Annales de biologie clinique最新文献_第7页

Inquilinus limosus, an atypical Gram-negative rod from lung transplant recipients and cystic fibrosis patients. Inquilinus limosus，一种来自肺移植受者和囊性纤维化患者的非典型革兰氏阴性杆菌。

Annales de biologie clinique Pub Date : 2024-04-01 DOI: 10.1684/abc.2024.1876

E. Farfour, Stéphane Corvec, Thomas Guillard, Hélène Revillet

引用次数: 0

Dutcher bodies in a Waldenström Macroglobulinaemia patient. 一名瓦尔登斯特伦巨球蛋白血症患者体内的杜氏体。

Annales de biologie clinique Pub Date : 2024-02-24 DOI: 10.1684/abc.2023.1855

Anne Checkouri, Carole Humbert, Yazid Arkam, Agathe Debliquis

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Serological screening for celiac disease, by endomysial antibodies, in patients with rheumatoid arthritis. 通过类风湿性关节炎患者的内膜抗体进行乳糜泻血清学筛查。

Annales de biologie clinique Pub Date : 2024-02-24 DOI: 10.1684/abc.2023.1851

Mariam Ghozzi, Fatma Mechi, Alma Ben Salem, Ikram El Ahmer, Donia Rachel Mbarki, Sarra Melayah, Amani Mankai, Ibtissem Ghedira

{"title":"Serological screening for celiac disease, by endomysial antibodies, in patients with rheumatoid arthritis.","authors":"Mariam Ghozzi, Fatma Mechi, Alma Ben Salem, Ikram El Ahmer, Donia Rachel Mbarki, Sarra Melayah, Amani Mankai, Ibtissem Ghedira","doi":"10.1684/abc.2023.1851","DOIUrl":"10.1684/abc.2023.1851","url":null,"abstract":"Celiac disease (CD) and rheumathoid arthritis (RA) are both multi-factorial chronic inflammatory auto-immune diseases. In this retrospective study, we determined the frequency of CD in patients with RA using IgA anti-endomysial antibodies (EmA) and tried to explain this association. Indirect immunofluorescence on human umbilical cord was used to detect EmA in 215 patients with seropositive RA collected over a 4-year-period. Two thousand and five hundred healthy blood donors (HBD) served as control group. Among the 215 patients with RA, 12 (9 females) were found positive for EmA while only 7 were positive for EmA in control group, EmA are significantly more frequent in RA patients than in HBD (5.58% vs. 0.28%, p < 10-6; 95% CI [8.21-54.01]; odds ratio: 21.05). In RA patients, the frequency of EmA was not statistically different between males and females. The frequency of EmA was significantly higher in female patients than in healthy females (5.32% vs. 0.40%, p < 10-3). Patients with RA can be considered as a high-risk group for CD based on the high frequency of EmA positivity observed in our study.","PeriodicalId":93870,"journal":{"name":"Annales de biologie clinique","volume":"81 6","pages":"569-575"},"PeriodicalIF":0.0,"publicationDate":"2024-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139934646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[An alarming health check-up: what a bloody plasma!] [令人震惊的健康检查：真是个该死的血浆！]

Annales de biologie clinique Pub Date : 2024-02-24 DOI: 10.1684/abc.2023.1850

Julie Labasque, Dorian Marchand, Clémentine Lhomme, Jacob Lavisse, Patrice Maboudou, Guillaume Grzych

引用次数: 0

Myeloma mimicking acute leukemia. 模仿急性白血病的骨髓瘤

Annales de biologie clinique Pub Date : 2024-02-24 DOI: 10.1684/abc.2023.1856

Maroua Mabrouk, Lucile Baseggio

引用次数: 0

The mRNA of solute carrier family 22, member 17 (SLC22A17) plays the potential diagnostic and prognostic role in advantage non-small cell lung cancer patients. 溶质运载体家族 22 成员 17（SLC22A17）的 mRNA 在非小细胞肺癌患者中具有潜在的诊断和预后作用。

Annales de biologie clinique Pub Date : 2024-02-24 DOI: 10.1684/abc.2023.1861

Wenwen Qin, Cuimin Ding, Fei Peng, Ping Wang

{"title":"The mRNA of solute carrier family 22, member 17 (SLC22A17) plays the potential diagnostic and prognostic role in advantage non-small cell lung cancer patients.","authors":"Wenwen Qin, Cuimin Ding, Fei Peng, Ping Wang","doi":"10.1684/abc.2023.1861","DOIUrl":"10.1684/abc.2023.1861","url":null,"abstract":"This study aims to evaluate the mRNA levels of solute carrier family 22, member 17 (SLC22A17) and its potential clinical value as a diagnostic and prognostic biomarker in non-small cell lung cancer. This prospective study measured SLC22A17 mRNA levels in lung cancer and paracancer tissues using quantitative reverse transcription-polymerase chain reaction (PCR). The levels of SLC22A17 mRNA in plasma samples from healthy control subjects and patients with lung cancer were also measured. The association between SLC22A17 mRNA levels in plasma and clinicopathological characteristics was determined. Receiver operating characteristic (ROC) curve analysis was performed to determine the diagnostic value of SLC22A17 in plasma. Survival curve analysis was performed using the Kaplan-Meier method. SLC22A17 mRNA levels were significantly higher in lung cancer samples than in the paired paracancerous tissues. Plasma SLC22A17 mRNA levels were also significantly higher in patients with lung cancer than in healthy controls. The COX analysis indicated that there was a significant correlation between elevated plasma SLC22A17 mRNA levels and lymph node metastasis, distant metastasis, and TNM stage. Furthermore, the ROC curve analysis demonstrated that plasma SLC22A17 had high diagnostic value. High plasma SLC22A17 mRNA levels are associated with a significantly shorter survival time. SLC22A17 is upregulated in lung cancer and may serve as a novel diagnostic and prognostic biomarker.","PeriodicalId":93870,"journal":{"name":"Annales de biologie clinique","volume":"81 6","pages":"602-609"},"PeriodicalIF":0.0,"publicationDate":"2024-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139934647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic effects of finasteride: inhibition of disease progression and serum prostate-specific antigen reduction in patients with prostatic intraepithelial neoplasia. 非那雄胺的治疗效果：抑制前列腺上皮内瘤变患者的疾病进展并降低血清前列腺特异性抗原。

Annales de biologie clinique Pub Date : 2024-02-24 DOI: 10.1684/abc.2023.1859

Jia Wei He, Zi-Xuan Huang, Jian-Liang Wu, Yan-Feng Su, Xiao-Long Xu

{"title":"Therapeutic effects of finasteride: inhibition of disease progression and serum prostate-specific antigen reduction in patients with prostatic intraepithelial neoplasia.","authors":"Jia Wei He, Zi-Xuan Huang, Jian-Liang Wu, Yan-Feng Su, Xiao-Long Xu","doi":"10.1684/abc.2023.1859","DOIUrl":"10.1684/abc.2023.1859","url":null,"abstract":"The objective of this study was to evaluate the impact of finasteride on the progression of prostate intraepithelial neoplasia and levels of prostate-specific antigen (PSA) in patients. A total of 120 patients with high-grade prostatic intraepithelial neoplasia were included in this study from January 2013 to January 2018. All patients underwent prostate biopsies. Among them, 60 patients were assigned to the observation group and received a daily dosage of 5 mg finasteride for 60 months, while the remaining 60 patients were assigned to the control group and did not receive finasteride. PSA levels were measured every six months, and imaging scans were conducted throughout the five-year study period. Additional biopsies were performed if PSA levels exceeded 10 ng/mL or imaging suggested the presence of prostate cancer. Statistical analysis was applied to the collected data. In total, 25 cases of prostate cancer were identified in this study. Of these cases, 7 patients belonged to the observation group, whereas the remaining 18 patients were from the control group. The observation group exhibited significantly lower levels of total serum PSA (p < 0.001) and Gleason scores (p < 0.001) compared to the control group. Our study, which involved 120 participants, demonstrated that finasteride effectively reduces serum PSA levels and mitigates the severity of prostate cancer. These findings suggest that finasteride holds potential as a treatment option for patients with -high-grade prostatic intraepithelial neoplasia.","PeriodicalId":93870,"journal":{"name":"Annales de biologie clinique","volume":"81 6","pages":"610-620"},"PeriodicalIF":0.0,"publicationDate":"2024-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139934648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MALDI-TOF mass spectrometry identification and antifungal susceptibility testing of yeasts causing vulvovaginal candidiasis (VVC) in Tebessa (Northeastern Algeria). 用 MALDI-TOF 质谱鉴定和测试阿尔及利亚东北部 Tebessa 地区引起外阴阴道念珠菌病 (VVC) 的酵母菌的抗真菌药敏性。

Annales de biologie clinique Pub Date : 2024-02-24 DOI: 10.1684/abc.2023.1852

Mabrouka Benhadj, Taha Menasria, Stéphane Ranque

{"title":"MALDI-TOF mass spectrometry identification and antifungal susceptibility testing of yeasts causing vulvovaginal candidiasis (VVC) in Tebessa (Northeastern Algeria).","authors":"Mabrouka Benhadj, Taha Menasria, Stéphane Ranque","doi":"10.1684/abc.2023.1852","DOIUrl":"10.1684/abc.2023.1852","url":null,"abstract":"Vulvovaginal candidiasis (VVC) alongside with antifungal resistance are becoming a major clinical problem in recent years. A prospective study aimed to evaluate the diversity of yeast strains associated with VVC in Tebessa city (northeastern Algeria) and investigate their susceptibility patterns. Over two months, yeasts were isolated on chromogenic medium from twenty-nine non-pregnant women with symptomatic VVC. The isolates were characterized with MALDI-TOF MS and antifungal susceptibility testing was performed for nine antifungal drugs using SensititreTM YeastOneTM YO10. Twenty-nine non-duplicate yeasts were recovered and the mass spectrometry profiles showed reliable scores of which four genera and five different species were identified. Candida albicans accounted for 65.5 % (n = 19) of the total number of isolates, followed by C. glabrata with 20.7% (n = 6). For the remaining non-albicans Candida (NCA) species, Kluyveromyces marxianus with 6.9% (n = 2), Pichia kudriavzevii and Saccharomyces cerevisiae with one isolate each. The antifungal susceptibilities showed wild type MICs of C. albicans to amphotericin B, azoles and echinocandins. In addition, four C. albicans isolates were resistant to flucytosine. For C. glabrata isolates, 100% non-WT phenotype was found for both posaconazole and itraconazole. For the very first time, the obtained outcomes bring out new data concerning the epidemiology of yeasts causing VVC in Algeria and their antimicrobial susceptibility profiles.","PeriodicalId":93870,"journal":{"name":"Annales de biologie clinique","volume":"81 6","pages":"576-584"},"PeriodicalIF":0.0,"publicationDate":"2024-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139378989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[RE : « Conversation entre un biologiste clinicien et une intelligence artificielle sur les biomarqueurs du cancer de la prostate »]. [RE: "临床生物学家与人工智能就前列腺癌生物标记物的对话"].

Annales de biologie clinique Pub Date : 2024-02-24 DOI: 10.1684/abc.2023.1849

Hinpetch Daungsupawong, Viroj Wiwanitkit

引用次数: 0

[Integrating pathology and biology into medical education: current state and future directions]. [将病理学和生物学融入医学教育：现状与未来方向]。

Annales de biologie clinique Pub Date : 2024-02-24 DOI: 10.1684/abc.2023.1857

Asmaa Tazi, Marion Rabant, Cédric Lemogne, Martin Flamant, Alain Cariou, Stéphanie Baron, Caroline Prot-Bertoye

{"title":"[Integrating pathology and biology into medical education: current state and future directions].","authors":"Asmaa Tazi, Marion Rabant, Cédric Lemogne, Martin Flamant, Alain Cariou, Stéphanie Baron, Caroline Prot-Bertoye","doi":"10.1684/abc.2023.1857","DOIUrl":"10.1684/abc.2023.1857","url":null,"abstract":"Pathology and biology are essential in the patient care. However, they suffer from a lack of attractiveness to medicine students. In order to gain insight and improve the visibility and attractiveness of these specialties, we designed a survey and submitted forms to medical students, laboratory medical staff, and clinical staff from the different hospitals and institutes attached to \"Université Paris Cité\". The responses (363 students (response rate: 9.1%), 109 medical -laboratory staff (25%), 61 clinical staff (10%)) confirmed the poor visibility of these specialties among students as well as the will of the -medical laboratory staff to be more involved in the student's training. The -development of partnerships between laboratories and clinical -departments, which would allow medical students to spend short periods of time in related laboratories during their clinical internship, is a prospect for improving the teaching of these disciplines. The main expected benefits are to \"discover a new specialty\" and \"to better understand the prescription of laboratory tests\", which are crucial aspects for understanding the role of laboratory disciplines and their interaction with clinicians to improve patient care.","PeriodicalId":93870,"journal":{"name":"Annales de biologie clinique","volume":"81 6","pages":"628-639"},"PeriodicalIF":0.0,"publicationDate":"2024-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139934612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0