Biomaterials research最新文献_第3页

Electricity-Based Locoregional Cancer Therapies and Their Associated Drug Delivery Technologies: From Principles of Action to Clinical Implications. 基于电的局部癌症治疗及其相关的药物输送技术：从作用原理到临床意义。

IF 9.8

Biomaterials research Pub Date : 2026-07-07 eCollection Date: 2026-01-01 DOI: 10.34133/bmr.0386

Ngoc-Thuan Truong, Arjaree Jobdeedamrong, Hye-Jin Yoo, Ratchapol Jenjob, Seokyoung Bang, Su-Geun Yang

{"title":"Electricity-Based Locoregional Cancer Therapies and Their Associated Drug Delivery Technologies: From Principles of Action to Clinical Implications.","authors":"Ngoc-Thuan Truong, Arjaree Jobdeedamrong, Hye-Jin Yoo, Ratchapol Jenjob, Seokyoung Bang, Su-Geun Yang","doi":"10.34133/bmr.0386","DOIUrl":"https://doi.org/10.34133/bmr.0386","url":null,"abstract":"Electric field-based therapies are rapidly emerging as innovative modalities in the fight against cancer, offering targeted, minimally invasive, and often immunomodulatory alternatives to conventional treatments. This review comprehensively examines the current landscape and prospects of electricity-based locoregional cancer therapies and their associated drug delivery technologies. Key modalities, including irreversible electroporation, tumor-treating fields, radiofrequency ablation, electrochemotherapy, and iontophoresis, are discussed regarding their mechanisms of action, clinical applications, and integration with immunotherapy. In addition, emerging strategies such as smart electro-responsive drug carriers and integrative therapeutic systems are highlighted as promising approaches for achieving electrically controlled, site-specific, and precision-guided drug delivery. Although electricity-based locoregional cancer therapies show promise, challenges such as variable tissue responses, device optimization, and long-term safety remain. Current research aims to address these issues and enhance outcomes through combinations with immunotherapy. By drawing on advances in bioelectricity, nanotechnology, and immunology, these therapies have the potential to substantially improve the precision and personalization of cancer treatment.","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"30 ","pages":"0386"},"PeriodicalIF":9.8,"publicationDate":"2026-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13483372/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148803110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Light-Curable Methacrylated Carboxymethyl Chitosan Hydrogel Incorporating Bone Morphogenic Protein-2-Immobilized Bioactive Glass for Spinal Bone Regeneration. 含骨形态发生蛋白-2固定化生物活性玻璃的光固化甲基丙烯酸羧甲基壳聚糖水凝胶用于脊柱骨再生。

IF 9.8

Biomaterials research Pub Date : 2026-07-07 eCollection Date: 2026-01-01 DOI: 10.34133/bmr.0391

Mi Yeon Ha, Gun-Jae Jeong, Jae Taek Hong, Hye June Byun, Dae Hyeok Yang, Ju Woong Jang, Heung Jae Chun

{"title":"Light-Curable Methacrylated Carboxymethyl Chitosan Hydrogel Incorporating Bone Morphogenic Protein-2-Immobilized Bioactive Glass for Spinal Bone Regeneration.","authors":"Mi Yeon Ha, Gun-Jae Jeong, Jae Taek Hong, Hye June Byun, Dae Hyeok Yang, Ju Woong Jang, Heung Jae Chun","doi":"10.34133/bmr.0391","DOIUrl":"10.34133/bmr.0391","url":null,"abstract":"Bioactive glass (BG) has emerged as a promising material for bone tissue engineering due to its ability to release osteogenic ions and establish robust interfaces with living tissues, thereby contributing to spinal bone regeneration by facilitating osteointegration and structural stability. Despite these advantageous properties, reconstructing spinal bone defects remains particularly challenging because BG is typically available in powder form, which lacks sufficient mechanical strength and is difficult to handle surgically, especially given the substantial mechanical demands of the spinal column. To overcome these limitations, we employed an injectable, light-curable methacrylated carboxymethyl chitosan (CMCSMA) hydrogel to enable minimally invasive delivery and precise defect filling. Furthermore, to complement BG's strong osteoconductive capacity with osteoinductive functionality, bone morphogenetic protein-2 (BMP-2) was immobilized onto BG particles (BG/BMP-2), creating a composite scaffold with dual biological activity. The BG/BMP-2/hydrogel system demonstrated sustained BMP-2 release, enhanced osteogenesis, and substantial new bone formation, underscoring the synergy between BG's bioactive ion release and hydroxyapatite-forming ability. The photocurable hydrogel matrix provided conformal adaptation to defect geometry, potentially improving surgical outcomes. Collectively, this composite represents a promising strategy for minimally invasive and mechanically resilient spinal bone regeneration.","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"30 ","pages":"0391"},"PeriodicalIF":9.8,"publicationDate":"2026-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13338563/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148407437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanoparticle-Based Antigen Delivery: Advancing Immunization Strategies against Infectious Pathogens. 基于纳米颗粒的抗原递送：推进针对感染性病原体的免疫策略。

IF 9.8

Biomaterials research Pub Date : 2026-07-03 eCollection Date: 2026-01-01 DOI: 10.34133/bmr.0385

Surajit Patra, Nida Irfan Pathan, Yogesh A Karpe, Virendra Gajbhiye

{"title":"Nanoparticle-Based Antigen Delivery: Advancing Immunization Strategies against Infectious Pathogens.","authors":"Surajit Patra, Nida Irfan Pathan, Yogesh A Karpe, Virendra Gajbhiye","doi":"10.34133/bmr.0385","DOIUrl":"10.34133/bmr.0385","url":null,"abstract":"Stimulation of adaptive immunity is a goal to defend against infectious agents. In recent years, vaccine development and improvements in their efficacy have been thoroughly investigated, and highly effective vaccines have been released to the market. The administration of vaccinations, safety, and the development of immunogenicity pose considerable challenges in this area. Investigations have been conducted on nanoparticle (NP)-based vaccines to address the issue. NPs are used in vaccine development to enhance antigen delivery, provide protection, and serve as adjuvants. The application of nanotechnology has substantially improved the delivery and effectiveness of vaccines by manipulating NP properties. Studies on NP-based immunizations have focused on viral pathogens and bacterial agents. Immunizations utilizing NPs enhance immune responses and stabilize viral antigens, facilitating the development of vaccines for hepatitis B, influenza, and HIV. Nanovaccines specifically target antigens associated with viruses, bacteria, and certain cancers. NP-based vaccines effectively stimulate and mature dendritic cells (DCs) in vitro and in vivo. Following vaccination, the NP-based vaccine resulted in increased cytokine levels and activated Th1 and Th2 cells in vivo. As a result, NP-based vaccines stimulate T-cell immune responses and adaptive immunity driven by immunoglobulin G and immunoglobulin M. This review has discussed the various NPs and antigens used in nanovaccine preparation; the role NPs play in activating adaptive immunity; and, specifically, the maturation of DCs; the activation of Th1 and Th2 cells against viruses, bacteria, and other microbial pathogens; and the safety of NPs.","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"30 ","pages":"0385"},"PeriodicalIF":9.8,"publicationDate":"2026-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13329038/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148392763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Hybrid Mesenchymal-Stem-Cell-Derived Decellularized Matrix Scaffold Supports Bone Repair and Vascular Perfusion in Steroid-Associated Osteonecrosis. 间充质干细胞衍生的脱细胞基质支架支持类固醇相关性骨坏死的骨修复和血管灌注。

IF 9.8

Biomaterials research Pub Date : 2026-06-29 eCollection Date: 2026-01-01 DOI: 10.34133/bmr.0383

Yijun He, Chu Hua, Lin Liang, Chen Huang, Yuan Li, Jiongfeng Huang, Cheng Luo, Zhi-Yong Zhang

{"title":"A Hybrid Mesenchymal-Stem-Cell-Derived Decellularized Matrix Scaffold Supports Bone Repair and Vascular Perfusion in Steroid-Associated Osteonecrosis.","authors":"Yijun He, Chu Hua, Lin Liang, Chen Huang, Yuan Li, Jiongfeng Huang, Cheng Luo, Zhi-Yong Zhang","doi":"10.34133/bmr.0383","DOIUrl":"10.34133/bmr.0383","url":null,"abstract":"Steroid-associated osteonecrosis (SAON) is characterized by glucocorticoid-associated vascular compromise, impaired bone repair, and a dysregulated inflammatory microenvironment. Although core decompression (CD) remains the main joint-preserving procedure, its efficacy is often limited by the hostile local niche. Here, we engineered a hybrid CDM@Fibrin/poly(ε-caprolactone) (PCL) scaffold by incorporating human umbilical cord mesenchymal-stem-cell-derived decellularized matrix (CDM) into a 3D-printed PCL framework. Proteomic profiling showed enrichment of extracellular-matrix-associated proteins linked to focal adhesion, extracellular matrix-receptor interaction, and phosphatidylinositol 3-kinase-Akt-related signaling. In vitro, solubilized CDM was biocompatible and modulated macrophage behavior in a context-dependent manner; under basal conditions, its effects on canonical polarization markers were modest, whereas under inflammatory challenge it attenuated lipopolysaccharide-induced M1-like activation and partially restored pro-healing features. In a rat femoral condyle defect model, CDM@Fibrin/PCL enhanced bone formation and was associated with lower CD86 and relatively higher CD206 signals than Fibrin/PCL controls. In a preclinical SAON model, scaffold-augmented CD markedly improved new bone formation and perfused vascular volume relative to CD alone. Exploratory transcriptomic analysis identified pathway-level associations related to immune regulation, extracellular matrix remodeling, and reparative signaling. Collectively, these findings suggest that mesenchymal-stem-cell-derived CDM functions as a bioactive matrix component that helps rebalance the local inflammatory niche and supports bone repair with improved vascularization-related outcomes in SAON.","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"30 ","pages":"0383"},"PeriodicalIF":9.8,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13311255/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148355206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeted Sirtuin 3 Activation by Biomimetic Black Phosphorus Nanosheets Mitigates Sepsis-Induced Acute Kidney Injury through Yeast Mitochondrial Escape 1-Like 1 Deacetylation. 仿生黑磷纳米片靶向激活Sirtuin 3通过酵母线粒体逃逸1- like 1去乙酰化减轻脓毒症诱导的急性肾损伤

IF 9.8

Biomaterials research Pub Date : 2026-06-29 eCollection Date: 2026-01-01 DOI: 10.34133/bmr.0379

Yiqiong Yang, Rui Zuo, Yi Wang, Rumeng Liu, Yi Zhou, Jun Wang

{"title":"Targeted Sirtuin 3 Activation by Biomimetic Black Phosphorus Nanosheets Mitigates Sepsis-Induced Acute Kidney Injury through Yeast Mitochondrial Escape 1-Like 1 Deacetylation.","authors":"Yiqiong Yang, Rui Zuo, Yi Wang, Rumeng Liu, Yi Zhou, Jun Wang","doi":"10.34133/bmr.0379","DOIUrl":"10.34133/bmr.0379","url":null,"abstract":"Sepsis-induced acute kidney injury (AKI) is characterized by mitochondrial dysfunction and dysregulated inflammation, with a lack of effective therapies. Studies have found that down-regulation of Sirtuin 3 (Sirt3) expression in renal tubular epithelial cells is associated with mitochondrial imbalance, suggesting its potential as a therapeutic target. Based on this, the research team developed a targeted nanodelivery system: black phosphorus nanosheets loaded with a cortistatin agonist were encapsulated with macrophage membranes modified with (KKEEE)₃K peptides to specifically deliver Sirt3-activating components to the kidneys. This nanosystem demonstrated favorable stability and biocompatibility. Ex vivo experiments confirmed its ability to alleviate lipopolysaccharide-induced oxidative stress, apoptosis, and inflammation in HK-2 cells, while restoring mitochondrial function. Mechanistically, the nanomaterial regulates mitochondrial homeostasis by activating the Sirt3-YME1L1 deacetylation axis. This study provides a novel nano-therapeutic strategy for sepsis-induced AKI, combining targeting capability with metabolism regulation, and holds broad implications for the treatment of inflammatory organ damage.","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"30 ","pages":"0379"},"PeriodicalIF":9.8,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13311258/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148355178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Restoring Zinc Homeostasis via a Bimetallic Nanozyme to Amplify Ferroptosis and Antitumor Immunity for Prostate Cancer Treatment. 通过双金属纳米酶恢复锌稳态，增强铁下垂和抗肿瘤免疫，用于前列腺癌治疗。

IF 9.8

Biomaterials research Pub Date : 2026-06-26 eCollection Date: 2026-01-01 DOI: 10.34133/bmr.0378

Jinzhuo Ning, Kun Jiang, Haoyong Li, Fan Cheng

{"title":"Restoring Zinc Homeostasis via a Bimetallic Nanozyme to Amplify Ferroptosis and Antitumor Immunity for Prostate Cancer Treatment.","authors":"Jinzhuo Ning, Kun Jiang, Haoyong Li, Fan Cheng","doi":"10.34133/bmr.0378","DOIUrl":"10.34133/bmr.0378","url":null,"abstract":"Prostate cancer therapy is hindered by treatment resistance and an immunosuppressive microenvironment. To address this, we developed an innovative bimetallic nanozyme, Fe/Zn-CNZ@LOx@PEG, that integrates catalytic activity with metabolic and immune modulation. This nanoplatform executes a novel \"metabolic-immuno\" co-regulation strategy. Its Fe-Zn catalytic sites drive a lactate-fueled cascade reaction within the acidic tumor milieu, generating a burst of cytotoxic hydroxyl radicals. Simultaneously, released zinc ions rectify tumor zinc deficiency, disrupting cellular metabolism and promoting ferroptosis-an iron-dependent cell death-through glutathione depletion and lipid peroxidation. This ferroptotic cell death, in turn, acts as a potent trigger for immunogenic cell death (ICD), stimulating dendritic cell maturation and cytotoxic T cell infiltration to reverse immunosuppression. Consequently, Fe/Zn-CNZ@LOx@PEG demonstrates potent tumor suppression and effectively enhances the efficacy of anti-PD-1 therapy in a prostate cancer mouse model. This work presents a catalytic nanoreactor that co-regulates metabolism and immunity, offering a robust and synergistic strategy for the ferroptosis-immunotherapy of advanced cancers.","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"30 ","pages":"0378"},"PeriodicalIF":9.8,"publicationDate":"2026-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13305028/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148347693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biomimetic Nanogels Programmed for Irreversible-Electroporation-Primed Tumor Microenvironments to Elicit Durable Antitumor Immunity. 不可逆电穿孔引发肿瘤微环境的仿生纳米凝胶可引发持久的抗肿瘤免疫。

IF 9.8

Biomaterials research Pub Date : 2026-06-25 eCollection Date: 2026-01-01 DOI: 10.34133/bmr.0359

Jun-Hyeok Han, Ha Eun Shin, Chun Gwon Park, Hyun-Do Jung, Jung-Hoon Park, Ji Hoon Jeong, Yong Taik Lim, Dong-Hyun Kim, Wooram Park

{"title":"Biomimetic Nanogels Programmed for Irreversible-Electroporation-Primed Tumor Microenvironments to Elicit Durable Antitumor Immunity.","authors":"Jun-Hyeok Han, Ha Eun Shin, Chun Gwon Park, Hyun-Do Jung, Jung-Hoon Park, Ji Hoon Jeong, Yong Taik Lim, Dong-Hyun Kim, Wooram Park","doi":"10.34133/bmr.0359","DOIUrl":"10.34133/bmr.0359","url":null,"abstract":"Irreversible electroporation (IRE) remodels the tumor microenvironment to enhance biomaterial and nanoparticle (NP) delivery and immune activation, making combinational IRE-nanomedicine a promising approach for effective cancer treatment. Here, we present a rational combination strategy that integrates IRE-induced immune modulation with M1 macrophage-membrane (M1-m)-coated nanogels to amplify and prolong antitumor immune responses. Transcriptomic and immunological profiling after IRE revealed a transient up-regulation of immune and inflammatory pathways, particularly the recruitment of macrophages and dendritic cells, followed by a rapid decline over time. To exploit this transient inflammatory state, we engineered an M1-m-coated nanogel hydrogel co-loaded with graphene quantum dots as a fluorescence probe and the immune modulator zoledronic acid (M1-GAZ). The IRE-enhanced tumor-targeting efficiency of M1-m-coated NPs was confirmed by comparing the tumor-targeting efficiency with other NP formulations including gold NPs (negatively or positively charged), lipid-based NPs (liposomes and lipid NPs, negatively or positively charged), and macrophage (M0 or M1) cell-membrane-coated NPs. Subsequently, the combination of IRE with intravenously injected M1-GAZ markedly increased the infiltration of activated macrophages and dendritic cells, resulting in superior tumor suppression and prolonged survival compared to monotherapies. This study demonstrates that engineering biomimetic M1-m-coated nanogels to synergize with IRE-induced tumor microenvironment remodeling enables selective delivery and durable immune activation, providing a robust platform for synergistic IRE cancer immunotherapy.","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"30 ","pages":"0359"},"PeriodicalIF":9.8,"publicationDate":"2026-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13294544/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148347649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioactive Chitin-Based Thermosensitive Hydrogel Reinforces Stem Cell Therapy for Osteoarthritis. 生物活性几丁质热敏水凝胶强化骨关节炎干细胞治疗。

IF 9.8

Biomaterials research Pub Date : 2026-06-23 eCollection Date: 2026-01-01 DOI: 10.34133/bmr.0382

Yiming Zhang, Xinbing Ren, Xiaoyu Duan, Xinyu Zhao, Yufeng Liu, Zicheng Dai, Weizhi Liu, Xiaohui Xu, Sudan Zhang, Guangmin Zhang, Xiaolei Dong, Yuping Yang, Jiane Liu, Yunfeng Gao, Daijie Wang, Chong Sun, Baoqin Han, Zheng Wang, Shaoqi Tian

{"title":"Bioactive Chitin-Based Thermosensitive Hydrogel Reinforces Stem Cell Therapy for Osteoarthritis.","authors":"Yiming Zhang, Xinbing Ren, Xiaoyu Duan, Xinyu Zhao, Yufeng Liu, Zicheng Dai, Weizhi Liu, Xiaohui Xu, Sudan Zhang, Guangmin Zhang, Xiaolei Dong, Yuping Yang, Jiane Liu, Yunfeng Gao, Daijie Wang, Chong Sun, Baoqin Han, Zheng Wang, Shaoqi Tian","doi":"10.34133/bmr.0382","DOIUrl":"10.34133/bmr.0382","url":null,"abstract":"Osteoarthritis (OA) is a progressive joint disorder that predominantly affects elderly and postmenopausal individuals. Current therapies offer only transient symptom relief and are associated with significant adverse effects. Mesenchymal stem cell (MSC) therapy holds promise for OA treatment, but challenges such as poor in vivo persistence and migration away from target sites hinder its clinical application. Here, we develop a bioactive, thermosensitive hydroxypropyl chitin (HPCT) hydrogel as an injectable platform to enhance MSC-based therapy. In both papain-induced early-stage and surgically induced late-stage OA models, intra-articular injections of MSCs combined with HPCT hydrogel significantly enhance therapeutic efficacy within the osteoarthritic joint environment. This bioactive, thermosensitive hydrogel is associated with attenuation of mechanical-stress-related ferroptotic signatures in chondrocytes through the establishment of a protective biomechanical microenvironment. MSCs embedded within the hydrogel adopt a spheroidal configuration, which improves their viability, enhances their anti-inflammatory properties, and prolongs their retention at the site of injury. These combined effects promote cartilage repair, regeneration, and sustained joint homeostasis. Mechanistically, these effects are accompanied by modulation of mechanotransduction-related pathways, including reduced Piezo1 expression and restoration of GPX4-associated antioxidant capacity. Our findings highlight HPCT-based tissue engineering as a promising therapeutic strategy for addressing OA pathophysiology and improving long-term clinical outcomes.","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"30 ","pages":"0382"},"PeriodicalIF":9.8,"publicationDate":"2026-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13287448/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148321241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanisms and Applications of Conductive Biomaterials in Spinal Cord Injury Repair. 导电性生物材料在脊髓损伤修复中的作用机制及应用。

IF 9.8

Biomaterials research Pub Date : 2026-06-11 eCollection Date: 2026-01-01 DOI: 10.34133/bmr.0381

Bin Zhao, Zhonghan Wang, Tong Yu, Xiangran Cui, Jinbo Zhang, Quezhu Danzeng, Wenjie Wang, Yi Shen, Chenhao Ma, Yaolin Zhao, Jianhang Jiao, Minfei Wu

{"title":"Mechanisms and Applications of Conductive Biomaterials in Spinal Cord Injury Repair.","authors":"Bin Zhao, Zhonghan Wang, Tong Yu, Xiangran Cui, Jinbo Zhang, Quezhu Danzeng, Wenjie Wang, Yi Shen, Chenhao Ma, Yaolin Zhao, Jianhang Jiao, Minfei Wu","doi":"10.34133/bmr.0381","DOIUrl":"10.34133/bmr.0381","url":null,"abstract":"Spinal cord injury (SCI) is a debilitating disorder of the central nervous system and remains a major challenge in neural regeneration and rehabilitation research. Spinal cord stimulation (SCS) has demonstrated notable efficacy in promoting neural repair and functional recovery following SCI. Its mechanisms include enhancing descending pathway conduction through neural plasticity, suppressing inflammation, and stimulating the secretion of neurotrophic factors, thereby creating a permissive microenvironment for axonal regeneration and remyelination. Nevertheless, in cases of complete SCI or extensive structural damage, SCS alone often shows limited therapeutic benefits. Advances in materials science have introduced conductive biomaterials as a promising strategy for SCI repair. These materials can replicate the spinal cord's electrical microenvironment, fill lesion sites, promote neural stem cell differentiation, guide directional axonal growth, facilitate remyelination, and modulate immune responses to mitigate secondary injury, collectively contributing to neuroprotection and functional recovery. This review systematically summarizes recent progress in the application of SCS and conductive biomaterials for SCI repair, highlights the current limitations of SCS in clinical settings, and provides an in-depth discussion on the mechanisms and translational potential of conductive biomaterials in neural regeneration.","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"30 ","pages":"0381"},"PeriodicalIF":9.8,"publicationDate":"2026-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13254569/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148254867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transdermal Delivery of Chinese Medicinal Formula Mitigates Pediatric Constipation by Modulating Intestinal Endocrine and Metabolic Homeostasis. 中药方剂经皮给药通过调节肠道内分泌和代谢稳态缓解小儿便秘。

IF 9.8

Biomaterials research Pub Date : 2026-06-10 eCollection Date: 2026-01-01 DOI: 10.34133/bmr.0374

Fengyuan Song, Yunhao Ren, Ming Zhu, Yuling Liu, Siping Wei, Hui Li, Lihua Peng

{"title":"Transdermal Delivery of Chinese Medicinal Formula Mitigates Pediatric Constipation by Modulating Intestinal Endocrine and Metabolic Homeostasis.","authors":"Fengyuan Song, Yunhao Ren, Ming Zhu, Yuling Liu, Siping Wei, Hui Li, Lihua Peng","doi":"10.34133/bmr.0374","DOIUrl":"10.34133/bmr.0374","url":null,"abstract":"Pediatric constipation, attributed to the functional immaturity of the gastrointestinal tract in children, is a common clinical disorder characterized by impaired gastrointestinal motility and infrequent bowel movements. Existing therapeutic strategies are frequently constrained by suboptimal efficacy owing to their single-target mechanisms and systemic toxicity. In contrast, Chinese medicinal formulas, with their multicomponent and multitarget intervention strategies, offer a highly suitable alternative for managing constipation. The traditional Chinese medicine formula \"YiNianJin\" (YNJ) is composed of cinnabar, rhubarb, stir-fried morning glory seeds, areca nut, and ginseng. It has demonstrated significant therapeutic efficacy in accelerating intestinal peristalsis through the synergistic regulation of aquaporin expression and the release of endocrine homeostatic transmitters. However, the clinical application of YNJ is significantly limited by conventional oral administration, which leads to Hg2+ accumulation and the low bioavailability of the active components. To address these challenges, we developed a sustained-release transdermal patch named YNJ patch (YNJP), which encapsulates cinnabar-loaded nanovesicles along with other active constituents in carboxymethyl cellulose sodium matrix. YNJP was shown to significantly enhance intestinal motility (as evidenced by a 24.02% increase in propulsion rate) by regulating the expression of mucin 2, aquaporin 3, and tight junction protein 1, while simultaneously promoting the release of endocrine homeostatic transmitters and Lactobacilli-mediated short-chain fatty acids. Therefore, YNJP is shown as a novel transdermal platform that alleviates pediatric constipation by modulating intestinal endocrine and metabolic homeostasis, enabling safe delivery of complex formulas with strong clinical potential for complex disorders.","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"30 ","pages":"0374"},"PeriodicalIF":9.8,"publicationDate":"2026-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13250285/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148229369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0