, particularly IL-6, to improve outcomes after SCI.</p>","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"30 ","pages":"0395"},"PeriodicalIF":9.8,"publicationDate":"2026-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13389045/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148564247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photoactivated <i>Hypericum perforatum</i>-Derived Exosome Nanovesicles Suppress Breast Cancer via miR-172f/CD24-Siglec-G/10-Driven Macrophage Reprogramming.","authors":"Peiyuan Zeng, Jiaojiao Lei, Yu Lu, Wenyu Zhang, Jingcan You, Youkun Zheng, Jianbo Wu","doi":"10.34133/bmr.0393","DOIUrl":"10.34133/bmr.0393","url":null,"abstract":"<p><p>Photodynamic therapy is traditionally based on reactive-oxygen-species-mediated tumor cell killing, but its immunomodulatory capacity is not fully explored. Plant-derived exosome-like nanovesicles provide a natural photosensitizer platform with potential for dual tumoricidal and immune-modulating effects. This study investigated whether light activation of <i>Hypericum perforatum</i>-derived exosome nanovesicles (HPDENs) remodels their microRNA cargo to enhance antitumor activity and reprogram the tumor immune microenvironment. Photoactivation significantly up-regulated miR-172f-p3 in HPDENs, which directly targeted CD24 messenger RNA and suppressed its expression in MCF-7 cells. CD24 down-regulation reprogrammed co-cultured M2 macrophages toward an M1 phenotype by attenuating the CD24-Siglec-G/10 axis. In vivo, light-treated HPDENs and miR-172f-p3 mimics inhibited tumor growth, promoted M1 polarization, and displayed excellent safety with no observable systemic toxicity. Photoactivated HPDENs exert dual antitumor effects by inducing direct tumor suppression and remodeling the immune microenvironment through miR-172f-p3/CD24-Siglec-G/10 signaling. This strategy offers a novel immunotherapeutic avenue that synergizes with photodynamic therapy, supporting the development of plant-derived nanovesicles as next-generation cancer therapeutics.</p>","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"30 ","pages":"0393"},"PeriodicalIF":9.8,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13376378/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148581548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tryptophan-Enriched <i>Lactobacillus rhamnosus</i> GG-derived Nanovesicles Promote Alveolar Bone Regeneration through Macrophage Fatty Acid Oxidation.","authors":"Zhendong Huang, Yuqi Liu, Qiudong Yang, Jiayi Ding, Zhengkun Yang, Heyu Liu, Xin Huang, Xiaoxuan Wang, Li Ma, Zhengguo Cao","doi":"10.34133/bmr.0370","DOIUrl":"10.34133/bmr.0370","url":null,"abstract":"<p><p>Inflammatory bone loss represents a major clinical challenge, leading to irreversible tissue damage and impaired function. Probiotic-derived nanovesicles show immense potential as novel cell-free nanomedicines; however, the lack of clarity regarding their precise mechanism of action in bone tissue regeneration restricts their clinical application. This study utilized a ligature-induced periodontitis mouse model (in vivo) and in vitro models, including macrophage functional assays and macrophage-osteoblast co-culture systems, to investigate the therapeutic effects and mechanism of <i>Lactobacillus rhamnosus</i> GG-derived extracellular vesicles (LEVs). In the periodontitis mouse model, LEVs effectively mitigated inflammatory infiltration and promoted alveolar bone regeneration. In vitro studies demonstrated that LEVs enhance macrophage polarization toward a reparative (M2) phenotype. Mechanistically, we identify LEVs as bioactive nanocarriers that deliver tryptophan metabolites. Upon internalization by macrophages, these metabolites trigger a critical metabolic and phenotypic shift by activating the aryl hydrocarbon receptor (AhR). Further research revealed that this effect is mediated by the AhR/NAD(P)H:quinone oxidoreductase 1 (NQO1)/carnitine palmitoyltransferase 1A (CPT1A) signaling axis: AhR transcriptionally up-regulates NQO1, which critically inhibits the 26S proteasome-mediated degradation of CPT1A. The resulting sustained CPT1A expression dramatically boosts fatty acid oxidation, which is essential for driving the reparative macrophage phenotype. These findings highlight the critical role and molecular delivery mechanisms of probiotic-derived nanovesicles in ameliorating inflammatory bone loss via immunometabolic reprogramming, thereby providing new targets and a theoretical basis for their application as nanocarriers in regenerative biomaterials.</p>","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"30 ","pages":"0370"},"PeriodicalIF":9.8,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13376381/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148581601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stigmasterol-Mediated Targeting of Rho-Associated Coiled-Coil Protein Kinase 1 Ameliorates Diabetic Kidney Disease and Attenuates Renal Tubular Lipid Deposition.","authors":"Yuchi Chen, Xinyao Xu, Ningning Yuan, Yangtian Yan, Yuxin Ye, Zhuoen He, Jinyue He, Chi Zhang, Hao Wang, Haitao Yuan, Jianxin Diao, Wei Xiao","doi":"10.34133/bmr.0389","DOIUrl":"10.34133/bmr.0389","url":null,"abstract":"<p><p>Diabetic kidney disease (DKD) is identified as the major contributor to the development of end-stage renal disease, with its clinical incidence increasing. Emerging studies link DKD closely to renal lipid deposition, tubular injury, and glomerulosclerosis-pathological processes driven by renal lipid metabolism disorders that ultimately induce renal fibrosis. However, targeted therapeutics for renal lipid deposition are scarce. This study fills this research gap: first, clinical database analyses identified a positive correlation between up-regulated rho-associated coiled-coil protein kinase 1 (ROCK1) expression in renal tubules and progressive renal function deterioration in DKD patients, a finding recapitulated in DKD mouse models, which also exhibited renal tubular ROCK1 up-regulation and concomitant lipid accumulation; second, molecular docking, surface plasmon resonance, and cellular thermal shift assay confirm that the natural molecule stigmasterol (ST) binds to ROCK1 and inhibits its expression with a dose-dependent trend; and, third, in vivo and in vitro experiments demonstrate that ST alleviates lipid accumulation, mitochondrial damage, and renal fibrosis in DKD via the ROCK1/p38 mitogen-activated protein kinase/peroxisome proliferator-activated receptor α axis. In conclusion, ST exerts direct renoprotective effects by regulating the ROCK1 pathway to improve renal lipid metabolism, reduce mitochondrial damage, and inhibit fibrosis, highlighting its potential as a novel ROCK1 inhibitor. This study identifies ST as a candidate for targeted intervention in DKD-related lipid metabolism, validates ROCK1 as a therapeutic target, provides an experimental basis for the DKD treatment strategy of \"targeting ROCK1 to synergistically improve lipid metabolism and mitochondrial function\", and opens new avenues for natural products in metabolism-related nephropathies.</p>","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"30 ","pages":"0389"},"PeriodicalIF":9.8,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13376380/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148581562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lectin-Directed Protein Aggregation Therapy toward Hyperfucosylated and Hypersialylated Metastatic Colorectal Cancers.","authors":"Xiao Han, Yufei Li, Yiling Liu, Shenghai Shen, Yitong Shen, Li-Sheng Zhang, Kenward Vong","doi":"10.34133/bmr.0394","DOIUrl":"10.34133/bmr.0394","url":null,"abstract":"<p><p>Aberrant glycosylation is a well-known pathological alteration that accompanies tumor onset, progression, and eventual metastasis. For colorectal cancers, there is strong evidence to show that glycans containing α2,3-sialic acid, α2,6-sialic acid, and fucose are frequently up-regulated. In this work, we report the application of lectin-directed protein aggregation therapy (LPAT) to target hypersialylated and hyperfucosylated colorectal cancer cells. This system relies on the concept of cancer-activated lectin multivalency, where tumor-associated proteases can elicit the self-assembly of multivalent lectin complexes that can selectively impair the metastatic activities of cancer cells. After screening LPAT agents against a panel of 5 colorectal cancer cell lines, the most effective targeting was identified against the hyperfucosylated/matrix metalloproteinase-9-overexpressing HCT-116 cell line, which showed significant reductions in invasion and migration upon treatment. Experiments then showed that hyperfucosylation targeting could be used as a viable approach to prevent liver and kidney tumor development in a metastatic colorectal mouse model. Overall, this work highlights the viability of using LPAT to discriminate the aberrant glycosylation of highly metastatic colorectal cancer cells as a means to prevent their onset and progression.</p>","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"30 ","pages":"0394"},"PeriodicalIF":9.8,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13376382/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148581592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tailored Ion Release of Polycaprolactone and Calcium Silicate Composite Fibers Attenuates Neutrophil Extracellular Trap Formation for Dentin-Pulp Complex Regeneration.","authors":"Jeong-Hyun Ryu, En Shi Jiang, Eunhye Lee, Jieun Bae, Wonjoon Moon, Shin Hye Chung, Kyung Mi Woo","doi":"10.34133/bmr.0388","DOIUrl":"10.34133/bmr.0388","url":null,"abstract":"<p><p>While calcium silicate (CS) remains a gold standard material for vital pulp therapy, its clinical efficacy is frequently compromised by an abrupt ion release during the initial setting phase that induces extreme alkalinity and acute cytotoxicity. We engineered electrospun poly-ε-caprolactone (PCL)/CS composite fibers to reconfigure CS hydration kinetics, achieving sustained and controlled ion release. In vitro evaluation using phase-specific eluates and defined pH/Ca²⁺ conditions demonstrated that CS eluates from the initial setting phase induced significant cytotoxicity and excessive NETosis in primary neutrophils, whereas PCL/CS eluates maintained both at control levels. Mechanistically, neutrophil extracellular traps (NETs) isolated from CS-stimulated neutrophils directly drove M1 macrophage polarization, while PCL/CS eluates promoted an anti-inflammatory and proregenerative macrophage phenotype. PCL/CS eluates, conditioned media from PCL/CS-treated macrophages, and PCL/CS nanofibrous substrates all promoted odontoblastic differentiation. In vivo validation using a rat molar pulp exposure model revealed that during the early host response (at days 2 and 7), CS provoked marked neutrophil infiltration and excessive NETosis, whereas PCL/CS attenuated the acute inflammatory response and promoted timely inflammatory resolution and M2 macrophage polarization. At 8 weeks, the PCL/CS group exhibited improved dentin-pulp regeneration characterized by organized tubular dentin and polarized odontoblasts, rather than amorphous osteodentin typically observed with CS. PCL/CS also mitigated furcal bone resorption. These findings indicate that immune modulation through tailored ion release via the NETosis-macrophage axis represents an effective strategy for supporting dentin-pulp complex regeneration.</p>","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"30 ","pages":"0388"},"PeriodicalIF":9.8,"publicationDate":"2026-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13365599/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148450870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sonodynamic CoMg-Quercetin Nanozyme for Antibacterial Therapy and Multifunctional Bone Regeneration in Infectious Bone Defects.","authors":"Yurong Xu, Jingyu Yan, Lihong Zhou, Chenying Cui, Kaifang Zhang, Kun Liu, Xiuping Wu, Bing Li","doi":"10.34133/bmr.0396","DOIUrl":"10.34133/bmr.0396","url":null,"abstract":"<p><p>Infectious bone defects remain a serious clinical challenge because infection-associated inflammation markedly hinders bone regeneration. To address this complicated pathological condition, a porphyrin-doped cobalt-magnesium bimetallic quercetin-based sonosensitive nanozyme (CoMg-Que) was engineered to integrate antibacterial therapy, redox modulation, and tissue regenerative functions within a single platform. Upon ultrasound (US) irradiation, CoMg-Que was activated and efficiently generated reactive oxygen species (ROS) for sonodynamic antibacterial treatment. Following termination of US stimulation, its inherent superoxide dismutase- and catalase-like activities further removed excessive ROS, thereby relieving inflammatory responses and re-establishing redox homeostasis. In vitro experiments demonstrated that CoMg-Que effectively eliminated methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) and exhibited favorable immunomodulatory, pro-angiogenic, and osteogenic properties. In an MRSA-infected rat calvarial defect model, CoMg-Que achieved an antibacterial efficiency of 95.24% and markedly enhanced bone regeneration, with the bone volume fraction reaching 26.76%. These findings indicate that CoMg-Que may serve as a promising multifunctional platform for infectious bone defect treatment through coordinated antibacterial, immunoregulatory, and regenerative activities.</p>","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"30 ","pages":"0396"},"PeriodicalIF":9.8,"publicationDate":"2026-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13365584/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148450893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug Delivery Systems Repurposing Taxanes as Antitumor Immune Modulators.","authors":"Sang-Hun Choi, Soo-Hyang Chi, Chae Yeon Han, Kyeong Jin Cho, Sejin Son, Susan N Thomas, Jihoon Kim","doi":"10.34133/bmr.0390","DOIUrl":"10.34133/bmr.0390","url":null,"abstract":"<p><p>Taxane chemotherapeutics, including paclitaxel, docetaxel, and cabazitaxel, are commonly used in cancer therapy because of their cytotoxic effects against malignant cells. Although their primary mechanisms involve microtubule stabilization and induction of apoptosis, emerging evidence suggests that taxanes also modulate antitumor immunity. Drug delivery systems (DDSs) have been used to enhance taxane therapeutic efficacy by improving tumor targeting and immune modulation. This review discusses the immunomodulatory effects of taxanes and their effects on spatially distinct immune processes within tumors and draining lymph nodes. We highlight recent advances in taxane DDSs that facilitate tumor- and lymphatic-targeted delivery, thereby enhancing antigen presentation, adaptive immune activation, and systemic antitumor immunity. Furthermore, we explore synergistic strategies that combined taxane-based DDSs with immune checkpoint inhibitors and other immunotherapeutic agents. By integrating these approaches, taxane-based chemoimmunotherapy presents potential for advancing next-generation cancer immunotherapy.</p>","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"30 ","pages":"0390"},"PeriodicalIF":9.8,"publicationDate":"2026-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13346661/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148427224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}