American journal of Alzheimer's disease and other dementias最新文献_第2页

Exercise Impact on Affective/Cognitive Symptoms and QoL in Subjective Cognitive Decline: An RCT. 运动对主观认知衰退患者情感/认知症状和生活质量的影响：一项随机对照试验

IF 2.7

American journal of Alzheimer's disease and other dementias Pub Date : 2026-01-01 Epub Date: 2026-08-10 DOI: 10.1177/15333175261476974

Rebecca Ann-Maria Watry, Niloufar Niakosari Hadidi, Mary Jo Kreitzer, Rozina Bhimani, Fang Yu, Dereck L Salisbury

{"title":"Exercise Impact on Affective/Cognitive Symptoms and QoL in Subjective Cognitive Decline: An RCT.","authors":"Rebecca Ann-Maria Watry, Niloufar Niakosari Hadidi, Mary Jo Kreitzer, Rozina Bhimani, Fang Yu, Dereck L Salisbury","doi":"10.1177/15333175261476974","DOIUrl":"10.1177/15333175261476974","url":null,"abstract":"IntroductionThe purpose of this secondary data analysis of an RCT, was to examine the preliminary efficacy of moderate-intensity cycling exercise versus control on cognitive and affective symptoms (i.e., depressive and anxiety), and quality of life (QoL) in older adults with subjective cognitive decline (SCD).MethodsCommunity-dwelling older adults with SCD (N=38) were randomized to 12 weeks/36 sessions. For this secondary data analysis, between-group change was evaluated by analysis of covariance, adjusting for baseline values.ResultsThe participants' mean age was 74.6(7.4) years, and 69% female. There were no significant between-group changes in all outcomes (p-values ranged from .06-.70. Large and moderate between-group effect sizes were seen in favor of the control group for anxiety symptoms (between-group change=-5.36 [4.74], ηp2=0.11.DiscussionAttention and social interaction received by this secluded population of older adults and COVID-19 losses likely impacted results. Further mixed-methods research with larger groups that does not span a pandemic, is necessary.Clinical Trial RegistryConcurrent Aerobic Exercise and Cognitive Training to Prevent Alzheimer's in At-risk Older Adults (Exergames): NCT04311736.","PeriodicalId":93865,"journal":{"name":"American journal of Alzheimer's disease and other dementias","volume":"41 ","pages":"15333175261476974"},"PeriodicalIF":2.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13458122/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148708856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison Study of Different Feature Selection Techniques for the Diagnosis of Alzheimer's Disease. 不同特征选择技术诊断阿尔茨海默病的比较研究。

IF 2.7

American journal of Alzheimer's disease and other dementias Pub Date : 2026-01-01 Epub Date: 2026-01-19 DOI: 10.1177/15333175261418472

Farah Masood, Abeer Al-Hyari, Wisam Al-Wajidi

{"title":"Comparison Study of Different Feature Selection Techniques for the Diagnosis of Alzheimer's Disease.","authors":"Farah Masood, Abeer Al-Hyari, Wisam Al-Wajidi","doi":"10.1177/15333175261418472","DOIUrl":"10.1177/15333175261418472","url":null,"abstract":"Objective: Alzheimer's disease (AD) continues to be a major challenge because handling high-dimensional data is time-consuming and expensive due to its complexity. A large feature space often increases computational costs and reduces model interpretability. This study addresses this problem by evaluating and comparing multiple feature selection techniques to identify the most informative biomarkers for AD diagnosis.Methods: Our study used data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) to implement and test three feature selection approaches, visualization-based, filter-based, and wrapper-based, within a Naive Bayes (NB) classification framework.Results: Based on the results of the analysis, the wrapper method achieved 96.77% classification accuracy, outperforming both visualization and filter methods with 86.19 and 91.87%, respectively. Interestingly, even when over 92.5% of the original features were removed the classifier still performed well, indicating that only a small set of features is necessary to ensure reliable diagnosis.Discussion: This study illustrates that strategically selecting features improves diagnostic accuracy while reducing computational burden, providing a more efficient framework for machine learning applications in Alzheimer's disease research.","PeriodicalId":93865,"journal":{"name":"American journal of Alzheimer's disease and other dementias","volume":"41 ","pages":"15333175261418472"},"PeriodicalIF":2.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12816535/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146004555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Construction and Interpretability of a Multimodal Deep Learning Model of Electronystagmography-Optical Coherence Tomography Angiography for Early Screening of Alzheimer's Disease. 用于阿尔茨海默病早期筛查的眼震电-光学相干断层扫描血管造影多模态深度学习模型的构建和可解释性。

IF 2.7

American journal of Alzheimer's disease and other dementias Pub Date : 2026-01-01 Epub Date: 2026-01-27 DOI: 10.1177/15333175261422037

Zhuoying Zhu, Xiaoling Zhang, Congying Xu, Yufei Shen

{"title":"Construction and Interpretability of a Multimodal Deep Learning Model of Electronystagmography-Optical Coherence Tomography Angiography for Early Screening of Alzheimer's Disease.","authors":"Zhuoying Zhu, Xiaoling Zhang, Congying Xu, Yufei Shen","doi":"10.1177/15333175261422037","DOIUrl":"10.1177/15333175261422037","url":null,"abstract":"We aimed to explore the value and interpretability of a multimodal deep learning model integrating optical coherence tomography angiography (OCTA) and electronystagmography (ENG) for the early screening of Alzheimer's disease (AD) and mild cognitive impairment (MCI). A total of 250 subjects were retrospectively recruited. OCTA images, ENG signals and neurocognitive scores were collected from all subjects. The model had an area under curve of 0.85 for the independent validation cohort, with the sensitivity and specificity of 0.73 and 0.90 at the optimal cut-off of receiver operating characteristic curve, respectively. According to Gradient-weighted Class Activation Mapping analysis, the model focused on regions with reduced microvascular density. SHapley Additive exPlanations analysis revealed that saccade accuracy (left eye), saccade latency (right eye) and smooth pursuit gain (left eye) contributed the most to the model. The multimodal model effectively improves early, non-invasive screening of AD/MCI with good interpretability.","PeriodicalId":93865,"journal":{"name":"American journal of Alzheimer's disease and other dementias","volume":"41 ","pages":"15333175261422037"},"PeriodicalIF":2.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12852582/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146069286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Social Determinants and Brain Health in PSEN1 E280A Carriers vs Non-Carriers: A Colombian Cohort. PSEN1 E280A携带者与非携带者的社会决定因素和脑健康：哥伦比亚队列

IF 2.7

American journal of Alzheimer's disease and other dementias Pub Date : 2026-01-01 Epub Date: 2026-09-22 DOI: 10.1177/15333175261492405

C Vanessa Tumbajoy-Arango, Natalia Trujillo, Juan Pablo Sánchez, Diego Camilo Díaz, Stella Valencia, Sandra Trujillo, Diana Gómez

{"title":"Social Determinants and Brain Health in PSEN1 E280A Carriers vs Non-Carriers: A Colombian Cohort.","authors":"C Vanessa Tumbajoy-Arango, Natalia Trujillo, Juan Pablo Sánchez, Diego Camilo Díaz, Stella Valencia, Sandra Trujillo, Diana Gómez","doi":"10.1177/15333175261492405","DOIUrl":"https://doi.org/10.1177/15333175261492405","url":null,"abstract":"Social determinants of health (SDOH), including education, socioeconomic status, place of residence, genetic risk, and perceived stress, influence brain health and Alzheimer's disease (AD), yet their role in genetically at-risk populations remains underexplored. This study examined the influence of SDOH on early brain health, specifically its cognitive dimension, in Colombian individuals from the world's largest kindred with autosomal dominant AD (ADAD) caused by the PSEN1 E280A mutation. Participants included 86 mutation carriers and 71 non-carriers. Brain health was assessed using the BHA_CS index from the TabCAT battery, and perceived stress using the PSS-14. Carriers showed significantly lower brain health and higher perceived stress than non-carriers. Multiple regression analyses identified genetic status, age, education, and place of residence as significant predictors of brain health, with higher education and urban residence associated with better performance. These results demonstrate that SDOH contribute to early cognitive variability even decades before clinical onset in ADAD.","PeriodicalId":93865,"journal":{"name":"American journal of Alzheimer's disease and other dementias","volume":"41 ","pages":"15333175261492405"},"PeriodicalIF":2.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149026846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Navigating the Continuum: System-Level Requirements for High-Quality Dementia Care Transitions. 导航连续体：高质量痴呆症护理过渡的系统级要求。

IF 2.7

American journal of Alzheimer's disease and other dementias Pub Date : 2026-01-01 Epub Date: 2026-07-23 DOI: 10.1177/15333175261471717

Elham Lotfalinezhad, Shannon Freeman, William Kearns, Maryam Chehrehgosha, Haidar Nadrian, Jeffrey E Stokes, Farzaneh Barati, Sama Amirkhani-Ardeh, Hamideh Mancheri, Leila Jouybari, Courtney Genge

{"title":"Navigating the Continuum: System-Level Requirements for High-Quality Dementia Care Transitions.","authors":"Elham Lotfalinezhad, Shannon Freeman, William Kearns, Maryam Chehrehgosha, Haidar Nadrian, Jeffrey E Stokes, Farzaneh Barati, Sama Amirkhani-Ardeh, Hamideh Mancheri, Leila Jouybari, Courtney Genge","doi":"10.1177/15333175261471717","DOIUrl":"10.1177/15333175261471717","url":null,"abstract":"The worldwide rise in dementia cases is creating significant pressures on healthcare systems, clinicians, and decision-makers. As dementia does not follow a single predictable pathway, individuals commonly move across different care settings as their needs evolve, requiring coordinated and integrated responses across the healthcare system rather than isolated efforts within single services. This perspective study explores service quality and underlying structural challenges throughout the dementia care pathway with a particular concentration on transitions between various stages. Key barriers to successful implementation include fragmented service delivery, short-term funding structures, weak coordination across care settings, staffing constraints, and challenges in staff retention. These challenges undermine care standards and result in avoidable emergency department and acute care utilization that contribute to increasing health systems expenditures. Strengthening integrated, person-centered, and transition-oriented care frameworks is critical to enhance outcomes and support sustainable health system responses to an increasing global impact of dementia.","PeriodicalId":93865,"journal":{"name":"American journal of Alzheimer's disease and other dementias","volume":"41 ","pages":"15333175261471717"},"PeriodicalIF":2.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13396560/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148581568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Daily Living, Depressive Symptoms, and Cognition in Older Adults With Chronic Diseases. 老年慢性病患者的日常生活、抑郁症状和认知

IF 2.7

American journal of Alzheimer's disease and other dementias Pub Date : 2026-01-01 Epub Date: 2026-05-11 DOI: 10.1177/15333175261451924

Cui Luo, Xiannan Xian, Jing Yin, Yu Shi

{"title":"Daily Living, Depressive Symptoms, and Cognition in Older Adults With Chronic Diseases.","authors":"Cui Luo, Xiannan Xian, Jing Yin, Yu Shi","doi":"10.1177/15333175261451924","DOIUrl":"10.1177/15333175261451924","url":null,"abstract":"This study examined the associations of activities of daily living (ADL) limitations and depressive symptoms with global and domain-specific cognition among older adults with chronic diseases. Data were drawn from the 2020 wave of the China Health and Retirement Longitudinal Study, including 5,112 participants aged ≥60 years. Functional ability and depressive symptoms were assessed using the ADL scale and CES-D-10, respectively. Cognitive function was assessed using CHARLS cognitive measures, including the Telephone Interview of Cognitive Status-10 and other cognition-related items. Spearman correlation and path analyses were performed using AMOS and Stata. ADL limitations were associated with poorer global and domain-specific cognitive function, and depressive symptoms accounted for part of these associations in the path models. The proportion accounted for by the indirect effect ranged from 17.39% for visuospatial ability to 60.27% for delayed recall. These findings suggest that functional status, depressive symptoms, and cognition are closely interrelated in this population.","PeriodicalId":93865,"journal":{"name":"American journal of Alzheimer's disease and other dementias","volume":"41 ","pages":"15333175261451924"},"PeriodicalIF":2.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13168718/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147870565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Validating the Use of TBI-CareQOL Measures in Caregivers of People Living With Dementia. 验证TBI-CareQOL测量在痴呆患者照护者中的应用。

IF 2.7

American journal of Alzheimer's disease and other dementias Pub Date : 2026-01-01 Epub Date: 2026-02-28 DOI: 10.1177/15333175261426872

Noelle E Carlozzi, Madison Fansher, Jonathan P Troost, Jennifer A Miner, Sophia Tsuker, Amanda N Leggett

{"title":"Validating the Use of TBI-CareQOL Measures in Caregivers of People Living With Dementia.","authors":"Noelle E Carlozzi, Madison Fansher, Jonathan P Troost, Jennifer A Miner, Sophia Tsuker, Amanda N Leggett","doi":"10.1177/15333175261426872","DOIUrl":"10.1177/15333175261426872","url":null,"abstract":"Understanding the clinical utility of patient-reported outcome measures is critical for using these measures in research and clinical practice. Therefore, the purpose of this analysis was to establish the psychometric properties of three TBI-CareQOL measures in caregivers of people living with Alzheimer's disease or Alzheimer's disease-related dementias (ADRD): Caregiver Strain, Caregiver-Specific Anxiety, and Feeling Trapped. One-hundred-and-ninety-seven caregivers of individuals living with ADRD (n=197) completed three TBI-CareQOL measures, three additional measures to establish convergent and discriminant validity (NIH Toolbox Perceived Stress, Dementia Management Strategies Scale, PROMIS Pain Intensity), and the Dementia Severity Rating Scale to establish known groups validity. Internal consistency and test-retest reliability of the TBI-CareQOL measures were supported (alphas >.70). The TBI-CareQOL measures were also free of floor and ceiling effects. Convergent, discriminant, and known groups validity were also supported. Taken together, findings support the clinical utility of the TBI-CareQOL measures for caregivers of people living with ADRD.","PeriodicalId":93865,"journal":{"name":"American journal of Alzheimer's disease and other dementias","volume":"41 ","pages":"15333175261426872"},"PeriodicalIF":2.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12954047/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147319212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations of Serum Lipids With Clinical-Amyloid Groups, CSF Aβ42, and SHBG in ADNI-1. ADNI-1患者血脂与临床淀粉样蛋白群、脑脊液Aβ42和SHBG的关系

IF 2.7

American journal of Alzheimer's disease and other dementias Pub Date : 2026-01-01 Epub Date: 2026-10-18 DOI: 10.1177/15333175261498635

Leilei Zhang, Xiaoyu Zhang, Qiangqiang Zhang, Xiang Chang, Lin Yang

引用次数: 0

A Unique Case of Post-Subarachnoid Hemorrhage Cerebral Atrophy and Its Implications on Alzheimer's Disease. 蛛网膜下腔出血后脑萎缩的独特病例及其对阿尔茨海默病的影响。

IF 2.7

American journal of Alzheimer's disease and other dementias Pub Date : 2026-01-01 Epub Date: 2026-01-23 DOI: 10.1177/15333175261420559

Sophia E Brown, Zoe J Bowen, Lily L Rosati Yoos, Sumathilatha Sakthi-Velavan

引用次数: 0

Multi-Index Brain Function-Cognition Correlation in Amnestic Mild Cognitive Impairment: A Resting-State fMRI Study. 遗忘性轻度认知障碍的多指标脑功能-认知相关性：静息状态fMRI研究。

IF 2.7

American journal of Alzheimer's disease and other dementias Pub Date : 2026-01-01 Epub Date: 2026-07-25 DOI: 10.1177/15333175261460967

ShuPing Chen, Haoyu Huang, Xiaoyi Xu, Qin Wang, Yingqi Lu, Zesen Zhuang, Wanqing Lin, Qing Zeng, Dan Wang, ShangJie Chen

引用次数: 0