Exosome-Based Therapeutics in Dermatology.

IF 8.1 Q1 ENGINEERING, BIOMEDICAL

Biomaterials research Pub Date : 2025-05-09 eCollection Date: 2025-01-01 DOI:10.34133/bmr.0148

Lanjie Lei, Shaoyu Zhou, Lingyao Zeng, Qiancheng Gu, Huaqian Xue, Fangyan Wang, Jiayin Feng, Shumao Cui, Liyun Shi

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Abstract

Exosomes (Exos) are tiny extracellular vesicles containing a variety of active biomolecules that play important parts in intercellular communication and influence the functions of target cells. The potential of Exos in the treatment of dermatological diseases has recently been well appreciated. This review highlights the constituents, function, and delivery of Exos, with a particular focus on their applications in skin therapy. Firstly, we offer a concise overview of the biochemical properties of Exos, including their sources, structures, and internal constituents. Subsequently, the biomedical functions of Exos and the latest advances in the extraction and purification of Exos are summarized. We further discuss the modes of delivery of Exos and underscore the potential of biomaterials in this regard. Finally, we summarize the application of Exo-aided therapy in dermatology. Overall, the objective of this review is to provide a comprehensive perspective on the applications and recent advancements of Exo-based approaches in treating skin diseases, with the intention of guiding future research efforts.

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皮肤病学中的外泌体疗法。

外泌体（Exos）是一种微小的细胞外囊泡，含有多种活性生物分子，在细胞间通讯和影响靶细胞的功能中起重要作用。Exos在治疗皮肤病方面的潜力最近得到了很好的认识。这篇综述重点介绍了Exos的成分、功能和递送，并特别关注了它们在皮肤治疗中的应用。首先，我们简要介绍了Exos的生物化学特性，包括它们的来源、结构和内部成分。随后，综述了Exos的生物医学功能以及Exos的提取纯化的最新进展。我们进一步讨论了Exos的递送模式，并强调了生物材料在这方面的潜力。最后，总结了外显辅助治疗在皮肤病学中的应用。综上所述，本文综述的目的是全面介绍基于外源性酶的方法在皮肤疾病治疗中的应用和最新进展，以期指导未来的研究工作。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Biomaterials research

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