Rishi Raj Chhipa, Biji T Kurien, Robert H Scofield, Roman F Wolf, Hao Huang, Pazhani Sundaram
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引用次数: 0
Abstract
Alzheimer's disease (AD) presents a pressing global health challenge, with amyloid-β (Aβ) accumulation in the brain being a hallmark feature. While monoclonal antibodies targeting Aβ have shown cognitive benefits, safety concerns remain. Here, we introduce the Amytrapper catheter, a novel extracorporeal device developed by Recombinant Technologies to trap circulating Aβ using a retro-inverso peptide conjugated to polyethylene glycol. Through in vivo experiments using a rat model of AD, we demonstrate significant reductions in blood Aβ levels and behavioral improvements following Amytrapper catheter treatment. This innovative approach holds promise as a disease-modifying therapy for AD, offering a complementary strategy to existing treatments and advocating for further clinical development.
阿尔茨海默病（AD）是一个紧迫的全球健康挑战，淀粉样蛋白-β (a β)在大脑中的积累是一个标志性特征。虽然靶向Aβ的单克隆抗体已显示出认知益处，但安全性问题仍然存在。在这里，我们介绍了Amytrapper导管，这是一种由重组技术公司开发的新型体外装置，利用聚乙二醇偶联的逆转录反肽来捕获循环中的a β。通过使用大鼠AD模型的体内实验，我们发现amytraper导管治疗后，血液中a β水平显著降低，行为改善。这种创新的方法有望作为阿尔茨海默病的疾病改善疗法，为现有治疗提供补充策略，并倡导进一步的临床开发。
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