Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme最新文献

{"title":"Short-Term Removal of Exercise Impairs Flow-Mediated Dilation Similarly in Older and Younger Adults.","authors":"Joel E Ernest Harden, Taskina Akhter, Michael Pokojovy, Leryn J Reynolds","doi":"10.1139/apnm-2024-0500","DOIUrl":"https://doi.org/10.1139/apnm-2024-0500","url":null,"abstract":"<p><p>Endothelial function is decreased following removal of exercise in young adults. However, whether older adults also experience the same reduction in endothelial function following removal of exercise is not known. The purpose of the study was to investigate the effects of 3 and 5 days of removal of exercise (NOEX3, NOEX5, respectively) on brachial and popliteal artery FMD in older (n=12, 63.8±2.2 years) and younger (n=12, 23.9±0.7 years) adults who habitually exercise. %FMD in both the brachial (Old- EX: 7.58 (6.89); NOEX3: 5.58 (7.26); NOEX5: 6.05 (10.43); Young- EX: 7.93 (13.13); NOEX3: 6.57 (12.61); NOEX5: 6.50 (10.74); p=0.029) and popliteal (Old- EX: 6.56 (8.11); NOEX3: 4.95 (8.52); NOEX5: 4.56 (9.56); Young- EX: 6.15 (8.38); NOEX3: 6.19 (6.72); NOEX5: 4.77 (6.58); p=0.013) arteries were reduced following NOEX compared to EX. Peak diameter in both the brachial (Old- EX: 4.02 (0.62); NOEX3: 3.94 (0.62); NOEX5: 3.97 (3.97); Young- EX: 4.40 (0.49); NOEX3: 4.31 (0.52); NOEX5: 4.28 (0.52); p<0.01) and popliteal (Old- EX 5.74 (1.25); NOEX3: 5.64 (1.28); NOEX5: 5.62 (1.32); Young- EX: 6.07 (0.94); NOEX3: 6.03 (0.87); NOEX5: 5.92 (0.90); p<0.01) arteries were reduced during NOEX compared to EX. No significant main effects of group or interaction of group by phase were observed for %FMD or peak diameter (p>0.05). Thus, short-term removal of exercise in older and younger adults reduced brachial and popliteal artery endothelial function. However, no difference in reduction was observed between groups.</p>","PeriodicalId":93878,"journal":{"name":"Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144164294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Pilot Study: The Effect of Intensity and Menstrual Cycle Phase on Exercise-Induced Leukocytosis in Females.","authors":"Vito Anthony Pipitone, Daniel Leonardo Scurto, Joey Pozzi, Fasih Ahmad Rahman, Joe Quadrilatero, Kevin J Milne","doi":"10.1139/apnm-2024-0344","DOIUrl":"https://doi.org/10.1139/apnm-2024-0344","url":null,"abstract":"<p><p>High-intensity exercise increases inflammation and elicits leukocytosis but may also increase infection risk. Interestingly, females have higher cell-mediated immunity than males. Sex hormones fluctuate across the menstrual cycle (MC), and the luteal phase has been linked to a more pro-inflammatory environment than the follicular phase. This study investigated whether white blood cell (WBC) count and WBC differential (i.e., neutrophils, lymphocytes, monocytes, eosinophils, and basophils), differed across two menstrual cycle phases following an acute bout of exercise that varied in intensity. Eight regularly menstruating females (age=21.6±3.0; BMI=20.9±4.1kg/m2) completed a VO2peak (37.8±11.0ml/min/kg) test and two 40-minute cycling exercise trials [30-mins of moderate-intensity (%HRmax=71.13±8.5, %VO2peak=49.8±21.6); and ~10-mins of high-intensity (%HRmax=93.3±6.7, %VO2peak=75.4±27.6)] 14±2 days apart. Blood samples were taken pre- and post-moderate-intensity exercise (30min), as well as immediately post-high-intensity exercise (~40min). Both moderate- and high-intensity exercise increased WBC counts [p<0.01,(d=1.11 and 1.34, respectively)]. More specifically, neutrophil counts increased following both moderate (p<0.05,d=0.72) and high (p<0.01,d=0.95) exercise intensities. However, lymphocytes (p<0.01,d=1.15) and monocytes (p<0.01;d=0.99) were only elevated following high-intensity exercise. MC phase did not significantly alter WBC counts nor differentials although trends were observed towards greater leukocytosis at moderate-intensity exercise during the luteal phase (observed in Figure 4). These results demonstrate, in some cases moderate-intensity exercise increased leukocytosis (in particular, neutrophils), while high-intensity exercise resulted in significant leukocytosis primarily as a result of increased neutrophils, lymphocytes, and monocytes. Future research should investigate this relationship in a larger sample observing inflammatory cytokines and WBC function/activity with the inclusion of a group in the early follicular phase.</p>","PeriodicalId":93878,"journal":{"name":"Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144153007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Animal and Plant Protein Usual Intakes are Not Adversely Associated with All-Cause, Cardiovascular Disease- or Cancer-Related Mortality Risk: An NHANES III Analysis.","authors":"Yanni Papanikolaou, Stuart M Phillips, Victor L Fulgoni","doi":"10.1139/apnm-2023-0594","DOIUrl":"https://doi.org/10.1139/apnm-2023-0594","url":null,"abstract":"<p><p>We used data from NHANES 1988-1994 to examine associations between animal and plant protein usual intakes and IGF-1 concentration with mortality from all causes, cancer, and cardiovascular disease (CVD). Adult data (N=15,937) were linked with mortality data (N=3,843 events) through 2006. Usual intakes for protein were estimated using the multivariate Markov Chain Monte Carlo method. Hazard ratio (HR) models were fit for mortality types (all-cause, cancer, and CVD) with protein intake measures (per 1g increase) and IGF-1 concentration (N=5753). There were no associations between animal protein (HR=0.99; 95% confidence interval [CI]: 0.98-1.01; P=0.29) or plant protein (HR=1.02; 95% CI: 0.95-1.10; P=0.55) intake for all-cause mortality. Similar results were seen for CVD mortality and animal protein (HR=1.02; 95% CI: 0.99-1.04; P=0.14) and plant protein (HR=1.01; 95% CI: 0.91-1.13; P=0.81). There was an (inverse) association between cancer mortality and animal protein (HR=0.95; 95% CI: 0.91-1.00; P=0.04) but no relationship with plant protein (HR=1.08; 95% CI: 0.93-1.24; P=0.30). We found no association between concentrations of IGF-1 (N=5,753) for all-cause mortality (HR=1.00; 95% CI: 0.99-1.00; P=0.81), CVD mortality (HR=0.99; 95% CI: 0.99-1.00; P=0.53) or cancer mortality (HR=1.00; 95% CI: 0.99-1.00; P=0.76). Our results remained unchanged when the sample was separated into younger (<65yr) and older (>65, or between 50-65yr) cohorts. Our data do not support the thesis that source-specific protein intake is associated with greater mortality risk; however, animal protein may be mildly protective for cancer mortality. Mortality risk was not associated with circulating IGF-1 in any age group.</p>","PeriodicalId":93878,"journal":{"name":"Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144153011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Context dependent trade-offs in body size among Olympic sports.","authors":"Shalaya Kipp, Martin Husen, Chad Wiggins, Ellen K Gorman, Andrew J Clayburn, Michael J Joyner, Jonathon W Jack Senefeld","doi":"10.1139/apnm-2025-0021","DOIUrl":"https://doi.org/10.1139/apnm-2025-0021","url":null,"abstract":"<p><p>There is a context-dependent trade-off in body size of elite runners, such that smaller body sizes are observed among longer distance runners. However, it is unclear if this trade-off in body size is observed in other Olympic sports, such as cycling and swimming. To understand the association between body size and athletic competition, we examined metrics of body size from male and female Olympic athletes competing in swimming, running, and cycling. We collected standard anthropometrics (height, mass, body mass index (BMI), and body surface area) of elite male and female athletes competing in the London 2012 Summer Olympics from a public repository. Anthropometric data were compared between sexes (male and female); between sports (swimming, running, and cycling); and between distances within sports (shorter and longer distance). Males were taller (P<0.001), heavier (P<0.001), and had a larger body mass index (P<0.001) compared to females. Relative to athletes competing in longer distance events, athletes competing in shorter distance were generally taller (running: P<0.001, swimming: P ≤0.014) and heavier (running: P<0.001, swimming: P=0.002 (males) and P=0.148 (females), cycling: P<0.001) for both males and females. Height was not different between shorter and longer distance cyclists. There was a trade-off between body size and distance for each of the three Olympics sports, such that smaller athletes were observed in longer distance events. Although there were large sex-based differences in body size, similar trade-offs in size and event were observed for both males and females. These data suggest that there is an optimal combination of skeletal muscle mass and body size to optimize movement economy that is generally preserved across different modes of human locomotion.</p>","PeriodicalId":93878,"journal":{"name":"Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144132083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between body mass index z-score and blood pressure among children with overweight and obesity involved in a lifestyle modification program.","authors":"Marie Cyrenne-Dussault, Maude Sirois, Julie St-Pierre, Jean-Philippe Drouin-Chartier","doi":"10.1139/apnm-2024-0537","DOIUrl":"https://doi.org/10.1139/apnm-2024-0537","url":null,"abstract":"<p><p>Documenting the relationship between body mass index z-score (BMIz) and blood pressure (BP) is crucial to better position the importance of adiposity reduction in managing cardiometabolic risk in children. This study assessed the relationship between BMIz and systolic and diastolic BP (SBP, DBP) among children with overweight or obesity receiving lifestyle counseling at a pediatric obesity management clinic in Montreal (Province of Quebec, Canada). This is a retrospective, longitudinal analysis of medical records of 438 children (2-17 years). At the first clinic appointment, 181 (41.3%) children had normal BP, 85 (19.4%) had prehypertension and 172 (39.3%) had hypertension. At baseline, each 1-point increment in BMIz was associated with 28.3% (95% confidence interval (CI): 7.9, 52.6; P=0.005) higher odds of prehypertension or hypertension. Between the first and the last appointment, each 1-point decrease in BMIz was associated with a reduction of -6.24 percentiles (95%CI: -11.17, -1.32; P=0.02) in SBP and -4.99 percentiles (95%CI: -9.31, -0.66; P=0.03) in DBP. Children who experienced BMIz reduction of -0.25 or more were more likely to achieving SBP reductions of -3.20 mm Hg or more relative to those smaller BMIz changes (OR: 2.00, 95% CI: 1.23, 3.25; P=0.006). Baseline BMIz, but not changes in BMIz over follow-up, was negatively associated with odds of normalizing BP among the 257 children with prehypertension or hypertension at baseline (OR: 0.70, 95%CI: 0.54, 0.91; P=0.007). This study leveraged real-world clinic data to provide further importance on adiposity reduction in pediatric cardiometabolic risk management.</p>","PeriodicalId":93878,"journal":{"name":"Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144129754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring perceptions and needs of school food programs among parents and caregivers: A mixed methods study.","authors":"Selina Mae Quibrantar, Mavra Ahmed, Erica Di Ruggiero, Daniel Sellen, Vasanti Malik","doi":"10.1139/apnm-2024-0501","DOIUrl":"https://doi.org/10.1139/apnm-2024-0501","url":null,"abstract":"<p><p>National school food programs (SFPs) have been implemented in several countries and can provide numerous benefits to children across the world. In June 2024, Canada released a National School Food Policy to support the development of a national SFP in Canada. As the enthusiasm to develop a national SFP grows, policymakers need evidence to inform a national SFP that can meet the needs of diverse communities in Canada. There is a paucity of recent information about the perceptions and needs of parents and caregivers in Canada regarding SFPs from various regions across the nation. To close this knowledge gap and gain insight on preferred program attributes, we conducted a mixed-methods study involving focus groups/interviews and surveys with parents and caregivers in the Greater Toronto Area (GTA) and examined perceptions about the cultural aspects of SFPs among ethnic-specific sub-groups (South Asian, East Asian, and Southeast Asian households). The perceptions and needs identified from all parents and caregivers in the study were used to develop a framework that highlights attributes of a holistic and multicomponent SFP. This framework can be tested and modified with additional information from other locations and can validate other frameworks to inform policymakers on the most important objectives, attributes, and cultural considerations for a national SFP grounded in the perceptions and needs of parents and caregivers.</p>","PeriodicalId":93878,"journal":{"name":"Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the Nutritional Quality of School Food Programs in Canada Compared to National Nutritional Guidelines.","authors":"Annette Blais, Mavra Ahmed, Mary R L'Abbé, Daniel Sellen, Vasanti Malik","doi":"10.1139/apnm-2024-0540","DOIUrl":"https://doi.org/10.1139/apnm-2024-0540","url":null,"abstract":"<p><p>While the potential of school food programs (SFPs) to influence healthy eating behaviors and improve child health outcomes is recognized globally, Canada currently lacks a well-established nationally coordinated and funded SFP. Instead, the fragmented nature of SFPs across Canada has resulted in a limited understanding of their nutritional quality. This study builds upon prior research assessing the characteristics of Canadian SFPs and aims to provide a baseline of SFP nutritional quality before federal policy implementation to identify priority areas for improvement in the current school food landscape. SFP menu data was collected from a diverse sample of school food providers. The mean content of nutrients of public health concern were calculated and two indices of dietary quality representing adherence to national nutrition guidelines were applied to SFP menu data: Healthy Eating Food Index 2019 (HEFI-2019) and Healthy Eating Index Canada (HEI-C) 2010. Nutritional quality results from 67 SFPs serving over 20% of Canadian schools revealed approximately 51% adherence to the 2019 and 2007 Canada's Food Guides, indicating similar adherence to national dietary guidelines as in the broader population. Snacks tended to be high in total sugars but low in protein and sodium was high across all meal types. Given the limited resources available to SFPs in Canada, these findings indicate that although school food providers are serving relatively healthful choices, a federally harmonized school food policy and program (including the development of national school food guidelines) can further improve the state of school food in Canada and its nutritional quality.</p>","PeriodicalId":93878,"journal":{"name":"Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144055356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sedentary Time in Older Adults: Absolute vs. Relative Measures and their Respective Association with Health conditions and Multimorbidity.","authors":"René Maréchal, Ahmed Ghachem, Isabelle J Dionne","doi":"10.1139/apnm-2024-0545","DOIUrl":"https://doi.org/10.1139/apnm-2024-0545","url":null,"abstract":"<p><p>Older adults (OA) accumulate a greater amount of sedentary time (ST) compared to other subgroups of the population which is associated with deleterious effects on multiple health outcomes and mortality. This study compared absolute sedentary behavior time (ASBT), which is generally used in studies, to relative SB time (RSBT), defined as the percentage of daily wake time, for their respective association with health conditions and multimorbidity. Two-thousand-sixty-one older adults (65 to 79 years) participated in the Canadian Health Measures Survey (2007-2017) and worn an accelerometer for ≥ 4 days, including a weekend day. Information regarding six health conditions categories was extracted: cancer, cardiovascular, metabolic, musculoskeletal, psychological and pulmonary. We combined these health conditions to create a multimorbidity variable. Participants were divided into ASBT quartiles and RSBT quartiles. Comparing the most sedentary (Q4) to the least sedentary (Q1) groups, we found no significant associations with any health conditions for ASBT. However, the same comparison for RSBT showed that RSBT-Q4 (the most sedentary; n=660), compared to RSBT-Q1 (n=660), was associated with a significant (p<0.01) greater prevalence of cancer (160>110), cardiovascular (422>326), metabolic (276>194), and musculoskeletal (407>345), as well as multimorbidity (462>350). After adjusting for confounding factors (moderate to vigorous physical activity, housing, income, education level, relationship status, accelerometer wear season, and status of drinking and smoking), these associations persisted with the exception of musculoskeletal conditions. These results demonstrate that RSBT could be more appropriate to capture the association between a sedentary lifestyle and health profiles in older adults.</p>","PeriodicalId":93878,"journal":{"name":"Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144037406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Association Between the Healthy Eating Food Index-2019 (HEFI-2019), the Canadian Healthy Eating Index 2007 (C-HEI 2007) and Health Among First Nation Adults Across Canada.","authors":"Ines Sebai, Milena Nardocci, Amy Ing, Karen Fediuk, Hing Man Chan, Malek Batal","doi":"10.1139/apnm-2024-0422","DOIUrl":"https://doi.org/10.1139/apnm-2024-0422","url":null,"abstract":"<p><p>Assessing diet quality is crucial in public health research, as it reveals relationships between dietary patterns and health. The Healthy Eating Food Index-2019 (HEFI-2019) and the Canadian Healthy Eating Index 2007 (C-HEI 2007) are robust tools used to evaluate adherence to dietary guidelines. While the C-HEI 2007 has been widely applied in nutritional epidemiology, research exploring associations between the HEFI-2019, which reflects the updated 2019 Canadian dietary guidelines, and health remains limited. Given the distinct dietary habits and health profiles of First Nations, evaluating these indices in this population is essential. This study investigates associations between HEFI-2019 and C-HEI 2007 scores and health variables, including obesity, type 2 diabetes (T2D), and self-perceived health among First Nations adults. Data were drawn from the First Nations Food, Nutrition, and Environment Study, which included interviews and 24-hour dietary recalls from 5455 adults across 92 communities. Higher HEFI-2019 scores were significantly associated with increased odds of T2D but not with obesity or self-perceived health. C-HEI 2007 scores were also associated with T2D, with stronger associations in the highest tertile. However, C-HEI 2007 scores were not significantly associated with obesity or self-perceived health. The study highlights the significant relationships between HEFI-2019 and C-HEI 2007 scores and T2D among First Nations adults, underscoring the role of diet quality in chronic disease management. The positive associations with T2D may reflect dietary improvements following diagnosis, wherein individuals adopt healthier eating habits. However, given the cross-sectional design, causal relationships cannot be established, and the observed associations should be interpreted with caution. These findings underscore the need for culturally relevant dietary interventions to improve health in Indigenous populations.</p>","PeriodicalId":93878,"journal":{"name":"Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144002049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of sleep restriction, with or without prior evening exercise, on morning postprandial lipemia.","authors":"Alan C Maloney, Matthew McDonald, Gregory F Petroski, Jill A Kanaley","doi":"10.1139/apnm-2024-0535","DOIUrl":"https://doi.org/10.1139/apnm-2024-0535","url":null,"abstract":"<p><p>Sleep restriction (SR) impairs postprandial glycemia following a high-glucose challenge and exercise improves it, their combined impact on postprandial lipemia to a high-fat challenge remains unknown. This project investigated whether one night of SR impairs morning postprandial lipemia and if prior evening exercise influences the response. We hypothesized SR would induce an exaggerated postprandial lipemic response to a high-fat morning challenge, and that prior evening exercise would fully or partially ameliorate these impairments. In ten sedentary individuals with overweight or obesity (females: 4, age: 28.1 ± 3.8 years, BMI: 30.4 ± 2.2 kg/m2), we compared one night of SR (4 h) to normal sleep (8 h), with and without prior moderate intensity aerobic exercise (45 min, 65% VO2max), on postprandial lipemia and satiety following a standardized high-fat morning challenge (4 h). Spline regression was used to compare differences in the time course of the blood-based outcomes between exercise and sleep conditions No significant differences were observed in fasting or 2-h concentrations of glucose, insulin, NEFA, or triglyceride concentrations, areas under the curves, indexes of metabolism, or satiety between conditions. However, exercise had an interaction between the spline term and exercise and sleep conditions (p <0.001) for glucose, insulin, non-esterified fatty acids, and triglycerides during the high-fat challenge. The findings indicate that one night of SR has minimal effects on morning postprandial lipemia, irrespective of previous aerobic exercise. Notably, exercise reduced triglyceride concentrations in the latter half of the testing period, although this effect was abolished during SR conditions.</p>","PeriodicalId":93878,"journal":{"name":"Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}