Advances in neurology and neuroscience最新文献

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Cognitive Impairments in Young Men Suffering from Epilepsy 年轻男性癫痫患者的认知障碍
Advances in neurology and neuroscience Pub Date : 2019-09-02 DOI: 10.33140/an.02.01.02
{"title":"Cognitive Impairments in Young Men Suffering from Epilepsy","authors":"","doi":"10.33140/an.02.01.02","DOIUrl":"https://doi.org/10.33140/an.02.01.02","url":null,"abstract":"Epilepsy is a chronic disease of the central system with a wide range of neuropsychiatric disorders. Cognitive\u0000disorders are quite common with this disease and significantly reduce the quality of life of patients and their families.\u0000In approximately 35% of patients, despite treatment, various impairments of memory, attention and bradyphrenia\u0000persist in the interictal period. Causes of cognitive impairment in patients with epilepsy can be directly the underlying\u0000factor of epilepsy (genetic disease, structural brain defect, etc.), epileptic seizures, interictal epileptiform activity,\u0000side effects of antiepileptic drugs (AEDs). Modern neurophysiological and neuroimaging diagnostic methods allow\u0000us to identify new features of the course and progression of dysfunctions of higher nervous activity in epilepsy","PeriodicalId":93246,"journal":{"name":"Advances in neurology and neuroscience","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46521121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Minimal Invazive Surgical Treatment of Piriformis Syndrome and the Results 梨状肌综合征的微创手术治疗及疗效
Advances in neurology and neuroscience Pub Date : 2019-08-07 DOI: 10.33140/an.02.01.01
{"title":"Minimal Invazive Surgical Treatment of Piriformis Syndrome and the Results","authors":"","doi":"10.33140/an.02.01.01","DOIUrl":"https://doi.org/10.33140/an.02.01.01","url":null,"abstract":"Piriformis syndrome is a neuromuscular pain syndrome occurring as a result of compression on the underlying\u0000sciatic nerve due to various causes including the hypertrophy, inflammation, mass lesions or anatomical variations\u0000occuring in the deep gluteal space. Patients with piriformis syndrome often experience pain and numbness in the\u0000hip, thigh and leg, similar to those of sciatica. In addition to clinical findings, electrophysiological examinations\u0000and magnetic resonance imaging (MRI) is useful for diagnosis. Once diagnosed, the treatment approach is stepwise\u0000and conservative treatment is successful in majority of cases. Surgical treatment should be performed for the\u0000cases in whom conservative treatment methods fail and when the sciatic nerve should be decompressed. Surgery\u0000is an important treatment option for unresolved piriformis syndrome with its simplicity and low morbidity. Several\u0000surgical procedures have been described for the decompression of affected sciatic nerve. Due to excessive fibrosis\u0000tissue that may be developed around the sciatic nerve in classical surgical procedures, person's return to social and\u0000work life may be delayed. In the present study, we will evaluate the surgical indication criteria of our cases who\u0000underwent minimally invasive surgical treatment due to piriformis syndrome, the definition of the surgical procedure\u0000and the outcomes.","PeriodicalId":93246,"journal":{"name":"Advances in neurology and neuroscience","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42258957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
A case of Japanese encephalitis misdiagnosed as tuberculous meningoencephalitis 日本脑炎误诊为结核性脑膜脑炎1例
Advances in neurology and neuroscience Pub Date : 2019-03-11 DOI: 10.21203/rs.2.438/v1
Yanjun Liu, Mingming Li, Jie Li, B. Ye
{"title":"A case of Japanese encephalitis misdiagnosed as tuberculous meningoencephalitis","authors":"Yanjun Liu, Mingming Li, Jie Li, B. Ye","doi":"10.21203/rs.2.438/v1","DOIUrl":"https://doi.org/10.21203/rs.2.438/v1","url":null,"abstract":"\u0000 Backgroud\u0000\u0000Japanese encephalitis is a kind of central nervous system infectious disease caused by Japanese encephalitis virus transmitted through mosquito[1].Most patients with JE are acute onset and critically ill, with high fever, disturbance of consciousness, epilepsy, abnormal mental behavior, cognitive impairment, and positive meningeal irritation.\u0000\u0000Case presentation\u0000\u0000A 15-year-old boy was admitted to the hospital with acute febrile illness,headache,jet vomiting,disorder of consciousness,diagnosed as central nervous system (CNS) infection. According to the characteristics of blood and cerebrospinal fluid (CSF), the patient was initially diagnosed with meningoencephalitis and took antituberculosis treatment.However,subsequent magnetic resonance images(MRI) did not match the performance of typical tuberculous meningoencephalitis.Further laboratory testing for infections was conducted. JE was confirmed by the Disease Control Center of Lanzhou City through the detection of Japanese encephalitis IgM antibodies in both blood and CSF of the patients.After diagnosis of JE, the patient was provided the treatment of Human immunoglobulin and methylprednisolone therapy.After 3 weeks, the patient was transferred to the department of rehabilitation medicine to continue treatment. After 3 months and 6 months of follow-up, the patient recovered and the FIM score were 126, which were completely independent.\u0000\u0000Conclusion\u0000\u0000Given the similar clinical manifestations of Japanese encephalitis and other types of encephalitis, it is essential to enhance the awareness of Japanese encephalitis.","PeriodicalId":93246,"journal":{"name":"Advances in neurology and neuroscience","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48276939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Is the Use of Cannabis During Pregnancy a Risk Factor for Autism? 怀孕期间使用大麻是自闭症的危险因素吗?
Advances in neurology and neuroscience Pub Date : 2019-01-01 DOI: 10.35248/2165-7890.19.9.245
S. A. Crawford
{"title":"Is the Use of Cannabis During Pregnancy a Risk Factor for Autism?","authors":"S. A. Crawford","doi":"10.35248/2165-7890.19.9.245","DOIUrl":"https://doi.org/10.35248/2165-7890.19.9.245","url":null,"abstract":"The use of marijuana by healthy adults is commonly viewed as having limited adverse health effects; however, its potential risks for fetal developmental abnormalities when used during pregnancy have not been thoroughly evaluated. It is, therefore, important that the effects of prenatal marijuana on the developing fetus be fully assessed in order to create a proper set of guidelines for use before, during and after pregnancy as is standard with other drugs such as alcohol and nicotine.","PeriodicalId":93246,"journal":{"name":"Advances in neurology and neuroscience","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69987964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharyngeal-Brachial-Cervical variant Guillain-Barre Syndrome in Children: ACase Report and Review of the Literature 儿童咽部-肱部-宫颈变异型格林-巴利综合征病例报告及文献复习
Advances in neurology and neuroscience Pub Date : 2018-09-12 DOI: 10.33140/an.01.01.05
{"title":"Pharyngeal-Brachial-Cervical variant Guillain-Barre Syndrome in Children: A\u0000Case Report and Review of the Literature","authors":"","doi":"10.33140/an.01.01.05","DOIUrl":"https://doi.org/10.33140/an.01.01.05","url":null,"abstract":"Guillain-Barre Syndrome (GBS) is a post-infectious neuropathy\u0000typically described as a bilateral ascending paralysis of the lower\u0000extremities. There are, however, multiple lesser known subtypes of\u0000the syndrome that can affect both adult and pediatric populations.\u0000The Pharyngeal- Brachial-Cervical (PCB) variant is one of the rarer\u0000forms, which presents with weakness of the neck, oropharynx, and\u0000upper extremities. This atypical presentation can be confused with\u0000other diagnoses, and early detection is important for preventing\u0000potentially life-threatening complications. To date, only ten cases\u0000of this entity have been reported in children. Below we report on\u0000a 15-year-old female who presented with left arm weakness who\u0000subsequently progressed to classic GBS and review the literature\u0000on this GBS variant in children.","PeriodicalId":93246,"journal":{"name":"Advances in neurology and neuroscience","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47836206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Increased Sympathetic Tone in Congestive Heart Failure and Comorbid PainAcute Friend Turns Chronic Foe and a Novel Pharmacologic Corrective Approach 充血性心力衰竭和合并症疼痛的交感神经张力增高——急性朋友变成慢性敌人和一种新的药物矫正方法
Advances in neurology and neuroscience Pub Date : 1900-01-01 DOI: 10.33140/an.04.01.03
{"title":"Increased Sympathetic Tone in Congestive Heart Failure and Comorbid PainAcute Friend Turns Chronic Foe and a Novel Pharmacologic Corrective Approach","authors":"","doi":"10.33140/an.04.01.03","DOIUrl":"https://doi.org/10.33140/an.04.01.03","url":null,"abstract":"Acute pain and congestive heart failure (CHF) both increase sympathetic (S) tone, decreasing pain and improving cardiac output. However, chronically high S increases pain and worsens CHF. Mechanisms will be discussed, and off-label ranolazine is a novel potential pharmacologic remedy in chronic CHF: (1) Fifty-four CHF patients were randomized to adjunctive RAN (RANCHF, 1000mg bid) vs. NORANCHF. Autonomic measurements (ANX 3.0 Autonomic Monitor) were taken at baseline and 1 yr. Fifty-nine % of patients in both groups were initially abnormal, including high sympathovagal balance (SB) that normalized in 10/12 (83%) RANCHF patients vs. 2/11 (18%) NORANCHF patients. High SB developed in 5/11 (45%) NORANCHF vs. 1/11(9%) RANCHF patients; (2) Matched CHF patients were given adjunctive RAN (1000 mg po-bid) (RANCHF, 41 systolic, 13 diastolic) vs. NORANCHF (43 systolic, 12 diastolic). Echocardiographic LVEF and autonomic measures were obtained at baseline and follow-up (mean 23.7 months). LVEF increased in 70% of RANCHF patients, an average of 11.3 units. Mean LVEF remained unchanged in NORANCHF patients. At baseline, 28% of patients had high SB. RAN normalized SB in >50%; the NORANCHF group had a 20% increase in patients with high SB. RAN reduced (composite endpoint) CHF admissions, cardiac death, ventricular tachycardia/fibrillation[vt/vf] by 40 % In conclusion, RAN substantially corrects the maladaptive SNS CHF response. Since 1 mechanism of action of RAN is a strongly use-dependent inhibition of the Nav1.7 in S ganglia, RAN should provide pain relief in chronically S-mediated pain syndromes.","PeriodicalId":93246,"journal":{"name":"Advances in neurology and neuroscience","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69507773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Attachment-Based Treatment of Chronic Medical Disorders: Learning from Stress-Based Mental Health Conditions 基于依恋的慢性疾病治疗:从基于压力的精神健康状况中学习
Advances in neurology and neuroscience Pub Date : 1900-01-01 DOI: 10.33140/an.04.01.02
{"title":"Attachment-Based Treatment of Chronic Medical Disorders: Learning from Stress-Based Mental Health Conditions","authors":"","doi":"10.33140/an.04.01.02","DOIUrl":"https://doi.org/10.33140/an.04.01.02","url":null,"abstract":"Adaptation to stressful conditions has been considered as a cause of chronic medical disorders for many years. However, the failure of adaptation involved in the genesis of these disorders has never been connected to mental health conditions that have the same adaptation failures to stress. A failure in the type of attachment in which parents help their children adapt to fearful conditions, which involves the hippocampus and amygdala regions in the brain, might be an underlying cause for both chronic medical disorders and mental health conditions. This paper will provide evidence for the underlying continuity of these conditions, as they relate to a similar type of attachment failure, as it impedes successful adaptation to stress. To demonstrate this continuity, case material is provided on patients with both conditions who are given model treatments that resolve each sequentially, indicating that they have a common attachment-based root. The importance of treating patients’ attachment-based deficits for both their medical and mental health issues concurrently supports using alternative, holistic medical strategies and attachment-based psychotherapy, in which the therapist can experience the fear of the patient and then advocate for them to help them resolve their problems for both types of conditions. The importance of using these therapies in treating chronic medical and mental health conditions is strongly supported by this evidence. These interventions are not adjunctive to the medical treatments but are as primary as the medical interventions in developing more pervasive resolution of the conditions.","PeriodicalId":93246,"journal":{"name":"Advances in neurology and neuroscience","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69507767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacological and Psychoactive Agents for Treatment Resistant Posttraumatic Stress Disorder 治疗难治性创伤后应激障碍的药理学和精神活性药物
Advances in neurology and neuroscience Pub Date : 1900-01-01 DOI: 10.33140/an.04.01.01
{"title":"Pharmacological and Psychoactive Agents for Treatment Resistant Posttraumatic Stress Disorder","authors":"","doi":"10.33140/an.04.01.01","DOIUrl":"https://doi.org/10.33140/an.04.01.01","url":null,"abstract":"The Food and Drug Administration (FDA) approved two selective serotonin reuptake inhibitors (SSRIs) sertraline and paroxetine for the treatment of posttraumatic stress disorder. Many patients do not respond to them and their side effects commonly occur before noticeable therapeutic effects, leading to their discontinuation. Other patients develop treatment resistance to the two approved SSRIs and are treated with other pharmacological agents. A sizable number of patients also do not respond to pharmacological agents and resort to the use of experimental psychoactive agents. This article reviews the definition of treatment resistant posttraumatic stress disorder, and summarizes the various pharmacological and psychoactive agents that have been used for treatment resistant posttraumatic stress disorder including various antidepressants, antipsychotics ,noradrenergic agents, anticonvulsants, mood stabilizers, anxiolytics, hypnotics ,antihistaminergic agents, naltrexone, buprenorphine, D-Cycloserine, neuropeptides, memantine, cannabinoids, 3,4-methylendioxymethamphetamine and ketamine.","PeriodicalId":93246,"journal":{"name":"Advances in neurology and neuroscience","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69507758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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