Cassidy Klein, Jess Gibson, Hayley N Pettigrew, Derek S Kimmerly, Shaun G Boe
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Session 2: Participants completed a moderate-intensity exercise session (20-min of cycling at 60% peak power output). Measures of CSE obtained from the first dorsal interosseous (FDI) muscle were assessed via transcranial magnetic stimulation before, immediately after, and 10-min following the exercise session. Lactate was obtained via blood sample at these same timepoints. RESULTS Linear regression demonstrated that lactate concentration did not predict an exercise-induced change in CSE immediately following exercise (R2 = 0.02184, F(1, 22) = 0.4913, p = 0.4907) or 10-min post-exercise (R2 = 0.02121 F(1, 22) = 0.4767, p = 0.4971). CONCLUSION These results suggest that lactate is not the primary mechanism behind alterations in CSE driven by moderate-intensity exercise.</p>","PeriodicalId":93878,"journal":{"name":"Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme","volume":" ","pages":""},"PeriodicalIF":2.0000,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Moderate-intensity exercise-induced changes in lactate do not predict changes in corticospinal excitability.\",\"authors\":\"Cassidy Klein, Jess Gibson, Hayley N Pettigrew, Derek S Kimmerly, Shaun G Boe\",\"doi\":\"10.1139/apnm-2025-0146\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>INTRODUCTION/PURPOSE Aerobic exercise increases corticospinal excitability (CSE), creating an optimal environment for learning to occur. It has been hypothesized that this may be a result of lactate accumulation in the blood during exercise. However, while prior literature has linked moderate-intensity exercise with enhanced CSE, previous lactate-based work has mainly used maximal or fatiguing exercise. To date, the effect of lactate concentration on CSE during steady-state moderate-intensity exercise has not been investigated. METHODS Twenty-four participants (13F, mean age 23.7 ± 2.7) attended two separate study sessions. Session 1: Participants completed a maximal graded exercise test on a cycle ergometer. Session 2: Participants completed a moderate-intensity exercise session (20-min of cycling at 60% peak power output). Measures of CSE obtained from the first dorsal interosseous (FDI) muscle were assessed via transcranial magnetic stimulation before, immediately after, and 10-min following the exercise session. Lactate was obtained via blood sample at these same timepoints. RESULTS Linear regression demonstrated that lactate concentration did not predict an exercise-induced change in CSE immediately following exercise (R2 = 0.02184, F(1, 22) = 0.4913, p = 0.4907) or 10-min post-exercise (R2 = 0.02121 F(1, 22) = 0.4767, p = 0.4971). CONCLUSION These results suggest that lactate is not the primary mechanism behind alterations in CSE driven by moderate-intensity exercise.</p>\",\"PeriodicalId\":93878,\"journal\":{\"name\":\"Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2025-09-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1139/apnm-2025-0146\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1139/apnm-2025-0146","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
有氧运动增加皮质脊髓兴奋性(CSE),为学习创造最佳环境。据推测,这可能是运动时血液中乳酸积累的结果。然而,虽然先前的文献将中等强度的运动与增强CSE联系起来,但先前基于乳酸的工作主要使用最大或疲劳运动。到目前为止,乳酸浓度对中等强度稳态运动中CSE的影响还没有研究。方法24名参与者(13F,平均年龄23.7±2.7)参加两个独立的研究。第一阶段:参与者在自行车测力仪上完成了最大强度运动测试。第二阶段:参与者完成了中等强度的锻炼(以60%的峰值功率输出骑车20分钟)。在运动前、运动后和运动后10分钟,通过经颅磁刺激评估第一背骨间肌(FDI)的CSE测量。在这些时间点通过血液样本获得乳酸。结果线性回归显示,乳酸浓度不能预测运动后立即(R2 = 0.02184, F(1,22) = 0.4913, p = 0.4907)或运动后10分钟(R2 = 0.02121, F(1,22) = 0.4767, p = 0.4971)引起的CSE变化。结论:这些结果表明乳酸不是中等强度运动导致CSE改变的主要机制。
Moderate-intensity exercise-induced changes in lactate do not predict changes in corticospinal excitability.
INTRODUCTION/PURPOSE Aerobic exercise increases corticospinal excitability (CSE), creating an optimal environment for learning to occur. It has been hypothesized that this may be a result of lactate accumulation in the blood during exercise. However, while prior literature has linked moderate-intensity exercise with enhanced CSE, previous lactate-based work has mainly used maximal or fatiguing exercise. To date, the effect of lactate concentration on CSE during steady-state moderate-intensity exercise has not been investigated. METHODS Twenty-four participants (13F, mean age 23.7 ± 2.7) attended two separate study sessions. Session 1: Participants completed a maximal graded exercise test on a cycle ergometer. Session 2: Participants completed a moderate-intensity exercise session (20-min of cycling at 60% peak power output). Measures of CSE obtained from the first dorsal interosseous (FDI) muscle were assessed via transcranial magnetic stimulation before, immediately after, and 10-min following the exercise session. Lactate was obtained via blood sample at these same timepoints. RESULTS Linear regression demonstrated that lactate concentration did not predict an exercise-induced change in CSE immediately following exercise (R2 = 0.02184, F(1, 22) = 0.4913, p = 0.4907) or 10-min post-exercise (R2 = 0.02121 F(1, 22) = 0.4767, p = 0.4971). CONCLUSION These results suggest that lactate is not the primary mechanism behind alterations in CSE driven by moderate-intensity exercise.