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A novel IVGTT model including interstitial insulin 包括间质胰岛素在内的新型IVGTT模型
Mathematics in applied sciences and engineering Pub Date : 2023-02-20 DOI: 10.5206/mase/15505
Jiaxu Li, Jin Jun, Xu Rui, Yu Lei, Jin Zhen
{"title":"A novel IVGTT model including interstitial insulin","authors":"Jiaxu Li, Jin Jun, Xu Rui, Yu Lei, Jin Zhen","doi":"10.5206/mase/15505","DOIUrl":"https://doi.org/10.5206/mase/15505","url":null,"abstract":"Minimal Model (MM) is the top-scoring model for assessing physiological characteristics to diagnose the potential or onset of type 2 diabetes mellitus (T2DM) through the intravenous glucose tolerance test (IVGTT) for the past four decades. Nevertheless it has been arguable that MM method either overestimates glucose effectiveness (GE) or underestimates insulin sensitivity (IS) in some cases by both biologists through in vivo experiments and mathematicians by analysis and/or simulations. We propose a novel model including the interstitial insulin according to physiology and adapted from the well accepted Sturis’ model for the glucose-insulin metabolic system suitable to the IVGTT setting. Our model consistently overcomes the aforementioned defects in a subgroup of subjects. In addition, the variable X for insulin action in MM might be appropriately interpreted as an increment of insulin in the interstitial space in response to the bolus stimulus, rather than being proportional to the interstitial insulin as believed.","PeriodicalId":93797,"journal":{"name":"Mathematics in applied sciences and engineering","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44030705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fisher information approach to understand the Gompertz model 理解Gompertz模型的Fisher信息方法
Mathematics in applied sciences and engineering Pub Date : 2022-12-26 DOI: 10.5206/mase/15447
A. Al-Saffar, Eun-jin Kim
{"title":"Fisher information approach to understand the Gompertz model","authors":"A. Al-Saffar, Eun-jin Kim","doi":"10.5206/mase/15447","DOIUrl":"https://doi.org/10.5206/mase/15447","url":null,"abstract":"As a measure of sustainability, Fisher information is employed in the Gompertz growth model. The effect of different oscillatory modulations is examined on the system's evolution and Probability Density Function (PDF). For a sufficiently large frequency of periodic fluctuations occurring in both positive and negative feedbacks, the system maintains its initial conditions. A similar PDF is shown regardless of the initial values when there are periodic fluctuations in positive feedback. By periodic fluctuations in negative feedback, the Gompertz model can lose its self-organization. Finally, despite the fact that the Gompertz and logistic systems evolve differently over time, the results show that they are exceptionally similar in terms of information and sustainability.","PeriodicalId":93797,"journal":{"name":"Mathematics in applied sciences and engineering","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49402682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
A study on the mild solution of special random impulsive fractional differential equations 一类特殊随机脉冲分数阶微分方程温和解的研究
Mathematics in applied sciences and engineering Pub Date : 2022-12-14 DOI: 10.5206/mase/14985
Sayooj Aby Jose, Varun Bose C S, Bijesh P Biju, Abin Thomas Nirappathu house
{"title":"A study on the mild solution of special random impulsive fractional differential equations","authors":"Sayooj Aby Jose, Varun Bose C S, Bijesh P Biju, Abin Thomas Nirappathu house","doi":"10.5206/mase/14985","DOIUrl":"https://doi.org/10.5206/mase/14985","url":null,"abstract":"In this article, we deal with mild solution of special random impulsive fractional differential equations. Initially, we present the existence of the mild solution via Leray-Schauder fixed point method. After that, we establish the exponential stability of the system. Finally, we give examples to illustrate the effectiveness of the theoretical results.","PeriodicalId":93797,"journal":{"name":"Mathematics in applied sciences and engineering","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43678073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Combination therapy for cancer with IL-27 and anti-PD-1: A simplified mathematical model IL-27和抗pd -1联合治疗癌症:一个简化的数学模型
Mathematics in applied sciences and engineering Pub Date : 2022-12-09 DOI: 10.5206/mase/15100
Kenton D. Watt, Kang-Ling Liao
{"title":"Combination therapy for cancer with IL-27 and anti-PD-1: A simplified mathematical model","authors":"Kenton D. Watt, Kang-Ling Liao","doi":"10.5206/mase/15100","DOIUrl":"https://doi.org/10.5206/mase/15100","url":null,"abstract":"Many experiential and clinical trials in cancer treatment show that a combination of immune checkpoint inhibitor with another agent can improve the tumor reduction. Anti Programmed death 1 (Anti-PD-1) is one of these immune checkpoint inhibitors that re-activate immune cells to inhibit tumor growth.  In this work, we consider a combination treatment of anti-PD-1 and Interleukin-27 (IL-27). IL-27 has anti-cancer functions to promote the development of Th1 and CD8$^+$ T cells, but it also upregulates the expression of PD-1 and Programmed death ligand 1 (PD-L1) to inactivate these T cells. Thus, the functions of IL-27 in tumor growth is controversial. Hence, we create a simplified mathematical model to investigate whether IL-27 is pro-cancer or anti-cancer in the combination with anti-PD-1 and to what degree anti-PD-1 improves the efficacy of IL-27. Our synergy analysis for the combination treatment of IL-27 and anti-PD-1 shows that (i) ant-PD-1 can efficiently improve the treatment efficacy of IL-27; and (ii) there exists a monotone increasing function $F_c(G)$ depending on the treatment efficacy of anti-PD-1 $G$ such that IL-27 is an efficient anti-cancer agent when its dose is smaller than $F_c(G)$, whereas IL-27 is a pro-cancer agent when its dose is higher than $F_c(G)$. Our analysis also provides the existence and the local stability of the trivial, non-negative, and positive equilibria of the model. Combining with simulation, we discuss the effect of the IL-27 dosage on the equilibria and find that the T cells and IFN-$gamma$ could vanish and tumor cells preserve, when the production rate of T cells by IL-27 is low or the dosage of IL-27 is low.","PeriodicalId":93797,"journal":{"name":"Mathematics in applied sciences and engineering","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48709606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The existence and uniqueness of solutions of a nonlinear toxin-dependent size-structured population model 一类非线性毒素依赖大小结构种群模型解的存在唯一性
Mathematics in applied sciences and engineering Pub Date : 2022-09-30 DOI: 10.5206/mase/15074
Y. Li, Qihua Huang
{"title":"The existence and uniqueness of solutions of a nonlinear toxin-dependent size-structured population model","authors":"Y. Li, Qihua Huang","doi":"10.5206/mase/15074","DOIUrl":"https://doi.org/10.5206/mase/15074","url":null,"abstract":"In this paper, we study a toxin-mediated size-structured population model with nonlinear reproduction, growth, and mortality rates. By using the characteristic method and the contraction mapping argument, we establish the existence-uniqueness of solutions to the model. We also prove the continuous dependence of solutions on initial conditions.","PeriodicalId":93797,"journal":{"name":"Mathematics in applied sciences and engineering","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47179530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Global stability of a delay HCV dynamics model with cellular proliferation 具有细胞增殖的延迟HCV动力学模型的全局稳定性
Mathematics in applied sciences and engineering Pub Date : 2022-09-10 DOI: 10.5206/mase/14918
Alexis Nangue, Armel Willy Fokam Tacteu, Ayouba Guedlai
{"title":"Global stability of a delay HCV dynamics model with cellular proliferation","authors":"Alexis Nangue, Armel Willy Fokam Tacteu, Ayouba Guedlai","doi":"10.5206/mase/14918","DOIUrl":"https://doi.org/10.5206/mase/14918","url":null,"abstract":"In this work, we propose and investigate a delay cell population model of hepatitis C virus (HCV) infection with cellular proliferation, absorption effect and a nonlinear incidence function. First of all, after having shown the existence of the local solutions of our model, we show the existence of the global solutions and positivity. Moreover, we determine the uninfected equilibrium point and the basic reproduction rate R0, which is a threshold number in mathematical epidemiology. After showing the existence and uniqueness of the infected equilibrium point, we proceed to the study of the local and global stability of this equilibrium. We show that if  R0 < 1, the uninfected equilibrium point is globally asymptotically stable, which means that the disease will disappear and if  R0 > 1, we have a unique infected equilibrium that is globally asymptotically stable under some conditions. Finally, we perform some numerical simulations to illustrate the obtained theoretical results.","PeriodicalId":93797,"journal":{"name":"Mathematics in applied sciences and engineering","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45026529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Macroscopic Analysis Of The Viscous-Diffusive Traffic Flow Model 粘性扩散交通流模型的宏观分析
Mathematics in applied sciences and engineering Pub Date : 2022-07-09 DOI: 10.5206/mase/14626
Gabriel Obed Fosu, A. Adu-Sackey, J. Ackora-Prah
{"title":"Macroscopic Analysis Of The Viscous-Diffusive Traffic Flow Model","authors":"Gabriel Obed Fosu, A. Adu-Sackey, J. Ackora-Prah","doi":"10.5206/mase/14626","DOIUrl":"https://doi.org/10.5206/mase/14626","url":null,"abstract":"Second-order macroscopic traffic models are characterized by a continuity equation and an acceleration equation. Convection, anticipation, relaxation, diffusion, and viscosity are the predominant features of the different classes of the acceleration equation. As a unique approach, this paper presents a new macro-model that accounts for all these dynamic speed quantities. This is done to determine the collective role of these traffic quantities in macroscopic modeling. The proposed model is solved numerically to explain some phenomena of a multilane traffic flow.  It also includes a linear stability analysis. Furthermore, the evolution of speed and density wave profiles are presented under the perturbation of some parameters.","PeriodicalId":93797,"journal":{"name":"Mathematics in applied sciences and engineering","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42538647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A mathematical model of quorum quenching in biofilm colonies and its potential role as an adjuvant for antibiotic treatment 生物膜菌落群体猝灭的数学模型及其作为抗生素治疗辅助剂的潜在作用
Mathematics in applied sciences and engineering Pub Date : 2022-06-16 DOI: 10.5206/mase/14612
M. Ghasemi, Viktoria Freingruber, C. Kuttler, H. Eberl
{"title":"A mathematical model of quorum quenching in biofilm colonies and its potential role as an adjuvant for antibiotic treatment","authors":"M. Ghasemi, Viktoria Freingruber, C. Kuttler, H. Eberl","doi":"10.5206/mase/14612","DOIUrl":"https://doi.org/10.5206/mase/14612","url":null,"abstract":"We extend a previously presented mesoscopic (i.e. colony scale) mathematical model of the reaction of bacterial biofilms to antibiotics. In that earlier model, exposure to antibiotics evokes two responses: inactivation as the antibiotics kill the bacteria, and inducing a quorum sensing based stress response mechanism upon exposure to small sublethal dosages. To this model we add now quorum quenching as an adjuvant to antibiotic therapy. Quorum quenchers are modeled like enzymes that degrade the quorum sensing signal concentration. The resulting model is a quasilinear system of seven reaction-diffusion equations for the dependent variables volume fractions of upregulated (protected), downregulated (unprotected) and inert (inactive) biomass [particulate substances], and for concentrations of a growth promoting nutrient, antibiotics, quorum sensing signal, and quorum quenchers [dissolved substances]. The biomass fractions are subject to two nonlinear diffusion effects: (i) degeneracy, as in the porous medium equation, where biomass vanishes, and (ii) a super-diffusion singularity where as it attains its theoretically possible maximum. We study this model in numerical simulations. Our simulations suggest that for maximum efficacy quorum quenchers should be applied early on before quorum sensing induction in the biofilm can take place, and that an antibiotic strategy that by itself might not be successful can be notably improved upon if paired with quorum quenchers as an adjuvant.\u0000 ","PeriodicalId":93797,"journal":{"name":"Mathematics in applied sciences and engineering","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43112018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Global Analysis of a generalized viral infection temporal model with cell-to-cell transmission and absorption effect under therapy 治疗下具有细胞间传播和吸收效应的广义病毒感染时间模型的全局分析
Mathematics in applied sciences and engineering Pub Date : 2022-05-15 DOI: 10.5206/mase/14663
Alexis Nangue, Paulin Tiomo Lemofouet, Simon Ndouvatama, Kengne Emmanuel
{"title":"Global Analysis of a generalized viral infection temporal model with cell-to-cell transmission and absorption effect under therapy","authors":"Alexis Nangue, Paulin Tiomo Lemofouet, Simon Ndouvatama, Kengne Emmanuel","doi":"10.5206/mase/14663","DOIUrl":"https://doi.org/10.5206/mase/14663","url":null,"abstract":"In virus dynamics, when a cell is infected, the number of virions outside the cells is reduced by one: this phenomenon is known as absorption effect. Most mathematical in vivo models neglect this phenomenon. Virus-to-cell infection and direct cell-to-cell transmission are two fundamental modes whereby viruses can be propagated and transmitted.  In this work, we propose a new virus dynamics model, which incorporates both modes and takes into account the absorption effect and treatment. First we show mathematically and biologically the well-posedness of our model preceded by the result on the existence and the uniqueness of the solutions. Also, an explicit formula for the basic reproduction number R0 of the model is determined. By analyzing the characteristic equations we establish the local stability of the uninfected equilibrium and the infected equilibrium in terms of R0. The global behavior of the model is investigated by constructing an appropriate Lyapunov functional for uninfected equilibrium and by applying a geometric approach to the study of the infected equilibrium. Numerical simulations are carried out, to confirm the obtained theoretical result in a particular case.","PeriodicalId":93797,"journal":{"name":"Mathematics in applied sciences and engineering","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42701270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Modeling road surface potholes within the macroscopic flow framework 在宏观流动框架下对路面凹坑进行建模
Mathematics in applied sciences and engineering Pub Date : 2022-05-15 DOI: 10.5206/mase/14625
Gabriel Obed Fosu, J. Opong, B. E. Owusu, S. Naandam
{"title":"Modeling road surface potholes within the macroscopic flow framework","authors":"Gabriel Obed Fosu, J. Opong, B. E. Owusu, S. Naandam","doi":"10.5206/mase/14625","DOIUrl":"https://doi.org/10.5206/mase/14625","url":null,"abstract":"The continual wearing of road surfaces results to crack and holes called potholes. These road surface irregularities often elongate travel time. In this paper, a second-order macroscopic traffic model is therefore proposed to account for these road surface irregularities that affect the smooth flow of vehicular traffic. Though potholes do vary in shape and size, for simplicity the paper assumes that all potholes have conic resemblances. The impact of different sized potholes on driving is experimented using fundamental diagrams. Besides, the width of these holes, driver reaction time amid these irregularities also determine the intensity of the flow rate and vehicular speed. Moreover, a local cluster analysis is performed to determine the effect of a small disturbance on flow. The results revealed that the magnitude of amplification on a road surface with larger cracks is not as severe as roads with smaller size holes, except at minimal and jam density where all amplifications quickly fade out.","PeriodicalId":93797,"journal":{"name":"Mathematics in applied sciences and engineering","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44229743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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