包括间质胰岛素在内的新型IVGTT模型

IF 0.4 Q4 MATHEMATICS, APPLIED
Jiaxu Li, Jin Jun, Xu Rui, Yu Lei, Jin Zhen
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引用次数: 0

摘要

最小模型(MM)是过去四十年来通过静脉葡萄糖耐量试验(IVGTT)评估生理特征以诊断2型糖尿病(T2DM)的潜在或发病的最高评分模型。然而,生物学家通过体内实验和数学家通过分析和/或模拟,在某些情况下,MM方法要么高估了葡萄糖有效性(GE),要么低估了胰岛素敏感性(IS),这是有争议的。我们根据生理学提出了一种新的模型,包括间质胰岛素,并改编自公认的Sturis模型,用于适合IVGTT环境的葡萄糖-胰岛素代谢系统。我们的模型一致地克服了受试者亚组中的上述缺陷。此外,MM中胰岛素作用的变量X可以适当地解释为间质空间中胰岛素对推注刺激的反应增加,而不是与间质胰岛素成比例。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A novel IVGTT model including interstitial insulin
Minimal Model (MM) is the top-scoring model for assessing physiological characteristics to diagnose the potential or onset of type 2 diabetes mellitus (T2DM) through the intravenous glucose tolerance test (IVGTT) for the past four decades. Nevertheless it has been arguable that MM method either overestimates glucose effectiveness (GE) or underestimates insulin sensitivity (IS) in some cases by both biologists through in vivo experiments and mathematicians by analysis and/or simulations. We propose a novel model including the interstitial insulin according to physiology and adapted from the well accepted Sturis’ model for the glucose-insulin metabolic system suitable to the IVGTT setting. Our model consistently overcomes the aforementioned defects in a subgroup of subjects. In addition, the variable X for insulin action in MM might be appropriately interpreted as an increment of insulin in the interstitial space in response to the bolus stimulus, rather than being proportional to the interstitial insulin as believed.
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来源期刊
CiteScore
1.40
自引率
0.00%
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审稿时长
21 weeks
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