Biomaterials research最新文献_第4页

Versatile and Marvelous Potentials of Polydeoxyribonucleotide for Tissue Engineering and Regeneration. 聚脱氧核糖核苷酸在组织工程和再生中的多用途和非凡潜力。

IF 8.1

Biomaterials research Pub Date : 2025-04-14 eCollection Date: 2025-01-01 DOI: 10.34133/bmr.0183

Nuri Oh, Juyoung Hwang, Moon Sung Kang, Chung-Yul Yoo, Minseok Kwak, Dong-Wook Han

{"title":"Versatile and Marvelous Potentials of Polydeoxyribonucleotide for Tissue Engineering and Regeneration.","authors":"Nuri Oh, Juyoung Hwang, Moon Sung Kang, Chung-Yul Yoo, Minseok Kwak, Dong-Wook Han","doi":"10.34133/bmr.0183","DOIUrl":"https://doi.org/10.34133/bmr.0183","url":null,"abstract":"Over the past decade, substantial focus has been placed on polydeoxyribonucleotide (PDRN) due to its promising pharmacological properties, making it a valuable candidate for tissue engineering applications. Accordingly, this paper aims to review and summarize the latest experimental research on PDRN in the context of tissue engineering and regeneration. The unique biochemical mechanisms of PDRN to promote cellular behavior and regeneration are summarized. We categorize commonly utilized PDRN-based tissue engineering fields as neuromuscular tissues, diabetic wound or skin, and bone regeneration. At the same time, we explore scaffold strategies for integrating PDRN into bioceramics, polymers, and cell/tissue-derived materials, along with its combination with photo/electromodulation techniques. Furthermore, we discuss potential opportunities and challenges in translating PDRN-based approaches into clinical practice. We expect future interdisciplinary research and clinical trials to evaluate the long-term efficacy and safety of PDRN while emphasizing standardization and quality control to ensure its consistency and effectiveness in regenerative applications.","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"29 ","pages":"0183"},"PeriodicalIF":8.1,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11994882/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engineered Endometrial Clear Cell Cancer-on-a-Chip Reveals Early Invasion-Metastasis Cascade of Cancer Cells. 工程子宫内膜透明细胞癌芯片揭示了癌细胞的早期侵袭-转移级联。

IF 8.1

Biomaterials research Pub Date : 2025-04-14 eCollection Date: 2025-01-01 DOI: 10.34133/bmr.0177

Chengpan Li, Jing Pan, Zhengdi Shi, Xinyan Zeng, Xiaoping Xia, Xiaogang He, Wei Wang, Bensheng Qiu, Weiping Ding, Dabing Huang

{"title":"Engineered Endometrial Clear Cell Cancer-on-a-Chip Reveals Early Invasion-Metastasis Cascade of Cancer Cells.","authors":"Chengpan Li, Jing Pan, Zhengdi Shi, Xinyan Zeng, Xiaoping Xia, Xiaogang He, Wei Wang, Bensheng Qiu, Weiping Ding, Dabing Huang","doi":"10.34133/bmr.0177","DOIUrl":"https://doi.org/10.34133/bmr.0177","url":null,"abstract":"Endometrial clear cell cancer (ECCC) is an extremely rare and highly malignant subtype of endometrial cancer. For most ECCC patients, cancer metastasis is the major cause of death. To date, due to the complexity of cancer evolution and the small number of cases, the metastasis of ECCC at the early stage remains largely unknown. Herein, we modeled the early invasion-metastasis cascade of ECCC by coculturing the ECCC patient-derived tumor cells (PDTCs) and primary human vascular endothelial cells on a microfluidic chip. With the chip, we for the first time replicated the dynamic migration of PDTCs into the surrounding stroma, including the intravasation and extravasation of PDTCs through the capillaries/microvessels, and presented the changes in the morphology and permeability of capillaries, with the decreased diameter and the increased permeability after cancer metastasis. We found that PDTCs were more invasive than the common endometrial adenocarcinoma cells. In addition, we preliminarily explored the inhibition of drugs on the early PDTC infiltration. This study provides new ideas for better understanding of ECCC evolution.","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"29 ","pages":"0177"},"PeriodicalIF":8.1,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11994883/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanomaterial-Based Autophagy Modulation: Multiple Weapons to Inflame Immune Systems and the Tumor Microenvironment. 基于纳米材料的自噬调节：多种武器炎症免疫系统和肿瘤微环境。

IF 8.1

Biomaterials research Pub Date : 2025-04-14 eCollection Date: 2025-01-01 DOI: 10.34133/bmr.0111

Min Jiang, Xinyi Zhang, Zhilei Cui, Meng Li, Huifen Qiang, Keqin Ji, Meigui Li, Xinyang Xuan Yuan, Beibei Wen, Qian Xue, Jie Gao, Zhengmao Lu, Yan Wu

{"title":"Nanomaterial-Based Autophagy Modulation: Multiple Weapons to Inflame Immune Systems and the Tumor Microenvironment.","authors":"Min Jiang, Xinyi Zhang, Zhilei Cui, Meng Li, Huifen Qiang, Keqin Ji, Meigui Li, Xinyang Xuan Yuan, Beibei Wen, Qian Xue, Jie Gao, Zhengmao Lu, Yan Wu","doi":"10.34133/bmr.0111","DOIUrl":"https://doi.org/10.34133/bmr.0111","url":null,"abstract":"Autophagy, a fundamental cellular process, is a sensitive indicator of environmental shifts and is crucial for the clearance of cellular debris, the remodeling of cellular architecture, and the facilitation of cell growth and development. The interplay between stromal, tumor, and immune cells within the tumor microenvironment is intricately linked to autophagy. Therefore, the modulation of autophagy in these cell types is essential for developing effective cancer treatment strategies. This review describes the design and optimization of nanomaterials that modulate autophagy in tumor-associated and immune cells. This review elucidates the primary mechanisms by which nanomaterials induce autophagy and discusses their application in cancer therapy, underscoring the potential of these materials to eradicate cancer cells, bolster the immune response, and elicit robust, enduring antitumor immunity, thereby advancing the frontiers of oncological treatment.","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"29 ","pages":"0111"},"PeriodicalIF":8.1,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11994884/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Application of Stem Cells and Exosomes in Promoting Nerve Conduits for Peripheral Nerve Repair. 干细胞和外泌体在促进神经导管修复周围神经中的应用。

IF 8.1

Biomaterials research Pub Date : 2025-04-14 eCollection Date: 2025-01-01 DOI: 10.34133/bmr.0160

Mengen Li, Ye Tang, Chengkai Zhou, Yan Geng, Chenxi Zhang, Yuwei Hsu, Le Ma, Wei Guo, Ming Li, Yanhua Wang

引用次数: 0

Myofibroblast-Targeting Extracellular Vesicles: A Promising Platform for Cardiac Fibrosis Drug Delivery. 肌成纤维细胞靶向细胞外囊泡：一个有前途的心脏纤维化药物递送平台。

IF 8.1

Biomaterials research Pub Date : 2025-04-11 eCollection Date: 2025-01-01 DOI: 10.34133/bmr.0179

Yi Wang, Hao Jiang, Qing Chen, Fei Guo, Bei Zhang, Lin Hu, Xuege Huang, Wenwen Shen, Jiapeng Gao, Wenwen Chen, Wei Xu, Zhijian Cai, Lin Wei, Min Li

{"title":"Myofibroblast-Targeting Extracellular Vesicles: A Promising Platform for Cardiac Fibrosis Drug Delivery.","authors":"Yi Wang, Hao Jiang, Qing Chen, Fei Guo, Bei Zhang, Lin Hu, Xuege Huang, Wenwen Shen, Jiapeng Gao, Wenwen Chen, Wei Xu, Zhijian Cai, Lin Wei, Min Li","doi":"10.34133/bmr.0179","DOIUrl":"https://doi.org/10.34133/bmr.0179","url":null,"abstract":"Current pharmacological treatments for cardiac fibrosis are often limited by their efficacy and specificity, leading to marked side effects. Fibroblast activation protein (FAP) is specifically expressed on activated myofibroblasts (myoFbs) but not on resting cardiac fibroblasts, making it a promising target for cardiac fibrosis therapy. In this study, we engineered extracellular vesicles (EVs) conjugated with an anti-FAP single-chain variable fragment, termed αFAP-EVs, which specifically target myoFbs. Our results demonstrated that αFAP-EVs successfully targeted activated myoFbs in vitro and localized to fibrotic regions in isoproterenol-induced mouse hearts in vivo. To further enhance delivery efficiency, αFAP-EVs were combined with clodronate-loaded liposomes (αFAP-EL@CLD) to reduce liver accumulation and improve cardiac fibrotic site targeting. αFAP-EL@CLD loaded with cholesterol-methylated- and phosphorothioate-modified miR-29b (Agomir-29b) or the transforming growth factor beta 1 receptor inhibitor GW788388 significantly inhibited myoFb activation and reduced fibrosis in isoproterenol-induced mouse models. Importantly, these drug-loaded αFAP-EL@CLD vesicles exhibited high therapeutic efficacy with minimal systemic toxicity, attributed to their stability and targeted delivery capabilities. These findings suggest that αFAP-EL@CLD vesicles are promising candidates for cardiac fibrosis therapy, offering a foundation for future clinical applications.","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"29 ","pages":"0179"},"PeriodicalIF":8.1,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11986206/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Novel Strategy to Enhance the Bone Healing Efficacy of Composite Scaffolds via Induction of Cell Recruitment and Vascularization. 一种通过诱导细胞募集和血管形成来增强复合支架骨愈合效果的新策略。

IF 8.1

Biomaterials research Pub Date : 2025-04-10 eCollection Date: 2025-01-01 DOI: 10.34133/bmr.0185

Jeong In Kim, Thi Thu Trang Kieu, Jeong-Chae Lee

{"title":"A Novel Strategy to Enhance the Bone Healing Efficacy of Composite Scaffolds via Induction of Cell Recruitment and Vascularization.","authors":"Jeong In Kim, Thi Thu Trang Kieu, Jeong-Chae Lee","doi":"10.34133/bmr.0185","DOIUrl":"https://doi.org/10.34133/bmr.0185","url":null,"abstract":"This study devised a novel strategy to develop a functionally improved scaffold that enhances the healing of large bone defects via synergistic activation of vascularization and cell recruitment. To this end, we fabricated round and ring-shaped silk fibroin/Broussonetia kazinoki (SFBK) composite scaffolds. The round scaffolds had a diameter of 1.5 mm, and the ring-shaped scaffolds had a 6-mm diameter with a 1.5-mm hole in the center. All scaffolds had a 3-mm thickness. A portion of round SFBKs was cross-linked with stromal cell-derived factor 1 (SDF-1), and ring-shaped scaffolds underwent in vitro angiogenic stimulation, in vivo vascularization, or both. These scaffolds were assembled by fitting a round SFBK into the center of a vascularized SFBK scaffold before implantation into a rat model with critical-sized calvarial defects. Implantation with puzzle-fitted scaffolds promoted bone regeneration, and the scaffold that underwent both SDF-1 immobilization and vascularization processes showed the greatest efficacy in the healing of defects. The bone healing efficacy of puzzle-fitted scaffolds involved their ability to stimulate microvascular network formation, collagen synthesis, and stem cell recruitment at defects. B. kazinoki-released calcium ions also participated in synergistic bone regeneration. These results suggest that the strategy of fitting SDF-1-linked SFBK into a vascularized ring-SFBK scaffold is useful in recruiting multipotent stem cells via newly formed blood vessels toward the center of scaffolds. This induces balanced and uniform bone regeneration. Overall, this study highlights the needs of calcium release, neovascularization, and stem cell recruitment for synergistic enhancement of bone regeneration.","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"29 ","pages":"0185"},"PeriodicalIF":8.1,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11982616/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144055033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Zinc Silicate-Loaded Microneedle Patch Reduces Reactive Oxygen Species Production and Enhances Collagen Synthesis for Ultraviolet B-Induced Skin Repair. 硅酸锌微针贴片减少活性氧的产生，促进胶原蛋白的合成，用于紫外线b诱导的皮肤修复。

IF 8.1

Biomaterials research Pub Date : 2025-04-10 eCollection Date: 2025-01-01 DOI: 10.34133/bmr.0180

Fang-Zhou Chen, Zhao-Wen-Bin Zhang, Qing-Feng Li, Poh-Ching Tan, Jiang Chang, Shuang-Bai Zhou

{"title":"Zinc Silicate-Loaded Microneedle Patch Reduces Reactive Oxygen Species Production and Enhances Collagen Synthesis for Ultraviolet B-Induced Skin Repair.","authors":"Fang-Zhou Chen, Zhao-Wen-Bin Zhang, Qing-Feng Li, Poh-Ching Tan, Jiang Chang, Shuang-Bai Zhou","doi":"10.34133/bmr.0180","DOIUrl":"https://doi.org/10.34133/bmr.0180","url":null,"abstract":"UVR-related skin damage is common in daily life. Excessive sunlight exposure, particularly in response to ultraviolet B (UVB) radiation, can have adverse effects on the skin and can even induce photosensitive skin diseases and skin malignancies. UVB exposure leads to the production of reactive oxygen species (ROS) in the skin, resulting in cell damage and inflammation. Furthermore, it directly inhibits the synthesis of collagen in skin fibroblasts, contributing to collagen degradation and subsequently causing skin aging, wrinkles, and erythema. To address this issue, our study introduces a biomaterial-based treatment plan for repairing UVB-induced photodamaged skin. We designed a sodium hyaluronate microneedle patch containing a hardystonite bioceramic (ZnCS/MN) with anti-ROS/inflammation/collagen degradation functions to deliver bioactive Zn2+ and SiO3 2- ions in situ to photodamaged skin areas. In addition, the cytological mechanism of ZnCS action was explored to explore the possibilities of its application in more areas. This study reveals the therapeutic potential of ZnCS for a variety of negative effects caused by photodamage. Owing to its advantages in preparation, storage, and transportation, ZnCS/MN has shown promise for clinical application in treating photodamaging.","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"29 ","pages":"0180"},"PeriodicalIF":8.1,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11982614/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144010077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perfluorocarbon Nanoparticles Loaded with Oxygen Alleviate Acute Kidney Injury via Ameliorating Renal Oxygenation Level. 载氧的全氟碳纳米颗粒通过改善肾氧合水平减轻急性肾损伤。

IF 8.1

Biomaterials research Pub Date : 2025-04-10 eCollection Date: 2025-01-01 DOI: 10.34133/bmr.0181

Dasheng Li, Yisong Ju, Qingsong Ye, Yuanyuan Chang, Chaoli An, Beibei Liu, Li Lu, Jinhui Wu, Xiaozhi Zhao

{"title":"Perfluorocarbon Nanoparticles Loaded with Oxygen Alleviate Acute Kidney Injury via Ameliorating Renal Oxygenation Level.","authors":"Dasheng Li, Yisong Ju, Qingsong Ye, Yuanyuan Chang, Chaoli An, Beibei Liu, Li Lu, Jinhui Wu, Xiaozhi Zhao","doi":"10.34133/bmr.0181","DOIUrl":"https://doi.org/10.34133/bmr.0181","url":null,"abstract":"Renal microcirculatory disturbances and tissue hypoxia play a pivotal role in acute kidney injury (AKI) initiation and progression, and addressing renal hypoxia during the acute phase presents a promising therapeutic strategy for preventing AKI or protecting kidney function. In this study, we explored the renal protective potential of perfluorocarbon nanoparticles (PFPs), engineered for superior oxygen-carrying and delivery capacities, in an AKI mouse. Specifically, PFP-treated mice exhibited significant reductions in tubular dilation, necrosis, and brush border loss in renal tubules. Additionally, PFP pretreatment reduced tissue inflammation and fibrosis, as indicated by decreased nuclear factor-kappa B, α-smooth muscle actin, fibronectin, and collagen I expression. Serum creatinine and blood urea nitrogen levels improved, decreasing by 26.9% and 41.7%, respectively. Flow cytometry further showed controlled levels of f4/80+ macrophages and CD45+ inflammatory markers, with f4/80+ macrophages reduced by approximately 31.2% and CD45+ inflammatory factors reduced by 40.5%. Metabolomic analyses highlighted PFP's modulation of key metabolic pathways linked to renal recovery, notably up-regulating slc22a19 by 48.3%, a gene encoding a short-chain fatty acid transporter, and down-regulating hyaluronic acid synthesis in renal tissue. These findings are the first to demonstrate that PFPs, as an oxygen carrier, can enhance renal resilience against IR (ischemia-reperfusion)-induced AKI, offering compelling evidence of PFP's clinical potential in AKI management.","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"29 ","pages":"0181"},"PeriodicalIF":8.1,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11982615/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144031923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Near-Infrared Light-Controlled Dynamic Hydrogel for Modulating Mechanosensitive Ion Channels in 3-Dimensional Environment. 近红外光控制动态水凝胶在三维环境中调节机械敏感离子通道。

IF 8.1

Biomaterials research Pub Date : 2025-04-09 eCollection Date: 2025-01-01 DOI: 10.34133/bmr.0182

Xiaoning Liu, Zimeng Zhang, Zhanshuo Cao, Hongbo Yuan, Chengfen Xing

{"title":"Near-Infrared Light-Controlled Dynamic Hydrogel for Modulating Mechanosensitive Ion Channels in 3-Dimensional Environment.","authors":"Xiaoning Liu, Zimeng Zhang, Zhanshuo Cao, Hongbo Yuan, Chengfen Xing","doi":"10.34133/bmr.0182","DOIUrl":"https://doi.org/10.34133/bmr.0182","url":null,"abstract":"The extracellular matrix (ECM) creates a dynamic mechanical environment for cellular functions, continuously influencing cellular activities via the mechanotransduction pathway. Mechanosensitive ion channels, recently identified as key mechanotransducers, convert mechanical stimuli into electrical or chemical signals when they detect membrane deformation. This process facilitates extracellular Ca2+ influx, cytoskeletal reorganization, and transcriptional regulation, all of which are essential for cellular physiological functions. In this study, we developed a fibrous hydrogel composite (PIC/OEG-NPs) with near-infrared (NIR) light-controlled dynamic mechanical properties to modulate mechanosensitive ion channels in cells, by using oligo-ethylene glycol (OEG)-assembled polyisocyanide (PIC) polymer and OEG-grafted conjugated polymer nanoparticles (OEG-NPs). PIC and OEG-NPs assemble into PIC/OEG-NPs composites through OEG-mediated hydrophobic interactions when heated. Under NIR stimulation, the PIC/OEG-NPs composites exhibit increased mechanical tension and form tighter fibrous networks due to their thermoresponsive behavior. These changes are reversible and allow for the dynamic regulation of mechanosensitive ion channels, including Piezo1 in transfected HEK-293T cells and the endogenous TRPV4 in human umbilical vein endothelial cells (HUVECs), by switching NIR on and off. Furthermore, this process enhances the angiogenic potential of HUVECs. In summary, we present a simple and effective platform for in situ modulation of mechanosensitive ion channels in 3 dimensions.","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"29 ","pages":"0182"},"PeriodicalIF":8.1,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11979339/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144000093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanotension Relief Agent Enhances Tissue Penetration by Reducing Solid Stress in Pancreatic Ductal Adenocarcinoma via Rho/ROCK Pathway Inhibition. 纳米张力缓解剂通过抑制Rho/ROCK通路减少固体应力，增强胰腺导管腺癌组织穿透性。

IF 8.1

Biomaterials research Pub Date : 2025-04-09 eCollection Date: 2025-01-01 DOI: 10.34133/bmr.0173

Feiran Yu, Gaorui Zhang, Jintang Sun, Yuxuan Zhao, Yafei Qi, Xiaoyu Han, Chen Ai, Weikai Sun, Jiazhi Duan, Dexin Yu

{"title":"Nanotension Relief Agent Enhances Tissue Penetration by Reducing Solid Stress in Pancreatic Ductal Adenocarcinoma via Rho/ROCK Pathway Inhibition.","authors":"Feiran Yu, Gaorui Zhang, Jintang Sun, Yuxuan Zhao, Yafei Qi, Xiaoyu Han, Chen Ai, Weikai Sun, Jiazhi Duan, Dexin Yu","doi":"10.34133/bmr.0173","DOIUrl":"https://doi.org/10.34133/bmr.0173","url":null,"abstract":"The formidable contractile tension exerted by cancer-associated fibroblasts (CAFs) in pancreatic ductal adenocarcinoma (PDAC) tissue is crucial for maintaining high tissue solid stress (TSS), which impedes the delivery and penetration of chemotherapeutic drugs. To address this obstacle, we constructed a pH-responsive nanotension relief agent (FS@MMS), in which fasudil (FS) was ingeniously conjugated to mesoporous silica encapsulated with magnetic iron oxide (MMS). The nanotension relief agent was demonstrated to inhibit the synthesis of phosphorylated myosin light chain by blocking the Rho/Rho-associated serine/threonine kinase (ROCK) pathway, triggering the swift transformation of high-tension CAFs into low-tension CAFs in PDAC tissue, which relieves TSS and enhances drug penetration in Panc02/NIH-3T3 multicellular tumor spheroids. When the nanotension relief agent was further loaded with the chemotherapeutic drug gemcitabine (GEM), as FS@MMS-GEM, the enhanced permeation of GEM progressively killed tumor cells and amplified their TSS-relief properties, thereby maximizing the anticancer efficacy of chemotherapeutic agents in Panc02/NIH-3T3 coplanted model mice. The magnetic resonance imaging results revealed that the synergistic effect substantially improved drug delivery and penetration efficiency. The developed approach holds great potential for improving chemotherapy efficacy in PDAC and provides a novel therapeutic approach for the treatment of related stroma-rich tumors.","PeriodicalId":93902,"journal":{"name":"Biomaterials research","volume":"29 ","pages":"0173"},"PeriodicalIF":8.1,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11979343/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144055189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0