Annales de biologie clinique最新文献_第6页

[Hormone anti-müllérienne (AMH) en pédiatrie : établissement de valeurs de référence avec le dosage de l'AMH Fujirebio^® Lumipulse G et comparaison avec le dosage Roche^® Elecsys sur les mêmes échantillons pédiatriques]. [儿科抗苗勒氏管激素 (AMH)：用富士比奥® Lumipulse G AMH 检测法确定参考值，并在相同儿科样本上与罗氏® Elecsys 检测法进行比较]。

Annales de biologie clinique Pub Date : 2024-04-19 DOI: 10.1684/abc.2024.1867

Jean-Baptiste Delaye, Olivier Le Tilly, Emmanuel Enard, Christine Collet, Patrick Emond, Diane Dufour-Rainfray

{"title":"[Hormone anti-müllérienne (AMH) en pédiatrie : établissement de valeurs de référence avec le dosage de l'AMH Fujirebio® Lumipulse G et comparaison avec le dosage Roche® Elecsys sur les mêmes échantillons pédiatriques].","authors":"Jean-Baptiste Delaye, Olivier Le Tilly, Emmanuel Enard, Christine Collet, Patrick Emond, Diane Dufour-Rainfray","doi":"10.1684/abc.2024.1867","DOIUrl":"https://doi.org/10.1684/abc.2024.1867","url":null,"abstract":"We performed a method comparison between the Fujirebio® Lumipulse G AMH assay and the Roche® Elecsys AMH assay using the same pediatric samples. We described full pediatric gender and age-specific reference ranges for AMH using the Fujirebio® AMH assay on the Lumipulse G 600 II. The study was performed on 281 plasma samples collected in tubes with lithium heparin. The samples were from patients (135 males and 146 females) aged from 3 days to 22 years collected at the University Hospital Center of Tours. The Fujirebio® Lumipulse method showed excellent correlation with Roche® Elecsys but had a significant proportional positive bias. The data were used to propose pediatric reference values adapted to the Fujirebio® method. Our study described full pediatric gender and age-related reference ranges for AMH using the Fujirebio® AMH assay on the Lumipulse G600II. The delineation between normal male and female AMH concentrations make them valuable clinical tools for the monitoring of pediatric sexual and reproductive development from early childhood through the pubertal transition into adulthood.","PeriodicalId":93870,"journal":{"name":"Annales de biologie clinique","volume":"82 1","pages":"59-69"},"PeriodicalIF":0.0,"publicationDate":"2024-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140864752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Summary of the 32nd national meeting of the Collège National de Biochimie des Hôpitaux]. [全国医院生物化学学会第 32 次全国会议纪要]。

Annales de biologie clinique Pub Date : 2024-04-19 DOI: 10.1684/abc.2024.1878

Magali Annette-Reisch, Édith Bigot-Corbel, Valery Brunel, Yohan Darrieux, Patrick Ray, Camille Richard, Batiste Simonet, Frédéric Sobas, Marie-Hélène Tournoys, Panagiotis Tsiamyrtzis

引用次数: 0

[Microcristaux de cholestérol dans le liquide synovial et polyarthrite rhumatoïde]. [滑液中的胆固醇微晶与类风湿性关节炎]。

Annales de biologie clinique Pub Date : 2024-04-19 DOI: 10.1684/abc.2024.1870

Jean-Marc Blouin, Nicolas Poursac, Sophie Gad, Emmanuel Richard

引用次数: 0

[Le miR-224-5p régulé sert de biomarqueur pour l'insuffisance hépatique aiguë pédiatrique et régule l'inflammation en modulant ZBTB20]. [受调控的 miR-224-5p 可作为儿科急性肝衰竭的生物标志物，并通过调节 ZBTB20 来调节炎症】。］

Annales de biologie clinique Pub Date : 2024-04-19 DOI: 10.1684/abc.2024.1874

Qin Wang, Gaoyin Zhang, Mengmeng Zhang, Yunxia Zhang, Lianying Ruan, Hengrui Hao

{"title":"[Le miR-224-5p régulé sert de biomarqueur pour l'insuffisance hépatique aiguë pédiatrique et régule l'inflammation en modulant ZBTB20].","authors":"Qin Wang, Gaoyin Zhang, Mengmeng Zhang, Yunxia Zhang, Lianying Ruan, Hengrui Hao","doi":"10.1684/abc.2024.1874","DOIUrl":"https://doi.org/10.1684/abc.2024.1874","url":null,"abstract":"Pediatric acute liver failure (PALF) is a severe liver dysfunction with complex pathological mechanisms and rapid development. MiRNAs have been identified as promising biomarkers for human disease screening and monitoring. This study focused on evaluating the clinical significance of miR-224-5p in PALF and revealing its potential molecular mechanism in regulating liver cell injury. This study enrolled 103 children with PALF and 55 healthy children without liver diseases. Serum miR-224-5p levels were compared between the two groups, and their clinical significance was estimated by analyzing the correlation with clinicopathological features and outcomes of PALF children. In vitro, a normal liver cell was treated with lipopolysaccharide (LPS), and cell growth and inflammation were assessed by CCK8 and ELISA assay. Upregulated miR-224-5p in PALF showed significance in screening PALF children from healthy children with the sensitivity and specificity of 78.64% and 84.47%, respectively. Increasing serum miR-224-5p in PALF children was closely associated with increasing prothrombin time, alanine transaminase, international normalized ratio, total bilirubin, ammonia, and aspartic transaminase and decreasing albumin of PALF children. MiR-224-5p was also identified as a risk factor for adverse outcomes in children with PALF. In LPS-treated liver cells, miR-224-5p could negatively regulate ZBTB20, and silencing miR-224-5p could alleviate the inhibited cell growth and promoted inflammation by LPS, which was reversed by ZBTB20 knockdown. Increasing miR-224-5p distinguished PALF children, predict severe disease development and risk of adverse prognosis. miR-224-5p also reguled LPS-induced liver cell injury via negatively regulating ZBTB20.","PeriodicalId":93870,"journal":{"name":"Annales de biologie clinique","volume":"82 1","pages":"70-80"},"PeriodicalIF":0.0,"publicationDate":"2024-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140874030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Newborn screening in France: news and perspectives]. [法国的新生儿筛查：新闻与展望]。

Annales de biologie clinique Pub Date : 2024-04-19 DOI: 10.1684/abc.2024.1869

Emeline Gernez, Estelle Roland, Claire-Marie Dhaenens, Gilles Renom, Karine Mention

引用次数: 0

[80 years of Annales de Biologie Clinique: time for renewal!] [临床生物年鉴》80 年：是时候更新了！]

Annales de biologie clinique Pub Date : 2024-04-19 DOI: 10.1684/abc.2024.1879

Laurence Piéroni

引用次数: 0

[Motivational factors for early option choice by laboratory medicine residents in France]. [法国检验医学住院医师早期选择的动机因素]。

Annales de biologie clinique Pub Date : 2024-04-19 DOI: 10.1684/abc.2024.1864

Enagnon Kazali Alidjinou, Quentin Pomorski, Maxence Bauvais, Annabelle Dupont, Frédéric Grenouillet, Myriam Labalette, Boualem Sendid, Thierry Brousseau, Didier Hober, Olivier Nicolas

{"title":"[Motivational factors for early option choice by laboratory medicine residents in France].","authors":"Enagnon Kazali Alidjinou, Quentin Pomorski, Maxence Bauvais, Annabelle Dupont, Frédéric Grenouillet, Myriam Labalette, Boualem Sendid, Thierry Brousseau, Didier Hober, Olivier Nicolas","doi":"10.1684/abc.2024.1864","DOIUrl":"https://doi.org/10.1684/abc.2024.1864","url":null,"abstract":"In France, both students from medicine and pharmacy background can have access to the residency in laboratory medicine (LM). The current curriculum of LM residency includes an early choice of option after the first two years of residency, which subsequently guides the rest of the training. This study aimed to analyze these choice and motivational factors, since its implementation in 2017. A national survey was conducted among LM residents and former residents who underwent the early option choice process. A questionnaire was developed and sent to residents via Google Forms. Several groups of items corresponding to potential motivational factors were included and rated on a 5-point Likert scale. A psychometric analysis allowed to identify the main motivational factors. A total of 178 responses from 24 residency regions were recorded. The median age was 28 years, with a slight female predominance (52%), and three-quarters of the participants had a pharmacy training background. The \"hematology and immunology\" option was the most chosen (35%). The psychometric analysis enabled to identify 7 motivational factors, and the most important is the training during the residency, which weights approximately 21 % in the choice. Several associations have been observed between the motivational factors and the background training, origin, the chosen option and the planned career. Several factors influence the choice of early option among LM residents, and some of these factors are associated with the background training, origin, chosen option and planned career.","PeriodicalId":93870,"journal":{"name":"Annales de biologie clinique","volume":"82 1","pages":"43-57"},"PeriodicalIF":0.0,"publicationDate":"2024-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140861791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Use of LDBIO Diagnostics^® TOXOPLASMA ICT IGG-IGM in association with Siemens Atellica^® IM in toxoplasmosis serological screening]. [将 LDBIO Diagnostics® TOXOPLASMA ICT IGG-IGM 与 Siemens Atellica® IM 联合用于弓形虫血清学筛查]。

Annales de biologie clinique Pub Date : 2024-04-19 DOI: 10.1684/abc.2024.1875

Mickael Fortun, Julien L'hirondel

{"title":"[Use of LDBIO Diagnostics® TOXOPLASMA ICT IGG-IGM in association with Siemens Atellica® IM in toxoplasmosis serological screening].","authors":"Mickael Fortun, Julien L'hirondel","doi":"10.1684/abc.2024.1875","DOIUrl":"https://doi.org/10.1684/abc.2024.1875","url":null,"abstract":"According to French recommendations for serological screening of toxoplasmosis, some profiles must be confirmed by additional methods, extending the time taken to produce results. Thus, the Laborizon Bretagne technical platform in Nantes studied the place of the LDBIO Diagnostics® TOXOPLASMA ICT IGG-IGM (ICT) test in addition to Siemens Atellica® serology. IgG-/IgM+ and equivocal or weak positive IgG/IgM- (IgGEq/IgM-) profiles on Atellica® will be confirmed by ICT, Alinity® Abbott and Platelia® Biorad. Among the 66 IgGEq/IgM- profiles, the concordance is perfect between ICT and complementary techniques: 21 weak positives were confirmed positive, 8 equivocal were considered negative and 37 were confirmed positive. Concerning the 76 IgG-/IgM+ profiles, 68 are negative and 7 are positive by complementary techniques and ICT. One discordance was observed. The Atellica®/ICT combination allows excellent discrimination of IgG-/IgM+ and IgGEq/IgM serological profiles with consistent diagnostic orientation in 99.3% of cases. Only 1 sample was found to be discordant but required monitoring at 15 days. The observed performances are compatible with routine use. This test simplifies the analytical process, improves the time to obtain results, while guaranteeing an excellent level of quality.","PeriodicalId":93870,"journal":{"name":"Annales de biologie clinique","volume":"82 1","pages":"81-92"},"PeriodicalIF":0.0,"publicationDate":"2024-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140861855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[New anticoagulants in 2024: Development of factor XI and XIa inhibitors]. [2024 年的新型抗凝剂：XI 因子和 XIa 抑制剂的发展]。

Annales de biologie clinique Pub Date : 2024-04-19 DOI: 10.1684/abc.2024.1865

Nûn K Bentounes, Sophie Melicine, Anne-Céline Martin, David M Smadja, Nicolas Gendron

引用次数: 0

[Fonction de l'ARNnc exosomal HEIH dans le carcinome hépatocellulaire associé au virus de l'hépatite B]. [HEIH 外泌体 ncRNA 在乙型肝炎病毒相关性肝细胞癌中的功能】。］

Annales de biologie clinique Pub Date : 2024-04-19 DOI: 10.1684/abc.2024.1877

Tao Yu, Huiming Li, Guijia Shen, Qifang Wu

{"title":"[Fonction de l'ARNnc exosomal HEIH dans le carcinome hépatocellulaire associé au virus de l'hépatite B].","authors":"Tao Yu, Huiming Li, Guijia Shen, Qifang Wu","doi":"10.1684/abc.2024.1877","DOIUrl":"https://doi.org/10.1684/abc.2024.1877","url":null,"abstract":"Long non-coding RNA-HEIH (lncRNA-HEIH) is a potential biomarker for patients with hepatocellular carcinoma (HCC), but exosomal lncRNA-HEIH in patients with hepatitis B virus-associated HCC (B-HCC) is unclear. This study aimed to investigate the expression of exosomal lncRNA-HEIH in B-HCC patients and explore its clinical significance. We collected blood samples from 60 B-HCC patients, 60 non-hepatitis virus-associated HCC (N-HCC) patients, and 50 healthy volunteers. Exosomal lncRNA-HEIH levels were measured by real-time PCR and analyzed for their correlation with patient prognosis using Kaplan-Meier analysis. Multivariate COX regression analysis was conducted to identify factors affecting patient outcomes. The effects of lncRNA-HEIH on carcinogenesis were also investigated by constructing a Huh7 cell line stably expressing the hepatitis B virus. In the B-HCC group, there was a positive correlation between hepatitis B virus and exosomal lncRNA-HEIH. The 5-year survival rate of the exosomal lncRNA-HEIH high-expression group was significantly lower than that of the low-expression group in the B-HCC group, but not in the N-HCC group. Exosomal lncRNA-HEIH level was related to the TNM stage, lymph node metastasis and AFP. Exosomal lncRNA-HEIH level was independent risk factors for poor prognosis in B-HCC patients. In Huh7-HBV cells, lncRNA-HEIH level was significantly higher than in control, and the migration capacity of Huh7-HBV cells decreased significantly after down-regulating lncRNA-HEIH. Our findings suggest that exosomal lncRNA-HEIH is abnormally expressed and closely related to poor prognosis in B-HCC patients, indicating its potential as a diagnostic and therapeutic target for HBV-associated HCC.","PeriodicalId":93870,"journal":{"name":"Annales de biologie clinique","volume":"82 1","pages":"93-102"},"PeriodicalIF":0.0,"publicationDate":"2024-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140873423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0