Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme最新文献

{"title":"The effect of consuming a sucrose-containing sports drink on acute kidney injury risk during a 4 h simulated occupational heat stress.","authors":"Maxime Jeanovitch Lignier, Hayden W Hess, Jessica A Freemas, Blair D Johnson, David Hostler, Zachary J Schlader","doi":"10.1139/apnm-2024-0261","DOIUrl":"10.1139/apnm-2024-0261","url":null,"abstract":"<p><p>Occupational heat stress increases acute kidney injury risk. Drinking a soft drink sweetened with high fructose corn syrup further elevates this acute kidney injury risk. However, the impact of sucrose, another fructose-containing sweetener, on acute kidney injury risk remains unexplored. We tested the hypothesis that drinking a sucrose-containing sports drink increases acute kidney injury risk when compared to drinking a sugar-free sports drink during 4 h of simulated occupational heat stress. Ten healthy adults consumed a sucrose-containing or sugar-free sport drink ad libitum during 4 h exposures to wet bulb globe temperatures of ∼28 °C. Thirty min of work and 30 min of rest were completed each hour. Work involved treadmill walking at a fixed rate of metabolic heat production (sucrose-containing: 6.0 ± 1.2 W/kg, sugar-free: 5.5 ± 0.9 W/kg, <i>p</i> = 0.267). The product of urinary insulin-like growth factor-binding protein 7 and tissue inhibitor of metalloproteinase-2, normalized to urine specific gravity ([IGFBP7·TIMP-2]_USG), provided an acute kidney injury risk index. Mean core (intestinal: <i>n</i> = 13, rectal: <i>n</i> = 7) temperature (sucrose-containing: 37.5 ± 0.1 °C, sugar-free: 37.5 ± 0.3 °C; <i>p</i> = 0.914), peak core temperature (sucrose-containing: 37.8 ± 0.2 °C, sugar-free: 37.9 ± 0.3 °C; <i>p</i> = 0.398), and percent changes in body mass (sucrose-containing: -0.5 ± 0.4%, sugar-free: -0.3 ± 0.6%; <i>p</i> = 0.386) did not differ between groups. [IGFBP7∙TIMP-2]_USG increased in both groups (time effect: <i>p</i> = 0.025) with no drink (<i>p</i> = 0.675) or interaction (<i>p</i> = 0.715) effects. Peak change [IGFBP7∙TIMP-2]_USG did not differ between sucrose-containing (median 0.0116 [-0.0012, 0.1760] (ng/mL)²/1000) and sugar-free (median 0.0021 [0.0003, 0.2077] (ng/mL)²/1000; <i>p</i> = 0.796). Sucrose-containing sports drink consumption during simulated occupational heat stress does not modify acute kidney injury risk when compared to sugar free-sport drink consumption.</p>","PeriodicalId":93878,"journal":{"name":"Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme","volume":" ","pages":"1-12"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142482826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute high-intensity exercise enhances T cell proliferation compared to moderate-intensity exercise.","authors":"Jacob A Siedlik, Jake A Deckert, Amanda J Dunbar, Anuja Bhatta, Nicole M Gigliotti, Marcia A Chan, Stephen H Benedict, Matthew Bubak, John P Vardiman, Philip M Gallagher","doi":"10.1139/apnm-2024-0420","DOIUrl":"10.1139/apnm-2024-0420","url":null,"abstract":"<p><p>Conventional belief is that high-intensity (HI) exercise inhibits immune function; however, recent work challenges this position. The purpose of this was to quantify changes in T cell proliferative capacity following either a HI or moderate-intensity (MI) exercise. Sixteen males were randomly selected to a HI or MI exercise group. Blood was obtained baseline and immediately, 1, 4, and 6 h post-exercise for analyses of CD3⁺ T cell proliferation (co-stimulation via phytohaemagglutinin or CD3 + CD28). The proliferative response increased in T cells in the HI group and remained significantly elevated up to 6 h post-exercise in both co-stimulation conditions. In contrast, the MI group saw no change proliferative ability following exercise. Analyses of serum stress hormones, and immunomodulatory cytokines failed to reveal any correlated variations that could clarify the T cell findings. We suggest the increase in proliferative capacity following HI exercise is indicative of an exercise-induced activation that provides for enhanced functional responses to stimuli. Moreover, this study shows that HI exercise increases T cell processes, effectively priming them for activation in response to stimuli. This study is registered with ClinicalTrials.gov (NCT06638684).</p>","PeriodicalId":93878,"journal":{"name":"Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme","volume":" ","pages":"1-12"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143416583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiometabolic health, socioeconomic status, and 2019 Canada's Food Guide Food Choices Assessment Score: findings from the Canadian Health Measures Survey.","authors":"Samer Hamamji, Daniel Zaltz, Mary L'Abbé","doi":"10.1139/apnm-2024-0357","DOIUrl":"10.1139/apnm-2024-0357","url":null,"abstract":"<p><p>Suboptimal diets are linked to higher cardiometabolic risks and influenced by socioeconomic status. In 2019, Health Canada released an updated Canda's Food Guide (CFG) supported with Canada's Dietary Guidelines (CDG) to help Canadians achieve healthy diet. This study aims to investigate the association between food choices assessed by a Food Choices Assessment Score (FCAS) according to 2019 CFG/CDG, and socioeconomic status and cardiometabolic risk factors among Canadian adults. Dietary choices of Canadian adults (<i>n</i> = 6352) from the food frequency questionnaire data of the Canadian Health Measures Survey cycles 5 and 6 (2016-2019) were used. Canadian adults with post-secondary education and high household income were associated with higher FCAS (+6.2; 95%CI 4.2, 8.2) and (+2.1; 95%CI 0.3, 3.8), respectively. Compared with the lowest quintile of the FCAS, Canadians in the highest quintile of the FCAS had lower odds of elevated BMI (0.63; 95%CI 0.44, 0.91), elevated WC (0.51; 95%CI 0.27, 0.97) in females but not in males, elevated systolic (0.69; 95%CI 0.48, 0.97), diastolic blood pressure (0.69; 95%CI 0.50, 0.96), TC (0.59; 95%CI 0.39, 0.89), non-HDL-C (0.51; 95%CI 0.31, 0.86), LDL-C (0.60; 95%CI 0.38, 0.95), Apo-B (0.62; 95%CI 0.39, 0.96), HbA1C (0.53; 95%CI 0.31, 0.93), FBG (0.62; 95%CI 0.4, 0.94), HOMA-IR (0.60; 95%CI 0.39, 0.91), and hs-CRP (0.59; 95%CI 0.36, 0.96). HDL-C and TG were not associated with FCAS. These analyses suggest strong associations between dietary choices, aligned with 2019 CFG/CDG as measured by the FCAS, and socioeconomic status and better cardiometabolic health among Canadian adults.</p>","PeriodicalId":93878,"journal":{"name":"Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme","volume":" ","pages":"1-12"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Professional development preferences and needs of healthcare providers working with older adults on exercise and nutrition: results of key informant interviews.","authors":"Christine M Mills, Lora Giangregario, Laura Middleton, Andrew D Robertson, Heather H Keller","doi":"10.1139/apnm-2024-0451","DOIUrl":"10.1139/apnm-2024-0451","url":null,"abstract":"<p><p>Most older adults want to age in place, and evidence-based health behaviours that support aging in place include healthy diets and physical activity. Healthcare professionals need training in the science and practice of nutrition and physical activity to support their older adult clients to age in place. In this study we investigated knowledge gaps among healthcare professionals and the organizations that employ them regarding exercise and nutrition for older adults. We also aimed to identify their perceptions of effective and ineffective continuing education approaches, how they choose continuing education opportunities, and what formats they prefer when engaging in continuing education. Using key informant interviews and an interpretive description approach, we identified four themes: \"<i>Being pragmatic about professional development</i>\", \"<i>Matching format to need</i>\", \"<i>Negotiating the tension between the convenience of online and the effectiveness of in-person learning</i>\", and \"<i>Focusing on practice is critical</i>\". Participants also identified current gaps in professional development offerings and desires for additional continuing education opportunities on certain topics, such as nutrition and aging, and dealing with multimorbidity. Participants indicated that continuing education offerings should reflect common health conditions that providers encounter in practice and that there should be a balance between online and in-person offerings. Participants also indicated that continuing education should focus on changing or improving practice, to assist healthcare providers in supporting older adults aging in place in their communities.</p>","PeriodicalId":93878,"journal":{"name":"Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme","volume":" ","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma and fecal bioactive mediators in relation to the prevention of atherogenesis in LDL-r-KO mice: insights from an African staple food.","authors":"Ramandeep Kaur, Rosemary Kobue-Lekalake, Kabo Masisi, Harold M Aukema, Mohammed H Moghadasian","doi":"10.1139/apnm-2024-0328","DOIUrl":"10.1139/apnm-2024-0328","url":null,"abstract":"<p><p>Our previous study revealed a significant anti-atherosclerotic effect of Kgengwe seed powder (KSP) in low-density lipoprotein receptor knockout (LDL-r-KO) mice. The importance of various lipid and protein metabolites, including certain amino acids and fatty acids on atherogenesis has been well established. Thus, we used plasma and fecal samples from our previous study to further study the association of such metabolites with atherosclerotic lesion development. Male LDL-r-KO mice were provided with an atherogenic diet supplemented with (treated, <i>n</i> = 10) or without (controls, <i>n</i> = 10) 10% (<i>w</i>/<i>w</i>) KSP for 20 weeks. The treated group showed significantly (<i>P</i> < 0.05) higher plasma levels of many amino acids plus propionic acid, indoleacetic acid, pyruvic acid, beta-hydroxybutyric acid, alpha-ketoglutaric acid, trimethylamine N-oxide, LYSOC16:0, LYSOC18:0, and LYSOC18:2, as compared with those of the control group. Similarly, several oxylipins, including 15-keto prostaglandin E₂, 9,10,13-trihydroxy-octadecenoic acid, 9,10-epoxy-octadecenoic acid, and 12,13-epoxy-octadecenoic acid increased by approximately 2.0 log₂ folds (<i>P</i> < 0.05) in the plasma of the treated group. Other oxylipins, including 15,16-epoxy-octadecadieonic acid, 13-hydroxy-octadecadienoic acid, and prostaglandin E₂ showed also an increased level, but to a lesser extent. Furthermore, our findings showed a significant positive correlation between plasma concentrations of prostaglandin E₂ and IL-10 in the treated mice. We also observed a significant negative association between atherosclerotic lesion size and plasma levels of citrulline, lysine, alpha-ketoglutaric acid, and 15,16 epoxy-octadecadienoic acid. Additional in vitro and in vivo studies are needed to explore the mechanisms of such associations.</p>","PeriodicalId":93878,"journal":{"name":"Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme","volume":" ","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143607214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tabata training in perspective.","authors":"Izumi Tabata","doi":"10.1139/apnm-2023-0506","DOIUrl":"10.1139/apnm-2023-0506","url":null,"abstract":"<p><p>Originally developed as a specific form of exhaustive intermittent training involving 6-8 × 20 s of supramaximal-intensity cycling exercises with 10 s of recovery for athletes, Tabata training has become universally recognized around the world. The purpose of this review article is to provide a perspective on Tabata training and discuss how this popular style of intermittent training has evolved and been applied over the last ∼30 years. The article will review the original motivation behind Tabata training with relevance to concepts such as maximal accumulated oxygen deficit and maximal oxygen uptake (V̇o₂max) and discuss how Tabata training has been adapted to involve sport-specific training and cross training. Studies of Tabata training on physiological responses and adaptations in muscle, blood vessels, bone, and brain across different populations will be reviewed. Finally, research on how Tabata-style training was applied to counteract inactivity during the COVID19 pandemic will be discussed. Evolving from the study of athletes, Tabata training represents an example of how high-intensity intermittent/interval training can be adapted and applied in various settings to enhance performance and health.</p>","PeriodicalId":93878,"journal":{"name":"Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme","volume":" ","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of daylong exposure to indoor overheating on enterocyte damage and inflammatory responses in older adults: a randomized crossover trial.","authors":"Ben J Lee, Robert D Meade, Sarah L Davey, Charles D Thake, James J McCormick, Kelli E King, Glen P Kenny","doi":"10.1139/apnm-2024-0368","DOIUrl":"10.1139/apnm-2024-0368","url":null,"abstract":"<p><p>We evaluated enterocyte damage (IFABP), immune activation (sCD14), and inflammatory responses (TNF-α, IL-6, CRP) in 16 older adults (66-78 years) during 8 h rest in conditions simulating homes maintained at 22 °C (control), the 26 °C indoor temperature upper limit proposed by health agencies, and homes without air-conditioning during heatwaves (31 °C, 36 °C). Relative to 22 °C, IFABP was elevated ∼181 pg/mL after exposure to 31 °C (<i>P</i> = 0.07), and by ∼378 pg/mL (<i>P</i> < 0.001) after exposure to 36 °C. No differences were observed for sCD14, TNF-α, IL-6, or CRP (all <i>P</i> ≥ 0.26). Our data support recommendations to maintain indoor temperatures ≤ 26 °C to preserve gastrointestinal barrier integrity in heat-vulnerable persons.</p>","PeriodicalId":93878,"journal":{"name":"Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme","volume":" ","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An exploration of physical literacy in masters athletes.","authors":"Garry McCracken, Elijah M K Haynes, Jennifer M Jakobi","doi":"10.1139/apnm-2024-0373","DOIUrl":"10.1139/apnm-2024-0373","url":null,"abstract":"<p><strong>Key concepts: </strong>Little is known about physical literacy in older adults. Master athletes are unaware of the construct of physical literacy but they intuitively engage in high levels of PA. Social connection should be considered an integral component of physical literacy for older adults.</p>","PeriodicalId":93878,"journal":{"name":"Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme","volume":" ","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143495018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feet-heating and calf-heating have opposing effects on glucose tolerance and heart rate variability: a randomized, controlled, crossover trial.","authors":"Gabriele Sanchez, Dena Prince, Shelby Glasser, Michael Buono, Jochen Kressler, Jeff M Moore","doi":"10.1139/apnm-2024-0265","DOIUrl":"10.1139/apnm-2024-0265","url":null,"abstract":"<p><p>Heat exposure's effect on glucose tolerance depends on the amount of body exposed, likely relating to autonomic nervous system balance. We assessed how partial-body heat exposure at two different levels of the lower extremities affects glucose tolerance and autonomic nervous system balance, measured via heart rate variability. We hypothesized feet-heating would improve glucose tolerance without affecting heart rate variability, while calf-heating would worsen glucose tolerance and decrease heart rate variability compared to a thermoneutral control condition. In a randomized, controlled, crossover trial, healthy participants' (<i>N</i> = 31, 23(3) years, 45% male) glucose tolerance was measured in (A) thermoneutral; (B) feet-heating; and (C) calf-heating conditions. Every 30 min for 2 h, blood glucose, heart rate, heart rate variability, tympanic temperature, thermal comfort scores, and blood pressure were measured. There were significant interactions between condition and time for blood glucose (<i>F</i> (4.6,72.6) = 2.6, <i>p</i> = 0.036), heart rate (<i>F</i> (3.4, 54.5) = 3.5, <i>p</i> = 0.017), heart rate variability (<i>F</i> (4.3,63.2) = 7.5, <i>p</i> < .0001), tympanic temperature (<i>F</i> (8, 268) = 2.4, <i>p</i> = 0.014), and thermal comfort scores (<i>F</i> (8, 248) = 22.1, <i>p</i> < 0.0001). Calf-heating increased 90 min glucose (+12 (95% confidence interval, CI: 3-21) mg/dL, <i>p</i> = 0.013) and decreased heart rate variability throughout (mean decrease: 13%-22%, <i>p</i> < 0.007), while feet-heating lowered 90 min glucose (-7 (95% CI: -16 to +1) mg/dL, <i>p</i> = 0.090) without affecting heart rate variability (<i>p</i> = 0.14-0.99). Blood pressure and body temperature were similar between conditions, but heart rate and thermal comfort scores increased with heating. Calf-heating worsens, while feet-heating may improve, glucose tolerance. Changes in heart rate variability coincided with changes in glucose tolerance despite unchanged body temperature. Whether heart rate variability can be used to monitor autonomic nervous system balance during heating to optimize its acute effect on glycemic indices should be further explored.</p>","PeriodicalId":93878,"journal":{"name":"Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme","volume":" ","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142376431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association of <i>SLC16A1</i> (<i>MCT1</i>) gene polymorphism with body composition changes during weight loss interventions: A randomized trial with sex-dependent analysis.","authors":"Rocío Cupeiro, Pedro J Benito, Teresa Amigo, Domingo González-Lamuño","doi":"10.1139/apnm-2024-0246","DOIUrl":"10.1139/apnm-2024-0246","url":null,"abstract":"<p><p>Monocarboxylates, transported by monocarboxylate transporters (MCTs), have been proposed to influence energy homeostasis and exhibit altered metabolism during exercise. This study investigated the association between the Asp490Glu (T1470A) (rs1049434) polymorphism of the <i>SLC16A1</i> (<i>MCT1</i>) gene and changes in body composition in males and females with overweight or obesity. The 173 participants (56.6% females) completed a 6-month randomized controlled trial, being assigned to the Supervised Exercise group (strength, endurance, or strength plus endurance training) or the Physical Activity (PA) Recommendations group. Participants were genotypically categorized as Asp/Asp (TT), Asp/Glu (TA), or Glu/Glu (AA). ANCOVA analysis showed main effects for genotype and interaction genotype × group (<i>p</i> < 0.05) for several variables, especially in females. Asp/Asp (TT) females showed greater reductions in total fat mass (-29.30 ± 8.75% change), percentage of body fat (-17.50 ± 8.06% change), and body weight (-13.90 ± 2.62% change) compared with Glu/Glu (AA) (<i>p</i> ≤ 0.020; <i>d</i> ≥ 0.18) and Asp/Glu (TA) (<i>p</i> ≤ 0.050; <i>d</i> ≥ 0.16) females, but only within the PA Recommendations group. Data indicated higher decreases in lean body mass of the Asp/Asp (TT) compared to Glu/Glu (AA) in females (<i>p</i> = 0.067, η² _p = 0.067) and to Asp/Glu (TA) in males (<i>p</i> = 0.026; η² _p = 0.101). Our investigation suggests an association of the single-nucleotide polymorphism with body composition changes especially in females following exercise recommendations, highlighting the importance of supervised training to offset genetic predisposition for different weight loss. Differences in males only appeared for lean body mass, suggesting sex differences for this genetic association. The study underscores the potential influence of MCT1 functionality on human adaptations to weight loss interventions. ClinicalTrials.gov information: registry name, Nutrition and Physical Activity for Obesity (PRONAF); registration number, NCT01116856.</p>","PeriodicalId":93878,"journal":{"name":"Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme","volume":" ","pages":"1-12"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142960227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}