Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme最新文献

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Adverse Event Reporting in Exercise Studies of Resistance Training (AERIES-RT) Recommendations and Toolkit: A modified Delphi process. 阻力训练运动研究中的不良事件报告(AERIES-RT)建议和工具包:改进的德尔菲过程。
Rasha El-Kotob, Justin Rodriguez Pagcanlungan, B Catharine Craven, Catherine Sherrington, Marina Mourtzakis, Lora Giangregorio
{"title":"Adverse Event Reporting in Exercise Studies of Resistance Training (AERIES-RT) Recommendations and Toolkit: A modified Delphi process.","authors":"Rasha El-Kotob, Justin Rodriguez Pagcanlungan, B Catharine Craven, Catherine Sherrington, Marina Mourtzakis, Lora Giangregorio","doi":"10.1139/apnm-2024-0490","DOIUrl":"https://doi.org/10.1139/apnm-2024-0490","url":null,"abstract":"<p><p>The objective of this study was to adapt existing adverse event (AE) reporting guidelines and develop AE Reporting In Exercise Studies of Resistance Training (AERIES-RT) recommendations and toolkit. We conducted purposeful and convenience sampling to identify researchers who published resistance training (RT) trials. We invited 80 research scientists to participate in a modified Delphi consensus process. Nineteen researchers from six countries (Canada, USA, UK, Australia, Greece, and Puerto Rico) agreed to participate. We drafted adapted AE-reporting recommendations informed by interviewing participants with common health conditions who experienced AEs after RT (n=12), and researchers who published RT trials (n=14). These recommendations were turned into a survey that was distributed electronically to the Delphi participants for rating. We conducted three rounds of voting until there was consensus (criterion: minimum 74% agreement) on each recommendation. All 19 participants responded to the three survey rounds (100% response rate). After each round, the recommendations were revised based on the participants' feedback. For the first round, ten of 24 recommendations did not meet the criterion for consensus. For the second round, one of 28 recommendations did not meet the criterion for consensus. For the final round, the remaining recommendation met the criterion for consensus. The agreed upon recommendations were used to develop the AERIES-RT toolkit including a checklist, template AE reporting form, and a decision tree. Our modified e-Delphi consensus process resulted in developing the AERIES-RT toolkit that researchers can use to improve the frequency and accuracy of AE reporting in RT trials.</p>","PeriodicalId":93878,"journal":{"name":"Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144710254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanisms of Muscle Atrophy in Type 2 Diabetes Mellitus: Factors Dysregulating Muscle Protein Synthesis and Breakdown. 2型糖尿病肌肉萎缩的机制:调节肌肉蛋白合成和分解的因素。
Moses Jeong, Taylor McColl, David Clarke
{"title":"Mechanisms of Muscle Atrophy in Type 2 Diabetes Mellitus: Factors Dysregulating Muscle Protein Synthesis and Breakdown.","authors":"Moses Jeong, Taylor McColl, David Clarke","doi":"10.1139/apnm-2025-0017","DOIUrl":"https://doi.org/10.1139/apnm-2025-0017","url":null,"abstract":"<p><p>Type 2 diabetes mellitus (T2DM) is rising in prevalence and incidence, which is leading to increased burden on healthcare systems. A less recognized consequence of T2DM is the accelerated loss of skeletal muscle, which can reduce quality of life and further exacerbate T2DM progression. Insulin resistance disrupts skeletal muscle maintenance by impairing insulin- and leucine-mediated signalling - processes challenging to study due to the number and complexity of dysregulated components. Several key areas in this field remain underexplored, such as the causal relationship between T2DM and muscle atrophy, the impact of insulin resistance on muscle protein balance, and the mechanisms driving muscle atrophy in humans with T2DM. Advancing understanding in these areas requires the integration of evidence from experimental, prospective, and computational studies to more precisely characterize the mechanisms and progression of T2DM-related muscle atrophy and to inform targeted interventions to mitigate muscle loss.</p>","PeriodicalId":93878,"journal":{"name":"Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144710256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Does moderate intensity continuous training promote muscle hypertrophy? A systematic review and meta-analysis of randomized controlled trials. 中等强度的持续训练会促进肌肉肥大吗?随机对照试验的系统回顾和荟萃分析。
Julio Benvenutti Bueno de Camargo, Deivid G Silva, João G A Bergamasco, Diego Bittencourt, Enya T A Nacafucasaco, Nathalia F Dias, Ana J F Neves, Maíra C Scarpelli, Cleiton A Libardi
{"title":"Does moderate intensity continuous training promote muscle hypertrophy? A systematic review and meta-analysis of randomized controlled trials.","authors":"Julio Benvenutti Bueno de Camargo, Deivid G Silva, João G A Bergamasco, Diego Bittencourt, Enya T A Nacafucasaco, Nathalia F Dias, Ana J F Neves, Maíra C Scarpelli, Cleiton A Libardi","doi":"10.1139/apnm-2025-0152","DOIUrl":"https://doi.org/10.1139/apnm-2025-0152","url":null,"abstract":"<p><p>The effects of moderate-intensity continuous training (MICT) on muscle hypertrophy remain controversial, largely due to the absence of non-exercise control groups in several trials and considerable heterogeneity in training protocols, assessment methods, and participant characteristics. This systematic review and meta-analysis aimed to examine the effects of MICT on skeletal muscle hypertrophy. Following PRISMA guidelines, searches were conducted in MEDLINE, Embase, Web of Science, Scopus, and the Cochrane Library for chronic human interventions comparing MICT to non-exercise controls, reporting both whole-body and localized muscle mass outcomes (lower limb lean mass, muscle cross-sectional area, fiber cross-sectional area, and muscle thickness) in healthy adults without chronic diseases or musculoskeletal injuries. A random-effects model compared MICT vs. control for total and regional muscle mass outcomes combined and separately. Thirteen studies met the inclusion criteria. The standardized mean difference was 0.050 (95% CI: -0.147 to 0.248) for total and regional outcomes combined, and 0.080 (95% CI: -0.277 to 0.437) for regional outcomes alone. In conclusion, the current evidence does not consistently support a hypertrophic effect of MICT. However, this conclusion should be interpreted with caution due to variability in study design, populations, and measurement sensitivity.</p>","PeriodicalId":93878,"journal":{"name":"Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144710255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Validity of the V̇O2 Master Pro for Measuring Oxygen Consumption During Sedentary Activity and Treadmill Walking and Jogging. v_o2 Master Pro测量久坐运动、跑步机步行和慢跑时耗氧量的有效性。
Jisu Kim, Kyu-Ri Hong, In-Whi Hwang, Xiaolin Wen, Jun-Hao Shen, Ho-Jun Kim, Jonathan Kenyon, Jessica Geller, Ronald K Evans, Jung-Min Lee, Youngdeok Kim
{"title":"The Validity of the V̇O2 Master Pro for Measuring Oxygen Consumption During Sedentary Activity and Treadmill Walking and Jogging.","authors":"Jisu Kim, Kyu-Ri Hong, In-Whi Hwang, Xiaolin Wen, Jun-Hao Shen, Ho-Jun Kim, Jonathan Kenyon, Jessica Geller, Ronald K Evans, Jung-Min Lee, Youngdeok Kim","doi":"10.1139/apnm-2025-0095","DOIUrl":"https://doi.org/10.1139/apnm-2025-0095","url":null,"abstract":"<p><p>Metabolic carts are commonly used to estimate oxygen consumption (V̇O2) during exercise, but are largely limited to controlled laboratory settings. The V̇O2 Master Pro (VMP) is a newer, portable metabolic analyzer designed to address this limitation; however, few studies have evaluated the validity of this device at varying activity levels.</p><p><strong>Objective: </strong>To assess the validity of the VMP in measuring V̇O2 compared with a stationary metabolic cart, the COSMED Quark CPET (CQ), during sedentary activity and treadmill walking/jogging in a laboratory setting.</p><p><strong>Approach: </strong>Twenty-seven healthy adults [mean age=22.1±7.6 years; female=51.8%] participated in two laboratory trials on separate days. In a counterbalanced order, participants used the CQ and VMP during 10-minute conditions of the following activities: sedentary activity (sitting quietly), slow walking (3.2 km/h), brisk walking (5.6 km/h), and jogging (7.2 km/h). The agreement between the two measures was evaluated using equivalence testing, mean absolute percentage error (MAPE), percentage bias, intraclass correlation coefficients (ICCs), and Bland-Altman analyses.</p><p><strong>Main results: </strong>The devices showed low agreement and significant proportional biases across all activity levels [ICCs=0.135-0.323]. Equivalence testing did not demonstrate statistically significant equivalence between the devices (p>.05), with the VMP underestimating V̇O2. The smallest error appeared during jogging [MAPE=20.05%; percentage bias= -19.29%].</p><p><strong>Significance: </strong>The VMP underestimated V̇O2 at all tested intensities, demonstrating low accuracy and agreement relative to the reference measure. This may be attributed to limited ventilatory flow capture or sensor responsiveness during submaximal activities. Observed bias and within-subject variability suggest caution when using the VMP across different submaximal activity levels.</p>","PeriodicalId":93878,"journal":{"name":"Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144644334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Examining placebo effects after a three-week repeated-sprint training program under hypoxic conditions in recreationally trained subjects: a randomized controlled trial. 在低氧条件下对娱乐性训练的受试者进行为期三周的重复短跑训练计划后的安慰剂效应:一项随机对照试验。
Alexandre P Gutknecht, Martin Gonzalez-Figueres, Guilhem Belda, Grégoire Vergotte, Stephane Perrey, François Favier
{"title":"Examining placebo effects after a three-week repeated-sprint training program under hypoxic conditions in recreationally trained subjects: a randomized controlled trial.","authors":"Alexandre P Gutknecht, Martin Gonzalez-Figueres, Guilhem Belda, Grégoire Vergotte, Stephane Perrey, François Favier","doi":"10.1139/apnm-2024-0468","DOIUrl":"https://doi.org/10.1139/apnm-2024-0468","url":null,"abstract":"<p><p>Repeated-sprint training in hypoxia (RSH) has been suggested to significantly enhance anaerobic performance. However, the widespread belief in the benefits of altitude training raises questions about potential placebo effect. The aim of this study was thus to investigate the physiological and placebo effects of normobaric hypoxia combined with repeated-sprint training on performance. Twenty-nine moderately trained participants were randomly assigned to normoxia (RSN), placebo (RSN-P), or hypoxia (RSH) groups. Participants in RSN-P group were led to believe they were training at simulated altitude (between 2500 and 3500 m), while participants in the RSN and RSH groups knew they were training at sea level and at altitude, respectively. Repeated-sprint training involved six cycling sessions over three weeks, consisting of three sets of 8 x 6-s sprint with 24 s of recovery. There was no difference in the estimation of the altitude level to which participants from the RSN-P and RSH groups thought they had been exposed. There was a main significant effect of training on mean power output during Wingate (+7.9%; p < 0.001; ηp² = 0.47) and repeated-sprint ability tests (+7.7%; p < 0.001; ηp² = 0.55). However, contrary to our hypotheses, the enhancement among the three groups did not differ. The lack of greater improvement in the RSH group compared to the other groups raises questions about the added value of hypoxia in these conditions. In conclusion, neither real nor perceived hypoxia enhanced training adaptations following repeated-sprint sessions.</p>","PeriodicalId":93878,"journal":{"name":"Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144556160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dietary Creatine Intake and All-Cause Mortality among U.S. Adults: A Linked Mortality Analysis from the NHANES Study. 膳食肌酸摄入与美国成人全因死亡率:NHANES研究中相关死亡率分析
Sergej M Ostojic
{"title":"Dietary Creatine Intake and All-Cause Mortality among U.S. Adults: A Linked Mortality Analysis from the NHANES Study.","authors":"Sergej M Ostojic","doi":"10.1139/apnm-2025-0001","DOIUrl":"https://doi.org/10.1139/apnm-2025-0001","url":null,"abstract":"<p><p>Evidence linking dietary creatine intake with mortality remains scarce and inconclusive. This study aimed to investigate the relationship between creatine consumption and all-cause mortality, as well as to evaluate the potential impact of meeting the recommended dietary creatine intake of ≥ 1 gram per day in a nationally representative sample of U.S. adults. We evaluated creatine intake, estimated from a single 24-hour dietary recall in the 1999-2000 National Health and Nutrition Examination Survey, with mortality follow-up extending through 2019. Of the 4,041 participants enrolled at baseline, 858 deaths were recorded over a median follow-up period of 19.8 years. Creatine as a continuous variable (grams per day) had inverse association with all-cause mortality (B=-0.094; P=0.04). The hazard ratio for all-cause mortality was 0.85 (95%CI: 0.72-1.00) for participants consuming at least 1 gram of creatine per day, compared to those consuming less than 1 g/day (P=0.05), suggesting that individuals meeting the recommended creatine intake had a significantly lower risk of early mortality compared to those with suboptimal intake. Proportional hazards regression analysis indicated that this association remained robust after adjusting for certain covariates, such as dietary macronutreints (B=-0.234; P=0.01) and physical examination measures (B=-0.206; P=0.02); however, it weakened when demographic and lifestyle factors were included in the model. In this sample of U.S. adults, higher creatine intake was inversely associated with all-cause mortality; however, this relationship may be influenced by other contributing factors. These findings underscore the need for further research on the relationship between dietary creatine intake and mortality outcomes.</p>","PeriodicalId":93878,"journal":{"name":"Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Arterial Stiffness and Subendocardial Viability Ratio: Temporal Responses to Ultra-Endurance Exercise. 动脉硬度和心内膜下活力比:对超耐力运动的时间反应。
Tasha Reiter, Daniel MacCallum, Michael Roberts, Justin D Roberts, Tony Dawkins
{"title":"Arterial Stiffness and Subendocardial Viability Ratio: Temporal Responses to Ultra-Endurance Exercise.","authors":"Tasha Reiter, Daniel MacCallum, Michael Roberts, Justin D Roberts, Tony Dawkins","doi":"10.1139/apnm-2025-0029","DOIUrl":"https://doi.org/10.1139/apnm-2025-0029","url":null,"abstract":"<p><p>Ultra-endurance exercise causes significant cardiovascular stress, yet the vascular responses during recovery remain incompletely understood. This study examined the short- (12-18 hours) and longer-term (7 and 28 days) effects of a long-distance triathlon on arterial stiffness and subendocardial viability ratio (SEVR) in novice triathletes. Eleven participants (2 females, 9 males), novice to long-distance exercise events, completed cardiovascular assessments at baseline (pre-race), 12-18 hours post-race, and 7- and 28-days post-race. Measures included carotid-femoral pulse wave velocity (PWV), augmentation index (Aix) and SEVR, obtained via applanation tonometry. PWV remained unchanged at all post-exercise time points (P = 0.310). Aix showed significant reduction at 7 days post-event (P = 0.024), though this effect was abolished after normalizing values to a heart rate of 75 beats per minute (Aix75, P = 0.162). SEVR decreased significantly 12-18 hours post-race (P < 0.001), indicating a transient imbalance between myocardial supply and demand, likely driven by elevated heart rates and reduced diastolic perfusion time. SEVR returned to baseline by 7 days post-event. These findings suggest that while no sustained changes in arterial stiffness were observed, hemodynamic conditions during recovery may signify altered myocardial supply-demand balance in novice athletes. Further research is needed to explore these mechanisms, with enhanced temporal resolution, to better understand the cardiovascular implications for novice endurance athletes.</p>","PeriodicalId":93878,"journal":{"name":"Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144499815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of visceral adiposity in the relationship between cardiorespiratory fitness and liver fat in asymptomatic adults. 在无症状成人中,内脏脂肪在心肺健康和肝脏脂肪之间的关系中的作用。
Dominic J Chartrand, Eric Larose, Paul Poirier, Patrick Mathieu, Natalie Alméras, Philippe Pibarot, Benoît Lamarche, Caroline Rheaume, Isabelle Lemieux, Jean-Pierre Després, Marie-Eve Piche
{"title":"Role of visceral adiposity in the relationship between cardiorespiratory fitness and liver fat in asymptomatic adults.","authors":"Dominic J Chartrand, Eric Larose, Paul Poirier, Patrick Mathieu, Natalie Alméras, Philippe Pibarot, Benoît Lamarche, Caroline Rheaume, Isabelle Lemieux, Jean-Pierre Després, Marie-Eve Piche","doi":"10.1139/apnm-2024-0478","DOIUrl":"https://doi.org/10.1139/apnm-2024-0478","url":null,"abstract":"<p><p>Excess liver fat (LF) is associated with low cardiorespiratory fitness (CRF), low physical activity and a deteriorated cardiometabolic health profile including increased visceral adipose tissue (VAT). Whether the association between LF and CRF is mediated by visceral adiposity is unknown. We studied the contribution of VAT to the relationship between CRF and LF in asymptomatic adults. The sample included 320 participants (43% women) who underwent LF quantification by magnetic resonance spectroscopy. VAT was measured by magnetic resonance imaging, CRF using maximal cardiorespiratory exercise testing, and moderate-to-vigorous intensity physical activity (MVPA) using a 3-day journal. Mean age was 50.3±8.6 years, waist circumference was 89.3±11.4 cm, and LF content was 4.3±5.7%. LF was inversely correlated with CRF (p<0.0001), MVPA (p<0.05) and cardiometabolic health score (p<0.0001), and positively related with VAT (p<0.0001) in both sexes. Higher levels of VAT (p<0.0001) and subcutaneous adipose tissue (p<0.0001) and a worsening cardiometabolic health score (p<0.05) and CRF (p=0.0001) were found across increasing sex-specific LF tertiles. Lower levels of LF (p<0.01), VAT (p<0.0001), a higher cardiometabolic health score (p<0.0001), and MVPA (p<0.05) were noted across increasing sex-specific CRF tertiles. Multivariable regression analyses showed that visceral adiposity explained the majority of the variance in LF in both sexes (p<0.0001). Finally, serial mediation analyses revealed that VAT but not body fat percentage was a mediator in the relationship between CRF and LF in both sexes. Thus, visceral adiposity appears to be an important mediator in the relationship between CRF and LF, even after controlling for total adiposity.</p>","PeriodicalId":93878,"journal":{"name":"Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144327993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Isotonic Resistance Exercise Outperforms Eccentric Quasi-Isometric Resistance Exercise for Increasing Elbow Flexor Muscle Thickness and Estimated One-Repetition Maximum in Untrained Individuals: Exploring the Influence of Sex and Volume. 在增加未训练个体肘关节屈肌厚度和估计单次重复最大值方面,等张阻力运动优于偏心准等距阻力运动:探索性别和容量的影响。
Zachariah Henderson, Shizhen Wang, Stephen Cornish, Trisha D Scribbans
{"title":"Isotonic Resistance Exercise Outperforms Eccentric Quasi-Isometric Resistance Exercise for Increasing Elbow Flexor Muscle Thickness and Estimated One-Repetition Maximum in Untrained Individuals: Exploring the Influence of Sex and Volume.","authors":"Zachariah Henderson, Shizhen Wang, Stephen Cornish, Trisha D Scribbans","doi":"10.1139/apnm-2025-0039","DOIUrl":"https://doi.org/10.1139/apnm-2025-0039","url":null,"abstract":"<p><p>As a novel, low-velocity resistance exercise method, eccentric quasi-isometric resistance exercise (EQI-RE) results in greater time under tension than traditional isotonic resistance exercise (TRD-RE) and is surmised to increase muscle mass and strength. However, females may be more fatigue resistant than males when performing acute EQI-RE, which could lead to long-term differences in time under tension and resistance exercise volume. At present, studies have yet to compare muscle hypertrophy or strength improvements following TRD-RE and EQI-RE training, and whether sex-differences exist in these outcomes. Twenty-two (n = 13 females) untrained individuals completed ~8-weeks of effort matched unilateral TRD-RE and EQI-RE of the elbow flexors. Muscle thickness and estimated one-repetition maximum (E-1RM) were evaluated before and after training. TRD-RE produced significantly larger relative increases in muscle thickness (6.7% ± 3.9% vs. 4.0 ± 3.3%, p =.004) and E-1RM (19.6 ± 8.5% vs. 12.8 ± 6.2%, p = .001) than EQI-RE. Although females accrued greater resistance exercise volume than males across the TRD-RE and EQI-RE training, there were no relative sex-differences in muscle thickness or E-1RM improvements (p > .25). Sex-differences in fatiguability may therefore manifest in differences in resistance exercise volume between males and females after 8-weeks of TRD-RE and EQI-RE of the elbow flexors, but this does not lead to relative differences in muscle thickness or E-1RM improvements. Although EQI-RE did produce significant increases, TRD-RE of the elbow flexors appears more effective at increasing muscle thickness and E-1RM.</p>","PeriodicalId":93878,"journal":{"name":"Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144289773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Type 2 Diabetes Duration and Irisin Response after an Aerobic Exercise Intervention: Results from the INTENSITY Study. 2型糖尿病 持续时间和有氧运动干预后鸢尾素反应:来自强度研究的结果。
Amy M Thomson, Yadab Paudel, Brittany V Rioux, Travis J Hrubeniuk, Martin Sénéchal
{"title":"Type 2 Diabetes Duration and Irisin Response after an Aerobic Exercise Intervention: Results from the INTENSITY Study.","authors":"Amy M Thomson, Yadab Paudel, Brittany V Rioux, Travis J Hrubeniuk, Martin Sénéchal","doi":"10.1139/apnm-2024-0533","DOIUrl":"https://doi.org/10.1139/apnm-2024-0533","url":null,"abstract":"<p><p>Irisin, an adipo-myokine, is positively associated with cardiorespiratory fitness and negatively associated with type 2 diabetes mellitus (T2DM). However, it is unclear if individuals with longer or shorter durations of T2DM express the same irisin levels following exercise. The objective of this study is to investigate the impact of 28 weeks of moderate-to-vigorous intensity aerobic exercise on irisin levels in individuals with short- and long-duration T2DM.  This secondary analysis included participants (n=34) aged ≥19 years old with T2DM who completed 28 weeks of aerobic exercise training for 150 minutes per week at a moderate-to-vigorous intensity - 16 weeks at a moderate intensity (4.5 metabolic equivalents of tasks (METs)) and then randomized to 12 weeks of maintained-intensity (4.5 METs) or increased-intensity (6.0 METs) aerobic exercise. Participants were categorized into two groups: 1) short-duration T2DM (<10 years) or 2) long-duration T2DM (≥10 years). Irisin was analyzed using enzyme-linked immunosorbent assay and western blotting techniques. All measurements were performed at baseline, 16 weeks, and 28 weeks. A significant time x T2DM duration group interaction (F(2)=8.062, p<0.01) was observed with 28 weeks of moderate-to-vigorous intensity aerobic exercise. Western blot analysis revealed a 1.37-fold increase in plasma irisin expression (p=0.03) in the long-duration increased-intensity group and no change in irisin expression (p>0.05) in the maintained-intensity groups of short- and long-duration. The results of this analysis suggest that 28 weeks of moderate-to-vigorous intensity aerobic exercise differently impacted plasma irisin in individuals with short- or long-duration T2DM.</p>","PeriodicalId":93878,"journal":{"name":"Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144210464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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