American journal of Alzheimer's disease and other dementias最新文献

Cognitive and Mental Health Differences Across Latent Profiles of Religiosity and Spirituality in Korean Older Adults With Mild Cognitive Impairment or Alzheimer's Disease. 轻度认知障碍或阿尔茨海默病的韩国老年人宗教信仰和灵性潜在特征的认知和心理健康差异

IF 2.7

American journal of Alzheimer's disease and other dementias Pub Date : 2026-01-01 Epub Date: 2026-01-28 DOI: 10.1177/15333175251415119

Mira Hur, Minkyung Kim, Sooyeon Min, Chang Hyun Lee, Do Hoon Kim

{"title":"Cognitive and Mental Health Differences Across Latent Profiles of Religiosity and Spirituality in Korean Older Adults With Mild Cognitive Impairment or Alzheimer's Disease.","authors":"Mira Hur, Minkyung Kim, Sooyeon Min, Chang Hyun Lee, Do Hoon Kim","doi":"10.1177/15333175251415119","DOIUrl":"10.1177/15333175251415119","url":null,"abstract":"Religiosity and spirituality (R/S) encompass organizational activity, private practice, and intrinsic beliefs, which may relate differently to cognitive and mental health outcomes in older adults. This study identified latent R/S profiles among South Korean older adults with mild cognitive impairment (MCI) and Alzheimer's disease (AD), and examined differences in cognitive function, psychological well-being, and depressive symptoms. Latent profile analysis using Duke University Religion Index indicators was conducted with 518 patients (MCI: n = 224; AD: n = 294). In MCI, three classes that differed in well-being and verbal fluency were identified; they showed no differences in depressive symptoms or other cognitive domains. In AD, four classes were identified that differed in the Short Blessed Test and Word List Recall; in these, well-being, depression, and other cognitive outcomes did not differ across classes. These findings underscore the relevance of diverse R/S patterns in individualized care for older adults with neurocognitive disorders.","PeriodicalId":93865,"journal":{"name":"American journal of Alzheimer's disease and other dementias","volume":"41 ","pages":"15333175251415119"},"PeriodicalIF":2.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12852587/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146095190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and Validation of a Machine Learning-Based Dementia Screening Tool: The Six-Question Dementia Screening Test. 基于机器学习的痴呆筛查工具的开发和验证：六题痴呆筛查测试。

IF 2.7

American journal of Alzheimer's disease and other dementias Pub Date : 2026-01-01 Epub Date: 2026-02-17 DOI: 10.1177/15333175261424333

Meng-Tien Wu, Kuan-Ying Li, Ching-Fang Chien, Ling-Chun Huang, Chen-Wen Yen, Yuan-Han Yang

引用次数: 0

Four Common Beliefs About Patient Memory Evaluations: Who Has Them and What Modifies Them? 关于患者记忆评估的四种常见信念：谁拥有它们，是什么改变了它们？

IF 2.7

American journal of Alzheimer's disease and other dementias Pub Date : 2026-01-01 Epub Date: 2026-05-02 DOI: 10.1177/15333175261447038

Shana D Stites, Carolyn Kuz, Emily A Largent, Kristin Harkins, Abba Krieger, Pamela Sankar, Sarah J Barber

{"title":"Four Common Beliefs About Patient Memory Evaluations: Who Has Them and What Modifies Them?","authors":"Shana D Stites, Carolyn Kuz, Emily A Largent, Kristin Harkins, Abba Krieger, Pamela Sankar, Sarah J Barber","doi":"10.1177/15333175261447038","DOIUrl":"https://doi.org/10.1177/15333175261447038","url":null,"abstract":"Understanding public beliefs about patients at memory centers may inform efforts to promote early diagnosis and guide clinical discussions of Alzheimer's disease (AD). Adults (N=3,527) read a vignette describing a fictional person at a memory center and rated the person's condition as a mental illness, part of typical aging, and psychological or biological origins. Vignettes varied by AD biomarker result, symptom stage, and treatment availability. Participants most strongly believed that the condition was part of typical aging and biological in origin, though beliefs varied across subgroups. Black and Asian participants reported stronger beliefs than White participants that the condition was a mental illness (β=0.39, P<0.001) and psychological (β=0.46, P<0.001). Men reported stronger beliefs that the condition was a mental illness (β=0.19, P<0.001), psychological (β=0.14, P<0.001), and part of typical aging (β=-0.08, P=0.04). Biomarker positivity heightened biological and lowered psychological attributions (all P<0.05). The findings offer specific insights to guide intervention.","PeriodicalId":93865,"journal":{"name":"American journal of Alzheimer's disease and other dementias","volume":"41 ","pages":"15333175261447038"},"PeriodicalIF":2.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147824527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Changes of Quality of Life, Behavioural Problems, and Cognition Among Older Adults With Severe Dementia Under Social Distancing Measures in Residential Homes. 居家社交距离措施对老年重度痴呆患者生活质量、行为问题和认知的影响

IF 2.7

American journal of Alzheimer's disease and other dementias Pub Date : 2026-01-01 Epub Date: 2026-03-26 DOI: 10.1177/15333175261437655

Suet-Lai Leung, Timothy Kwok

{"title":"The Changes of Quality of Life, Behavioural Problems, and Cognition Among Older Adults With Severe Dementia Under Social Distancing Measures in Residential Homes.","authors":"Suet-Lai Leung, Timothy Kwok","doi":"10.1177/15333175261437655","DOIUrl":"10.1177/15333175261437655","url":null,"abstract":"This study examined the association between social distancing measures and Quality of Life (QoL), behavioural problems, and cognition among older adults with severe dementia in residential homes. QoL (Chinese version of the Quality of Life for Late-Stage Dementia), behavioural problems (Chinese version of the Neuropsychiatric Inventory), cognition (Chinese version of the Cognitive Test for Severe Dementia), and clinical variables were evaluated at baseline, 6, and 12 months. Activity involvement was recorded on a monthly basis. Sixty-four participants completed the one-year follow-up. QoL worsened continuously from baseline to month-12; correlated with reduced activity involvement and increased depression level. Behavioural problems increased significantly from baseline to month-12; correlated with reduced activity involvement and deteriorated self-care function. Cognition declined significantly from baseline to month-12; correlated with reduced non-sedentary time. The findings suggest that social restrictions may be negatively related to the QoL, behavioural problems, and cognition of residents with severe dementia.","PeriodicalId":93865,"journal":{"name":"American journal of Alzheimer's disease and other dementias","volume":"41 ","pages":"15333175261437655"},"PeriodicalIF":2.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13031726/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147517504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Construction and Interpretability of a Multimodal Deep Learning Model of Electronystagmography-Optical Coherence Tomography Angiography for Early Screening of Alzheimer's Disease. 用于阿尔茨海默病早期筛查的眼震电-光学相干断层扫描血管造影多模态深度学习模型的构建和可解释性。

IF 2.7

American journal of Alzheimer's disease and other dementias Pub Date : 2026-01-01 Epub Date: 2026-01-27 DOI: 10.1177/15333175261422037

Zhuoying Zhu, Xiaoling Zhang, Congying Xu, Yufei Shen

{"title":"Construction and Interpretability of a Multimodal Deep Learning Model of Electronystagmography-Optical Coherence Tomography Angiography for Early Screening of Alzheimer's Disease.","authors":"Zhuoying Zhu, Xiaoling Zhang, Congying Xu, Yufei Shen","doi":"10.1177/15333175261422037","DOIUrl":"10.1177/15333175261422037","url":null,"abstract":"We aimed to explore the value and interpretability of a multimodal deep learning model integrating optical coherence tomography angiography (OCTA) and electronystagmography (ENG) for the early screening of Alzheimer's disease (AD) and mild cognitive impairment (MCI). A total of 250 subjects were retrospectively recruited. OCTA images, ENG signals and neurocognitive scores were collected from all subjects. The model had an area under curve of 0.85 for the independent validation cohort, with the sensitivity and specificity of 0.73 and 0.90 at the optimal cut-off of receiver operating characteristic curve, respectively. According to Gradient-weighted Class Activation Mapping analysis, the model focused on regions with reduced microvascular density. SHapley Additive exPlanations analysis revealed that saccade accuracy (left eye), saccade latency (right eye) and smooth pursuit gain (left eye) contributed the most to the model. The multimodal model effectively improves early, non-invasive screening of AD/MCI with good interpretability.","PeriodicalId":93865,"journal":{"name":"American journal of Alzheimer's disease and other dementias","volume":"41 ","pages":"15333175261422037"},"PeriodicalIF":2.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12852582/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146069286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison Study of Different Feature Selection Techniques for the Diagnosis of Alzheimer's Disease. 不同特征选择技术诊断阿尔茨海默病的比较研究。

IF 2.7

American journal of Alzheimer's disease and other dementias Pub Date : 2026-01-01 Epub Date: 2026-01-19 DOI: 10.1177/15333175261418472

Farah Masood, Abeer Al-Hyari, Wisam Al-Wajidi

{"title":"Comparison Study of Different Feature Selection Techniques for the Diagnosis of Alzheimer's Disease.","authors":"Farah Masood, Abeer Al-Hyari, Wisam Al-Wajidi","doi":"10.1177/15333175261418472","DOIUrl":"10.1177/15333175261418472","url":null,"abstract":"Objective: Alzheimer's disease (AD) continues to be a major challenge because handling high-dimensional data is time-consuming and expensive due to its complexity. A large feature space often increases computational costs and reduces model interpretability. This study addresses this problem by evaluating and comparing multiple feature selection techniques to identify the most informative biomarkers for AD diagnosis.Methods: Our study used data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) to implement and test three feature selection approaches, visualization-based, filter-based, and wrapper-based, within a Naive Bayes (NB) classification framework.Results: Based on the results of the analysis, the wrapper method achieved 96.77% classification accuracy, outperforming both visualization and filter methods with 86.19 and 91.87%, respectively. Interestingly, even when over 92.5% of the original features were removed the classifier still performed well, indicating that only a small set of features is necessary to ensure reliable diagnosis.Discussion: This study illustrates that strategically selecting features improves diagnostic accuracy while reducing computational burden, providing a more efficient framework for machine learning applications in Alzheimer's disease research.","PeriodicalId":93865,"journal":{"name":"American journal of Alzheimer's disease and other dementias","volume":"41 ","pages":"15333175261418472"},"PeriodicalIF":2.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12816535/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146004555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Validating the Use of TBI-CareQOL Measures in Caregivers of People Living With Dementia. 验证TBI-CareQOL测量在痴呆患者照护者中的应用。

IF 2.7

American journal of Alzheimer's disease and other dementias Pub Date : 2026-01-01 Epub Date: 2026-02-28 DOI: 10.1177/15333175261426872

Noelle E Carlozzi, Madison Fansher, Jonathan P Troost, Jennifer A Miner, Sophia Tsuker, Amanda N Leggett

{"title":"Validating the Use of TBI-CareQOL Measures in Caregivers of People Living With Dementia.","authors":"Noelle E Carlozzi, Madison Fansher, Jonathan P Troost, Jennifer A Miner, Sophia Tsuker, Amanda N Leggett","doi":"10.1177/15333175261426872","DOIUrl":"10.1177/15333175261426872","url":null,"abstract":"Understanding the clinical utility of patient-reported outcome measures is critical for using these measures in research and clinical practice. Therefore, the purpose of this analysis was to establish the psychometric properties of three TBI-CareQOL measures in caregivers of people living with Alzheimer's disease or Alzheimer's disease-related dementias (ADRD): Caregiver Strain, Caregiver-Specific Anxiety, and Feeling Trapped. One-hundred-and-ninety-seven caregivers of individuals living with ADRD (n=197) completed three TBI-CareQOL measures, three additional measures to establish convergent and discriminant validity (NIH Toolbox Perceived Stress, Dementia Management Strategies Scale, PROMIS Pain Intensity), and the Dementia Severity Rating Scale to establish known groups validity. Internal consistency and test-retest reliability of the TBI-CareQOL measures were supported (alphas >.70). The TBI-CareQOL measures were also free of floor and ceiling effects. Convergent, discriminant, and known groups validity were also supported. Taken together, findings support the clinical utility of the TBI-CareQOL measures for caregivers of people living with ADRD.","PeriodicalId":93865,"journal":{"name":"American journal of Alzheimer's disease and other dementias","volume":"41 ","pages":"15333175261426872"},"PeriodicalIF":2.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12954047/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147319212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Unique Case of Post-Subarachnoid Hemorrhage Cerebral Atrophy and Its Implications on Alzheimer's Disease. 蛛网膜下腔出血后脑萎缩的独特病例及其对阿尔茨海默病的影响。

IF 2.7

American journal of Alzheimer's disease and other dementias Pub Date : 2026-01-01 Epub Date: 2026-01-23 DOI: 10.1177/15333175261420559

Sophia E Brown, Zoe J Bowen, Lily L Rosati Yoos, Sumathilatha Sakthi-Velavan

引用次数: 0

Health of Bi+ Dementia Caregivers: Moderation Effects of Minority and Caregiving Stress. Bi+痴呆照护者健康：少数民族与照护压力的调节作用

IF 2.7

American journal of Alzheimer's disease and other dementias Pub Date : 2026-01-01 Epub Date: 2026-02-17 DOI: 10.1177/15333175251415106

Krystal R Kittle, Ethan C Cicero, Jordan Pelkmans, Jason D Flatt, Joel G Anderson

{"title":"Health of Bi+ Dementia Caregivers: Moderation Effects of Minority and Caregiving Stress.","authors":"Krystal R Kittle, Ethan C Cicero, Jordan Pelkmans, Jason D Flatt, Joel G Anderson","doi":"10.1177/15333175251415106","DOIUrl":"10.1177/15333175251415106","url":null,"abstract":"Despite comprising the largest segment of the sexual minority population and experiencing unique stressors and health disparities, bi+ dementia caregivers remain underrepresented in health and caregiving research. This secondary analysis of cross-sectional survey data from LGBTQ+ dementia caregivers (bi+, n = 125; gay[g]/lesbian[l], n = 161) examined whether associations between minority and caregiving stressors and global health differed by caregiver group. Bi+ caregivers reported significantly higher minority stress and lower family quality of life but better health than g/l caregivers. Moderation analyses revealed: higher perceived stress predicted worse health for bi+ but better health for g/l; higher family quality of life predicted better health for both groups, with a stronger effect among bi+ caregivers; and more lifetime discrimination predicted worse health for both groups, with a stronger effect among bi+ caregivers. Results underscore the need for inclusive, affirming research and interventions addressing bi+ caregiver stress experiences.","PeriodicalId":93865,"journal":{"name":"American journal of Alzheimer's disease and other dementias","volume":"41 ","pages":"15333175251415106"},"PeriodicalIF":2.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12917183/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146215376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Impact of Inappropriate Sexual Behaviors in People With Dementia on Family Caregivers: A Scoping Review. 痴呆患者不适当性行为对家庭照顾者的影响：一项范围审查。

IF 2.7

American journal of Alzheimer's disease and other dementias Pub Date : 2026-01-01 Epub Date: 2026-01-20 DOI: 10.1177/15333175261418909

Huiping Lin, Leah Macaden, Colin Chandler

{"title":"The Impact of Inappropriate Sexual Behaviors in People With Dementia on Family Caregivers: A Scoping Review.","authors":"Huiping Lin, Leah Macaden, Colin Chandler","doi":"10.1177/15333175261418909","DOIUrl":"10.1177/15333175261418909","url":null,"abstract":"This scoping review examines the impact of inappropriate sexual behaviors (ISBs) in people with dementia on their family caregivers. Through synthesizing 15 studies from 8 countries, 6 themes were identified: complex emotional responses, psychological distress, increased caregiver burden, practical caregiving challenges, impaired marital relationships, and social isolation. Findings reveal caregivers frequently experience helplessness, embarrassment, anger, anxiety, depression, and social withdrawal, exacerbated by societal taboos surrounding sexuality and limited professional support. Spousal caregivers are particularly affected, reporting increased emotional strain and marital distress. Practical caregiving difficulties, including safety and privacy concerns, limited access to care services, and challenging institutionalization decisions, further intensify caregiver burden. The review highlights significant research gaps, including the need for specialized assessment tools, broader and culturally diverse studies, and exploration of ISBs as distinct phenomena. Addressing these gaps is crucial for developing targeted interventions and adequately supporting caregivers, particularly within home-based and culturally sensitive dementia care services.","PeriodicalId":93865,"journal":{"name":"American journal of Alzheimer's disease and other dementias","volume":"41 ","pages":"15333175261418909"},"PeriodicalIF":2.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12819981/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146013911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0