{"title":"一种体液识别-行为应激应对糖脂被认为是精神分裂症精神病症状的另一生物标志物","authors":"","doi":"10.33140/an.03.01.07","DOIUrl":null,"url":null,"abstract":"Background: Mammalians have the recognition-behavioral stress-coping system regulated via the neuronal modules\nfollowed by some humoral glycolipids. A sulfated Galbeta1-4GlcNAc-lipid which promotes the serotonergic module,\nkeeps physical strength by regulating emotional behaviors. GalNAcalpha1-3GalNAc-lipid which promotes the\nadrenergic module, induces stress-coping behaviors. A sulfated Fucalpha1-2Gal-lipid protects the cholinergic module\nmaintaining stress-coping memories from the ischemic stress. Sialalpha2-3Gal-lipid which promotes the dopaminergic\nmodule, integrates these recognition-behaviors. It is considered stresses are closely related to onset of schizophrenia,\nand the psychotic symptoms are not necessarily deleted after long-time medication. Schizophrenic patients might\nabnormally produce the humoral recognition-behavioral stress-coping glycolipids even under medication.\nMaterials and Methods: I examined the humoral stress-coping glycolipids of medicated schizophrenic patients and\nthose of medicated manic patients without psychotic symptoms for comparison.\nResults: The medicated manic patients increased sulfated Galbeta1-4GlcNAc-lipid production. The medicated\nschizophrenic patients increased sulfated Galbeta1-4GlcNAc-lipid production, and remarkably produced Sialalpha2-\n3Gal-lipid. These indicate the manic patients and the schizophrenic patients had a stress to be coped with the\nserotonergic module activity, and psychotic symptoms of the schizophrenic patients would be induced via stress-coping\nSialalpha2-3Gal-lipid production.\nConclusion: The stressors are not clear, however, I understood humoral Sialalpha2-3Gal-lipid would be considered\nas another biomarker of psychotic symptoms of schizophrenia.","PeriodicalId":93246,"journal":{"name":"Advances in neurology and neuroscience","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2020-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":"{\"title\":\"A Humoral Recognition-Behavioral Stress-Coping Glycolipid Considered As another\\nBiomarker of Psychotic Symptoms of Schizophrenia\",\"authors\":\"\",\"doi\":\"10.33140/an.03.01.07\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: Mammalians have the recognition-behavioral stress-coping system regulated via the neuronal modules\\nfollowed by some humoral glycolipids. A sulfated Galbeta1-4GlcNAc-lipid which promotes the serotonergic module,\\nkeeps physical strength by regulating emotional behaviors. GalNAcalpha1-3GalNAc-lipid which promotes the\\nadrenergic module, induces stress-coping behaviors. A sulfated Fucalpha1-2Gal-lipid protects the cholinergic module\\nmaintaining stress-coping memories from the ischemic stress. Sialalpha2-3Gal-lipid which promotes the dopaminergic\\nmodule, integrates these recognition-behaviors. It is considered stresses are closely related to onset of schizophrenia,\\nand the psychotic symptoms are not necessarily deleted after long-time medication. Schizophrenic patients might\\nabnormally produce the humoral recognition-behavioral stress-coping glycolipids even under medication.\\nMaterials and Methods: I examined the humoral stress-coping glycolipids of medicated schizophrenic patients and\\nthose of medicated manic patients without psychotic symptoms for comparison.\\nResults: The medicated manic patients increased sulfated Galbeta1-4GlcNAc-lipid production. The medicated\\nschizophrenic patients increased sulfated Galbeta1-4GlcNAc-lipid production, and remarkably produced Sialalpha2-\\n3Gal-lipid. These indicate the manic patients and the schizophrenic patients had a stress to be coped with the\\nserotonergic module activity, and psychotic symptoms of the schizophrenic patients would be induced via stress-coping\\nSialalpha2-3Gal-lipid production.\\nConclusion: The stressors are not clear, however, I understood humoral Sialalpha2-3Gal-lipid would be considered\\nas another biomarker of psychotic symptoms of schizophrenia.\",\"PeriodicalId\":93246,\"journal\":{\"name\":\"Advances in neurology and neuroscience\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-02-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advances in neurology and neuroscience\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.33140/an.03.01.07\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advances in neurology and neuroscience","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.33140/an.03.01.07","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
A Humoral Recognition-Behavioral Stress-Coping Glycolipid Considered As another
Biomarker of Psychotic Symptoms of Schizophrenia
Background: Mammalians have the recognition-behavioral stress-coping system regulated via the neuronal modules
followed by some humoral glycolipids. A sulfated Galbeta1-4GlcNAc-lipid which promotes the serotonergic module,
keeps physical strength by regulating emotional behaviors. GalNAcalpha1-3GalNAc-lipid which promotes the
adrenergic module, induces stress-coping behaviors. A sulfated Fucalpha1-2Gal-lipid protects the cholinergic module
maintaining stress-coping memories from the ischemic stress. Sialalpha2-3Gal-lipid which promotes the dopaminergic
module, integrates these recognition-behaviors. It is considered stresses are closely related to onset of schizophrenia,
and the psychotic symptoms are not necessarily deleted after long-time medication. Schizophrenic patients might
abnormally produce the humoral recognition-behavioral stress-coping glycolipids even under medication.
Materials and Methods: I examined the humoral stress-coping glycolipids of medicated schizophrenic patients and
those of medicated manic patients without psychotic symptoms for comparison.
Results: The medicated manic patients increased sulfated Galbeta1-4GlcNAc-lipid production. The medicated
schizophrenic patients increased sulfated Galbeta1-4GlcNAc-lipid production, and remarkably produced Sialalpha2-
3Gal-lipid. These indicate the manic patients and the schizophrenic patients had a stress to be coped with the
serotonergic module activity, and psychotic symptoms of the schizophrenic patients would be induced via stress-coping
Sialalpha2-3Gal-lipid production.
Conclusion: The stressors are not clear, however, I understood humoral Sialalpha2-3Gal-lipid would be considered
as another biomarker of psychotic symptoms of schizophrenia.