旁观者之眼的创伤:儿童创伤、精神病理学和神经生物学中的报告不一致。

IF 4.8
John McClellan France, Shaurel Amaria Valbrun, Lana Ruvolo Grasser, Charis Wiltshire, Sattvik Basarkod, William M Davie, Mariam H Reda, Sophie A George, Sterling Winters, Bekh Bradley-Davino, Anaïs F Stenson, Sanne J H van Rooij, Jennifer S Stevens, Ana M Daugherty, Tanja Jovanovic
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引用次数: 0

摘要

背景:童年创伤是青少年精神病理的危险因素,包括创伤后应激障碍(PTSD)。大多数研究依赖于照顾者(即父母或法定监护人)关于儿童创伤的报告。本研究调查了报告者、儿童和照顾者在评估儿童创伤和创伤后应激障碍的神经生物学相关性方面的影响。方法:2个独立的青年样本(原始n=76, 47%女性,M(SD)年龄=9.39(1.492);重复率:n=98, 51%女性,M(SD)年龄=9.38。(89))和他们的照顾者接受了关于他们孩子的创伤暴露和创伤后应激障碍严重程度的采访。对原始样本青年在恐惧条件反射期间的恐惧增强惊吓(FPS)和在情绪面对功能性MRI任务期间的双侧杏仁核反应进行评估。为了评估报告效应,使用多元线性回归比较了访谈措施和神经生物学相关因素之间的关联的效应大小和方向。结果:儿童自我报告的创伤暴露与儿童自我报告的创伤后应激障碍严重程度相关(原始数据:β= 0.55, p.05)。结论:这些发现提示记者的视角可能影响创伤、PTSD及其神经生物学相关性之间的关联。儿童而不是看护人的报告可能更符合儿童的感知经验,从而更好地预测潜在的神经生物学。这些发现支持在调查创伤暴露青少年创伤后应激障碍易损性的候选生物标志物时纳入儿童创伤和创伤后应激障碍的自我报告。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Trauma from the Eye of the Beholder: Reporter Discordance in Child's Trauma, Psychopathology, and Neurobiology.

Background: Childhood trauma is a risk factor for adolescent psychopathology, including posttraumatic stress disorder (PTSD). Most research has relied on caregiver (i.e. parent or legal guardian) reports of child trauma. This study investigated the impact of reporter, child versus caregiver, in assessing neurobiological correlates of trauma and PTSD in children.

Methods: Two independent samples of youth (Original n=76, 47%Female, M(SD)age=9.39(.492); Replication: n=98, 51%Female, M(SD)age=9.38(.089)) and their caregivers were interviewed regarding their child's trauma exposure and PTSD severity. Original sample youth were assessed for fear-potentiated startle (FPS) during fear conditioning, and bilateral amygdala reactivity during an emotional faces functional MRI task. To assess reporter effects, effect sizes and directions of associations between interview measures and neurobiological correlates were compared using multiple linear regression.

Results: Child's self-reported trauma exposure was associated with child's self-reported PTSD severity (Original: β=.55, p<.001; Replication: β=.37, p<.01), while caregivers' report of child's trauma exposure was not associated with child's self-reported PTSD severity (Original: β=-.01, p=.99; Replication: β=.07, p=.57). Child's self-report of PTSD severity was positively associated with FPS (Original: β=.29, p<.05) and amygdala reactivity (Original: β=.39, p<.05), while caregivers' report of child's PTSD were not (ps>.05).

Conclusions: These findings suggest the reporter's perspective may influence associations between trauma, PTSD, and their neurobiological correlates. Child rather than caregiver reports may better align with the child's perceived experience, and thereby better predict underlying neurobiology. These findings support the inclusion of child's self-reports of trauma and PTSD when investigating candidate biomarkers of PTSD vulnerability in trauma-exposed youth.

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