IF 2
Jessica A Dickenson, Mathew I B Debenham, Brian H Dalton, Taylor S Harman, Ajaya J Kunwar, Nilam Thakur, Sunil Dhungel, Nima Sherpa, Abigail W Bigham, Tom D Brutsaert, Trevor A Day, Nicholas D J Strzalkowski
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引用次数: 0

摘要

缺氧影响姿势控制和前庭功能。然而,在高海拔站立平衡的前庭控制知之甚少。利用前庭电刺激和中外侧力之间的累积密度和相干性(0-5 Hz和5-10 Hz)对前庭诱发平衡反应进行量化。在±2mA刺激下,两组前庭平衡反应峰间幅值在高海拔处较低海拔处下降(P=0.003)。在±4mA的刺激下,只有低地人在高海拔地区表现出峰对峰幅度的降低(P=0.046)。对于频域结果,在±2mA刺激下,低地人在高海拔地区表现出比低海拔地区更小的0- 5hz相干区(P=0。在±4mA刺激下,两组脑内相干区无明显差异。这些发现表明,尽管低地人和高地人的前庭平衡控制在高海拔地区变得迟钝,但低地人的海拔效应更大。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Vestibular-evoked balance responses are blunted in lowlanders and Tibetan highlanders with ascent to 4,300 m.

Hypoxia influences postural control and vestibular function. However, the vestibular control of standing balance at high altitude is poorly understood. Furthermore, Tibetan highlanders are physiologically adapted to high-altitude, but it is unclear if vestibular-driven signals for balance within this population acclimate differently than lowlanders with ascent. This study investigated vestibular-evoked balance responses in unacclimatized lowlanders and Tibetan highlanders at low altitude (1,400m) and after six- or seven-days of incremental ascent to high altitude (4,300m). Twenty-eight participants (15 lowlanders, 8F, 7M; 13 Tibetan highlanders, 7F, 6M) stood on a force plate facing forward with their eyes closed and underwent 90-second stochastic electrical vestibular stimulation trials at a peak-to-peak amplitude of ±2 or ±4 mA. Vestibular-evoked balance responses were quantified using cumulant density and coherence (0-5 Hz and 5-10 Hz) between electrical vestibular stimulation and mediolateral forces. With ±2mA stimulation, the peak-to-peak amplitude of vestibular-evoked balance responses decreased at high compared to low altitude for both groups (P=0.003). With ±4mA stimulation, only lowlanders showed a reduction in peak-to-peak amplitude at high altitude (P=0.03), and their responses were smaller than Tibetan highlanders at high altitude (P=0.046). For frequency-domain outcomes, lowlanders exhibited a smaller 0-5 Hz coherence area at high compared to low altitude with ±2mA stimulation (P=0.002), whereas Tibetan highlanders showed no change. No differences in coherence area were observed in either group with ±4mA stimulation. These findings indicate that while the vestibular control of balance is blunted at high altitude for lowlanders and highlanders, the altitude effect is greater in lowlanders.

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