长期暴露于室内过热对老年人肠细胞损伤和炎症反应的影响：一项随机交叉试验。

Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme Pub Date : 2025-01-01 DOI:10.1139/apnm-2024-0368

Ben J Lee, Robert D Meade, Sarah L Davey, Charles D Thake, James J McCormick, Kelli E King, Glen P Kenny

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引用次数: 0

摘要

我们评估了16名老年人（66-78岁）在8小时的休息条件下的肠细胞损伤（IFABP）、微生物易位（sCD14）和炎症反应（TNF-α、IL-6、CRP），这些条件分别是模拟22°C（对照）、卫生机构建议的26°C室内温度上限，以及在高温（31°C、36°C）没有空调的家庭。与22°C相比，31°C时IFABP升高~181 pg/mL (P=0.07)， 31°C时升高~378 pg/mL （P=0.07）

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Effects of daylong exposure to indoor overheating on enterocyte damage and inflammatory responses in older adults: a randomized crossover trial.

We evaluated enterocyte damage (IFABP), immune activation (sCD14), and inflammatory responses (TNF-α, IL-6, CRP) in 16 older adults (66-78 years) during 8 h rest in conditions simulating homes maintained at 22 °C (control), the 26 °C indoor temperature upper limit proposed by health agencies, and homes without air-conditioning during heatwaves (31 °C, 36 °C). Relative to 22 °C, IFABP was elevated ∼181 pg/mL after exposure to 31 °C (P = 0.07), and by ∼378 pg/mL (P < 0.001) after exposure to 36 °C. No differences were observed for sCD14, TNF-α, IL-6, or CRP (all P ≥ 0.26). Our data support recommendations to maintain indoor temperatures ≤ 26 °C to preserve gastrointestinal barrier integrity in heat-vulnerable persons.

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Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme

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