Biological psychiatry. Cognitive neuroscience and neuroimaging最新文献

{"title":"Torture Exposure Modulates Cognitive Control and Attention Neural Network Connectivity During a Go/NoGo Task.","authors":"Belinda J Liddell, Pritha Das, Gin S Malhi, Kim L Felmingham, Mirjana Askovic, Angela Nickerson, Jorge Aroche, Mariano Coello, Tim Outhred, Richard A Bryant","doi":"10.1016/j.bpsc.2024.07.025","DOIUrl":"10.1016/j.bpsc.2024.07.025","url":null,"abstract":"<p><strong>Background: </strong>Torture trauma is characterized by intentional uncontrollable acts, but the long-term effects of torture exposure on cognitive control brain mechanisms are unknown.</p><p><strong>Methods: </strong>A final sample of 33 torture survivors (TSs) and 44 non-TSs, all with a refugee background, completed a Go/NoGo response inhibition task during functional magnetic resonance imaging scanning. Data-driven independent component analysis identified active networks across the task and on Go, NoGo, and error of commission trials. Groups were compared on within-/between-network connectivity while controlling for demographic and psychological symptom covariates. Secondary analyses investigated whether network connectivity moderated the associations between torture exposure and severity on fear (e.g., re-experiencing) and dysphoria (e.g., anhedonia) posttraumatic stress disorder symptoms.</p><p><strong>Results: </strong>The TS group exhibited decreased connectivity (compared with the non-TS control group) within the posterior default mode network (specifically the left precuneus) and auditory-motor network (specifically the right superior temporal gyrus) and reduced connectivity between the dorsomedial frontal network and dorsal attention network across the Go/NoGo task. The TS group also showed more negative ventral attention network connectivity during NoGo (i.e., inhibition) trials. No behavioral effects were observed. Secondary analyses revealed that the association between torture exposure and elevated posttraumatic stress dysphoria (not fear) symptoms was moderated by reduced connectivity in the right superior temporal gyrus and between the dorsomedial frontal network and the dorsal attention network.</p><p><strong>Conclusions: </strong>Response inhibition, attention, and motor networks appear to be less connected in TSs, which may be specifically linked to a posttraumatic stress dysphoria symptom profile. The findings suggest that targeting cognitive control processes may hold promise for alleviating posttraumatic symptoms among survivors of torture.</p>","PeriodicalId":93900,"journal":{"name":"Biological psychiatry. Cognitive neuroscience and neuroimaging","volume":" ","pages":"1291-1300"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141914861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dysfunctional Alpha Modulation as a Mechanism of Working Memory Impairment in Serious Mental Illness.","authors":"Molly A Erickson, Megan A Boudewyn, Kurt Winsler, Charlotte Li, Deanna M Barch, Cameron S Carter, Michael J Frank, James M Gold, Angus W MacDonald, John D Ragland, Steven M Silverstein, Andrew Yonelinas, Steven J Luck","doi":"10.1016/j.bpsc.2024.07.022","DOIUrl":"10.1016/j.bpsc.2024.07.022","url":null,"abstract":"<p><strong>Background: </strong>People with psychosis and mood disorders experience disruptions in working memory; however, the underlying mechanism remains unknown. We focused on 2 potential mechanisms: poor attentional engagement should be associated with elevated levels of prestimulus alpha-band activity within the electroencephalogram (EEG), whereas impaired working memory encoding should be associated with reduced poststimulus alpha suppression.</p><p><strong>Methods: </strong>We collected EEG data from 68 people with schizophrenia, 43 people with bipolar disorder with a history of psychosis, 53 people with major depressive disorder, and 90 healthy comparison subjects while they completed a spatial working memory task. We quantified attention lapsing, memory precision, and memory capacity from the behavioral responses, and we quantified alpha using traditional wavelet analysis as well as a novel approach for isolating oscillatory alpha power from aperiodic elements of the EEG signal.</p><p><strong>Results: </strong>We found that 1) greater prestimulus alpha power estimated using traditional wavelet analysis predicted behavioral errors; 2) poststimulus alpha suppression was reduced in the patient groups; and 3) reduced suppression was associated with a lower likelihood of memory storage. However, we also observed that the prestimulus alpha was larger among healthy control participants than patients, and single-trial analyses showed that it was the aperiodic elements of the prestimulus EEG-not oscillatory alpha-that predicted behavioral errors.</p><p><strong>Discussion: </strong>These results suggest that working memory impairments in serious mental illness primarily reflect an impairment in the poststimulus encoding processes rather than reduced attentional engagement prior to stimulus onset.</p>","PeriodicalId":93900,"journal":{"name":"Biological psychiatry. Cognitive neuroscience and neuroimaging","volume":" ","pages":"1271-1280"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11625623/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141908660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Working Memory Training Is Good for Your World View and for Your Cortical Connectivity, Too.","authors":"Philip D Harvey","doi":"10.1016/j.bpsc.2024.10.005","DOIUrl":"https://doi.org/10.1016/j.bpsc.2024.10.005","url":null,"abstract":"","PeriodicalId":93900,"journal":{"name":"Biological psychiatry. Cognitive neuroscience and neuroimaging","volume":"9 12","pages":"1232-1233"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142793021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Change in Resting-State Functional Connectivity Following Working Memory Training in Individuals With Repetitive Negative Thinking.","authors":"Jessica Bomyea, Shirley Feng, Raeanne C Moore, Alan N Simmons, Michael L Thomas","doi":"10.1016/j.bpsc.2024.04.017","DOIUrl":"10.1016/j.bpsc.2024.04.017","url":null,"abstract":"<p><strong>Background: </strong>Repetitive negative thinking (RNT) symptoms, which are characterized by pervasive, uncontrollable negative thoughts, are common in individuals with mood, anxiety, and traumatic stress disorders. Inability to regulate the contents of working memory is a hypothesized etiological factor in RNT, which suggests that training to improve working memory may be beneficial. This study examined the effects of working memory training on resting-state functional connectivity (rsFC) in individuals with elevated RNT and whether such changes would be associated with clinical improvement.</p><p><strong>Methods: </strong>We conducted a secondary analysis of pre-post resting-state data collected as part of a randomized controlled trial (NCT04912089) of working memory training interventions (n = 42) compared with a waitlist control group (n = 23). We hypothesized that individuals who completed training would show increased rsFC between the 2 key intrinsic connectivity networks-the default mode network (posterior cingulate cortex) and the frontoparietal network (dorsolateral prefrontal cortex). We explored whether the magnitude of rsFC change was associated with change in RNT symptom severity.</p><p><strong>Results: </strong>rsFC increased between the posterior cingulate cortex and regions including the frontal and parietal cortex in the training group compared with the waitlist group. Increased connectivity between the posterior cingulate cortex and superior frontal cortex was associated with RNT symptom reduction.</p><p><strong>Conclusions: </strong>These data provide evidence that working memory training can modulate neural circuitry at rest in individuals with RNT. Results are consistent with accounts of working memory training effects on large-scale neurocircuitry changes and suggest that these changes may contribute to clinical promise of this type of intervention on transdiagnostic RNT symptoms.</p>","PeriodicalId":93900,"journal":{"name":"Biological psychiatry. Cognitive neuroscience and neuroimaging","volume":" ","pages":"1262-1270"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140861890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medial Amygdalar Tau Is Associated With Mood Symptoms in Preclinical Alzheimer's Disease.","authors":"Joyce S Li, Samantha M Tun, Bronte Ficek-Tani, Wanwan Xu, Selena Wang, Corey L Horien, Takuya Toyonaga, Shreya S Nuli, Caroline J Zeiss, Albert R Powers, Yize Zhao, Elizabeth C Mormino, Carolyn A Fredericks","doi":"10.1016/j.bpsc.2024.07.012","DOIUrl":"10.1016/j.bpsc.2024.07.012","url":null,"abstract":"<p><strong>Background: </strong>While the amygdala receives early tau deposition in Alzheimer's disease (AD) and is involved in social and emotional processing, the relationship between amygdalar tau and early neuropsychiatric symptoms in AD is unknown. We sought to determine whether focal tau binding in the amygdala and abnormal amygdalar connectivity were detectable in a preclinical AD cohort and identify relationships between these and self-reported mood symptoms.</p><p><strong>Methods: </strong>We examined 598 individuals (347 amyloid positive [58% female], 251 amyloid negative [62% female] subset in tau positron emission tomography and functional magnetic resonance imaging cohorts) from the A4 (Anti-Amyloid Treatment in Asymptomatic AD) Study. In the tau positron emission tomography cohort, we used amygdalar segmentations to examine representative nuclei from 3 functional divisions of the amygdala. We analyzed between-group differences in division-specific tau binding in the amygdala in preclinical AD. We conducted seed-based functional connectivity analyses from each division in the functional magnetic resonance imaging cohort. Finally, we conducted exploratory post hoc correlation analyses between neuroimaging biomarkers of interest and anxiety and depression scores.</p><p><strong>Results: </strong>Amyloid-positive individuals demonstrated increased tau binding in the medial and lateral amygdala, and tau binding in these regions was associated with mood symptoms. Across amygdalar divisions, amyloid-positive individuals had relatively higher regional connectivity from the amygdala to other temporal regions, the insula, and the orbitofrontal cortex, but medial amygdala to retrosplenial cortex connectivity was lower. Medial amygdala to retrosplenial connectivity was negatively associated with anxiety symptoms, as was retrosplenial tau.</p><p><strong>Conclusions: </strong>Our findings suggest that preclinical tau deposition in the amygdala and associated changes in functional connectivity may be related to early mood symptoms in AD.</p>","PeriodicalId":93900,"journal":{"name":"Biological psychiatry. Cognitive neuroscience and neuroimaging","volume":" ","pages":"1301-1311"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11625605/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141768228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imaging the Unseen: Charting Amygdalar Tau's Link to Affective Symptoms in Preclinical Alzheimer's Disease.","authors":"Yilamujiang Abuduaini, Yi Pu, Wei Chen, Xiang-Zhen Kong","doi":"10.1016/j.bpsc.2024.10.003","DOIUrl":"https://doi.org/10.1016/j.bpsc.2024.10.003","url":null,"abstract":"","PeriodicalId":93900,"journal":{"name":"Biological psychiatry. Cognitive neuroscience and neuroimaging","volume":"9 12","pages":"1236-1238"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Torture as a Trauma of Disconnection: Neuroplastic Alterations in Survivors of Torture.","authors":"Negar Fani","doi":"10.1016/j.bpsc.2024.10.006","DOIUrl":"https://doi.org/10.1016/j.bpsc.2024.10.006","url":null,"abstract":"","PeriodicalId":93900,"journal":{"name":"Biological psychiatry. Cognitive neuroscience and neuroimaging","volume":"9 12","pages":"1234-1235"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142793020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural Interoceptive Processing is Modulated by Deep Brain Stimulation to Subcallosal Cingulate Cortex for Treatment Resistant Depression.","authors":"Elisa Xu, Samantha Pitts, Jacob Dahill-Fuchel, Sara Scherrer, Tanya Nauvel, Jacqueline Guerra Overton, Patricio Riva-Posse, Andrea Crowell, Martijn Figee, Sankaraleengam Alagapan, Christopher Rozell, Ki Sueng Choi, Helen S Mayberg, Allison C Waters","doi":"10.1016/j.bpsc.2024.11.021","DOIUrl":"10.1016/j.bpsc.2024.11.021","url":null,"abstract":"<p><strong>Background: </strong>Symptoms of depression are associated with impaired interoceptive processing of bodily sensation. The antidepressant effects of subcallosal cingulate deep brain stimulation (SCC DBS) include acute change in bodily sensation, and the SCC target is connected to cortical regions critically involved in interoception. This study tests whether cortical interoceptive processing is modulated by SCC DBS for treatment resistant depression (TRD).</p><p><strong>Methods: </strong>In eight patients receiving SCC DBS for TRD, we used electroencephalography (EEG) to measure the heartbeat-evoked potential (HEP), a putative read-out of neural interoception, before surgery and over six months of treatment with DBS. We also examined the immediate effect of DBS on the HEP, and correlated HEP change over time with outcomes of treatment for depression.</p><p><strong>Results: </strong>HEP amplitude increased from baseline after six months of DBS treatment, and this increase was associated with faster antidepressant response. Recording with stimulation on (versus off) had an immediate effect on HEP in the laboratory. Overall, modulation of the HEP was most pronounced in sensors over the left parietal cortex.</p><p><strong>Conclusion: </strong>Brain-based evidence implies an interoceptive element in the mechanism of treatment efficacy with deep brain stimulation for TRD, and substantiates a theorized connection between interoception and depression.</p>","PeriodicalId":93900,"journal":{"name":"Biological psychiatry. Cognitive neuroscience and neuroimaging","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural Signatures of Cognitive Control Predict Future Adolescent Substance Use Onset and Frequency.","authors":"Ya-Yun Chen, Morgan Lindenmuth, Tae-Ho Lee, Jacob Lee, Brooks Casas, Jungmeen Kim-Spoon","doi":"10.1016/j.bpsc.2024.11.020","DOIUrl":"https://doi.org/10.1016/j.bpsc.2024.11.020","url":null,"abstract":"<p><strong>Background: </strong>Adolescent substance use is a significant predictor of future addiction and related disorders. Understanding neural mechanisms underlying substance use initiation and frequency during adolescence is critical for early prevention and intervention.</p><p><strong>Methods: </strong>The current longitudinal study followed 91 substance-naïve adolescents annually for seven years from ages 14 to 21 to identify potential neural precursors that predict substance use initiation and frequency. Cognitive control processes were examined using the Multi-Source Interference Task to assess functional neural connectivity. A questionnaire assessed substance use frequency.</p><p><strong>Results: </strong>Stronger connectivity between the dorsal anterior cingulate cortex (dACC) and dorsolateral prefrontal cortex (dlPFC) at Time 1 predicted a delayed onset of substance use, indicative of a protective effect. A notable decline in this dACC-dlPFC connectivity was observed one year prior to substance use initiation. Conversely, lower connectivity of the dACC with the supplementary motor area and heightened connectivity of the aINS with the dorsal medial prefrontal cortex and Angular gyrus were predictive of greater frequency of future substance use. These findings remained after controlling for demographic and socioeconomic covariates.</p><p><strong>Conclusions: </strong>This study highlights the critical role of cognitive control-related neural connectivity in forecasting substance use initiation and frequency during adolescence. The results imply that efforts to strengthen and monitor the development of the top-down cognitive control system in the brain from early adolescence can be protective and deter progression into problematic substance use. Furthermore, for adolescents with heightened frequency of substance use, interventions may prove more effective by targeting interoceptive processes in cognitive control training.</p>","PeriodicalId":93900,"journal":{"name":"Biological psychiatry. Cognitive neuroscience and neuroimaging","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intranasal insulin increases brain glutathione (GSH) and enhances antioxidant capacity in healthy participants, but not in those with early psychotic disorders.","authors":"Virginie-Anne Chouinard, Wirya Feizi, Xi Chen, Boyu Ren, Kathryn E Lewandowski, Jacey Anderson, Steven Prete, Emma Tusuzian, Kyle Cuklanz, Shuqin Zhou, Paula Bolton, Abigail Stein, Bruce M Cohen, Fei Du, Dost Öngür","doi":"10.1016/j.bpsc.2024.11.018","DOIUrl":"https://doi.org/10.1016/j.bpsc.2024.11.018","url":null,"abstract":"<p><strong>Background: </strong>We examined the acute effects of intranasal insulin on cognitive function and brain glutathione, a central factor in resistance to oxidative stress, in both participants with early psychosis and healthy participants.</p><p><strong>Methods: </strong>Twenty-one patients with early-stage psychotic disorders and 18 healthy controls underwent magnetic resonance spectroscopy (MRS) scans and cognitive assessments pre- and post- administration of intranasal insulin 40 IU. We conducted ¹H-magnetic resonance spectroscopy (MRS) in the prefrontal cortex at 4T to measure glutathione (GSH) and glutamate metabolites. We assessed cognition using the Brief Assessment of Cognition in Schizophrenia (BACS) symbol coding, digit sequencing, and verbal fluency tasks, in addition to Stroop Task.</p><p><strong>Results: </strong>The mean (SD) age of participants was 25.7(4.6); 51.3% were female. There were no significant group differences at baseline in age, sex, body mass index, homeostatic model assessment of insulin resistance (HOMA-IR), or cognition. Patients had higher baseline GSH (p<0.001) and glutamate (p=0.007). After insulin administration, GSH increased in controls (Mean change 0.15;95%CI 0.03, 0.26; p=0.015), but not in patients. Symbol coding improved in both patients (0.74;95%CI 0.37,1.11;p<0.001) and controls (0.83;95%CI 0.58,1.09;p<0.001) and verbal fluency improved in controls (0.43;95%CI 0.14, 0.72; p=0.006). Lower baseline HOMA-IR was associated with greater change in GSH (Coeff -0.22; 95%CI -0.40, -0.04; p=0.017).</p><p><strong>Conclusions: </strong>Intranasal insulin increases brain GSH in healthy participants, but not in early psychotic disorders. These novel findings demonstrate that intranasal insulin enhances antioxidant capacity and resilience to oxidative stress in healthy individuals, in contrast to an absent antioxidant response in those with early psychotic disorders.</p>","PeriodicalId":93900,"journal":{"name":"Biological psychiatry. Cognitive neuroscience and neuroimaging","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}