Biomaterials research最新文献_第3页

A Cross-Linked Cyclosiloxane Polymer Matrix as a Platform Enabling Long-Term Culture of Human Induced Pluripotent Stem Cells with Naïve-Like Features. 交联环硅氧烷聚合物基质作为长期培养具有Naïve-Like特征的人类诱导多能干细胞的平台。

IF 8.1

Biomaterials research Pub Date : 2025-04-28 eCollection Date: 2025-01-01 DOI: 10.34133/bmr.0197

Changjin Seo, Junhyuk Song, Yoonjung Choi, Taemook Kim, Daeyoup Lee, Sangyong Jon

{"title":"A Cross-Linked Cyclosiloxane Polymer Matrix as a Platform Enabling Long-Term Culture of Human Induced Pluripotent Stem Cells with Naïve-Like Features.","authors":"Changjin Seo, Junhyuk Song, Yoonjung Choi, Taemook Kim, Daeyoup Lee, Sangyong Jon","doi":"10.34133/bmr.0197","DOIUrl":"https://doi.org/10.34133/bmr.0197","url":null,"abstract":"Culture platforms for human induced pluripotent stem cells (hiPSCs) that rely on feeder cells or extracellular matrices (ECMs) face substantial limitations for practical regenerative medicine applications, including undefined components, high costs, and a tendency to maintain hiPSCs in the primed pluripotent state, which has lower differentiation potential than the naïve state. To overcome these challenges, we developed a long-term hiPSC culture platform based on a cross-linked cyclosiloxane polymer matrix that preserves pluripotency with naïve-like characteristics. Through optimization, we identified an ideal cyclosiloxane polymer matrix, designated as poly-Z, which supported the growth of hiPSCs as spheroids. Even after 60 d of continuous culture, hiPSC spheroids maintained on poly-Z retained pluripotency markers and normal karyotypes at levels comparable to those of hiPSC colonies cultured on conventional vitronectin (VN)-coated plates. Furthermore, mRNA sequencing revealed that hiPSC spheroids cultured on poly-Z not only exhibited up-regulation of typical pluripotency-related genes but also showed increased expression of genes associated with the naïve pluripotent state, in contrast to the primed state observed in hiPSCs cultured on VN-coated plates or in suspension culture. Gene ontology (GO) analysis and gene set enrichment analysis (GSEA) further suggested that the down-regulation of genes involved in cell-ECM interactions contributed to the induction of naïve-like features in poly-Z-cultured hiPSC spheroids. These findings highlight the potential of cross-linked cyclosiloxane-based polymer matrices as an innovative platform for human pluripotent stem cell research and regenerative medicine.","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"29 ","pages":"0197"},"PeriodicalIF":8.1,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12034926/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A pH-Responsive Polyetheretherketone Implant Modified with a Core-Shell Metal-Organic Framework to Promote Antibacterial and Osseointegration Abilities. 核-壳金属-有机框架修饰的ph响应型聚醚醚酮种植体促进抗菌和骨整合能力。

IF 8.1

Biomaterials research Pub Date : 2025-04-25 eCollection Date: 2025-01-01 DOI: 10.34133/bmr.0188

Shiqing Ma, Shiyu Yao, Yumeng Li, Yilin Yang, Tianyi Tong, Hong Zheng, Beibei Ma, Pengfei Wei, Zhengyi Di, Bo Zhao, Jiayin Deng

{"title":"A pH-Responsive Polyetheretherketone Implant Modified with a Core-Shell Metal-Organic Framework to Promote Antibacterial and Osseointegration Abilities.","authors":"Shiqing Ma, Shiyu Yao, Yumeng Li, Yilin Yang, Tianyi Tong, Hong Zheng, Beibei Ma, Pengfei Wei, Zhengyi Di, Bo Zhao, Jiayin Deng","doi":"10.34133/bmr.0188","DOIUrl":"https://doi.org/10.34133/bmr.0188","url":null,"abstract":"Polyetheretherketone (PEEK) is considered to be a potential material for oral implants due to its elastic modulus being similar to that of human cortical bone. However, the poor antibacterial, anti-inflammatory, and osseointegration properties of bioinert PEEK have hindered its clinical application. Therefore, this study designed and constructed a pH-responsive PEEK implant with a bilayer core-shell zeolitic imidazolate framework-8 (ZIF-8) structure loaded on its surface, with an antimicrobial peptide (KR12) encapsulated in the outer shell and an osteogenic peptide (osteogenic growth peptide ) encapsulated in its inner core. In this study, the bilayer core-shell ZIF-8 structure was confirmed to have pH-responsive properties. In vitro studies proved that the implant could promote bone marrow mesenchymal stem cells' proliferation and differentiation and the M1 phenotype to M2 phenotype conversion of RAW 264.7 and could inhibit bacterial adhesion and proliferation. By constructing rats' distal femur with/without infection models, it was further demonstrated that the novel implant could effectively inhibit bacterial adhesion and growth, inhibit inflammation, and promote peri-implant osseointegration, which was more substantial when the local area was infected and the pH was lower than that of normal tissue. Collectively, the results suggest that this novel pH-responsive PEEK implant loaded with a bilayer core-shell ZIF-8 structure is a promising peptide delivery implant system, which is well suited for dental applications and offers a potential solution for the prevention of infection during the early phase after implantation.","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"29 ","pages":"0188"},"PeriodicalIF":8.1,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12022397/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144031394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multiaction Antimicrobial, Anti-inflammatory, and Prohealing Hydrogel as a Novel Strategy for Preventing Postoperative Pancreatic Fistula. 多作用抗菌、抗炎和促愈合水凝胶作为预防术后胰瘘的新策略。

IF 8.1

Biomaterials research Pub Date : 2025-04-23 eCollection Date: 2025-01-01 DOI: 10.34133/bmr.0194

Yuan Zhou, Lan Li, Fangsheng Chen, Tingting Huang, Maoen Pan, Heguang Huang

{"title":"Multiaction Antimicrobial, Anti-inflammatory, and Prohealing Hydrogel as a Novel Strategy for Preventing Postoperative Pancreatic Fistula.","authors":"Yuan Zhou, Lan Li, Fangsheng Chen, Tingting Huang, Maoen Pan, Heguang Huang","doi":"10.34133/bmr.0194","DOIUrl":"https://doi.org/10.34133/bmr.0194","url":null,"abstract":"Postoperative pancreatic fistula remains a challenging complication after pancreaticoduodenectomy. Addressing this issue requires effective strategies to promote anastomotic healing. In this study, we developed a novel hydrogel designed to close pancreaticoenteric anastomosis after pancreaticoduodenectomy. The hydrogel-composed of polyvinyl alcohol, chitosan, and dopamine-modified oxidized hyaluronic acid-exhibited excellent antibacterial, anti-inflammatory, and wound healing properties. It was designed to conform well to the anastomotic site for clinical application. The hydrogel demonstrated good biocompatibility, appropriate mechanical strength, low swelling, and strong adhesive properties, meeting specific requirements for pancreaticoenteric anastomosis environments. Moreover, by activating the cell cycle, it promoted cell proliferation and migration, thereby accelerating anastomotic closure. Addition of the potent broad-spectrum antibiotic meropenem further enhanced its antibacterial efficacy, targeting common microbial species involved in delayed healing and fistula formation after pancreatic surgery. In a rat model of pancreatic fistula, the hydrogel effectively sealed the anastomosis, filled potential suture gaps, and exerted antibacterial, anti-inflammatory, and tissue regeneration-promoting effects around the anastomotic site. Therefore, this hydrogel, with its ideal degradation properties, shows promising application prospects in closing pancreaticoenteric anastomosis following pancreaticoduodenectomy, thereby offering an effective solution to reduce complications such as pancreatic fistula after pancreatic surgery.","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"29 ","pages":"0194"},"PeriodicalIF":8.1,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12015097/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144059694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Injectable Brain Extracellular Matrix Hydrogels Enhance Neuronal Migration and Functional Recovery After Intracerebral Hemorrhage. 可注射脑细胞外基质水凝胶促进脑出血后神经元迁移和功能恢复。

IF 8.1

Biomaterials research Pub Date : 2025-04-22 eCollection Date: 2025-01-01 DOI: 10.34133/bmr.0192

Jiajie Xia, Xinjie Gao, Jun Yao, Yuchao Fei, Dagang Song, Zhiwei Gu, Gang Zheng, Yuxiang Gu, Chuanjian Tu

{"title":"Injectable Brain Extracellular Matrix Hydrogels Enhance Neuronal Migration and Functional Recovery After Intracerebral Hemorrhage.","authors":"Jiajie Xia, Xinjie Gao, Jun Yao, Yuchao Fei, Dagang Song, Zhiwei Gu, Gang Zheng, Yuxiang Gu, Chuanjian Tu","doi":"10.34133/bmr.0192","DOIUrl":"https://doi.org/10.34133/bmr.0192","url":null,"abstract":"Neural repair within the lesion cavity caused by intracerebral hemorrhage (ICH) remains a major therapeutic challenge. Hydrogels hold great potential in regenerative medicine as functional scaffolds. However, inadequate host cell infiltration and suboptimal delivery methods have limited their application in tissue engineering. Here, we describe an optimized decellularization approach to create injectable brain extracellular matrix (ECM) hydrogels for the treatment of ICH. The hydrogel exhibits excellent biodegradability and biocompatibility. In an ICH rat model, the hydrogel implanted into the stroke cavity promoted neural recovery, facilitated cell recruitment, enhanced angiogenesis, and inhibited inflammation in the peri-cavity region at 14 d post-implantation. Furthermore, the hydrogel improved cell proliferation and migration, reversed cell apoptosis, and modulated transcriptomic changes in vitro. Notably, the hydrogel may promote neuronal migration and neural functional recovery after ICH through the slit guidance ligand 2-receptor roundabout guidance receptor 1 (Slit2-Robo1) signaling pathway. These findings highlight the potential of brain ECM hydrogels as a promising strategy for brain tissue regeneration.","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"29 ","pages":"0192"},"PeriodicalIF":8.1,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12012376/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nucleic Acid-Functionalized Gold Nanorods Modulate Inflammation and Dysregulated Intestinal Barriers for Treatment of Ulcerative Colitis. 核酸功能化金纳米棒调节炎症和失调肠道屏障治疗溃疡性结肠炎。

IF 8.1

Biomaterials research Pub Date : 2025-04-18 eCollection Date: 2025-01-01 DOI: 10.34133/bmr.0195

Wanghong He, Yanxue Wang, Yifan Zhao, Bingqing Wu, Yilong Chen, Lu Jia, Xinfeng Tan, Yi Liu

{"title":"Nucleic Acid-Functionalized Gold Nanorods Modulate Inflammation and Dysregulated Intestinal Barriers for Treatment of Ulcerative Colitis.","authors":"Wanghong He, Yanxue Wang, Yifan Zhao, Bingqing Wu, Yilong Chen, Lu Jia, Xinfeng Tan, Yi Liu","doi":"10.34133/bmr.0195","DOIUrl":"https://doi.org/10.34133/bmr.0195","url":null,"abstract":"Traditional oral treatments for ulcerative colitis (UC) face marked limitations including their single therapeutic effect, potential off-target interactions, and toxic side effects. In this study, we present nucleic acid-functionalized gold nanorods (NAF AuNRs), a biocompatible nanomaterial designed for the oral treatment of dextran sulfate sodium (DSS)-induced colitis. The NAF AuNRs alleviate immune responses by inhibiting pro-inflammatory macrophages and enhancing the expression of barrier proteins in intestinal epithelial cells. Due to the negatively charged nucleic acid shell, NAF AuNRs preferentially target anionic, inflamed colon tissues upon oral administration, reducing pro-inflammatory cytokine levels and promoting the recovery of intestinal barrier in DSS-induced colitis mice. Collectively, these findings suggest that NAF AuNRs represent an innovative and promising therapeutic approach for UC management, offering novel insights into the application of nucleic acid-functionalized nanomaterials.","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"29 ","pages":"0195"},"PeriodicalIF":8.1,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12006742/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decellularized Extracellular Matrix Scaffold Loaded with Regulatory T Cell-Conditioned Medium Induces M2 Macrophage Polarization. 负载调节性T细胞条件培养基的脱细胞细胞外基质支架诱导M2巨噬细胞极化。

IF 8.1

Biomaterials research Pub Date : 2025-04-18 eCollection Date: 2025-01-01 DOI: 10.34133/bmr.0196

Hongjing Jiang, Xuheng Sun, Jiang Liu, Lijun Fang, Yuanfeng Liang, Jiahui Zhou, Yueheng Wu, Zhanyi Lin

{"title":"Decellularized Extracellular Matrix Scaffold Loaded with Regulatory T Cell-Conditioned Medium Induces M2 Macrophage Polarization.","authors":"Hongjing Jiang, Xuheng Sun, Jiang Liu, Lijun Fang, Yuanfeng Liang, Jiahui Zhou, Yueheng Wu, Zhanyi Lin","doi":"10.34133/bmr.0196","DOIUrl":"https://doi.org/10.34133/bmr.0196","url":null,"abstract":"Biomaterials often induce local inflammatory responses following implantation. Scaffolds that cause continuous M1 polarization typically hinder tissue healing and regeneration. Regulating the transformation of macrophages to the M2 phenotype in the inflammatory environment is crucial. We propose that regulatory T cell-conditioned medium (Treg CM) effectively promotes M2 polarization of macrophages induced by decellularized extracellular matrix (dECM) materials in inflammatory environments. In vitro results showed that in the presence of dECM, Treg CM induces the polarization of RAW264.7 macrophages to M2 and inhibits M1 macrophage polarization under inflammatory conditions (lipopolysaccharide + IFN-γ). Additionally, dECM promotes the polarization of bone marrow-derived macrophages (BMDMs) to M2, while Treg CM further promotes M2 polarization and inhibits M1 polarization in an inflammatory environment. These findings were confirmed by transcriptome sequencing. Treg CM inhibited IκB kinase/NF-κB signaling and cellular responses to oxidative stress. In vivo subcutaneous transplantation showed an increase in M2 macrophages, a decrease in M1 macrophages, and an increased M2/M1 ratio in dECM materials loaded with Treg CM. These results suggest that Treg CM can create a pro-M2 polarized microenvironment for dECM, guiding immune responses toward favorable tissue regeneration. Ultimately, this research highlights the potential of Treg CM as a therapeutic approach to modulate the immune response and improve the efficacy of regenerative biomaterials.","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"29 ","pages":"0196"},"PeriodicalIF":8.1,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12006722/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adipose Decellularized Matrix: A Promising Skeletal Muscle Tissue Engineering Material for Volume Muscle Loss. 脂肪脱细胞基质：一种有前途的骨骼肌组织工程材料。

IF 8.1

Biomaterials research Pub Date : 2025-04-17 eCollection Date: 2025-01-01 DOI: 10.34133/bmr.0174

Zimo Wang, Wei Liang, Rigele Ao, Yang An

{"title":"Adipose Decellularized Matrix: A Promising Skeletal Muscle Tissue Engineering Material for Volume Muscle Loss.","authors":"Zimo Wang, Wei Liang, Rigele Ao, Yang An","doi":"10.34133/bmr.0174","DOIUrl":"https://doi.org/10.34133/bmr.0174","url":null,"abstract":"Volume muscle loss is a severe injury often caused by trauma, fracture, tumor resection, or degenerative disease, leading to long-term dysfunction or disability. The current gold-standard treatment is autologous muscle tissue transplantation, with limitations due to donor site restrictions, complications, and low regeneration efficiency. Tissue engineering shows potential to overcome these challenges and achieve optimal muscle regeneration, vascularization, nerve repair, and immunomodulation. In the field of muscle tissue engineering, skeletal muscle decellularized matrices are regarded as an ideal material due to their similarity to the defect site environment, yet they suffer from difficulties in preparation, severe fibrosis, and inconsistent experimental findings. Adipose decellularized matrices (AdECMs) have demonstrated consistent efficacy in promoting muscle regeneration, and their ease of preparation and abundant availability make them even more attractive. The full potential of AdECMs for muscle regeneration remains to be explored. The aim of this review is to summarize the relevant studies on using AdECMs to promote muscle regeneration, to summarize the preparation methods of various applied forms, and to analyze their advantages and shortcomings, as well as to further explore their mechanisms and to propose possible improvements, so as to provide new ideas for the clinical solution of the problem of volume muscle loss.","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"29 ","pages":"0174"},"PeriodicalIF":8.1,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12003953/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Physicochemical Properties and Efficacy of Poloxamer Bone Wax on Hemostasis at the Bone-Amputation Site. 泊洛沙姆骨蜡对截骨部位止血的理化性质及疗效观察。

IF 8.1

Biomaterials research Pub Date : 2025-04-15 eCollection Date: 2025-01-01 DOI: 10.34133/bmr.0191

Dae Hyung Lee, Miri Kim, Yeji Choi, Mi Hee Lee, Jong-Chul Park

{"title":"Physicochemical Properties and Efficacy of Poloxamer Bone Wax on Hemostasis at the Bone-Amputation Site.","authors":"Dae Hyung Lee, Miri Kim, Yeji Choi, Mi Hee Lee, Jong-Chul Park","doi":"10.34133/bmr.0191","DOIUrl":"https://doi.org/10.34133/bmr.0191","url":null,"abstract":"Bone wax, an essential material for bone hemostasis in orthopedic, thoracic, and neurological surgeries, is defined as a substance that physically controls bleeding caused by bone fractures. Absorbable bone-wax products such as poloxamer multiblock copolymers can be topically applied, form a physical barrier, are biocompatible, and can be absorbed by/excreted from the body. However, absorbable bone waxes continue to have limited physical properties, poor bone adhesion, and low hemostatic quality. When applied to the affected area, they quickly dissolve in blood and body fluids, preventing maintenance of the physical barrier over a certain period and thereby reducing the hemostatic effect. This study introduces a new type of absorbable bone wax (OSSTOP) constructed from 2 poloxamer multiblock copolymers with different molecular weight ranges. To determine whether OSSTOP overcomes the limitations of the existing products, the physicochemical properties and efficacy of OSSTOP were compared with those of 2 existing absorbable bone-wax products, OSTENE and NOVOSEAL. The adhesive strengths, yield loads, and solubilities of the products were evaluated and compared in vitro. Hemostasis at the bone-amputation site and absorption/degradation of the products were then evaluated through animal experiments in vivo. The biological safety (cytotoxicity) of the newly developed OSSTOP was also assessed. A histological analysis confirmed superior hemostasis at the bone-amputation site and a favorable biological response after treatment with OSSTOP. We expect that OSSTOP will improve the convenience, hemostatic performance, and biocompatibility of bleeding cessation at bone-amputation sites in the clinical environment.","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"29 ","pages":"0191"},"PeriodicalIF":8.1,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11997309/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144055278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Radiation-Activated Cobalt-Based Zeolite Imidazolate Frameworks for Tumor Multitherapy. 辐射激活钴基咪唑酸沸石框架用于肿瘤的综合治疗。

IF 8.1

Biomaterials research Pub Date : 2025-04-15 eCollection Date: 2025-01-01 DOI: 10.34133/bmr.0164

Qijun Du, Hongwei Jiang, Di Wu, Changlong Song, Wenqi Hu, Qinrui Lu, Chenwei Sun, Jie Liu, Guohua Wu, Shuqi Wang

{"title":"Radiation-Activated Cobalt-Based Zeolite Imidazolate Frameworks for Tumor Multitherapy.","authors":"Qijun Du, Hongwei Jiang, Di Wu, Changlong Song, Wenqi Hu, Qinrui Lu, Chenwei Sun, Jie Liu, Guohua Wu, Shuqi Wang","doi":"10.34133/bmr.0164","DOIUrl":"https://doi.org/10.34133/bmr.0164","url":null,"abstract":"Radiation dynamic therapy (RDT) is known to induce cancer apoptosis and death with minimal side effects and high accuracy. However, low efficiency of radiation sensitization and persistent hypoxic environment in tumors pose marked challenges for successful RDT. To address these challenges, a novel biodegradable drug delivery system was developed, using quercetin and sorafenib-loaded ZIF67 nanoparticles (QSZP NPs) coated with polydopamine. This system effectively controlled the tumor microenvironment (TME), overcame hypoxia, and was thus utilized for collaborative RDT and radiotherapy (RT). The QSZP NPs demonstrated great potential in x-ray sensitization and reactive oxygen species (ROS)-mediated effects in vitro. Furthermore, they continuously generated oxygen and increased ROS levels in the TME with x-ray irradiation to achieve RDT. In vivo studies showed that QSZP NPs had no apparent systemic toxicity and showed good therapeutic effect in a HepG2 tumor-bearing model. Due to its unique and outstanding combinational effect of RDT/RT/antiangiogenic cancer therapy, these synthesized NPs offer a promising method for radiation-based cancer treatment.","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"29 ","pages":"0164"},"PeriodicalIF":8.1,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11997308/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144038313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rat Sarcoma (RAS)-Protein-Targeting Synthetic Cell-Penetrating Peptide as an Anticancer Biomaterial. 大鼠肉瘤（RAS）蛋白靶向合成细胞穿透肽作为抗癌生物材料。

IF 8.1

Biomaterials research Pub Date : 2025-04-15 eCollection Date: 2025-01-01 DOI: 10.34133/bmr.0175

Gookjin Yoon, Jinsook Suh, Beom Soo Jo, Dong Woo Lee, Deogil Kim, Moonsil Choi, Eui Kyun Jeong, Hoo Cheol Lee, Hye Min Shin, Yu-Bin Kim, Sanghui Seok, Yoon Shin Park, Chong Pyung Chung, Jue-Yeon Lee, Yoon Jeong Park

{"title":"Rat Sarcoma (RAS)-Protein-Targeting Synthetic Cell-Penetrating Peptide as an Anticancer Biomaterial.","authors":"Gookjin Yoon, Jinsook Suh, Beom Soo Jo, Dong Woo Lee, Deogil Kim, Moonsil Choi, Eui Kyun Jeong, Hoo Cheol Lee, Hye Min Shin, Yu-Bin Kim, Sanghui Seok, Yoon Shin Park, Chong Pyung Chung, Jue-Yeon Lee, Yoon Jeong Park","doi":"10.34133/bmr.0175","DOIUrl":"https://doi.org/10.34133/bmr.0175","url":null,"abstract":"Various bioactive materials, including peptides, have become potential candidates for slowing cancer growth and metastasis. Among bioactive peptides, a synthetic cell-penetrating peptide referred to as rat sarcoma (RAS)-binding peptide (RBP) was suggested as a potential entity that targets RAS with high affinity in MDA-MB-231 cancer cells. This RAS binding further inhibits the RAS-rapidly accelerated fibrosarcoma (RAF) protein-protein interaction. The current study revealed that RBP effectively suppresses proliferation and extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation by disrupting the RAS-RAF interaction. This intervention not only inhibits cell migration and invasion but also has substantial potential for preventing metastasis. The RAS-RAF-ERK1/2 pathway is a key target for anticancer drug development because of frequent ERK and mitogen-activated protein kinase activation in human cancers. MDA-MB-231, a triple-negative breast cancer cell line, harbors a G13D Kirsten rat sarcoma viral oncogene homolog mutation, making it resistant to many drugs. In addition to its in vitro antitumor activity, RBP was identified as a potent antagonist that substantially arrests tumor growth and invasiveness in in vivo chicken egg and mouse xenograft tumor models. Notably, histopathological analyses revealed increased immune cell infiltration and decreased Ki-67 expression, confirming the ability of RBP to inhibit tumor cell proliferation. Taken together, these findings highlight RBP as a therapeutic anticancer biomaterial capable of impeding the progression and metastasis of RAS-mutated cancers.","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"29 ","pages":"0175"},"PeriodicalIF":8.1,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11997307/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144038101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0