Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme最新文献

{"title":"Relationship of irisin and apelin levels with sarcopenia and body composition in community-dwelling older adults: a paired case-control study.","authors":"Liangchuan Zhang, Yating Peng, Yaling Qie, Jia Guo, Yuan Kong, Xue Zhang, Zetian Li, Hong Jia","doi":"10.1139/apnm-2024-0473","DOIUrl":"10.1139/apnm-2024-0473","url":null,"abstract":"<p><p>Irisin and apelin levels continue to decrease with age, and although many previous studies have explored their association with sarcopenia and body composition, there is still a paucity of evidence relating to them in community-dwelling elderly populations. The aim of this study was to provide new evidence for the association of irisin and apelin with sarcopenia in older adults. This case-control study included 80 individuals with sarcopenia and 80 individuals without sarcopenia. The definition of sarcopenia was based on the Asian Working Group for Sarcopenia 2019 criteria. Plasma levels of irisin and apelin were measured using an enzyme-linked immunosorbent assay. Conditional logistic regression analysis was performed to estimate odds ratios (ORs) and 95% CIs. The sarcopenia group exhibited significantly lower levels of irisin (73.75 ± 30.97 ng/mL vs. 131.15 ± 88.38 ng/mL, <i>p</i> < 0.001) and apelin (21.51 ± 14.89 ng/mL vs. 27.87 ± 14.41 ng/mL, <i>p</i> = 0.007) compared to the control group. Increased levels of irisin (OR, 0.98, 95% CI, 0.97-0.99) and apelin (OR, 0.97, 95% CI, 0.95-0.99) were associated with a decreased risk of sarcopenia. In women, irisin was positively associated with body mass index, intracellular water (ICW), extracellular water (ECW), total water (TW), protein, mineral, fat, fat-free mass, skeletal muscle mass (SMM), percentage body fat, waist circumference, visceral fat area, and basal metabolic rate. Apelin was positively associated with ICW, ECW, TW, protein, and SMM (all <i>p</i> < 0.05). In men, positive correlations were found between irisin, apelin, and handgrip strength (all <i>p</i> < 0.05). Receiver operating characteristic analysis showed that irisin and apelin had moderate predictive power in identifying sarcopenia. Plasma irisin and apelin were lower than in controls in elderly patients with sarcopenia, and elevated levels of irisin and apelin were associated with a reduced risk of sarcopenia. In addition, irisin and apelin levels are associated with body composition and irisin showed a stronger ability to predict sarcopenia in women.</p>","PeriodicalId":93878,"journal":{"name":"Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme","volume":" ","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143416587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutrient intakes of Canadian children and adolescents at school by meal occasion and location of food preparation.","authors":"Emily R Ziraldo, Mavra Ahmed, Christine Mulligan, Daniel W Sellen, Mary R L'Abbé","doi":"10.1139/apnm-2024-0027","DOIUrl":"https://doi.org/10.1139/apnm-2024-0027","url":null,"abstract":"<p><p>Canadian children consume a significant proportion of daily foods at school, do not benefit from any federal school food program, and have historically inadequate diets. Assessment of dietary intakes at school can inform policy discussions for the design, funding, and delivery of school-based nutrition interventions. The objectives were to examine the most recent nationally representative dietary intake data of Canadian children at school by (i) location of food preparation, (ii) meal occasion, and (iii) as a proportion of total daily intakes. Intake data from the first day 24 h dietary recalls of the 2015 Canadian Community Health Survey-Nutrition were examined for children 4-18 years old (<i>n</i> = 1690). Intakes were reported by location of food preparation and meal occasion and were expressed as means and as a proportion of daily intake. At school, 98.6% of children consumed foods that did not require preparation, while 37.1% consumed foods prepared at home. Lunch and snacks were the meal occasions consumed most often at school, by 85.5% and 66.1% of children. Children consumed 32.6% of their daily energy intake and between 28.4% and 35.6% of daily nutrient intakes at school. School-based nutrition interventions for frequently consumed meal occasions, such as snack or lunch programs, that include foods lower in added sugar and sodium and higher in calcium, fibre, and iron may improve the health of Canadian children.</p>","PeriodicalId":93878,"journal":{"name":"Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme","volume":"50 ","pages":"1-12"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143061752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modulation of gut microbiota through physical activity in individuals with obesity-a systematic review.","authors":"Javiera Cancino Ramírez, Luis González Rojas, Fabien Magne, Martin Gotteland","doi":"10.1139/apnm-2024-0329","DOIUrl":"10.1139/apnm-2024-0329","url":null,"abstract":"<p><p>Overweight/obesity (OW/OB) has been associated with gut dysbiosis, changes in gastrointestinal motility and sedentary behavior, contributing to metabolic and inflammatory alterations. This systematic review aims to assess the evidence supporting the influence of physical activity and exercise on gut microbiota composition and diversity in OW/OB and was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, using MEDLINE, EMBASE, EBSCO, and Scopus databases. Risk of bias was assessed with RoB 2 for randomized controlled trials (RCTs), ROBINS-I for non-RCT, and JBI Critical Appraisal tool for cross-sectional studies. Eleven studies were selected including 476 OW/OB and 382 normal weight individuals. Seven studies included different types of exercise intervention while the other four were cross-sectional studies assessing physical activity. Results show no clear evidence of a less diverse microbiota in OW/OB. Exercise does not significantly affect alpha diversity of gut microbiota but modifies beta diversity depending on OB status. Moderate to vigorous physical activity positively associates with gut microbiota composition and short-chain fatty acid producing bacteria. These findings highlight the importance of considering gut microbiota contribution to inter-individual variability of response to obesity treatments. Modulation of gut microbiota through physical activity should be considered in the design of personalized therapeutic strategies in obesity. PROSPERO registration number: CRD42021262107.</p>","PeriodicalId":93878,"journal":{"name":"Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme","volume":" ","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142787990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute ketone monoester supplementation in young adults: modulating metabolic and neurocognitive functions across body weights.","authors":"Qian Yu, Ka Kit Wong, On Kei Lei, Paulo A S Armada-da-Silva, Zongze Wu, Jinlei Nie, Qingde Shi, Zhaowei Kong","doi":"10.1139/apnm-2024-0229","DOIUrl":"10.1139/apnm-2024-0229","url":null,"abstract":"<p><p>This study investigated the acute effects of ketone monoester on metabolic and neurocognitive indicators and underlying metabolism-brain-cognition interactions among young adults of healthy weight (HW) and those with overweight/obesity (OW). Forty participants were divided into two groups: HW (<i>n</i> = 20, age 23.80 ± 3.96 years, body mass index (BMI) 21.49 ± 1.80 kg/m²) and OW (<i>n</i> = 20, age 22.00 ± 2.13 years, BMI 28.23 ± 3.48 kg/m²). Each participant completed two trials (ketone monoester vs. placebo, 395 mg/kg dose) in a randomized order. Metabolic indicators (blood beta-hydroxybutyrate (BHB) and glucose) and neurocognitive function (causal density via functional near-infrared spectroscopy and cognitive interference via the Stroop task) were measured at baseline, 30 min, and 90 min post-supplementation. A chain mediation model was constructed to test the indirect effects of BHB level on cognitive interference through mediators like blood glucose and causal density. In the linear mixed models, significant effects were observed for trial (<i>β</i> = -0.92, 0.20, -0.04, 25.53) and assessment time (<i>β</i> = 0.50, -0.14, 0.09, -62.88) in BHB, glucose, causal density, and cognitive interference (<i>p</i> < 0.05), but not for group factors. Compared to OW, the effects of ketone monoester on prefrontal connectomes were more enduring in the HW (<i>p</i> < 0.05). Elevated BHB level improved cognitive function through decreasing glucose level and increasing causal density, with an estimate of -0.63. Acute ketone monoester supplementation elevated levels of blood BHB and prefrontal connectomes and decreased levels of glucose and cognitive interference, regardless of weight status. Elevated blood BHB enhanced cognitive function through multi-tiered neurometabolic pathways. Clinical trial registration: ClinicalTrials.gov (ID: NCT06368297).</p>","PeriodicalId":93878,"journal":{"name":"Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme","volume":" ","pages":"1-12"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142482824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between sleep, energy balance, and obesity markers over 6 months in Black emerging adults-pilot study findings from the Sleep, Health Outcomes, and Body Weight (SHOW) study.","authors":"Hannah R Koch, Jesse N L Sims, Stephanie Pickett, Laurie Wideman, Jessica McNeil","doi":"10.1139/apnm-2024-0263","DOIUrl":"10.1139/apnm-2024-0263","url":null,"abstract":"<p><p>Insufficient sleep (short sleep duration and poor sleep quality) is associated with obesity risk. Emerging adults (ages 18-28 years) have a greater risk of excess weight gain and insufficient sleep, and these risks are higher in Black individuals. Using a measurement burst design, we assessed associations between sleep with energy balance components and obesity marker changes over 6 months in 15 Black emerging adults (12 females; age: 21 ± 2.5 years; body mass index: 25.7 ± 4.5 kg/m²; body fat: 25.8 ± 11.9%). Since our sample was predominantly female (80%), we repeated our analyses for females only. Participants completed the following measurements at baseline (BLN) and 6 months later (6MO): 7 days of actigraphy-based sleep and physical activity energy expenditure (EE) and 2 nights of in-home polysomnography-based sleep; resting EE and thermic effect of food with indirect calorimetry; ad libitum energy intake (EI) via self-reported methods over 4 days and directly measured over 3 days with provided meals. Body weight (2.6 kg, <i>p</i> = 0.01) and waist circumference (2.4 cm, <i>p</i> = 0.03) increased from BLN to 6MO. Changes in actigraphy-based sleep duration were associated with changes in body weight (β = 0.03, standard error (SE) = 0.02, <i>p</i> = 0.04) and fat mass (β = 0.07, SE = 0.03 <i>p</i> = 0.03) in females only. Greater rapid eye movement sleep duration was associated with increases in resting EE (β = 2.24, SE = 0.84, <i>p</i> = 0.02). Greater slow-wave sleep was associated with increases in self-reported EI (β = 18.34, SE = 4.7, <i>p</i> < 0.01). Sleep may impact components of energy balance and risk of weight gain in Black emerging adults. Additional research is needed to confirm our pilot findings.</p>","PeriodicalId":93878,"journal":{"name":"Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme","volume":" ","pages":"1-13"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142692949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A descriptive study of the timing and type of physical activity that is being resumed in early postpartum.","authors":"Kelly-Anne Benoît, Audrey St-Laurent, Véronique Babineau, Stephanie-May Ruchat","doi":"10.1139/apnm-2024-0283","DOIUrl":"https://doi.org/10.1139/apnm-2024-0283","url":null,"abstract":"<p><p>Postpartum physical activity (PA) is an important component of the woman's health. Recently, more attention has been paid to develop guidance for safe return to PA after delivery, including return to running. Little is known about when women start PA after delivery and what type of PA they are practicing. The objectives were to (1) describe early postpartum PA (≤6 weeks), (2) compare women's characteristics between those who started any kind of PA and those who did not, and those who started and did not start running, and (3) explore predictors of PA and running. Ninety-one women, who were part of a longitudinal cohort study, were included. At 6 weeks postpartum, PA was assessed using a questionnaire. Predictors of PA and running were age, education, parity, pre-pregnancy body mass index, prenatal PA, gestational weight gain, prematurity, delivery mode, season, and breastfeeding. The Wilcoxon rank-sum test, Fischer's exact test, and logistic regression analyses were used. Eighty-five women (93%) resumed PA by 6 weeks postpartum. Walking was practiced by 92% of women for 127.0 ± 81.3 min/week. Running was the second most popular activity, practiced by 11% of women for 57.5 ± 31.8 min/week. Walking and running were started around 2.0 and 3.6 weeks after delivery, respectively. Women who delivered in spring or summer were more likely to resume PA by 6 weeks postpartum, and those who ran while pregnant had five-fold higher odds of starting to run by 6 weeks postpartum (OR:5.03, 95%CI 1.27; 19.92). These findings improve our understanding of PA practice, including running, in early postpartum.</p>","PeriodicalId":93878,"journal":{"name":"Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme","volume":"50 ","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143607364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skeletal muscle oxidative capacity related to intramyocellular lipid in young but not in older individuals.","authors":"Akito Yoshiko, Kana Shiozawa, Shiori Niwa, Hideyuki Takahashi, Teruhiko Koike, Kohei Watanabe, Keisho Katayama, Hiroshi Akima","doi":"10.1139/apnm-2024-0272","DOIUrl":"https://doi.org/10.1139/apnm-2024-0272","url":null,"abstract":"<p><p>Skeletal muscles contain lipids inside and outside cells, namely intramyocellular lipids (IMCL) and extramyocellular lipids (EMCL), respectively; lipids have also been found to be interspersed between these muscles as adipose tissue, namely intermuscular adipose tissue (IMAT). Metabolized IMCL has been recognized as an important substrate for energy production and their metabolism is determined by the muscle oxidative capacity. Therefore, it has been speculated that muscle oxidative capacity is related to muscle lipid content. Excessive accumulation of EMCL and IMAT has been confirmed in older individuals, leading to metabolic disorders and a decline in muscle strength. However, whether EMCL and IMAT contribute to muscle lipid metabolism remains unknown. This study aimed to investigate whether muscle oxidative capacity is related to IMCL, EMCL, and IMAT in young and older individuals. A total of 18 young and 14 older individuals were included and their muscle oxidative capacity was assessed based on the recovery rate of muscle oxygen saturation after exercise, using near-infrared spectroscopy of the medial gastrocnemius. IMCL, EMCL, and IMAT were assessed using magnetic resonance spectroscopy and imaging. A relationship between muscle oxidative capacity and IMCL was confirmed in young (<i>r</i> = -0.47, <i>P</i> < 0.05) but not older individuals (<i>r</i> = 0.22, <i>P</i> = 0.45). Muscle oxidative capacity was not related to EMCL or IMAT in either young or older individuals. These results suggest that IMCL in young individuals can contribute to muscle lipid metabolism, but not EMCL and IMAT, and this relationship differs with aging.</p>","PeriodicalId":93878,"journal":{"name":"Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme","volume":"50 ","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute physiological and perceptual responses to three blood flow restricted interval exercise protocols: a randomised controlled trial.","authors":"Man Tong Chua, Alexiaa Sim, Stephen Francis Burns","doi":"10.1139/apnm-2024-0423","DOIUrl":"10.1139/apnm-2024-0423","url":null,"abstract":"<p><p>Blood flow restriction (BFR) may enhance the acute training stimulus of exercise. This study examined acute physiological and perceptual responses to three lower-limb BFR + interval exercise protocols. Twenty-four club/university male athletes (age 25 ± 3.5, V̇O_2max 47.0 ± 5.5 mL∙kg∙min^- ¹) completed four experimental conditions in a randomised crossover manner: (i) high-intensity control (HI) - 100% maximal aerobic power (W_max); (ii) high-intensity recovery occlusion (HIRO) - 100% W_max, 80% limb occlusion pressure (LOP) during rest; (iii) moderate-intensity low occlusion (MILO) - 70% W_max, 50% LOP during exercise; and (iv) moderate-intensity high occlusion (MIHO) - 70% W_max, 80% LOP during exercise. All interval exercise protocols were three sets of five × 30 s cycling, 30 s unloaded active recovery with 3 min seated rest between sets. During recovery, HIRO condition indicated lower tissue saturation index, higher deoxyhaemoglobin, oxyhaemoglobin and total haemoglobin levels than other conditions (all <i>p <</i> 0.05). HIRO exhibited significantly higher heart rate (HR) from set 2 and blood lactate (bLa) at 5 min post-exercise than other conditions (all <i>p <</i> 0.05). Higher vastus lateralis muscle activity was exhibited on the last exercise repetition of HIRO than HI (<i>p <</i> 0.05). MIHO elicited significantly higher deoxygenation, lower muscle activation but similar HR and bLa than HI during exercise; and higher perceived pain and exertion than other conditions (all <i>p <</i> 0.05). Applying BFR during rest between high-intensity interval exercise sets increases physiological stresses without affecting exercise intensity or perceptual responses; applying BFR during moderate-intensity exercise may increase both physiological and perceptual responses beyond those of high-intensity exercise. <b>Study registration:</b> Clinicaltrials.gov (NCT05835544).</p>","PeriodicalId":93878,"journal":{"name":"Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme","volume":" ","pages":"1-13"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143371360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carnosine-enriched functional food enhances micro- and macrovascular endothelium-independent vasodilation in competitive athletes-a randomized study.","authors":"Leon Perić, Ines Drenjančević, Ivana Jukić, Alina Boris, Petar Šušnjara, Nikolina Kolobarić, Zrinka Mihaljević, Zlata Kralik, Gordana Kralik, Manuela Košević, Olivera Galović, Ana Stupin","doi":"10.1139/apnm-2024-0458","DOIUrl":"10.1139/apnm-2024-0458","url":null,"abstract":"<p><p>This randomized interventional study aimed to investigate the effect of carnosine-enriched chicken meat consumption on systemic endothelium-dependent and -independent micro- and macrovascular reactivity in thirty-five healthy competitive male athletes. Both forearm skin micro- and macrovascular endothelium-independent vasodilation were increased, and diastolic and mean arterial blood pressure (BP) were decreased in Carnosine group (<i>n</i> = 19) following the 3-week dietary protocol. Microvascular endothelium-dependent response (post-occlusion reactive hyperemia) was increased in the Carnosine group and significantly associated with decreased mean arterial BP level. Following dietary protocol, Controls (<i>n</i> = 16) had substantially higher urate (but still normal) levels than the Carnosine group. Carnosine supplementation in the form of functional food enhances endothelium-dependent and vascular smooth muscle-dependent vasodilation in peripheral micro- and microcirculation. Carnosine's effect on vascular endothelium could be attributed to its BP-lowering effect. Results suggest that carnosine has the potential to resist hyperuricemia in healthy individuals. ClinicalTrials.gov (NCT05723939).</p>","PeriodicalId":93878,"journal":{"name":"Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme","volume":" ","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143473263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The longitudinal evaluation of the Canadian 24-Hour Movement Guidelines for Adults: lessons learned and considerations for future research.","authors":"Kaitlyn D Kauffeldt, Amy E Latimer-Cheung, Guy Faulkner, Melissa C Brouwers, Rebecca Jones, Kirstin N Lane, Zachary J Weston, Tamara L Morgan, Olivia Varkul, Jennifer R Tomasone","doi":"10.1139/apnm-2024-0348","DOIUrl":"https://doi.org/10.1139/apnm-2024-0348","url":null,"abstract":"<p><p>National movement behaviour guidelines, in isolation, are unlikely to influence practice or policy unless accompanied by robust knowledge mobilization (KMb) strategies. However, without pairing KMb strategies with systematic evaluation, the impact of large-scale dissemination is unknown. The objectives of this study were to (1) systematically assess the dissemination of the Canadian 24-Hour Movement Guidelines for Adults Aged 18-64 Years and Adults Aged 65 Years or Older (24HMG) using the Reach Effectiveness Adoption Implementation and Maintenance (RE-AIM) framework and (2) provide recommendations to support the KMb and future impact of national movement behaviour guidelines. Intermediary organizations involved in the development and dissemination of the 24HMG were invited to participate in this study. A combination of methods-including cross-sectional surveys, media monitoring, and website content analysis-were performed at multiple timepoints over a 12-month period to assess the dissemination of the 24HMG. Findings suggest that the multi-pronged dissemination approach used for the 24HMG had a large reach to guideline target audiences (approximately 11.9 million) but resulted in low awareness and knowledge of the 24HMG among adults living in Canada (31.9% and 1.6%, respectively). Dissemination activities performed by intermediary organizations peaked in the first 4-months post-guideline release (76% of responding organizations), trending downwards over time (53% of responding organizations at 12 months). The complexity of disseminating national movement behaviour guidelines presents many challenges to systemic adoption. However, the impact of future national movement behaviour guidelines may be improved by augmenting current dissemination approaches to include coordinated, scalable, and capacity-building strategies.</p>","PeriodicalId":93878,"journal":{"name":"Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme","volume":"50 ","pages":"1-16"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143451289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}