Annales de biologie clinique最新文献_第5页

[Interference of oral anti-Xa anticoagulants during monitoring of unfractionated heparin treatments: practical and future attitudes]. [口服抗 Xa 抗凝剂在监测非分数肝素治疗过程中的干扰：现实与未来的态度]。

Annales de biologie clinique Pub Date : 2024-06-05 DOI: 10.1684/abc.2024.1873

Sophie Melicine, Laure Maucorps, Valérie Eschwège, Julie Carré, Dominique Helley, Isabelle Gouin-Thibault, Nicolas Gendron, Fabienne Nédélec-Gac, Laetitia Mauge

{"title":"[Interference of oral anti-Xa anticoagulants during monitoring of unfractionated heparin treatments: practical and future attitudes].","authors":"Sophie Melicine, Laure Maucorps, Valérie Eschwège, Julie Carré, Dominique Helley, Isabelle Gouin-Thibault, Nicolas Gendron, Fabienne Nédélec-Gac, Laetitia Mauge","doi":"10.1684/abc.2024.1873","DOIUrl":"10.1684/abc.2024.1873","url":null,"abstract":"Contrary to direct oral anticoagulants (DOAC), unfractionated heparin (UFH) requires daily monitoring when administered at therapeutic dose. At present, UFH monitoring is preferably carried out by measuring plasma anti-Xa activity, however, in patients previously treated with an anti-Xa DOAC and switched to UFH, there is a high risk of DOAC interfering with the measurement of UFH anti-Xa activity. Residual anti-Xa DOAC in the sample can lead to an overestimation of the anticoagulant activity attributed to heparin and thus to incorrect anticoagulation. This risk of interference should not be overlooked because interference may occur even at concentration of DOAC below the hemostatic safety threshold and can last several days. To overcome this issue, several alternatives are being studied. This note provides an update on anti-Xa DOAC interference and different strategies available in current practice. It also underlines the importance of communication between biologists and clinicians on anticoagulant treatments received by patients.","PeriodicalId":93870,"journal":{"name":"Annales de biologie clinique","volume":"82 2","pages":"129-138"},"PeriodicalIF":0.0,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141238940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Evaluation of an algorithm based on quantitative assays of glomerular parameters (albuminuria and urinary IgG) for proteinuria typing]. [基于肾小球参数（白蛋白尿和尿 IgG）定量检测的蛋白尿分型算法评估]。

Annales de biologie clinique Pub Date : 2024-06-05 DOI: 10.1684/abc.2024.1887

Ihsane Benlyamani, Nathalie Rousseau, Christine Lombard, Emmanuel Villar, Matthieu Pecquet

{"title":"[Evaluation of an algorithm based on quantitative assays of glomerular parameters (albuminuria and urinary IgG) for proteinuria typing].","authors":"Ihsane Benlyamani, Nathalie Rousseau, Christine Lombard, Emmanuel Villar, Matthieu Pecquet","doi":"10.1684/abc.2024.1887","DOIUrl":"10.1684/abc.2024.1887","url":null,"abstract":"The first orientation test for proteinuria typing is electrophoresis. However, this technique has several drawbacks, such as delayed turnaround time and subjective readings. Some laboratories therefore use quantitative assays of glomerular markers combined with tubular markers. However, the cost of reagents and the instability of certain markers are significant drawbacks for some peripheral laboratories. The aim of this study is to evaluate the implementation of an algorithm based on parameters that can be used by all laboratories for proteinuria typing within a timeframe compatible with the urgency of the situation. Albuminuria and urinary IgG were determined on 161 urines. ROC curves were produced, using urine electrophoresis read by an expert center as the reference method. The decision thresholds used are: glomerular proteinuria is defined by a Albumin+IgGproteinsratio greater than 75.4% (100% specificity), and tubular or overload proteinuria is defined by by a Albuminproteinsratio less than 37.3% (100% sensitivity). Agreement between the results of the algorithm selected and the reference method used in our study was 88 %, with a kappa value of 0.807 (95% CI [0.729 to 0.885]). The algorithm's performance suggests that it can find its place in the diagnostic strategy for clinically significant proteinuria, despite its limited indications. It is up to each biologist to assess the value of this algorithm in relation to the recruitment, habits and needs of clinicians.","PeriodicalId":93870,"journal":{"name":"Annales de biologie clinique","volume":"82 2","pages":"201-213"},"PeriodicalIF":0.0,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140892177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Artificial intelligence: to a better predictive strategy for testicular sperm extraction outcome in azoospermia]. [人工智能：为无精症患者的睾丸取精结果提供更好的预测策略]。

Annales de biologie clinique Pub Date : 2024-06-05 DOI: 10.1684/abc.2024.1882

Guillaume Bachelot, Anna Ly, Diane Rivet-Danon, Nathalie Sermondade, Valentine Frydman, Antonin Lamazière, Rahaf Haj Hamid, Rachel Levy, Charlotte Dupont

{"title":"[Artificial intelligence: to a better predictive strategy for testicular sperm extraction outcome in azoospermia].","authors":"Guillaume Bachelot, Anna Ly, Diane Rivet-Danon, Nathalie Sermondade, Valentine Frydman, Antonin Lamazière, Rahaf Haj Hamid, Rachel Levy, Charlotte Dupont","doi":"10.1684/abc.2024.1882","DOIUrl":"10.1684/abc.2024.1882","url":null,"abstract":"Azoospermia, defined as the absence of sperm in the semen, is found in 10-15 % of infertile patients. Two-thirds of these cases are caused by impaired spermatogenesis, known as non-obstructive azoospermia (NOA). In this context, surgical sperm extraction using testicular sperm extraction (TESE) is the best option and can be offered to patients as part of fertility preservation, or to benefit from in vitro fertilization. The aim of the preoperative assessment is to identify the cause of NOA and evaluate the status of spermatogenesis. Its capacity to predict TESE success remains limited. As a result, no objective and reliable criteria are currently available to guide professionals on the chances of success and enable them to correctly assess the benefit-risk balance of this procedure. Artificial intelligence (AI), a field of research that has been rapidly expanding in recent years, has the potential to revolutionize medicine by making it more predictive and personalized. The aim of this review is to introduce AI and its key concepts, and then to examine the current state of research into predicting the success of TESE.","PeriodicalId":93870,"journal":{"name":"Annales de biologie clinique","volume":"82 2","pages":"139-149"},"PeriodicalIF":0.0,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140873775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

LncRNA RP11-773H22.4 is upregulated in severe pneumonia and may be a diagnostic and prognostic marker for severe pneumonia. LncRNA RP11-773H22.4 在重症肺炎中上调，可能是重症肺炎的诊断和预后标志物。

Annales de biologie clinique Pub Date : 2024-06-05 DOI: 10.1684/abc.2024.1886

Yan Cao, Feiyan Wang

{"title":"LncRNA RP11-773H22.4 is upregulated in severe pneumonia and may be a diagnostic and prognostic marker for severe pneumonia.","authors":"Yan Cao, Feiyan Wang","doi":"10.1684/abc.2024.1886","DOIUrl":"10.1684/abc.2024.1886","url":null,"abstract":"The incidence of pneumonia has become increasingly prevalent, and its severity has been continuously escalating, bringing significant damage and stress to people's lives. The regulatory role of RP11-773H22.4 in the onset and development of severe pneumonia is emerging as an important factor, however, the exact mechanisms controlling its effects have not been fully elucidated. ROC curve and Kaplan-Meier curve were employed to assess the diagnostic and prognostic significance of RP11-773H22.4 in severe pneumonia. qRT-PCR was employed to assess the RP11-773H22.4 and miR-1287-5p expression. The CCK-8 was employed to assess cell viability. The rate of apoptosis was measured utilizing flow cytometric. The concentration of inflammatory factors was detected by ELISA kit. The interaction between RP11-773H22.4 and miR-1287-5p was verified by dual luciferase reporter gene assay. In individuals afflicted with severe pneumonia, there was an observed up-regulation in RP11-773H22.4 expression and a corresponding decline in miR-1287-5p expression. RP11-773H22.4 demonstrated diagnostic and prognostic significance for severe pneumonia. RP11-773H22.4 augmented the viability of MRC-5 cells with LPS treatment by modulating miR-1287-5p, leading to a reduction in apoptosis and lower levels of inflammatory cytokines. RP11-773H22.4 was highly expressed in severe pneumonia and may serve as a diagnostic and prognostic marker for severe pneumonia. miR-1287-5p was downregulated in severe pneumonia, and RP11-773H22.4 participated in the pathogenesis of severe pneumonia by regulating the expression of miR-1287-5p.","PeriodicalId":93870,"journal":{"name":"Annales de biologie clinique","volume":"82 2","pages":"187-199"},"PeriodicalIF":0.0,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140871702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Toxicology of synthetic cannabinoids]. [合成大麻素的毒理学]。

Annales de biologie clinique Pub Date : 2024-06-05 DOI: 10.1684/abc.2024.1888

Youssef Mouraouakkil, Radia Mounir, Mina Ait El Cadi, Jamal Lamsaouri, Yassir Bousliman, Rachid ElJaoudi

引用次数: 0

[Professor Philippe Gillery honoured at WorldLab Dubai (UAE) with the IFCC Howard Morris 2024 Prize]. [Philippe Gillery 教授在迪拜世界实验室（阿联酋）荣获 IFCC 霍华德-莫里斯 2024 奖]。

Annales de biologie clinique Pub Date : 2024-06-01 DOI: 10.1684/abc.2024.1894

Bernard Gouget, Katell Peoc'h

引用次数: 0

[Dr David Barthelemy, winner of the IFCC Gérard Siest Prize awarded at the WorldLab Congress, Dubai 2024]. [David Barthelemy 博士，在 2024 年迪拜世界实验室大会上荣获国际化学理事会热拉尔-西斯特奖]。

Annales de biologie clinique Pub Date : 2024-06-01 DOI: 10.1684/abc.2024.1901

Bernard Gouget, Delphine Collin-Chavagnac, Katell Peoc'h