ACS agricultural science & technology最新文献

{"title":"Naturally Degradable Capsules Loaded with Pickering Emulsions for Slow Release of Liquid Nutrients","authors":"Qinyuan Li,&nbsp;Xin Xie,&nbsp;Yuli Zhang,&nbsp;Lufan Jia,&nbsp;Haoyue Hou,&nbsp;Hao Yuan,&nbsp;Ting Guo and Tao Meng*,&nbsp;","doi":"10.1021/acsagscitech.4c0064010.1021/acsagscitech.4c00640","DOIUrl":"https://doi.org/10.1021/acsagscitech.4c00640https://doi.org/10.1021/acsagscitech.4c00640","url":null,"abstract":"<p >Liquid fertilizers with a high plant uptake and low energy consumption have aroused wide attention in the world for the agriculture industry. However, the slow release of liquid fertilizers remains a challenge because the molecules with an angstrom scale (e.g., urea) in water are easy to pass through the nanopores even in the hydrophobic encapsulating materials. In this study, a Pickering emulsion slow-release strategy is for the first time developed for the delivery of liquid nitrogen fertilizer. In the whole process, the Pickering emulsifier concentration and oil/water ratio are used to regulate the emulsion stability, leading to the slow release of liquid fertilizer in calcium alginate capsules encapsulated with urea-loaded water-in-oil Pickering emulsions (CUPEs), allowing for a rate of release to be achieved at 81.30% in 96 days in soil with a release curve that follows the “S” curve of plant growth, which is higher than the previous literature. More importantly, the CUPE-treated maize plants exhibit favorable growth conditions. Overall, this work presents an effective slow-release method and mechanism for delivering liquid nutrients, which is expected to open a new avenue for the effective use of agrochemicals to address population and environmental crises.</p>","PeriodicalId":93846,"journal":{"name":"ACS agricultural science & technology","volume":"5 2","pages":"246–256 246–256"},"PeriodicalIF":2.3,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143418691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tris(2,4-di-tert-butylphenyl) Phosphate Is the Key Toxicant in Aged Polyvinyl Chloride Microplastics to Wheat (Triticum aestivum L.) Roots","authors":"Huiqian Wang,&nbsp;Dongru Wang,&nbsp;Qiuping Zheng,&nbsp;Yuan He,&nbsp;Qian Yang,&nbsp;Jiani Du,&nbsp;Jiawei Wang and Xinhua Zhan*,&nbsp;","doi":"10.1021/acsagscitech.4c0052010.1021/acsagscitech.4c00520","DOIUrl":"https://doi.org/10.1021/acsagscitech.4c00520https://doi.org/10.1021/acsagscitech.4c00520","url":null,"abstract":"<p >Polyvinyl chloride microplastics (PVC-MPs) pollution is drawing increasing attention, especially due to concerns about the environmental safety of the diverse additives that they contain. To date, few ecotoxicity data are available for PVC MP-derived chemicals. Here, wheat (<i>Triticum aestivum</i> L.) seedling roots were used to comparatively evaluate the toxicity of three commonly studied PVC MP-derived chemicals (<i>2,4-dimethyl-6-s-hexadecylphenol</i>─Irganox 1076 and <i>tris (2,4-ditert-butylphenyl) phosphate</i>─Irgafos 168-ox, and <i>erucamide</i>─Eru). These chemicals were evaluated individually and in combination. Exposure to these chemicals caused dose-dependent reductions in root dry weight (0.39%–19.29%) and root length (0.11%–8.15%). While Irganox 1076 and Eru had minimal impact on root activity and the antioxidant system, Irgafos 168-ox and its mixture induced significant elevations of antioxidant enzymes (SOD, CAT, and APX) activities and antioxidants (AsA and GSH) concentrations in the roots, enhancing the antioxidant level. Our findings indicate that the coexposure of PVC MP-derived chemicals exerts an additive effect on antioxidant response inhibition. Irgafos 168-ox showed stronger effects with the maximum toxic concentration of 10 mg L^–1, whether alone or in additive mixtures, due to its higher potential for root accumulation and oxidative stress induction. These results highlight the need for further research into ecological risks of PVC MP-derived chemicals, particularly under combined exposure scenarios.</p>","PeriodicalId":93846,"journal":{"name":"ACS agricultural science & technology","volume":"5 2","pages":"166–175 166–175"},"PeriodicalIF":2.3,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143418689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Facile Synthesis and Optimization of Graphitic Carbon Nitride Nanoparticles to Effectively Photodegrade Tetracycline under Visible Light in Water","authors":"Sheng-Eng Huang,&nbsp;Kok-Hou Tan,&nbsp;Rama Shanker Sahu,&nbsp;Tesfaye Abebe Geleta,&nbsp;Ashkan Miri,&nbsp;Chen-yu Lin,&nbsp;Yang-hsin Shih* and Wen-Ling Chen,&nbsp;","doi":"10.1021/acsagscitech.4c0063710.1021/acsagscitech.4c00637","DOIUrl":"https://doi.org/10.1021/acsagscitech.4c00637https://doi.org/10.1021/acsagscitech.4c00637","url":null,"abstract":"<p >The rapid development of industry and medicine in modern society has produced a group of emerging contaminants (ECs) that are harmful to the ecosystem and difficult to remove from the environment. In this study, several graphitic carbon nitrides (GCNs) have been successfully synthesized by the calcination method, and their efficiency in the photocatalytic degradation of tetracyclines (TCs) was evaluated under the irradiation of visible light (λ = 420 nm). CNU achieved the highest TC degradation efficiency by completely degrading tetracycline within 90 min. The best degradation rate constant of 18.9 × 10^–3 min^–1 was obtained at pH 7, which is 17-fold and 1.5-fold than that at pH 3 and pH 5, respectively. Above pH 7, the degradation rate sharply rose due to the alkaline hydrolysis of TCs. The addition of common electrolytes has been shown to reduce the photocatalytic degradation rate as a result of photocatalyst aggregation. The results of EPR, scavenging tests, and LC-QTOF/MS analysis showed that the photogenerated holes and •O₂^– produced by CNU upon photoirradiation degrade TC into small organic molecules such as 1-tetralone and 3-formyl propanoic acid. This study demonstrated the ease of environmentally friendly GCN preparation and their potential for the removal of ECs from the environment.</p>","PeriodicalId":93846,"journal":{"name":"ACS agricultural science & technology","volume":"5 2","pages":"235–245 235–245"},"PeriodicalIF":2.3,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsagscitech.4c00637","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143418636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can Quantum Science and Technology Accelerate the Pace and Impact of Agricultural Research?","authors":"Laura L. McConnell*,&nbsp; and ,&nbsp;Thomas Hofmann,&nbsp;","doi":"10.1021/acsagscitech.4c0081610.1021/acsagscitech.4c00816","DOIUrl":"https://doi.org/10.1021/acsagscitech.4c00816https://doi.org/10.1021/acsagscitech.4c00816","url":null,"abstract":"","PeriodicalId":93846,"journal":{"name":"ACS agricultural science & technology","volume":"5 1","pages":"1–2 1–2"},"PeriodicalIF":2.3,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143089496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Silico Evaluation and Simulation-Based Prioritization of Herbicide-like Compounds Targeting Phalaris minor Acetyl-CoA Carboxylase","authors":"Bikash Kumar Rajak,&nbsp;Priyanka Rani,&nbsp;Nitesh Singh and Durg Vijay Singh*,&nbsp;","doi":"10.1021/acsagscitech.4c0063510.1021/acsagscitech.4c00635","DOIUrl":"https://doi.org/10.1021/acsagscitech.4c00635https://doi.org/10.1021/acsagscitech.4c00635","url":null,"abstract":"<p ><i>Phalaris minor</i>, a notorious weed commonly found in wheat fields, exhibits an aggressive growth rate that makes it a persistent threat to wheat crops. Complicating matters, the weed and wheat share phenotypic similarities during their early growth stages, making manual weeding challenging. As a result, herbicide application has become the primary method for controlling <i>P. minor</i> infestations. However, the excessive use of herbicides has led to the evolution of resistant <i>P. minor</i> biotypes, rendering many commercially available herbicides less effective. This pressing issue underscores the need for developing novel herbicides, which are the central focus of our study. A computational structure-based virtual screening approach has been employed on ZINC15, CHEMBL, and DrugBank databases to identify herbicide-like compounds. The filtered candidates have been evaluated for their binding affinity, benchmarked against the widely used herbicides diclofop (aryloxyphenoxypropionates, i.e., FOP) and tepraloxydim (cyclohexanediones, i.e., DIM), which have inhibiting activity against acetyl-CoA carboxylase (ACCase). Subsequently, molecular dynamics simulations for 100 ns were conducted on the filtered compounds complexed with the modeled ACCase protein of <i>P. minor</i>. Simulated trajectory analysis revealed the interaction dynamics and stability of the selected candidate compounds (CID 44331977, CID 118061654, CID 25783158, and CID 136016466). Simulated trajectories have also been analyzed for their binding free energies to stipulate the stability and strength of interactions. A deeper insight into the dynamics of simulated complex principal component analysis of the trajectories has been analyzed followed by mapping of Gibbs free energy on the free energy landscape plot, which ensured the stability of selected molecules. The in silico analysis proved these compounds possess herbicide-like properties with possible activity against the ACCase protein of <i>P. minor</i>.</p>","PeriodicalId":93846,"journal":{"name":"ACS agricultural science & technology","volume":"5 2","pages":"222–234 222–234"},"PeriodicalIF":2.3,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143418740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Soybean Expeller Dietary Supplementation on the Antioxidant Status of Heifers during the Breeding Season","authors":"Daniela C. García*,&nbsp;Daiana R. Peralta,&nbsp;Mariela Roldán-Olarte,&nbsp;Alfredo A. Martín,&nbsp;Milda A. Vella,&nbsp;Elisa M. García,&nbsp;Olegario Hernández and Mónica A. Nazareno,&nbsp;","doi":"10.1021/acsagscitech.4c0062310.1021/acsagscitech.4c00623","DOIUrl":"https://doi.org/10.1021/acsagscitech.4c00623https://doi.org/10.1021/acsagscitech.4c00623","url":null,"abstract":"<p >This study evaluated the effect of soybean expeller (SBE) dietary supplementation on plasma antioxidant status in beef heifers during a four-month natural breeding season. Thirty-two heifers were assigned into two groups over two consecutive years. One group grazed on <i>Rhodes grass</i> without SBE supplementation during the breeding season (LSBE; <i>n</i> = 16), while the other received SBE supplementation at 0.6% of body weight (BW) during the breeding season (HSBE; <i>n</i> = 16). Plasma was analyzed for total phenolic compounds, flavonoids, antiradical activity, and overall antioxidant capacity. Oxidative stress was measured using the thiobarbituric acid reactive substances (TBARS) assay to assess malondialdehyde (MDA) levels. Heifers receiving SBE had significantly higher antioxidant levels and lower oxidative stress, as indicated by reduced MDA levels, compared to the LSBE group. However, no significant differences were found on pregnancy rates, calving attributes, or postparturition recovery between the groups. These findings suggest that SBE supplementation enhances plasma antioxidant capacity and reduces oxidative damage in beef heifers without affecting reproductive outcomes.</p>","PeriodicalId":93846,"journal":{"name":"ACS agricultural science & technology","volume":"5 2","pages":"201–205 201–205"},"PeriodicalIF":2.3,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143418741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Residual Levels of Three Fungicide (Difenoconazole, Flusilazole, Tebuconazole) Seed Coating Treatments in Corn and Chronic Dietary Risk Assessment for Different Populations","authors":"Dongliang Li,&nbsp;Yigeng Wang,&nbsp;Ning Nan,&nbsp;Fengwen Zhang*,&nbsp;Chuanying Cheng,&nbsp;Xiaoyan Zhao,&nbsp;Xingyin Jiang*,&nbsp;Xiangdong Li and Yanping Tian,&nbsp;","doi":"10.1021/acsagscitech.4c0065710.1021/acsagscitech.4c00657","DOIUrl":"https://doi.org/10.1021/acsagscitech.4c00657https://doi.org/10.1021/acsagscitech.4c00657","url":null,"abstract":"<p >To reduce the negative effects of excessive pesticide use, advancements have been made in the development and application of seed coating agents that require low application rates while maintaining prolonged efficacy. However, the distribution of systemic pesticides in seed coating agents across various parts of the crop can be uneven. Therefore, it is important to study the distribution and transport of systemic pesticides in seed coating agents during crop growth. This study used high-performance liquid chromatography coupled with triple quadrupole mass spectrometry to analyze the growth rate of corn treated with seed coating agents containing three commonly used triazole fungicides: difenoconazole, tebuconazole, and flusilazole. The differences in the absorption and transport of these triazole fungicides were examined, and a chronic dietary risk assessment was conducted. Results showed that all three triazole fungicides were absorbed into corn via roots and were subsequently transported to the stems and leaves; however, the absorption and transport rates of the different pesticides varied significantly. The concentrations of the fungicide residues were consistently the highest in the roots, with tebuconazole being transported upward and difenoconazole exhibiting minimal upward transport. Dietary risk assessment revealed that the chronic risk quotients for difenoconazole, flusilazole, and tebuconazole in corn were 76.625, 55.143, and 36.095%, respectively, indicating that these fungicides posed no significant risk to human health in China. This study provides an important reference for the scientific application of triazole fungicide seed coating agents in corn.</p>","PeriodicalId":93846,"journal":{"name":"ACS agricultural science & technology","volume":"5 2","pages":"268–279 268–279"},"PeriodicalIF":2.3,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143418728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rice-YOLO: An Automated Insect Monitoring in Rice Storage Warehouses with the Deep Learning Model","authors":"P Vinass Jamali,&nbsp;Eyarkai Nambi*,&nbsp;Loganathan M,&nbsp;Shanmugasundaram Saravanan and Chandrasekar V,&nbsp;","doi":"10.1021/acsagscitech.4c0063310.1021/acsagscitech.4c00633","DOIUrl":"https://doi.org/10.1021/acsagscitech.4c00633https://doi.org/10.1021/acsagscitech.4c00633","url":null,"abstract":"<p >Grain storage is an essential component of grain supply chain management that guarantees food security within the nation. Inaccurate diagnosis of insect infestation during grain storage might lead to misinterpretation of fumigation, resulting in substantial qualitative and quantitative losses of grains. This work introduces a new deep learning model called “Rice-YOLO” (You Only Look Once) that addresses the shortcomings of existing insect detection methods. The model offers a high level of accuracy and real-time performance. This model has been optimized to accurately identify <i>Tribolium castaneum</i> and <i>Rhyzopertha dominica</i> in stored rice grains, under different background and lighting circumstances. YOLOv7 (YOLOv7 and x) and YOLOv8 (l/m/x/s/n) were the models used to train, test, and validate the insect data sets. The performance of these state-of-the-art deep learning models was assessed. YOLOv8 obtained remarkable outcomes on the Rice data set. It achieved 97.7% mean average precision (mAP) and 97.5% recall for <i>T. castaneum</i>, as well as a precision of 95.5%. <i>R. dominica</i> scored a mAP of 96.2% and a recall of 93%. The model took around 7.68 min to process and detect <i>T. castaneum</i> and <i>R. dominica</i>. The top-performing YOLOv8n model was then deployed on a laptop achieving a detection speed of 22 fps and an inference time of 6.4 ms. The findings indicated that the algorithm was rapid and effective in detecting, identifying, and quantifying insect pests in stored grains. This could facilitate the automatic identification of insects in warehouses and grain storage facilities involved in effective postharvest management.</p>","PeriodicalId":93846,"journal":{"name":"ACS agricultural science & technology","volume":"5 2","pages":"206–221 206–221"},"PeriodicalIF":2.3,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143418775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing the Catalytic Specificity of the β-Glucuronidase AtGUS from Aspergillus terreus Li-20 by Site-Directed Mutagenesis on Loop 8","authors":"Yanli Liu,&nbsp;Xinying Li,&nbsp;Ruichen Cheng,&nbsp;Chao Wang,&nbsp;Dazhang Dai* and Chun Li*,&nbsp;","doi":"10.1021/acsagscitech.4c0047710.1021/acsagscitech.4c00477","DOIUrl":"https://doi.org/10.1021/acsagscitech.4c00477https://doi.org/10.1021/acsagscitech.4c00477","url":null,"abstract":"<p ><i>At</i>GUS, identified in the genome of <i>Aspergillus terreus</i> Li-20, can hydrolyze glycyrrhetinic (GL) into glycyrrhetinic acid monoglucuronide (GAMG) and glycyrrhetinic acid (GA). However, the poor substrate specificity of <i>At</i>GUS often limits its further application. In this study, the highly conserved Glu416 and Glu507 residues were identified as the catalytic sites of <i>At</i>GUS, while Glu158, Asp163, and Arg565, which form hydrogen bonds with the substrate, play critical roles in the enzymatic activity, with Arg565 being particularly important. When Arg565 on loop 8 of the surface of the TIM barrel was mutated to glutamate, GAMG became the sole catalytic product, and the yield of GAMG from GL conversion was up to 85%. When the hydrolysis reaction was terminated, the yield of GAMG was 7.32-fold higher than that of the wild enzyme. Molecular docking and dynamic simulation analyses revealed that the affinity for the mutant R565E (<i>K</i>_m = 0.192 mmol/L) to the substrate GL was improved, but with reduced catalytic efficiency toward GAMG (<i>k</i>_<i>c</i>at = 5.515 ± 0.07 mmol^–1 L s^–1). This study provides new insights into understanding the catalytic mechanism and new ideas for efficient enzymatic preparation of GAMG.</p>","PeriodicalId":93846,"journal":{"name":"ACS agricultural science & technology","volume":"5 2","pages":"158–165 158–165"},"PeriodicalIF":2.3,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143418789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the Impact of Crop Oil Concentrate on the Persistence and Penetration of Pesticides Applied on Apples","authors":"Xinyi Du,&nbsp;Jeffery Doherty,&nbsp;Junghak Lee,&nbsp;John M. Clark and Lili He*,&nbsp;","doi":"10.1021/acsagscitech.4c0058710.1021/acsagscitech.4c00587","DOIUrl":"https://doi.org/10.1021/acsagscitech.4c00587https://doi.org/10.1021/acsagscitech.4c00587","url":null,"abstract":"<p >The present study systemically investigated the influence of crop oil concentrate (COC) on the pesticide behavior on apples. Surface-enhanced Raman scattering was employed to monitor the persistence and penetration of carbaryl (a systemic insecticide) and thiram (a nonsystemic fungicide). The results revealed that COC significantly enhanced the penetration depth of carbaryl by 38.7% and increased the relative Raman intensity within plant tissue (<i>Z</i> = −120 μm) by 81.3% after 1-day exposure. Liquid chromatography with tandem mass spectrometry confirmed that COC increased the internalized carbaryl residues by 176.6%. For thiram, COC reduced its persistence when exposed to NaHCO₃ hydrolysis, decreasing removal efficiency by 38.96% after 1 day and 38.13% after 3 days, while not affecting its penetration profile. These findings highlight COC’s potential to enhance systemic pesticide penetration while facilitating the removal of surface residue, offering valuable insights for developing safer and more effective pesticide application strategies.</p>","PeriodicalId":93846,"journal":{"name":"ACS agricultural science & technology","volume":"5 2","pages":"176–187 176–187"},"PeriodicalIF":2.3,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143418768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}