American journal of Alzheimer's disease and other dementias最新文献_第2页

Association Between Lymphocyte-High Density Lipoprotein Ratio and Cognitive Impairment in Chinese Older Adults: A Population-Based Cross-Section Study. 中国老年人淋巴细胞-高密度脂蛋白比值与认知障碍的关系：一项基于人群的横断面研究。

IF 2.7

American journal of Alzheimer's disease and other dementias Pub Date : 2025-01-01 Epub Date: 2025-07-30 DOI: 10.1177/15333175251361748

Jinhui Yang, Wenbin Lu, Hao Wang, Xiaofei Li, Liangliang Lu, Jinjun Bian, Xiaoming Deng

{"title":"Association Between Lymphocyte-High Density Lipoprotein Ratio and Cognitive Impairment in Chinese Older Adults: A Population-Based Cross-Section Study.","authors":"Jinhui Yang, Wenbin Lu, Hao Wang, Xiaofei Li, Liangliang Lu, Jinjun Bian, Xiaoming Deng","doi":"10.1177/15333175251361748","DOIUrl":"10.1177/15333175251361748","url":null,"abstract":"ObjectiveTo explore the association between lymphocyte-high density lipoprotein ratio (LHR) and cognitive impairment in Chinese older adults.MethodsThis study included participants aged ≥65 years from the 2008 to 2014 waves of the Chinese Longitudinal Healthy Longevity Survey (CLHLS). Cognitive function was assessed using the Mini-Mental State Examination, with a score of less than 24 points considered indicative of cognitive impairment. Multiple logistic regression analysis and restricted cubic spline were applied to investigate the association between LHR and cognitive impairment.ResultsOf 3556 participants, 1625 (45.7%) suffered from cognitive impairment. Multivariate logistic regression analysis indicated that low LHR was associated with cognitive impairment [odds ratio (OR) = 1.34; 95% confidence interval (CI) = 1.11-1.62, P = 0.002].ConclusionsLower LHR was associated with cognitive impairment in Chinese older people. This finding suggests LHR could serve as a novel and accessible biomarker for identifying high-risk aging populations.","PeriodicalId":93865,"journal":{"name":"American journal of Alzheimer's disease and other dementias","volume":"40 ","pages":"15333175251361748"},"PeriodicalIF":2.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12317171/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144746448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Olfactory Testing With Focus on Odor Identification for Early Detection of Alzheimer's Disease in Mild Cognitive Impairment. 嗅觉测试与气味识别在轻度认知障碍患者阿尔茨海默病早期检测中的应用。

IF 2.7

American journal of Alzheimer's disease and other dementias Pub Date : 2025-01-01 Epub Date: 2025-09-30 DOI: 10.1177/15333175251385615

Feiyan Zhou, Zhuowen Zhao, Jingyu Dai, Jinan Xu, Ke Jiang, Zhiqian Tong

{"title":"Olfactory Testing With Focus on Odor Identification for Early Detection of Alzheimer's Disease in Mild Cognitive Impairment.","authors":"Feiyan Zhou, Zhuowen Zhao, Jingyu Dai, Jinan Xu, Ke Jiang, Zhiqian Tong","doi":"10.1177/15333175251385615","DOIUrl":"10.1177/15333175251385615","url":null,"abstract":"This review examines the application of olfactory testing in the early stages of mild cognitive impairment (MCI) associated with Alzheimer's disease (AD), highlighting its potential and challenges in early screening and intervention. Olfactory function is typically divided into three domains: odor identification, odor discrimination, and odor threshold. Among these, odor identification and discrimination are closely linked to higher cognitive processes and exhibit significant impairment in patients with AD and MCI. Moreover, the anatomical and functional characteristics of the olfactory system make it a promising target for the early detection of neurodegenerative disorders. This review also outlines various olfactory assessment tools and evaluates their clinical utility. Future research should aim to enhance the accuracy and cultural adaptability of olfactory tests and integrate them with multimodal diagnostic approaches to advance early detection and intervention strategies for AD.","PeriodicalId":93865,"journal":{"name":"American journal of Alzheimer's disease and other dementias","volume":"40 ","pages":"15333175251385615"},"PeriodicalIF":2.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12484899/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145202490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study on Effect of Different Pulses of rTMS on Visual Working Memory in Elderly With SCD. 不同脉冲rTMS对老年SCD患者视觉工作记忆影响的研究。

American journal of Alzheimer's disease and other dementias Pub Date : 2025-01-01 Epub Date: 2025-03-13 DOI: 10.1177/15333175251322351

Liu Meng, Ren-Ren Li, Zhang Wei, Janelle Si Yi Yeo, Jia-Xin Yan, XueKeEr BuMaYiLaMu, Tu Zhao-Xi, Li Yun-Xia

引用次数: 0

Translation and Validation of the Chinese Version of the Brief Adolescent Attitudes Towards Dementia Scale (Brief AADS-C): A Psychometric Study. 青少年痴呆症态度量表中文版的翻译与验证：一项心理测量学研究。

American journal of Alzheimer's disease and other dementias Pub Date : 2025-01-01 Epub Date: 2025-07-14 DOI: 10.1177/15333175251361268

Jianwei Wu, Qun Wang, Meijing Tan, Ion Hong Wong, Wai In Lei, Yi Wen, Xuan Gao, Ning Liu, Iat Kio Van

{"title":"Translation and Validation of the Chinese Version of the Brief Adolescent Attitudes Towards Dementia Scale (Brief AADS-C): A Psychometric Study.","authors":"Jianwei Wu, Qun Wang, Meijing Tan, Ion Hong Wong, Wai In Lei, Yi Wen, Xuan Gao, Ning Liu, Iat Kio Van","doi":"10.1177/15333175251361268","DOIUrl":"10.1177/15333175251361268","url":null,"abstract":"BackgroundA validated instrument for assessing adolescent attitudes toward dementia in Chinese-speaking communities is currently lacking. This study aims to translate the Brief-AADS into Chinese and examine the psychometric properties of the Brief AADS-C.MethodsThe methodological study employed a cross-sectional design with 2 phases. Data was collected in Macao and Shenzhen, China.ResultsThe scale demonstrated excellent content validity(S-CVI = 0.99) and good internal consistency (Cronbach's α = 0.814). Test-retest reliability was acceptable (ICC = 0.647). EFA identified a three-factor solution \"Perceptions\", \"Acceptance\", and \"Engagement\" with 11items-accounting for 56.07% of the variance. CFA supported this 3-factor structure with acceptable goodness of fit indices (χ2/df = 3.076, GFI = 0.937, SRMR = 0.0579, RMSEA = 0.077). All factor loadings of the items ranged from 0. 33to 0.82, indicating strong item-factor relationships.ConclusionsThe Brief AADS-C is reliable and valid for assessing adolescent attitudes toward dementia in Chinese-speaking regions.","PeriodicalId":93865,"journal":{"name":"American journal of Alzheimer's disease and other dementias","volume":"40 ","pages":"15333175251361268"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12260332/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144638890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Faith Care Family Project: A Pilot Intervention for African American Dementia Family Caregivers. 信仰关怀家庭项目：对非裔美国人痴呆症家庭照顾者的试点干预。

IF 2.7

American journal of Alzheimer's disease and other dementias Pub Date : 2025-01-01 Epub Date: 2025-08-03 DOI: 10.1177/15333175251363706

Noelle L Fields, Ling Xu, Ishan C Williams, Fayron Epps, Samantha Tinker

{"title":"The Faith Care Family Project: A Pilot Intervention for African American Dementia Family Caregivers.","authors":"Noelle L Fields, Ling Xu, Ishan C Williams, Fayron Epps, Samantha Tinker","doi":"10.1177/15333175251363706","DOIUrl":"10.1177/15333175251363706","url":null,"abstract":"The Faith Care Family (FCF) Project was a telephone based, volunteer-led intervention for African American Alzheimer's disease and related dementias (AD/ADRD) family caregivers that was piloted in one predominantly African American church. Focus groups with faith leaders and parishioners informed the training and intervention. Eighteen church volunteers participated in the FCF Project training, but 9 of them were paired with family caregivers and completed the FCF Project intervention. Church volunteers indicated overall significant improvements knowledge of AD/ADRD after the training as well as after the intervention. Quantitative results indicated that caregivers increased their knowledge of dementia, reported improved coping skills, and reported increased positive aspects of caregiving. Feeling a connection, normalizing the challenges of caregiving, gaining or reinforcing knowledge, and sharing community resources were themes from qualitative interviews with the family caregivers. Overall, findings indicate that the FCF Project shows promise as an intervention for African American AD/ADRD family caregivers.","PeriodicalId":93865,"journal":{"name":"American journal of Alzheimer's disease and other dementias","volume":"40 ","pages":"15333175251363706"},"PeriodicalIF":2.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12319281/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144777221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design and Validation of a Hybrid Machine Learning Model for Alzheimer's Detection Using Handwriting Data. 基于手写数据的阿尔茨海默病检测混合机器学习模型的设计与验证。

IF 2.7

American journal of Alzheimer's disease and other dementias Pub Date : 2025-01-01 Epub Date: 2025-09-14 DOI: 10.1177/15333175251374913

Deniz Demircioglu Diren

引用次数: 0

Identification of Dementia & Mild Cognitive Impairment in Chinese Elderly Using Machine Learning. 利用机器学习识别中国老年人的痴呆症和轻度认知障碍。

American journal of Alzheimer's disease and other dementias Pub Date : 2024-01-01 DOI: 10.1177/15333175241275215

Tong-Tong Ying, Li-Ying Zhuang, Shan-Hu Xu, Shu-Feng Zhang, Li-Jun Huang, Wei-Wei Gao, Lu Liu, Qi-Lun Lai, Yue Lou, Xiao-Li Liu

{"title":"Identification of Dementia & Mild Cognitive Impairment in Chinese Elderly Using Machine Learning.","authors":"Tong-Tong Ying, Li-Ying Zhuang, Shan-Hu Xu, Shu-Feng Zhang, Li-Jun Huang, Wei-Wei Gao, Lu Liu, Qi-Lun Lai, Yue Lou, Xiao-Li Liu","doi":"10.1177/15333175241275215","DOIUrl":"10.1177/15333175241275215","url":null,"abstract":"Objective: To assess the role of Machine Learning (ML) in identification critical factors of dementia and mild cognitive impairment.Methods: 371 elderly individuals were ultimately included in the ML analysis. Demographic information (including gender, age, parity, visual acuity, auditory function, mobility, and medication history) and 35 features from 10 assessment scales were used for modeling. Five machine learning classifiers were used for evaluation, employing a procedure involving feature extraction, selection, model training, and performance assessment to identify key indicative factors.Results: The Random Forest model, after data preprocessing, Information Gain, and Meta-analysis, utilized three training features and four meta-features, achieving an area under the curve of 0.961 and a accuracy of 0.894, showcasing exceptional accuracy for the identification of dementia and mild cognitive impairment.Conclusions: ML serves as a identification tool for dementia and mild cognitive impairment. Using Information Gain and Meta-feature analysis, Clinical Dementia Rating (CDR) and Neuropsychiatric Inventory (NPI) scale information emerged as crucial for training the Random Forest model.","PeriodicalId":93865,"journal":{"name":"American journal of Alzheimer's disease and other dementias","volume":"39 ","pages":"15333175241275215"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11320688/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141918304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and Validation of an Automatic Computerized Neurocognitive Battery in Chinese. 中文自动计算机化神经认知测验的开发与验证。

American journal of Alzheimer's disease and other dementias Pub Date : 2024-01-01 DOI: 10.1177/15333175241271910

Ji Zhang, Ze-Yu Hong, Liu Yang, Xiao-Jia Li, Fang Ye

{"title":"Development and Validation of an Automatic Computerized Neurocognitive Battery in Chinese.","authors":"Ji Zhang, Ze-Yu Hong, Liu Yang, Xiao-Jia Li, Fang Ye","doi":"10.1177/15333175241271910","DOIUrl":"10.1177/15333175241271910","url":null,"abstract":"Objectives: Neuropsychological test batteries, which accurately and comprehensively assess cognitive functions, are a crucial approach in the early detection of and interventions for cognitive impairments. However, these tests have yet to gain wide clinical application in China owing to their complexity and time-consuming nature. This study aimed to develop the Computerized Neurocognitive Battery for Chinese-Speaking participants (CNBC), an autorun and autoscoring cognitive assessment tool to provide efficient and accurate cognitive evaluations for Chinese-Speaking individuals.Methods: The CNBC was developed through collaboration between clinical neurologists and software engineers. Qualified volunteers were recruited to complete CNBC and traditional neurocognitive batteries. The reliability and validity of the CNBC were evaluated by analyzing the correlations between the measurements obtained from the computerized and the paper-based assessment and those between software-based scoring and manual scoring.Results: The CNBC included 4 subtests and an autorun version. Eighty-six volunteers aged 51-82 years with 7-22 years of education were included. Significant correlations (0.256-0.666) were observed between paired measures associated with attention, executive function, and episodic memory from the CNBC and the traditional paper-based neurocognitive batteries. This suggests a strong construct validity of the CNBC in assessing these cognitive domains. Furthermore, the correlation coefficients between manual scoring and system scoring ranged from 0.904-1.0, indicating excellent inter-rater reliability for the CNBC.Interpretation: A novel CNBC equipped with automated testing and scoring features was developed in this study. The preliminary results confirm its strong reliability and validity, indicating its promising potential for clinical utilization.","PeriodicalId":93865,"journal":{"name":"American journal of Alzheimer's disease and other dementias","volume":"39 ","pages":"15333175241271910"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11457180/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142376416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuropsychiatric Behavioral Assessments in Mice After Acute and Long-Term Treatments of Low-Intensity Pulsed Ultrasound. 低强度脉冲超声波急性和长期治疗后的小鼠神经精神行为评估

American journal of Alzheimer's disease and other dementias Pub Date : 2024-01-01 DOI: 10.1177/15333175231222695

Ye Li, Yiqing Wu, Qi Luo, Xuanjie Ye, Jie Chen, Yuanlin Su, Ke Zhao, Xinmin Li, Jing Lin, Zhiqian Tong, Qi Wang, Dongwu Xu

{"title":"Neuropsychiatric Behavioral Assessments in Mice After Acute and Long-Term Treatments of Low-Intensity Pulsed Ultrasound.","authors":"Ye Li, Yiqing Wu, Qi Luo, Xuanjie Ye, Jie Chen, Yuanlin Su, Ke Zhao, Xinmin Li, Jing Lin, Zhiqian Tong, Qi Wang, Dongwu Xu","doi":"10.1177/15333175231222695","DOIUrl":"10.1177/15333175231222695","url":null,"abstract":"Introduction: To evaluate whether both acute and chronic low-intensity pulsed ultrasound (LIPUS) affect brain functions of healthy male and female mice. Methods: Ultrasound (frequency: 1.5 MHz; pulse: 1.0 kHz; spatial average temporal average (SATA) intensity: 25 mW/cm2; and pulse duty cycle: 20%) was applied at mouse head in acute test for 20 minutes, and in chronic experiment for consecutive 10 days, respectively. Behaviors were then evaluated. Results: Both acute and chronic LIPUS at 25 mW/cm2 exposure did not affect the abilities of movements, mating, social interaction, and anxiety-like behaviors in the male and female mice. However, physical restraint caused struggle-like behaviors and short-time memory deficits in chronic LIPUS groups in the male mice. Conclusion: LIPUS at 25 mW/cm2 itself does not affect brain functions, while physical restraint for LIPUS therapy elicits struggle-like behaviors in the male mice. An unbound helmet targeted with ultrasound intensity at 25-50 mW/cm2 is proposed for clinical brain disease therapy.","PeriodicalId":93865,"journal":{"name":"American journal of Alzheimer's disease and other dementias","volume":"39 ","pages":"15333175231222695"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10771054/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139106995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

"It's Opened My Eyes to a Whole New World": Positive Behaviour Support Training for Staff and Family Members Supporting Residents With Dementia in Aged Care Settings. "它让我看到了一个全新的世界"：为支持老年护理机构中患有痴呆症的住户的工作人员和家庭成员提供积极行为支持培训。

American journal of Alzheimer's disease and other dementias Pub Date : 2024-01-01 DOI: 10.1177/15333175241241168

Alinka C Fisher, Katrina Reschke, Nijashree Shah, Sau Cheung, Claire O'Connor, Olivier Piguet

{"title":"\"It's Opened My Eyes to a Whole New World\": Positive Behaviour Support Training for Staff and Family Members Supporting Residents With Dementia in Aged Care Settings.","authors":"Alinka C Fisher, Katrina Reschke, Nijashree Shah, Sau Cheung, Claire O'Connor, Olivier Piguet","doi":"10.1177/15333175241241168","DOIUrl":"10.1177/15333175241241168","url":null,"abstract":"Objectives: This study examined the acceptability and usefulness of Positive Behaviour Support (PBS) training in enhancing the capabilities of support staff and family members providing behaviour support to residents with dementia in residential aged care (RAC).Methods: A mixed-methods pilot study was conducted across 3 RAC organisations, involving pre- and post-training questionnaire assessments for clinical leaders (n = 8), support staff (n = 37) and family members (n = 18).Results: Findings indicated increased confidence among support staff and family members in providing behaviour support, with 96% indicating it would support their practices across settings. Key training benefits included identifying and addressing underlying causes of challenging behaviours. A majority (89%) expressed the need for further behaviour support training.Conclusion: Recommendations focus on developing systems to enable effective and collaborative behaviour support practices. Further research is needed to examine application of PBS principles and planning for residents living with dementia.","PeriodicalId":93865,"journal":{"name":"American journal of Alzheimer's disease and other dementias","volume":"39 ","pages":"15333175241241168"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10976499/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140308231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0