Nucleic Acid-Functionalized Gold Nanorods Modulate Inflammation and Dysregulated Intestinal Barriers for Treatment of Ulcerative Colitis.

IF 8.1 Q1 ENGINEERING, BIOMEDICAL

Biomaterials research Pub Date : 2025-04-18 eCollection Date: 2025-01-01 DOI:10.34133/bmr.0195

Wanghong He, Yanxue Wang, Yifan Zhao, Bingqing Wu, Yilong Chen, Lu Jia, Xinfeng Tan, Yi Liu

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Abstract

Traditional oral treatments for ulcerative colitis (UC) face marked limitations including their single therapeutic effect, potential off-target interactions, and toxic side effects. In this study, we present nucleic acid-functionalized gold nanorods (NAF AuNRs), a biocompatible nanomaterial designed for the oral treatment of dextran sulfate sodium (DSS)-induced colitis. The NAF AuNRs alleviate immune responses by inhibiting pro-inflammatory macrophages and enhancing the expression of barrier proteins in intestinal epithelial cells. Due to the negatively charged nucleic acid shell, NAF AuNRs preferentially target anionic, inflamed colon tissues upon oral administration, reducing pro-inflammatory cytokine levels and promoting the recovery of intestinal barrier in DSS-induced colitis mice. Collectively, these findings suggest that NAF AuNRs represent an innovative and promising therapeutic approach for UC management, offering novel insights into the application of nucleic acid-functionalized nanomaterials.

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核酸功能化金纳米棒调节炎症和失调肠道屏障治疗溃疡性结肠炎。

溃疡性结肠炎（UC）的传统口服治疗存在明显的局限性，包括单一的治疗效果、潜在的脱靶相互作用和毒副作用。在这项研究中，我们提出了核酸功能化金纳米棒（NAF AuNRs），一种生物相容性纳米材料，设计用于口服治疗葡聚糖硫酸钠（DSS）诱导的结肠炎。NAF - aunr通过抑制促炎巨噬细胞和增强肠上皮细胞中屏障蛋白的表达来减轻免疫反应。NAF - AuNRs由于其核酸壳带负电荷，口服后优先靶向阴离子、炎症性结肠组织，降低促炎细胞因子水平，促进dss诱导结肠炎小鼠肠道屏障的恢复。总的来说，这些发现表明NAF aunr代表了UC管理的一种创新和有前途的治疗方法，为核酸功能化纳米材料的应用提供了新的见解。

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Biomaterials research

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