Advances in neurology and neuroscience最新文献

{"title":"Ntenga Syndrome: About an Observation","authors":"","doi":"10.33140/an.03.03.03","DOIUrl":"https://doi.org/10.33140/an.03.03.03","url":null,"abstract":"Ntenga syndrome, is one of the highly epileptogenic, non-metabolic craniopathy whose aetiology is not yet known. This syndrome makes a differential diagnosis with that of Morgagni-Stewart-Morel which is rare and / or rarely mentioned in current clinical practice (entity made of frontal hyperostosis, neuropsychiatric and endocrine disorders). We report here a 58 years old female patient from Lubumbashi/ Democratic republic of Congo, followed for several years for multiform seizures, in whom the explorations of a status epilepticus, made possible to set up a new syndromic entity, called Ntenga syndrome made of a symptomatic triad (persistent multiform epileptic seizures, absence of endocrine disorder, hyperostosis frontalis interna). To date, a therapeutic protocol made of valproic acid and levetiracetam has significantly reduced to one seizure per month or even every 2 months. I think it is not without interest to report a very rare and / or new entity in the clinic.","PeriodicalId":93246,"journal":{"name":"Advances in neurology and neuroscience","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46739334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Study of Suicidal Behavior and Indicators of Electrolyte Blood Composition in Borderline Mental Disorders under the Influence of Combined Psychopharmacotherapy","authors":"","doi":"10.33140/an.03.03.01","DOIUrl":"https://doi.org/10.33140/an.03.03.01","url":null,"abstract":"The formation of new approaches to the treatment of neurotic disorders, taking into account pathogenetic mechanisms, is an urgent task in neurology and psychiatry, due to the high prevalence of this group of diseases, the risk of developing suicidal behavior, a negative impact on the quality of human life, aggravating the course of somatic diseases, contributing to the development of physical and mental and social maladaptation with limited professional activity and disability. According to the WHO, in 2015 Anxiety Depressive Disorder (MAD) caused 50 million people to be disabled. A disappointing forecast of WHO experts is that while maintaining current trends in the spread of the disease by 2020, TDR will be in second place after coronary heart disease in the number of years lost due to disability [6]. In this regard, the purpose of this study was to study the structure of depressive disorders, suicidal behavior of patients in the Republic of Mordovia (Russia), as well as to study the characteristics of the course of psychopathological anxiety-depressive disorders in the framework of the most frequent nosological forms of diseases in Mordovia - neurotic and reactive depressions, as well as chronic forms - neurotic personality development in comparison with psychopathy under the influence of traditional psychopharmacotherapy and combined treatment with antioxidant drugs.","PeriodicalId":93246,"journal":{"name":"Advances in neurology and neuroscience","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44696202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of LedEmitting and Fluorescent Lighting on the Stress Evoked Cerebral Dysfunctions and Electric Activity of the Brain","authors":"","doi":"10.33140/an.03.02.06","DOIUrl":"https://doi.org/10.33140/an.03.02.06","url":null,"abstract":"The study of the effect of LED lighting on the physiological functions of the body takes on a special role, taking into account the already proven facts of the effectiveness of such effects primarily on the organ of vision, especially on the retina, skin condition and various mechanisms of protein metabolism, as well as the activity of expression of certain genes. In our study, an attempt was made to study the role of this radiation on the main indicators of brain function under stress, especially the nature of changes in its bioelectric activity. It seems to us that this study will help to better understand the work of this key human organ in conditions of protective light-emitting radiation under various stress effects.","PeriodicalId":93246,"journal":{"name":"Advances in neurology and neuroscience","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47456041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spinal Subdural Abscess Mimicking An Intradural-Extramedullary Tumor- A Rare Case Scenario","authors":"","doi":"10.33140/an.03.02.08","DOIUrl":"https://doi.org/10.33140/an.03.02.08","url":null,"abstract":"Spinal subdural abscesses (SSA) are very rare disease. The etiologies of SSA are hematogenous spread, iatrogenic contamination, and local extension. Elevated WBC counts, ESR, and C-reactive protein are usually found in laboratory tests. But they are not sensitive indicators of SSA, especially chronic abscesses patient tend to have a less specific characteristic. We report the case of a healthy child with subdural abscess referred to our hospital as an intradural– extramedullary (IDEM) tumor.","PeriodicalId":93246,"journal":{"name":"Advances in neurology and neuroscience","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42966662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparision of Spinopelvis Alignment with Short Segment Reduction and Fusion (Plif) In Low and High Grade Spondylolistesis","authors":"","doi":"10.33140/an.03.02.07","DOIUrl":"https://doi.org/10.33140/an.03.02.07","url":null,"abstract":"Study Design: A prospective clinicoradiological study of PLIF was conducted in similar types and high grades > 2 spondylolisthesis in 40 patients, with 20 patients as controls with grade < 2. Objective: The objective was to assess the clinicoradiological profile of various spinopelvic parameters like pelvic incidence, pelvic version, sacrohorizontal angle, slip reduction and disc height increment using structural and standalone graft and its consequences on the post-operative outcome as assessed by Visual Analogue Score and Oswestry Disability Index. Methods: Before starting the study Institutional ethical committee approval was taken and approval no 654 was given for the study and prior consents were taken by all the patients included in the study and was documented. This study involved a total number of 40 patients of spondylolisthesis >2 and 20 patients of <2 of all the age groups with progressive neurological deficits, and pain not relieved by conservative measures. All patients underwent wide laminectomy, facetectomy, complete discectomy and posterior lumbar interbody fusion with intraoperative slip reduction maneuvers, disc height maintained with interbody stand-alone graft or structured grafts made of PEEK or Titanium cages. Conclusions: There was no correlation between duration of symptoms and post operative pain reduction. A fusion rates of 92% were achieved with intra operative slip reduction. The results obtained in comparison with slip reduction and post operative pain reduction are directly proportional and statistically not significant. A decrease in pelvic version and increase in sacrohorizontal angle were noted following surgery. Restoration and incrementing the disc height is associated with statistically significant pain relief. Polyetheretherketone (PEEK) inter body spacer has best clinical and radiological outcome in terms of maintenance of the disc height followed by titanium cage and stand alone graft respectively. All these results had significant positive predictive value in all cases of spondylolisthesis > 2 and was statistically insignificant in patients with grade <2.","PeriodicalId":93246,"journal":{"name":"Advances in neurology and neuroscience","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43921993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Humoral Recognition-Behavioral Stress-Coping Glycolipids Produced By Mice Given Repeated Electroconvulsive Treatment","authors":"","doi":"10.33140/an.03.02.05","DOIUrl":"https://doi.org/10.33140/an.03.02.05","url":null,"abstract":"Background: Stress-coping is a core event of mammalians. Depression symptoms are induced by the stress-coping failures. Repeated electroconvulsive treatment gives a strong stress to mammalians, however, the treatment has been used to improve depression symptoms. Mammalians have recognition-behavioral stress-coping neuronal module-system followed by some humoral glycolipids. A sulfated Galbeta1-4GlcNAc-lipid promotes the serotonergic module. GalNAcalpha1-3GalNAc-lipid promotes the adrenergic module. A sulfated Fucalpha1-2Gal-lipid protects the cholinergic module keeping the stress-coping memories from the ischemia-stress. I hypothesized mammalians given repeated electroconvulsive treatment would produce these glycolipids, and would increase the stress-coping ability.Materials and Methods: I examined the glycolipid productions of mice given repeated electroconvulsive treatment under general-anesthesia.Results: I found mice only given the general-anesthesia produced sulfated Galbeta1-4GlcNAc-lipid and GalNAcalpha1-3GalNAc-lipid, and mice given the repeated electroconvulsive treatment under general-anesthesia further produced sulfated Galbeta1-4GlcNAc-lipid and GalNAcalpha1-3GalNAc-lipid, and increased sulfated Fucalpha1-2Gal-lipid production. Conclusion: Depression symptoms are closely related to serotonergic and adrenergic module activities. I understood repeated electroconvulsive treatment would improve depression symptoms via the sulfated Galbeta1-4GlcNAc-lipid and GalNAcalpha1-3GalNAc-lipid productions.","PeriodicalId":93246,"journal":{"name":"Advances in neurology and neuroscience","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43520572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Loss of Smell and Taste: Potential of Using Them as Markers for Early Detection of Covid-19.","authors":"Pinky Kain","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":93246,"journal":{"name":"Advances in neurology and neuroscience","volume":"3 2","pages":"49-50"},"PeriodicalIF":0.0,"publicationDate":"2020-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7611330/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39211248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Loss of Smell and Taste: Potential of Using Them as Markers for Early Detection of Covid-19","authors":"Pinky Kain","doi":"10.33140/an.03.02.04","DOIUrl":"https://doi.org/10.33140/an.03.02.04","url":null,"abstract":"The world is currently witnessing a severe health crisis of its time. Everyone is juggling and struggling to fight a viral disease named Covid-19 (Corona virus disease 2019) caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2). The genome of newly identified virus is less than 30,000 letters long where pathogenesis involve from being asymptomatic to deadly in all age groups. Almost everybody is at a grave risk in such an unpredictable scenario where range of symptoms are so variable from people to people making this pandemic a threat to human race.","PeriodicalId":93246,"journal":{"name":"Advances in neurology and neuroscience","volume":"3 1","pages":"49 - 50"},"PeriodicalIF":0.0,"publicationDate":"2020-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44613289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased Hmgb1 Associated With Low Zinc and Symptom Severity in Children\u0000with Autism","authors":"","doi":"10.33140/an.03.02.03","DOIUrl":"https://doi.org/10.33140/an.03.02.03","url":null,"abstract":"Autistic children often have a high prevalence of immune-related pathologies, such as allergies and autoimmune\u0000diseases, and there is compelling evidence that immune dysfunction is related to the etiology of autism. High-mobility\u0000group box proteins (HMGB1) constitute a family of non-histone and ubiquitous molecules with a pro-inflammatory\u0000function. In this study, we measured HMGB1 levels in autistic individuals and compared these levels to plasma zinc\u0000concentration. We found that in individuals with autism increased levels of HMGB1 was associated with low zinc\u0000levels, as well as increased selected symptom severity. These results suggest that there is a relationship between Zinc\u0000and HMGB1levels in autistic individuals, and that low zinc levels may be exasperating inflammation in these patients.","PeriodicalId":93246,"journal":{"name":"Advances in neurology and neuroscience","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47291968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Humoral Recognition-Behavioral Stress-Coping Glycolipid Considered As another\u0000Biomarker of Psychotic Symptoms of Schizophrenia","authors":"","doi":"10.33140/an.03.01.07","DOIUrl":"https://doi.org/10.33140/an.03.01.07","url":null,"abstract":"Background: Mammalians have the recognition-behavioral stress-coping system regulated via the neuronal modules\u0000followed by some humoral glycolipids. A sulfated Galbeta1-4GlcNAc-lipid which promotes the serotonergic module,\u0000keeps physical strength by regulating emotional behaviors. GalNAcalpha1-3GalNAc-lipid which promotes the\u0000adrenergic module, induces stress-coping behaviors. A sulfated Fucalpha1-2Gal-lipid protects the cholinergic module\u0000maintaining stress-coping memories from the ischemic stress. Sialalpha2-3Gal-lipid which promotes the dopaminergic\u0000module, integrates these recognition-behaviors. It is considered stresses are closely related to onset of schizophrenia,\u0000and the psychotic symptoms are not necessarily deleted after long-time medication. Schizophrenic patients might\u0000abnormally produce the humoral recognition-behavioral stress-coping glycolipids even under medication.\u0000Materials and Methods: I examined the humoral stress-coping glycolipids of medicated schizophrenic patients and\u0000those of medicated manic patients without psychotic symptoms for comparison.\u0000Results: The medicated manic patients increased sulfated Galbeta1-4GlcNAc-lipid production. The medicated\u0000schizophrenic patients increased sulfated Galbeta1-4GlcNAc-lipid production, and remarkably produced Sialalpha2-\u00003Gal-lipid. These indicate the manic patients and the schizophrenic patients had a stress to be coped with the\u0000serotonergic module activity, and psychotic symptoms of the schizophrenic patients would be induced via stress-coping\u0000Sialalpha2-3Gal-lipid production.\u0000Conclusion: The stressors are not clear, however, I understood humoral Sialalpha2-3Gal-lipid would be considered\u0000as another biomarker of psychotic symptoms of schizophrenia.","PeriodicalId":93246,"journal":{"name":"Advances in neurology and neuroscience","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45942862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}