Biological psychiatry. Cognitive neuroscience and neuroimaging最新文献

{"title":"Metabolic Status Modulates Global and Local Brain Age Estimates in Overweight and Obese Adults.","authors":"Shalaila S Haas, Fahim Abbasi, Kathleen Watson, Thalia Robakis, Alison Myoraku, Sophia Frangou, Natalie Rasgon","doi":"10.1016/j.bpsc.2024.11.017","DOIUrl":"https://doi.org/10.1016/j.bpsc.2024.11.017","url":null,"abstract":"<p><strong>Background: </strong>As people live longer, maintaining brain health becomes essential for extending healthspan and preserving independence. Brain degeneration and cognitive decline are major contributors to disability. This study investigates how metabolic health influences brain-age-gap-estimate (brainAGE), which measures the difference between neuroimaging-predicted brain age and chronological age.</p><p><strong>Methods: </strong>K-means clustering was applied to fasting metabolic markers including insulin, glucose, leptin, cortisol, triglycerides, high-density lipoprotein cholesterol and low-density lipoprotein cholesterol, steady-state-plasma glucose and of body mass index of 114 physically and cognitively healthy adults. The Homeostatic Model Assessment for Insulin Resistance served as a reference. T1-weighted brain MRIs were used to calculate voxel-level and global (G-brainAGE). Longitudinal data were available for 53 participants over a 3-year interval.</p><p><strong>Results: </strong>K-mean clustering divided the sample into two groups: those with favorable (N=56) and suboptimal metabolic health (N=58). The suboptimal group showed signs of insulin resistance and dyslipidemia (P_FDR<0.05) and had older G-brainAGE and L-brainAGE, with deviations most prominent in cerebellar, ventromedial prefrontal, and medial temporal regions (P_FWE<0.05). Longitudinal analysis revealed group differences but no significant time or interaction effects on brainAGE measures.</p><p><strong>Conclusions: </strong>Suboptimal metabolic status is linked to accelerated brain aging, particularly in brain regions rich in insulin receptors. These findings highlight the importance of metabolic health in maintaining brain function and suggest that promoting metabolic well-being may help extend healthspan.</p>","PeriodicalId":93900,"journal":{"name":"Biological psychiatry. Cognitive neuroscience and neuroimaging","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An in vivo examination of the relationship between metabotropic glutamate receptor 5 and suicide attempts in people with borderline personality disorder.","authors":"Margaret T Davis, Ruth H Asch, Emily R Weiss, Ashley Wagner, Sarah K Fineberg, Nabeel Nabulsi, David Matuskey, Richard E Carson, Irina Esterlis","doi":"10.1016/j.bpsc.2024.11.014","DOIUrl":"https://doi.org/10.1016/j.bpsc.2024.11.014","url":null,"abstract":"<p><strong>Background: </strong>Borderline Personality Disorder (BPD) is a serious psychiatric condition, associated with a high risk for suicide attempts and death by suicide. However, relatively little is known about the pathophysiology of BPD. The metabotropic glutamate receptor type 5 (mGlu5) has been specifically implicated in the pathophysiology of BPD and suicide attempts, with more general roles in emotion regulation, social and cognitive functioning, and pain processing. Here, we examined the relationship between mGlu5 availability, BPD, and suicide attempts in vivo for the first time.</p><p><strong>Methods: </strong>Eighteen individuals with BPD, and 18 age-, sex-, and smoking-status matched healthy (HC) and 18 clinical comparison controls with major depressive disorder (MDD) completed comprehensive clinical assessments and participated in an [¹⁸F]FPEB positron emission tomography (PET) scan to measure mGlu5 availability. Volume of distribution (V_T) in the frontolimbic circuit implicated in BPD pathophysiology was the PET outcome measure.</p><p><strong>Results: </strong>We observed significantly higher frontolimbic mGlu5 availability in BPD compared to both HC (p=.009, d=0.84, 18.43% difference), and MDD (p=.03, d=0.69, 15.21% difference). In the BPD, but not MDD group, higher mGlu5 availability was also associated with history of suicide attempts (SA; 19-25% higher, p's=.005-.02). Further, mGlu5 availability was positively correlated with risk factors for suicide (e.g., sexual victimization, perceived burdensomeness) in BPD-SA group.</p><p><strong>Conclusions: </strong>Results show higher mGlu5 availability in BPD and suicide attempt for the first time. Our preliminary findings suggest mGlu5 may be a critical treatment target for BPD symptoms, including suicide attempts, and warrant further investigation in larger samples.</p>","PeriodicalId":93900,"journal":{"name":"Biological psychiatry. Cognitive neuroscience and neuroimaging","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142756045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Variable Presence of an Evolutionarily New Brain Structure is Related to Trait Impulsivity.","authors":"Ethan H Willbrand, Samira A Maboudian, Matthew V Elliott, Gabby M Kellerman, Sheri L Johnson, Kevin S Weiner","doi":"10.1016/j.bpsc.2024.11.015","DOIUrl":"10.1016/j.bpsc.2024.11.015","url":null,"abstract":"<p><strong>Background: </strong>Impulsivity is a multidimensional construct reflecting poor constraint over one's behaviors. Clinical psychology research identifies separable impulsivity dimensions that are each unique transdiagnostic indicators for psychopathology. Yet, despite this apparent clinical importance, the shared and unique neuroanatomical correlates of these factors remain largely unknown. Concomitantly, neuroimaging research identifies variably present human brain structures implicated in cognition and disorder: the folds (sulci) of the cerebral cortex located in the latest developing and most evolutionarily expanded hominoid-specific association cortices.</p><p><strong>Methods: </strong>We tethered these two fields to test whether variability in one such structure in anterior cingulate cortex (ACC)-the paracingulate sulcus (PCGS)-was related to individual differences in trait impulsivity. 120 adult participants with internalizing or externalizing psychopathology completed a magnetic resonance imaging scan and the Three-Factor Impulsivity Index. Using precision imaging techniques, we manually identified the PCGS, when present, and acquired quantitative folding metrics (PCGS length and ACC local gyrification index).</p><p><strong>Results: </strong>Neuroanatomical-behavioral analyses revealed that participants with leftward or symmetrical PCGS patterns had greater severity of Lack of Follow Through (LFT)-which captures inattention and lack of perseverance-than those with rightward asymmetry. Neuroanatomical-functional analyses identified that the PCGS co-localized with a focal locus found in a neuroimaging meta-analysis on a feature underlying LFT. Both quantitative folding metrics did not relate to any impulsivity dimension.</p><p><strong>Conclusions: </strong>This study advances understanding of the neuroanatomical correlates of impulsivity and establishes the notion that the topographical organization of distinct, hominoid-specific cortical expanses underlie separable impulsivity dimensions with robust, transdiagnostic implications for psychopathology.</p>","PeriodicalId":93900,"journal":{"name":"Biological psychiatry. Cognitive neuroscience and neuroimaging","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142756046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Claustrum volumes are lower in schizophrenia and mediate patients' attentional deficits.","authors":"David Schinz, Antonia Neubauer, Rebecca Hippen, Julia Schulz, Hongwei Bran Li, Melissa Thalhammer, Benita Schmitz-Koep, Aurore Menegaux, Jil Wendt, Sevilay Ayyildiz, Felix Brandl, Josef Priller, Michael Uder, Claus Zimmer, M Dennis Hedderich, Christian Sorg","doi":"10.1016/j.bpsc.2024.11.013","DOIUrl":"https://doi.org/10.1016/j.bpsc.2024.11.013","url":null,"abstract":"<p><strong>Background: </strong>While the last decade of extensive research revealed the prominent role of the claustrum for mammalian forebrain organization, i.e., widely distributed claustral-cortical circuits coordinate basic cognitive functions such as attention, it is poorly understood whether the claustrum is relevant for schizophrenia and related cognitive symptoms. We hypothesized firstly, that claustrum volumes are lower in schizophrenia and secondarily, that potentially lower volumes mediate patients' attention deficits.</p><p><strong>Methods: </strong>Based on T1-weighted MRI, advanced automated claustrum segmentation, and attention symbol coding task (SCT) in 90 patients with schizophrenia and 96 healthy controls from two independent sites, the COBRE open-source database and MUNICH dataset, we compared total-intracranial-volume-normalized claustrum volumes and SCT scores across groups via ANCOVA and related variables via correlation and mediation analysis.</p><p><strong>Results: </strong>Patients had lower claustrum volumes of about 13 % (p<0.001, Hedges g=0.63), which not only correlated with (r=0.24, p=0.014) but also mediated lower SCT scores (indirect effect ab = -1.30 ± 0.69; CI [-3.73; -1.04]). Results were not confounded by age, sex, global and claustrum-adjacent gray matter changes, scanner site, smoking, and medication.</p><p><strong>Conclusions: </strong>Results demonstrate lower claustrum volumes that mediate patients' attention deficits in schizophrenia. Data indicate the claustrum as being relevant for schizophrenia pathophysiology and cognitive functioning.</p>","PeriodicalId":93900,"journal":{"name":"Biological psychiatry. Cognitive neuroscience and neuroimaging","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142752459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cortical hypoactivation of frontal areas modulate resting EEG microstates in children with ADHD.","authors":"Chaithanya Leon, Simran Kaur, Rajesh Sagar, Prashant Tayade, Ratna Sharma","doi":"10.1016/j.bpsc.2024.11.012","DOIUrl":"https://doi.org/10.1016/j.bpsc.2024.11.012","url":null,"abstract":"<p><strong>Background: </strong>The present study examined EEG microstate alterations and their neural generators during resting state in children with ADHD to explore a potential state biomarker.</p><p><strong>Methods: </strong>A total of seventy-six participants, thirty-eight each, combined type ADHD, and neurotypical children (NC) participated in the study. Five-minute resting (eyes open) 128 channel eeg data were acquired and two-minute clean EEG data were analyzed for microstates, its sources and connectivity in both the groups. Between groups comparisons were done for microstate parameters using modified k means clustering in Cartool software. Further, the cortical sources and functional connectivity of significant microstate maps were explored using LORETA software. Subsequently microstate parameters were correlated with the behavioral scores from Conner's parent rating scale.</p><p><strong>Results: </strong>Among the microstate parameters examined, children with ADHD displayed significant difference (p<0.05) in time frames and time coverage of map B (decreased) and transition probability of map D (increased) respectively. Interestingly, source analysis of both microstate maps showed hypoactivation of frontal areas predominantly while functional connectivity showed hyperconnectivity between medial frontal gyrus and anterior cingulate gyrus (executive function area) for map B and hypoconnectivity between medial frontal gyrus and middle temporal gyrus (both are suggested to be part of DMN areas) for map D. Further CSD values of map B was found to be correlated with executive function scores of conners questionnaire.</p><p><strong>Conclusion: </strong>EEG microstate features, alongside source and connectivity measures, could discern children with ADHD from neurotypical controls. The hypoactivation of predominantly frontal areas and its connectivity was found to determine microstate maps.</p>","PeriodicalId":93900,"journal":{"name":"Biological psychiatry. Cognitive neuroscience and neuroimaging","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142752500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modulation of cerebellar-cortical connectivity induced by modafinil and its relationship with receptor and transporter expression.","authors":"Stefano Delli Pizzi, Federica Tomaiuolo, Antonio Ferretti, Giovanna Bubbico, Valeria Onofrj, Stefania Della Penna, Carlo Sestieri, Stefano L Sensi","doi":"10.1016/j.bpsc.2024.11.010","DOIUrl":"https://doi.org/10.1016/j.bpsc.2024.11.010","url":null,"abstract":"<p><strong>Background: </strong>Modafinil is primarily employed to treat narcolepsy but also as an off-label cognitive enhancer. Functional Magnetic Resonance Imaging (fMRI) studies indicate that modafinil modulates the connectivity of neocortical networks primarily involved in attention and executive functions. However, much less is known about the drug's effects on subcortical structures. Following preliminary findings, we evaluated modafinil's activity on the connectivity of distinct cerebellar regions with the neocortex. We assessed the spatial relationship of these effects with the expression of neurotransmitter receptors/transporters.</p><p><strong>Methods: </strong>Patterns of resting-state fMRI (rs-fMRI) connectivity were estimated in 50 participants from scans acquired pre- and post-administration of a single (100 mg) dose of modafinil (n=25) or placebo (n=25). Using specific cerebellar regions as seeds for voxel-wise analyses, we examined modafinil's modulation on cerebellar-neocortical connectivity. Next, we conducted a quantitative evaluation of the spatial overlap between the modulation of cerebellar-neocortical connectivity and the expression of neurotransmitter receptors/transporters obtained by publicly available databases.</p><p><strong>Results: </strong>Modafinil increased the connectivity of Crus I and Vermis IX with prefrontal regions. Crus I connectivity changes were associated with the expression of dopaminergic D₂ receptors. The Vermis I-II showed enhanced coupling with the dorsal anterior cingulate cortex and matched the expression of histaminergic H₃ receptors. The Vermis VII-VIII displayed increased connectivity with the visual cortex, an activity associated with dopaminergic and histaminergic neurotransmission.</p><p><strong>Conclusion: </strong>Our study reveals modafinil's modulatory effects on cerebellar-neocortical connectivity. The modulation mainly involves Crus I and the Vermis and spatially overlaps the distribution of dopaminergic and histaminergic receptors and serotonin transporters.</p>","PeriodicalId":93900,"journal":{"name":"Biological psychiatry. Cognitive neuroscience and neuroimaging","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social Buffering of PTSD: Longitudinal Effects and Neural Mediators.","authors":"Justin L C Santos, Nathaniel G Harnett, Sanne J H van Rooij, Timothy D Ely, Tanja Jovanovic, Lauren A M Lebois, Francesca L Beaudoin, Xinming An, Thomas C Neylan, Sarah D Linnstaedt, Laura T Germine, Kenneth A Bollen, Scott L Rauch, John P Haran, Alan B Storrow, Christopher Lewandowski, Paul I Musey, Phyllis L Hendry, Sophia Sheikh, Christopher W Jones, Brittany E Punches, Jose L Pascual, Mark J Seamon, Erica Harris, Claire Pearson, David A Peak, Roland C Merchant, Robert M Domeier, Niels K Rathlev, Brian J O'Neil, Paulina Sergot, Leon D Sanchez, Steven E Bruce, Diego A Pizzagalli, Steven E Harte, Kerry J Ressler, Karestan C Koenen, Samuel A McLean, Jennifer S Stevens","doi":"10.1016/j.bpsc.2024.11.011","DOIUrl":"https://doi.org/10.1016/j.bpsc.2024.11.011","url":null,"abstract":"<p><strong>Background: </strong>Post-traumatic stress disorder (PTSD) is a well characterized psychiatric disorder featuring changes in mood and arousal following traumatic events. Prior animal and human studies on social support in the peri-traumatic window demonstrate a buffering effect with regards to acute biological and psychological stress symptoms. Fewer studies have explored the magnitude and mechanism on how early, post-trauma social support can reduce longitudinal PTSD severity.</p><p><strong>Methods: </strong>In this study we investigated the beneficial impact of social support on longitudinal PTSD symptoms, and probed brain regions sensitive to this buffering phenomenon, such as the amygdala and ventromedial prefrontal cortex. In the multi-site AURORA study, n=315 participants reported PTSD symptoms (PCL-5) and perceived emotional support (PROMIS) at 2-weeks, 8-weeks, 3-months, and 6-months post-ED visit. Additionally, neuroimaging data was collected at 2 weeks post trauma.</p><p><strong>Results: </strong>We hypothesized that early, post-trauma social support would be linked with greater fractional anisotropic (FA) values in white matter tracts that have known connectivity between the amygdala and prefrontal cortex and would predict reduced neural reactivity to social threat cues in the amygdala. Interestingly, while we observed greater FA in the bilateral cingulum and bilateral uncinate fasciculus as a function of early post-trauma emotional support, we also identified greater threat reactivity in the precuneus/posterior cingulate, a component of the default mode network.</p><p><strong>Conclusion: </strong>Our findings suggest that the neurocircuitry underlying the response to social threat cues are facilitated through broader pathways that involve the posterior hub of the default mode network.</p>","PeriodicalId":93900,"journal":{"name":"Biological psychiatry. Cognitive neuroscience and neuroimaging","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Overview of Neurophenomenological Approaches to Meditation and their Relevance to Clinical Research.","authors":"Antoine Lutz, Oussama Abdoun, Yair Dor-Ziderman, Fynn-Mathis Trautwein, Aviva Berkovich-Ohana","doi":"10.1016/j.bpsc.2024.11.008","DOIUrl":"https://doi.org/10.1016/j.bpsc.2024.11.008","url":null,"abstract":"<p><p>There is a renewed interest in taking phenomenology seriously in consciousness research, contemporary psychiatry, and neurocomputation. The neurophenomenology research program, pioneered by Varela (1996), rigorously examines subjective experience using first-person methodologies, inspired by phenomenology and contemplative practices. This review explores recent advancements in neurophenomenological approaches, particularly their application to meditation practices and potential clinical research translations. We first examine innovative multi-dimensional phenomenological assessment tools designed to capture subtle, dynamic shifts in experiential contents and structures of consciousness during meditation. These experience sampling approaches allow shedding new light on the mechanisms and dynamic trajectories of meditation practice and retreat. Secondly, we highlight how empirical studies in neurophenomenology leverage the expertise of experienced meditators to deconstruct aversive and self-related processes, providing detailed first-person reports that guide researchers in identifying novel behavioral and neurodynamic markers associated with pain regulation, self-dissolution and acceptance of mortality. Finally, we discuss a recent framework, deep computational neurophenomenology, which updates the theoretical ambitions of neurophenomenology to \"naturalize phenomenology\" (Varela, 1997). This framework uses the formalism of deep parametric active inference, where parametric depth refers to a property of generative models that can form beliefs about the parameters of their own modeling process. Collectively, these methodological innovations, centered around rigorous first-person investigation, highlight the potential of epistemologically beneficial mutual constraints among phenomenological, computational, and neurophysiological domains. This could contribute to an integrated understanding of the biological basis of mental illness, its treatment and its tight connections to the lived experience of the patient.</p>","PeriodicalId":93900,"journal":{"name":"Biological psychiatry. Cognitive neuroscience and neuroimaging","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142696062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revisiting Resting-State Functional Connectivity of the Amygdala and Subgenual Anterior Cingulate Cortex in Depressed Adolescents and Adults.","authors":"Shijia Fan, Yuxi Wang, Yin Wang, Yinyin Zang","doi":"10.1016/j.bpsc.2024.11.004","DOIUrl":"https://doi.org/10.1016/j.bpsc.2024.11.004","url":null,"abstract":"<p><strong>Background: </strong>Adolescent depression is a growing public health concern, and neuroimaging offers a promising approach to its pathology. We focused on the functional connectivity of the amygdala and subgenual anterior cingulate cortex (sgACC), which is theoretically important in major depressive disorder (MDD), but empirical evidence has remained inconsistent. This discrepancy is likely due to the limited statistical power of small sample sizes.</p><p><strong>Methods: </strong>We rigorously examined sgACC-amygdala connectivity in depressed adolescents and adults using data from the Healthy Brain Network (n=321; 170 females), the Adolescent Brain Cognitive Development study (n=141; 56 females), the Boston Adolescent Neuroimaging of Depression and Anxiety study (n=108; 75 females), and the REST-meta-MDD project (n=1436; 880 females). Linear mixed models, Bayesian factor analyses, and meta-analysis were employed to assess connectivity.</p><p><strong>Results: </strong>Our analyses revealed that sgACC-amygdala connectivity in adolescents with MDD was comparable to that in healthy controls, whereas adults with recurrent MDD exhibited reduced connectivity. Resampling analysis demonstrated that small sample sizes (i.e., n<30 MDDs) tend to inflate effects, potentially leading to misinterpretations.</p><p><strong>Conclusions: </strong>These findings clarify the state of sgACC-amygdala connectivity in MDD and underscore the importance of refining neurocognitive models separately for adolescents and adults. The study also highlights the necessity for large-scale replication studies to ensure robust and reliable findings.</p>","PeriodicalId":93900,"journal":{"name":"Biological psychiatry. Cognitive neuroscience and neuroimaging","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142683867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multimodal brain age indicators of internalising problems in early adolescence: A longitudinal investigation.","authors":"Niamh MacSweeney, Dani Beck, Lucy Whitmore, Kathryn L Mills, Lars T Westlye, Tilmann von Soest, Lia Ferschmann, Christian K Tamnes","doi":"10.1016/j.bpsc.2024.11.003","DOIUrl":"https://doi.org/10.1016/j.bpsc.2024.11.003","url":null,"abstract":"<p><strong>Background: </strong>Adolescence is a time of increased risk for the onset of internalising problems, particularly in females. However, how individual differences in brain maturation relate to the increased vulnerability for internalising problems in adolescence remains poorly understood due to a scarcity of longitudinal studies.</p><p><strong>Methods: </strong>Using Adolescent Brain Cognitive Development (ABCD) Study data, we examined longitudinal associations between multimodal brain age and youth internalising problems. Brain age models were trained, validated, and tested independently on T1-weighted (T1; N=9523), diffusion tensor (DTI; N=8834), and resting-state functional (rs-fMRI; N=8233) MRI data at baseline (M_age= 9.9 years) and 2-year follow-up (M_age= 11.9 years). Self-reported internalising problems were measured at 3-year follow-up (M_age= 12.9 years) using the Brief Problem Monitor.</p><p><strong>Results: </strong>Latent change score models demonstrated that although brain age gap (BAG) at baseline was not related to later internalising problems, an increase in BAG between timepoints was positively associated with internalising problems at 3-year follow-up in females but not males. This association between an increasing BAG and higher internalising problems was observed in the T1 (β = 0.067, SE = 0.050, p_FDR = 0.020) and rs-fMRI β = 0.090, SE = 0.025, p_FDR = 0.007) models but not DTI (β=-0.002, SE=0.053, p_FDR = 0.932), and remained significant when accounting for earlier internalising problems.</p><p><strong>Conclusions: </strong>A greater increase in BAG in early adolescence may reflect the heightened vulnerability shown by female youth to internalising problems. Longitudinal research is necessary to understand if this increasing BAG signifies accelerated brain development and its relationship to the trajectory of internalising problems throughout adolescence.</p>","PeriodicalId":93900,"journal":{"name":"Biological psychiatry. Cognitive neuroscience and neuroimaging","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142683866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}