{"title":"中国老年人淋巴细胞-高密度脂蛋白比值与认知障碍的关系：一项基于人群的横断面研究。","authors":"Jinhui Yang, Wenbin Lu, Hao Wang, Xiaofei Li, Liangliang Lu, Jinjun Bian, Xiaoming Deng","doi":"10.1177/15333175251361748","DOIUrl":null,"url":null,"abstract":"<p><p>ObjectiveTo explore the association between lymphocyte-high density lipoprotein ratio (LHR) and cognitive impairment in Chinese older adults.MethodsThis study included participants aged ≥65 years from the 2008 to 2014 waves of the Chinese Longitudinal Healthy Longevity Survey (CLHLS). Cognitive function was assessed using the Mini-Mental State Examination, with a score of less than 24 points considered indicative of cognitive impairment. Multiple logistic regression analysis and restricted cubic spline were applied to investigate the association between LHR and cognitive impairment.ResultsOf 3556 participants, 1625 (45.7%) suffered from cognitive impairment. Multivariate logistic regression analysis indicated that low LHR was associated with cognitive impairment [odds ratio (OR) = 1.34; 95% confidence interval (CI) = 1.11-1.62, P = 0.002].ConclusionsLower LHR was associated with cognitive impairment in Chinese older people. This finding suggests LHR could serve as a novel and accessible biomarker for identifying high-risk aging populations.</p>","PeriodicalId":93865,"journal":{"name":"American journal of Alzheimer's disease and other dementias","volume":"40 ","pages":"15333175251361748"},"PeriodicalIF":2.7000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12317171/pdf/","citationCount":"0","resultStr":"{\"title\":\"Association Between Lymphocyte-High Density Lipoprotein Ratio and Cognitive Impairment in Chinese Older Adults: A Population-Based Cross-Section Study.\",\"authors\":\"Jinhui Yang, Wenbin Lu, Hao Wang, Xiaofei Li, Liangliang Lu, Jinjun Bian, Xiaoming Deng\",\"doi\":\"10.1177/15333175251361748\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>ObjectiveTo explore the association between lymphocyte-high density lipoprotein ratio (LHR) and cognitive impairment in Chinese older adults.MethodsThis study included participants aged ≥65 years from the 2008 to 2014 waves of the Chinese Longitudinal Healthy Longevity Survey (CLHLS). Cognitive function was assessed using the Mini-Mental State Examination, with a score of less than 24 points considered indicative of cognitive impairment. Multiple logistic regression analysis and restricted cubic spline were applied to investigate the association between LHR and cognitive impairment.ResultsOf 3556 participants, 1625 (45.7%) suffered from cognitive impairment. Multivariate logistic regression analysis indicated that low LHR was associated with cognitive impairment [odds ratio (OR) = 1.34; 95% confidence interval (CI) = 1.11-1.62, P = 0.002].ConclusionsLower LHR was associated with cognitive impairment in Chinese older people. This finding suggests LHR could serve as a novel and accessible biomarker for identifying high-risk aging populations.</p>\",\"PeriodicalId\":93865,\"journal\":{\"name\":\"American journal of Alzheimer's disease and other dementias\",\"volume\":\"40 \",\"pages\":\"15333175251361748\"},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2025-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12317171/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"American journal of Alzheimer's disease and other dementias\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1177/15333175251361748\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/7/30 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"American journal of Alzheimer's disease and other dementias","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/15333175251361748","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/7/30 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
目的探讨中国老年人淋巴细胞-高密度脂蛋白比值（LHR）与认知功能障碍的关系。方法本研究纳入2008 - 2014年中国健康寿命纵向调查（CLHLS）中年龄≥65岁的参与者。认知功能评估使用迷你精神状态检查，得分低于24分被认为表明认知障碍。应用多元logistic回归分析和限制三次样条分析LHR与认知功能障碍的关系。结果在3556名参与者中，1625名（45.7%）患有认知障碍。多因素logistic回归分析显示低LHR与认知功能障碍相关[比值比(OR) = 1.34；95%置信区间(CI) = 1.11-1.62, P = 0.002]。结论较慢的LHR与中国老年人认知功能障碍有关。这一发现表明，LHR可以作为一种新的、可获得的生物标志物，用于识别高危老龄化人群。
Association Between Lymphocyte-High Density Lipoprotein Ratio and Cognitive Impairment in Chinese Older Adults: A Population-Based Cross-Section Study.
ObjectiveTo explore the association between lymphocyte-high density lipoprotein ratio (LHR) and cognitive impairment in Chinese older adults.MethodsThis study included participants aged ≥65 years from the 2008 to 2014 waves of the Chinese Longitudinal Healthy Longevity Survey (CLHLS). Cognitive function was assessed using the Mini-Mental State Examination, with a score of less than 24 points considered indicative of cognitive impairment. Multiple logistic regression analysis and restricted cubic spline were applied to investigate the association between LHR and cognitive impairment.ResultsOf 3556 participants, 1625 (45.7%) suffered from cognitive impairment. Multivariate logistic regression analysis indicated that low LHR was associated with cognitive impairment [odds ratio (OR) = 1.34; 95% confidence interval (CI) = 1.11-1.62, P = 0.002].ConclusionsLower LHR was associated with cognitive impairment in Chinese older people. This finding suggests LHR could serve as a novel and accessible biomarker for identifying high-risk aging populations.
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