Larissa Schlösser, Fernando K Borszcz, Laís Smeha, Natália M Peres, Thalita I Assumpção, Vivian M Burin, Edson L da Silva, Ricardo D de Lucas, Fernanda Hansen
{"title":"No effect of grape juice on exercise-induced muscle damage or performance in male runners: a randomized, placebo-controlled, triple-blind clinical trial.","authors":"Larissa Schlösser, Fernando K Borszcz, Laís Smeha, Natália M Peres, Thalita I Assumpção, Vivian M Burin, Edson L da Silva, Ricardo D de Lucas, Fernanda Hansen","doi":"10.1139/apnm-2024-0300","DOIUrl":"10.1139/apnm-2024-0300","url":null,"abstract":"<p><p>This study aimed to verify the effect of grape juice (<i>Vitis Labrusca</i>) intake on exercise-induced muscle damage (EIMD) and exercise performance parameters (5 km running time-trial (TT), running economy, and countermovement jump (CMJ)). Twenty trained male runners were randomized into two blinded groups and consumed either placebo (<i>n</i> = 9) or grape juice (<i>n</i> = 11) for six consecutive days (600 mL/day). On the fourth day, the participants performed a downhill running (-15%) at speed that elicited 70% V̇O<sub>2</sub>max for 20 min, to induce muscle damage, followed by assessment of running economy, 5 km TT, and CMJ tests. Blood samples were obtained before and after the exercise tests for quantifying total phenols, creatine kinase (CK), aspartate aminotransferase (AST), and lactate dehydrogenase (LDH). On the sixth day, blood parameters and CMJ were evaluated. A two-way Analysis of covariance (ANCOVA) mixed model was employed for data analysis, the effects were the juice groups, measurement and a interaction between the factors. EIMD was confirmed by increased levels of indirect markers (serum AST and LDH activities) and an impairment in TT and CMJ performances after 48 h. The 5 km TT, economy, and CMJ were compromised after EIMD, to a similar extent in the groups. Blood concentrations of CK, LDH, AST, and total phenolic compounds presented similar time course behavior between the groups, showing no group × time interaction effects. In conclusion, grape juice consumption over 6 days did not attenuate EIMD markers or the impairment in running performance in trained male runners. (ReBEC number: RBR-9jkkvbb).</p>","PeriodicalId":93878,"journal":{"name":"Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme","volume":" ","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142633400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Campbell Menzies, Neil D Clarke, Christopher J A Pugh, Charles J Steward, C Douglas Thake, Tom Cullen
{"title":"Passive heating in sport: context-specific benefits, detriments, and considerations.","authors":"Campbell Menzies, Neil D Clarke, Christopher J A Pugh, Charles J Steward, C Douglas Thake, Tom Cullen","doi":"10.1139/apnm-2024-0381","DOIUrl":"10.1139/apnm-2024-0381","url":null,"abstract":"<p><p>Exercise and passive heating share some acute physiological responses. These include increases in body temperature, sweat rate, blood flow, heart rate, and redistribution of plasma and blood volume. These responses can vary depending on the heating modality or dose (e.g., temperature, duration, body coverage) and are beneficial to athletes in specific scenarios. These scenarios include being applied to increase muscle or force production, induce rapid weight loss, stimulate thermoregulatory or cardiovascular adaptation, or to accelerate recovery. The rationale being to tailor the specific passive heating protocol to target the desired physiological response. However, some acute responses to passive heating may also be detrimental to sporting outcomes, such as exercising in the heat, having unintended residual negative effects on performance or perceptions of fatigue, or even resulting in hospitalisation if implemented inappropriately. Accordingly, the effects of passive heating should be carefully considered prior to implementation by athletes, coaches, and support staff. Therefore, the purpose of this review is to evaluate the physiological responses to different modes and doses of passive heating and explore the various sport contexts where these effects may either benefit or hinder athletes. Understanding these responses can aid the implementation of passive heating in sport and identify potential recommended heating protocols in each given scenario.</p>","PeriodicalId":93878,"journal":{"name":"Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme","volume":" ","pages":"1-15"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142981001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Stretching, isometrics, and aerobic exercise for decreasing blood pressure post-exercise: a randomized crossover study.","authors":"Charlie Keller, Philip D Chilibeck","doi":"10.1139/apnm-2024-0439","DOIUrl":"10.1139/apnm-2024-0439","url":null,"abstract":"<p><p>We compared stretching, isometrics, and aerobic exercise for effectiveness in decreasing blood pressure post-exercise. Using a randomized crossover design, 5 males and 4 females (21.3 years; normotensive) participated in four 30 min sessions on separate days: static stretching (30 s stretches, major muscle groups), isometric exercise, aerobic cycling (75% VO<sub>2</sub>peak), and control (rest), with blood pressure and heart rate measured before exercise (or rest) and for 60 min post-exercise (or rest). Aerobic exercise and stretching decreased post-exercise systolic blood pressure (∼10 mmHg each) (<i>p</i> < 0.05), whereas isometric exercise and the control condition did not significantly decrease post-exercise blood pressure. Stretching is similar to aerobic exercise for reducing blood pressure post-exercise. ClinicalTrials.gov Identifier: NCT06628635.</p>","PeriodicalId":93878,"journal":{"name":"Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme","volume":" ","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Danja J Den Hartogh, Rebecca E K MacPherson, Evangelia Tsiani
{"title":"Muscle cell palmitate-induced insulin resistance, JNK, IKK/NF-κB, and STAT3 activation are attenuated by carnosic and rosmarinic acid.","authors":"Danja J Den Hartogh, Rebecca E K MacPherson, Evangelia Tsiani","doi":"10.1139/apnm-2024-0302","DOIUrl":"10.1139/apnm-2024-0302","url":null,"abstract":"<p><p>The worldwide epidemic of obesity has drastically worsened with the increase in more sedentary lifestyles and increased consumption of fatty foods. Increased blood free fatty acids, often observed in obesity, lead to impaired insulin action, and promote the development of insulin resistance and type 2 diabetes mellitus. c-Jun N-terminal kinase (JNK), inhibitor of kappa B (IκB) kinase (IKK)-nuclear factor-kappa B (NF-κB), and signal transducer and activator of transcription 3 (STAT3) are known to be involved in skeletal muscle insulin resistance. We reported previously that carnosic acid (CA) and rosmarinic acid (RA) attenuated the palmitate-induced skeletal muscle insulin resistance, an effect that was associated with increased AMPK activation and reduced mammalian target of rapamycin-p70S6K signaling. In the present study, we examined the effects of CA and RA on JNK, IKK-NF-κB, and STAT3. Exposure of cells to palmitate increased the phosphorylation/activation of JNK, IKKα/β, IκBα, NF-κBp65, and STAT3. Importantly, CA and RA attenuated the deleterious effects of palmitate. Our data indicate that CA and RA have the potential to counteract the palmitate-induced skeletal muscle cell insulin resistance by modulating JNK, IKK-NF-κB, and STAT3 signaling.</p>","PeriodicalId":93878,"journal":{"name":"Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme","volume":" ","pages":"1-14"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142981000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Emily R Ziraldo, Hayun Jeong, Annette Blais, Mavra Ahmed, Momiji Uji, Yahan Yang, Vasanti S Malik, Daniel W Sellen, Mary R L'Abbé
{"title":"Grocery and chain restaurant foods and beverages allowed for sale in Ontario schools: an evaluation against Ontario's School Food and Beverage Policy.","authors":"Emily R Ziraldo, Hayun Jeong, Annette Blais, Mavra Ahmed, Momiji Uji, Yahan Yang, Vasanti S Malik, Daniel W Sellen, Mary R L'Abbé","doi":"10.1139/apnm-2024-0495","DOIUrl":"10.1139/apnm-2024-0495","url":null,"abstract":"<p><p>The Ontario School Food and Beverage policy, also known as Policy/Program Memorandum 150 (PPM150), was established in 2010 to promote healthier food choices among children by setting nutrition standards for foods and beverages sold in publicly funded elementary and secondary schools. Schools face barriers to complying with the PPM150 nutrition standards including a lack of human resources, technical tools, and financial means. Therefore, to support school food providers in sourcing foods that meet the nutrition standards in PPM150, this cross-sectional study assessed the alignment of foods and beverages from grocery stores and menu offerings from chain restaurants with the PPM150 nutrition standards. We compared nutrition data for foods and beverages available at grocery stores and menu items available at chain restaurants from the Food Label Information and Price (FLIP) 2020 (<i>n</i> = 35 103) and Menu-FLIP 2020 (<i>n</i> = 18 649) databases, respectively, against the PPM150 nutrition standards. Half of foods from grocery stores (51%) and most from chain restaurants (85%) did not meet PPM150 standards and are not permitted for sale. For beverages, 91% from grocery stores and 98% from chain restaurants are not permitted at elementary schools. At secondary schools, 56% of beverages from grocery stores and 94% from restaurants are not permitted. Findings suggest few foods, beverages and chain restaurant menu items meet the PPM150 nutrition standards, potentially posing an additional barrier for Ontario schools to procure and offer healthy foods to students.</p>","PeriodicalId":93878,"journal":{"name":"Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme","volume":" ","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Saniya Rodrigues, Fergus K O'Connor, Norman R Morris, Georgia K Chaseling, Surendran Sabapathy, Aaron J E Bach
{"title":"Passive heat therapy for cardiovascular disease: current evidence and future directions.","authors":"Saniya Rodrigues, Fergus K O'Connor, Norman R Morris, Georgia K Chaseling, Surendran Sabapathy, Aaron J E Bach","doi":"10.1139/apnm-2024-0406","DOIUrl":"10.1139/apnm-2024-0406","url":null,"abstract":"<p><p>Passive heat therapy is gaining popularity as an intervention to promote cardiovascular, physiological, and, to a lesser degree, thermoregulatory adaptations in patients with cardiovascular disease. Despite this, the efficacy of heat therapy to elicit these adaptations remains unknown. We searched five databases for original research, screening 2913 studies and identifying 18 eligible studies. Heat therapies included Waon therapy, balneotherapy, water perfused trousers, Finnish sauna, and foot immersion. Interventions were administered across various time frames (20-90 min) and performed 3-7 times per week, for durations of 2-8 weeks. The studies collectively involved a diverse population (mean age: 67 (10) years) with cardiovascular diseases. Heat therapy was consistently shown to improve ejection fraction, flow-mediated dilation, brain natriuretic peptide levels, New York Heart Association classification, and 6 min walk distance. However, positive effects on resting heart rate and blood pressure were infrequently observed, and thermoregulatory responses scarcely reported. Heat therapy may increase sweat rate during heat exposure and reduce resting core temperature, but adaptive skin blood flow responses were not observed. Passive heat therapy shows promising utility in patients with cardiovascular disease, while secondary benefits such as markers of thermoregulatory adaptation may also be observed, these require further investigation.</p>","PeriodicalId":93878,"journal":{"name":"Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme","volume":" ","pages":"1-14"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143018113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yujiro Yamada, William B Hammert, Ryo Kataoka, Jun Seob Song, Anna Kang, Witalo Kassiano, Jeremy P Loenneke
{"title":"The role of the muscle metaboreflex on cardiovascular responses to submaximal resistance exercise with different pressures and modes of blood flow restriction.","authors":"Yujiro Yamada, William B Hammert, Ryo Kataoka, Jun Seob Song, Anna Kang, Witalo Kassiano, Jeremy P Loenneke","doi":"10.1139/apnm-2024-0383","DOIUrl":"10.1139/apnm-2024-0383","url":null,"abstract":"<p><p>This study investigated the role of the muscle metaboreflex on cardiovascular responses to submaximal resistance exercise using different pressures and modes of blood flow restriction. Fifty-three adults completed six visits. The first visit involved a performance test (two sets of unilateral knee extension exercise until task failure at 30% 1RM) with continuous blood flow restriction (80% arterial occlusion pressure). In subsequent visits, participants performed (1) a nonexercise control (Control), 70% of the repetitions completed in the performance test with the cuff inflated to (2) continuously 80% arterial occlusion (LL + 80%), (3) continuously 40% arterial occlusion (LL + 40%), (4) intermittently 80% arterial occlusion during exercise (LL + 80%Int), and (5) 0 mmHg (LL), in a randomized order. Three minutes of post-exercise circulatory occlusion was employed to assess the muscle metaboreflex activation. Blood pressure and heart rate were measured at various time points. The pre-post increase in systolic blood pressure was not greater with LL + 80%Int (<i>p</i> = 0.987) but was greater with LL + 80% and LL + 40% (LL + 80% > LL + 40%, <i>p</i> = 0.005) than LL by 7 [95%CI: 4, 9] and 4 [95%CI; 2, 6] mmHg, respectively. Heart rate increased only with LL + 80% over LL and Control (<i>p</i> < 0.001). The changes in systolic blood pressure (<i>p</i> > 0.468) and heart rate (<i>p</i> > 0.543) did not differ among exercise conditions from immediate post-exercise to the end of the circulatory occlusion. Systolic/diastolic blood pressure returned to a similar level as Control (∼120, ∼70 mmHg, respectively) immediately after the cuff deflation. Continuous blood flow restriction, especially with higher pressure, accentuates muscle metaboreflex activation, resulting in amplified cardiovascular responses to the exercise.</p>","PeriodicalId":93878,"journal":{"name":"Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme","volume":" ","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143124214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The effects of morning versus evening high-intensity interval exercise on the magnitude of the morning blood pressure surge.","authors":"Julian C Bommarito, Philip J Millar","doi":"10.1139/apnm-2024-0449","DOIUrl":"10.1139/apnm-2024-0449","url":null,"abstract":"<p><p>Blood pressure (BP) follows a circadian rhythm, dipping during sleep and surging in the morning. A larger morning BP surge is an independent predictor of cardiovascular events. Acute exercise can produce sustained periods of post-exercise hypotension that last up to 24 h; however, the timing of exercise (morning vs. evening) may influence this response. Whether the timing of exercise influences the morning BP surge remains unknown. The current study investigated the effects of a bout of high-intensity interval exercise (HIIE) performed in the morning versus evening on the magnitude of the morning BP surge in young healthy adults. Twenty-six young, otherwise healthy adults (23 ± 4 years; 15 females) completed a randomized crossover trial where, on different days, they completed a no exercise control visit or performed either morning (0800-1000 h) or evening (1700-1900 h) HIIE. Following each visit, ambulatory BP was assessed in 30 min intervals for 24 hrs. HIIE at either time did not alter the magnitude of the morning BP surge compared to control values (control: 22 ± 5 mmHg; morning exercise: 20 ± 8 mmHg; evening exercise: 22 ± 10 mmHg, <i>P</i> = 0.40) or when grouped separately by sex (visit × sex <i>P</i> = 0.42). A positive correlation existed between Morningness-Eveningness Questionnaire score and the change in nighttime BP following both exercise times (both <i>r</i> = 0.42 and <i>P</i> = 0.04). These findings suggest that HIIE does not attenuate the morning BP surge in young healthy adults and that chronotype can predict nighttime BP responses following HIIE, irrespective of exercise time of day. This study was registered on ClinicalTrials.gov (NCT06702930).</p>","PeriodicalId":93878,"journal":{"name":"Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme","volume":" ","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Derek P D Bornath, Seth F McCarthy, Jessica A L Tucker, Tamara R Cohen, Philip J Medeiros, Tom J Hazell
{"title":"Are post-exercise plasma glucose elevations involved in exercise-induced appetite suppression?","authors":"Derek P D Bornath, Seth F McCarthy, Jessica A L Tucker, Tamara R Cohen, Philip J Medeiros, Tom J Hazell","doi":"10.1139/apnm-2024-0331","DOIUrl":"10.1139/apnm-2024-0331","url":null,"abstract":"<p><p>Changes in glucose and insulin are potentially involved in the appetite-regulatory effects of exercise considering their role post-prandially. The purpose of this study was to examine whether glucose and insulin play a role in post-exercise appetite regulation. Twelve participants (<i>M</i> = 8; 26 ± 5 years) completed 3 experimental sessions in a systematically rotated randomized crossover design: (1) no-exercise control (CTRL); (2) moderate-intensity continuous training (MICT; 30 min, 70% maximal oxygen consumption (V̇O<sub>2max</sub>)); and (3) sprint interval training (SIT; 4 × 30 s \"all-out\" sprints, interspersed with 4 min rest). Plasma glucose, insulin, acylated ghrelin, active peptide tyrosine tyrosine (PYY), active glucagon-like peptide-1 (GLP-1), and overall appetite perceptions were measured pre-exercise, 0, 30, 60, and 120 min post-exercise. Energy intake was recorded the day before, of, and after experimental sessions. Glucose was elevated 0 min post-exercise (<i>p</i> < 0.097, <i>d</i> > 0.52) compared to CTRL with no differences between exercise bouts. Acylated ghrelin was suppressed by MICT (60, 120 min) and SIT (0, 30, 60, 120 min; <i>p</i> < 0.080, <i>d</i> > 0.56) compared to CTRL, while also suppressed in SIT compared to MICT at 30, 60, 120 min (<i>p</i> < 0.026, <i>d</i> > 0.74). GLP-1 was elevated following MICT (0, 30, and 60 min) and SIT (60 min; <i>p</i> < 0.094, <i>d</i> > 0.53) compared to CTRL and following MICT compared to SIT (0 min; <i>p</i> = 0.005, <i>d</i> = 1.03). Overall appetite was suppressed by SIT post-exercise (<i>p</i> < 0.058, <i>d</i> > 0.61) compared to CTRL and MICT, and by MICT 0 min post-exercise compared to CTRL (<i>p</i> = 0.036, <i>d</i> = 0.71). There were no exercise effects on insulin, PYY, or free-living energy intake (<i>p</i> > 0.217, η<sub>p</sub> <sup>2 </sup>< 0.130). Glucose and insulin do not appear to play a role in exercise-induced appetite suppression.</p>","PeriodicalId":93878,"journal":{"name":"Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme","volume":" ","pages":"1-16"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143473261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Retraction: Magnesium-zinc-calcium-vitamin D co-supplementation improves glycemic control and markers of cardiometabolic risk in gestational diabetes: a randomized, double-blind, placebo-controlled trial.","authors":"","doi":"10.1139/apnm-2025-0087","DOIUrl":"https://doi.org/10.1139/apnm-2025-0087","url":null,"abstract":"","PeriodicalId":93878,"journal":{"name":"Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme","volume":"50 ","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143766043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}