Advances in neurology and neuroscience最新文献_第5页

Repercussions of Stress during Pregnancy and Beyond 怀孕期间及以后压力的影响

Advances in neurology and neuroscience Pub Date : 2021-09-30 DOI: 10.33140/an.04.04.01

引用次数: 0

Psychological Services During the Pandemic and Isolation Period. 流行病和隔离期间的心理服务。

Advances in neurology and neuroscience Pub Date : 2021-09-30 DOI: 10.33140/an.04.04.02

引用次数: 0

Blunt Cerebrovascular Injury with Severe Head Injury 钝性脑血管损伤伴严重颅脑损伤

Advances in neurology and neuroscience Pub Date : 2021-09-30 DOI: 10.33140/an.04.04.03

{"title":"Blunt Cerebrovascular Injury with Severe Head Injury","authors":"","doi":"10.33140/an.04.04.03","DOIUrl":"https://doi.org/10.33140/an.04.04.03","url":null,"abstract":"Blunt Cerebrovascular Injury (BCVI) are rare and comprises of less than 1% of total head injury in our tertiary neurocenter. This leads to significant morbidity and mortality of patient. This case report is to focus on the BCVI with head injury. Because of rarity of this disease, there’s no treatment guidelines. However whatever the treatment we have is based on the experience of the surgeons/physician our case came to our Emergency Room with alleged history of lying along the road side in pool of blood .He was evaluated in peripheral hospital and he was later transferred to our center. Patient on evaluation was found to have transaction of Right ICA just distal to right Common carotid artery bifurcation. There was associated fracture of spinous process C5, C6. Probable mechanism of injury was sudden hyperextension of neck. Patient presented with delayed stroke following BCVI. He was managed with Right Decompressive hemicraniectomy and anticoagulation therapy was started for Right ICA injury. Thus early diagnosis and treatment of Blunt Cerebrovascular injury is essential in traumatic brain injury patients with risk factors for BCVI for definitive treatment of vascular injury with either stenting or surgery and thereby limiting morbidity and mortality of the patient.","PeriodicalId":93246,"journal":{"name":"Advances in neurology and neuroscience","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46919658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neonates with the KCNQ2 Y755C Variants: Not Associated with Neonatal Epileptic Encephalopathy 携带KCNQ2 Y755C变异的新生儿:与新生儿癫痫性脑病无关

Advances in neurology and neuroscience Pub Date : 2021-07-20 DOI: 10.33140/an.04.03.02

{"title":"Neonates with the KCNQ2 Y755C Variants: Not Associated with Neonatal Epileptic Encephalopathy","authors":"","doi":"10.33140/an.04.03.02","DOIUrl":"https://doi.org/10.33140/an.04.03.02","url":null,"abstract":"Background: Pediatric epilepsy caused by a KCNQ2 gene mutation usually manifests the phenotype of a neonatal seizure. KCNQ2 encephalopathy in newborns continues to be reported on. Objectives: The exact mechanism and phenotype of the KCNQ2 mutation still require investigation. Methods: One hundred twenty-one patients with childhood epilepsy without an identified cause underwent KCNQ2 sequencing. KCNQ2 mutation variants were transfected into human embryonic kidney 293 (HEK293) cells to investigate functional changes. Results: Two patients with the c.2264G>G/A (p.Y755C) variant had neonatal epileptic encephalopathy: one had electroencephalography (EEG) burst suppression and the other had multiple focal spikes. However, the mutation was not found in the 80 healthy adult claiming without ever seizures before. A functional study showed that p.Y755C currents were not different from those in the wild-type and from those in the benign (p.N780T) polymorphism in homomeric and heteromeric (wild-type KCNQ2: mutant = 1:1) transfected HEK293 cells. Electrical current differences between HEK293 cells with wildtype mutations and cells transfected with the wild-type KCNQ2, KCNQ3, and p.Y755C mutations in a 1:2:1 ratio were not significant. Their seizures remitted after they turned 1 year old. Conclusion: We suggest that patients with the KCNQ2 p.Y755C mutations are not associated with neonatal epileptic encephalopathy","PeriodicalId":93246,"journal":{"name":"Advances in neurology and neuroscience","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47297344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Goal Directed Physiotherapy vs a Goal Directed Home Program in AtRisk Infants: A Randomized Clinical Trial 目标导向物理治疗与目标导向家庭计划在高危婴儿中的效果:一项随机临床试验

Advances in neurology and neuroscience Pub Date : 2021-07-20 DOI: 10.33140/an.04.03.04

{"title":"Effect of Goal Directed Physiotherapy vs a Goal Directed Home Program in AtRisk Infants: A Randomized Clinical Trial","authors":"","doi":"10.33140/an.04.03.04","DOIUrl":"https://doi.org/10.33140/an.04.03.04","url":null,"abstract":"Background: Goal directed physiotherapy is a task oriented therapy based on neurodevelopmental principles used in rehabilitation process. The aim of this study is to compare the neurodevelopmental effects of early goal directed physiotherapy with a detailed goal directed home program in infants with risk. Methods: Forty at-risk infants (18 male, 22 female, median age 5.69 mo) were assigned to early goal directed physiotherapy and detailed goal directed home program group randomely. Both early goal directed physiotherapy and detailed goal directed home program continued for 12 weeks. The outcome measures were Hammersmith Infant Neurological Examination, Alberta Infant Motor Scale and Goal Attainment Scale. Results: Significant difference was found in Hammersmith Infant Neurological Examination in early goal directed physiotherapy group (p<0.05) whereas no difference was found in Alberta Infant Motor Scale and Goal Attainment Scale between the groups (p>0.05). In all test results the effect size of early goal directed physiotherapy was more than detailed goal directed home program. Conclusions: According to our results, though Hammersmith Infant Neurological Examination results are better in the early goal directed physiotherapy group, it can be concluded that if parents had good, attainable and eligible guidelines received from the physiotherapist, detailed goal directed home program is also a useful approach in rehabilitation programs of infants with risk.","PeriodicalId":93246,"journal":{"name":"Advances in neurology and neuroscience","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48821222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Primary Carnitine Deficiency and Autism Spectrum Disorder is there a Relationship? 原发性肉碱缺乏与自闭症谱系障碍有关系吗?

Advances in neurology and neuroscience Pub Date : 2021-07-20 DOI: 10.33140/an.04.03.03

{"title":"Primary Carnitine Deficiency and Autism Spectrum Disorder is there a Relationship?","authors":"","doi":"10.33140/an.04.03.03","DOIUrl":"https://doi.org/10.33140/an.04.03.03","url":null,"abstract":"Carnitine plays essential role in energy metabolism .Systemic primary carnitine deficiency is a genetic disorder caused by decreased or absent organic cation transporter type 2 (OCTN2) carnitine transporter activity, resulting in low serum carnitine levels and decreased carnitine accumulation inside cells. The decrease carnitine results in impaired fatty acid oxidation. Primary carnitine deficiency presents a hypoketotic, hypoglycemia and hepatic encephalopathy. Recently, primary carnitine deficiency has been associated with neurodevelopmental disorders including autism spectrum disorders. A seven year-old schoolgirl with intellectual deficit, autistic features and primary carnitine deficiency has been reported. A significant decrease in carnitine levels has been shown in patients with autism and this has been related to the existence of a mitochondrial disease and more severe autism. The early identification of patients with low levels of carnitine or primary carnitine deficiency, with the different methods of measuring free carnitine, including tandem mass spectrometry could help to identify these patients early and achieve an early treatment and better neurological prognosis, because autism spectrum disorders may be preventable in this subgroup. We hope that this paper is useful to neurologists and pediatricians, and may give them more reason to suspect a diagnosis of PCD and autism.","PeriodicalId":93246,"journal":{"name":"Advances in neurology and neuroscience","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42531358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Review of the Co-Occurrence of Posttraumatic Stress Disorder and Mild Traumatic Brain Injury 创伤后应激障碍与轻度颅脑损伤并发研究综述

Advances in neurology and neuroscience Pub Date : 2021-07-20 DOI: 10.33140/an.04.03.05

引用次数: 0

Effect of Bilateral Repetitive Protraction in Antispastic Position Of Suspended Upper Extremity on Motor Performance and Scapular Position in Stroke 上肢悬吊反痉挛位双侧重复牵拉对脑卒中患者运动性能和肩胛位的影响

Advances in neurology and neuroscience Pub Date : 2021-07-20 DOI: 10.33140/an.04.03.01

{"title":"Effect of Bilateral Repetitive Protraction in Antispastic Position Of Suspended Upper Extremity on Motor Performance and Scapular Position in Stroke","authors":"","doi":"10.33140/an.04.03.01","DOIUrl":"https://doi.org/10.33140/an.04.03.01","url":null,"abstract":"Purpose: To find out the effect of bilateral repetitive protraction of suspended upper extremity in anti-spastic position with conventional therapy in patients with hemiplegia due to stroke. Methodology: A total of 36 subjects of hemiplegia due to stroke (post stroke duration more than 3 months) were recruited and distributed in two groups. Group 1 received bilateral repetitive scapular protraction in anti-spastic position of suspended upper extremity along with scapular mobilization in addition to conventional therapeutic exercises. Group 2 received Conventional therapeutic exercises consisted of task specific activity such as bilateral activity on pegboard, ball throwing activity and reaching activities, bilateral active range of motion exercises and weight bearing exercises for upper extremity. Outcome Measures: Universal Goniometer measurements and Fugl-Meyer upper extremity scale were taken prior to the beginning of treatment and after the completion of 4 weeks treatment protocol. Results: Overall results of the study showed significant improvement in active range of motion of the affected upper extremity for shoulder and elbow except wrist in experimental group only. Scapular spine distance improved in both the groups but more significantly in the experimental group. Fugl-Meyer assessment of upper extremity showed more significant improvement in experimental group post 4 week of intervention. Conclusion: Bilateral repetitive protraction in anti-spastic position of suspended upper extremity along with conventional therapeutic exercises for 4 weeks is more effective in improving scapular position and upper extremity motor performance as compared to conventional therapeutic exercise alone.","PeriodicalId":93246,"journal":{"name":"Advances in neurology and neuroscience","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47349717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Features of A Depressive Episode in People Who Had and Haven’t Had Covid-19 患有和未患有Covid-19的人抑郁发作的临床特征

Advances in neurology and neuroscience Pub Date : 2021-06-10 DOI: 10.33140/an.04.02.01

{"title":"Clinical Features of A Depressive Episode in People Who Had and Haven’t Had Covid-19","authors":"","doi":"10.33140/an.04.02.01","DOIUrl":"https://doi.org/10.33140/an.04.02.01","url":null,"abstract":"Objective: In publications, indicate increased anxiety, depression, and aggression of other mental disorders. The literature on psychiatric disorders associated with the depressive episode in people who had COVID-19. However, there are practically is not study clinical features of a depressive episode in people who had and haven’t had COVID-19. Materials and Methods: Eligible 100 participants all women to meeting the DSM-5 criteria, Hamilton Depression Rating Scale and PHQ-9 for depressive episode. Results: Patients who had a depressive episode after the COVID-19 disease were clinically different from those who had had major depressive episodes before COVID-19. On the one hand, this was expressed as a share in the fact that, in the clinical picture of a depressive episode manifested after the COVID-19 disease, visual hallucinations of various contents were encountered. On the other hand, patients who could not tolerate COVID-19, the presence of a pandemic exacerbated the onset of a depressive episode. Conclusion: Clinical features of a depressive episode in people who had and haven’t had COVID-19 dramatically differ from each other. Accordingly, therapy for these conditions is recommended.","PeriodicalId":93246,"journal":{"name":"Advances in neurology and neuroscience","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48300500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deep Brain Stimulation Surgery for Movement Disorders 脑深部刺激手术治疗运动障碍

Advances in neurology and neuroscience Pub Date : 2020-07-25 DOI: 10.33140/an.03.03.02

引用次数: 0